{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:47:58Z","timestamp":1792712878625,"version":"4.5.0"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Molecular Genetics"],"published-print":{"date-parts":[[1999,11,1]]},"DOI":"10.1093\/hmg\/8.12.2325","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T22:20:49Z","timestamp":1027722049000},"page":"2325-2333","source":"Crossref","is-referenced-by-count":320,"title":["Mutations in the Gene Encoding KRIT1, a Krev-1\/rap1a Binding Protein, Cause Cerebral Cavernous Malformations (CCM1)"],"prefix":"10.1093","volume":"8","author":[{"given":"T.","family":"Sahoo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. W.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Kuehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. G.","family":"Dokken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. W.","family":"Touchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. J.","family":"Gallione","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.-Q.","family":"Lee-Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Kosofsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. H.","family":"Kurth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. N.","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Mettler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gil-Nagel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"Rich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Zabramski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. S.","family":"Boguski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A.","family":"Marchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"6","key":"1_4960494","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1056\/NEJM198808113190605","volume":"319","author":"Rigamonti","year":"1988","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"1","key":"2_15973636","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0920-1211(95)00005-U","volume":"21","author":"Gil-Nagel","year":"1995","journal-title":"Epilepsy research","ISSN":"https:\/\/id.crossref.org\/issn\/0920-1211","issn-type":"print"},{"issue":"5","key":"3_15570222","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/00006123-199410000-00041","volume":"34","author":"Tomlinson","year":"1994","journal-title":"Neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0148-396X","issn-type":"print"},{"issue":"3","key":"4_14683014","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3171\/jns.1994.80.3.0422","volume":"80","author":"Zabramski","year":"1994","journal-title":"Journal of neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3085","issn-type":"print"},{"issue":"5","key":"5_16040249","doi-asserted-by":"crossref","first-page":"820","DOI":"10.3171\/jns.1995.83.5.0820","volume":"83","author":"Kondziolka","year":"1995","journal-title":"Journal of neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3085","issn-type":"print"},{"issue":"4","key":"6_16127969","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1227\/00006123-199510000-00001","volume":"37","author":"Maraire","year":"1995","journal-title":"Neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0148-396X","issn-type":"print"},{"issue":"9144","key":"7_6272967","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1016\/S0140-6736(98)03011-6","volume":"352","author":"Labauge","year":"1998","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0140-6736","issn-type":"print"},{"issue":"3","key":"8_15920965","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1093\/hmg\/4.3.453","volume":"4","author":"Dubovsky","year":"1995","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"14","key":"9_15932605","doi-asserted-by":"publisher","first-page":"6620","DOI":"10.1073\/pnas.92.14.6620","volume":"92","author":"Gunel","year":"1995","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"2","key":"10_16027565","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1006\/geno.1995.1147","volume":"28","author":"Marchuk","year":"1995","journal-title":"Genomics","ISSN":"https:\/\/id.crossref.org\/issn\/0888-7543","issn-type":"print"},{"issue":"12","key":"11_37684094","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1093\/hmg\/7.12.1851","volume":"7","year":"1998","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"4","key":"12_16357001","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1101\/gr.5.4.368","volume":"5","author":"Johnson","year":"1995","journal-title":"Genome Research","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"13_37686760","first-page":"492497","volume":"45","year":"1995","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"6","key":"14_16337789","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1097\/00006123-199606000-00059","volume":"38","author":"G\u00a0\u00a0nel","year":"1996","journal-title":"Neurosurgery","ISSN":"https:\/\/id.crossref.org\/issn\/0148-396X","issn-type":"print"},{"issue":"15","key":"15_16183006","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1056\/NEJM199604113341503","volume":"334","author":"Gunel","year":"1996","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"3","key":"16_16714545","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1212\/WNL.48.3.752","volume":"48","author":"Polymeropoulos","year":"1997","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"issue":"9","key":"17_5723304","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1038\/sj.onc.1201268","volume":"15","author":"Serebriiskii","year":"1997","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"issue":"4","key":"18_5891995","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1073\/pnas.95.4.1681","volume":"95","author":"Korkko","year":"1998","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"8","key":"19_10914021","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0968-0004(99)01426-7","volume":"24","author":"Sedgwick","year":"1999","journal-title":"Trends in biochemical sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0167-7640","issn-type":"print"},{"issue":"2","key":"20_16701169","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0968-0004(96)10071-2","volume":"22","author":"Tsukita","year":"1997","journal-title":"Trends in biochemical sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0167-7640","issn-type":"print"},{"issue":"8","key":"21_6169854","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0968-0004(98)01237-7","volume":"23","author":"Chishti","year":"1998","journal-title":"Trends in biochemical sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0167-7640","issn-type":"print"},{"issue":"7","key":"22_16874024","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1101\/gr.7.7.673","volume":"7","author":"Bouffard","year":"1997","journal-title":"Genome Research","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"issue":"2","key":"23_10730006","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1101\/gr.9.2.189","volume":"9","author":"Kuehl","year":"1999","journal-title":"Genome Research","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"issue":"1","key":"24_5102821","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0092-8674(89)90985-9","volume":"56","author":"Kitayama","year":"1989","journal-title":"Cell","ISSN":"https:\/\/id.crossref.org\/issn\/0092-8674","issn-type":"print"},{"issue":"4965","key":"25_9110451","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1126\/science.2164710","volume":"249","author":"Frech","year":"1990","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"4965","key":"26_9110449","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1126\/science.2115210","volume":"249","author":"Zhang","year":"1990","journal-title":"Science","ISSN":"https:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"issue":"8","key":"27_9515087","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1128\/MCB.11.8.3997","volume":"11","author":"Marshall","year":"1991","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"18","key":"28_9483353","doi-asserted-by":"crossref","first-page":"11661","DOI":"10.1016\/S0021-9258(18)99008-3","volume":"266","author":"Maruta","year":"1991","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"12","key":"29_16221321","doi-asserted-by":"publisher","first-page":"6794","DOI":"10.1074\/jbc.271.12.6794","volume":"271","author":"Horn","year":"1996","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"30_23310976","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/j.1460-2075.1996.tb00416.x","volume":"15","author":"Urano","year":"1996","journal-title":"The EMBO Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0261-4189","issn-type":"print"},{"issue":"18","key":"31_16764810","doi-asserted-by":"publisher","first-page":"11702","DOI":"10.1074\/jbc.272.18.11702","volume":"272","author":"Hu","year":"1997","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"2","key":"32_4999960","first-page":"201","volume":"3","author":"Pizon","year":"1988","journal-title":"Oncogene","ISSN":"https:\/\/id.crossref.org\/issn\/0950-9232","issn-type":"print"},{"issue":"2","key":"33_9699229","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1128\/MCB.12.2.758","volume":"12","author":"Ruggieri","year":"1992","journal-title":"Molecular and Cellular Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0270-7306","issn-type":"print"},{"issue":"8","key":"34_10914021","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0968-0004(99)01426-7","volume":"24","year":"1999","journal-title":"Trends in biochemical sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0167-7640","issn-type":"print"},{"key":"35_37686761","first-page":"363374","volume":"17","year":"1993","journal-title":"Proteins","ISSN":"https:\/\/id.crossref.org\/issn\/0887-3585","issn-type":"print"},{"issue":"1","key":"36_16675420","first-page":"43","volume":"150","author":"Wienecke","year":"1997","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"27","key":"37_15937130","doi-asserted-by":"publisher","first-page":"16409","DOI":"10.1074\/jbc.270.27.16409","volume":"270","author":"K\u00a0nig","year":"1995","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"11","key":"38_37677421","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1093\/hmg\/6.11.1991","volume":"6","year":"1997","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"46","key":"39_5797502","doi-asserted-by":"publisher","first-page":"29301","DOI":"10.1074\/jbc.272.46.29301","volume":"272","author":"Soucek","year":"1997","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"5","key":"40_14484279","first-page":"1079","volume":"53","author":"Weber","year":"1993","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"2","key":"41_13194081","first-page":"460","volume":"36","author":"Lathrop","year":"1984","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"18","key":"42_9971455","doi-asserted-by":"publisher","first-page":"8794","DOI":"10.1073\/pnas.89.18.8794","volume":"89","author":"Shizuya","year":"1992","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"43_14698028","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/ng0194-84","volume":"6","author":"Ioannou","year":"1994","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"4","key":"44_5825035","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/ng1297-411","volume":"17","author":"Everett","year":"1997","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"6","key":"45_10884470","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1101\/gr.9.6.568","volume":"9","author":"Ellsworth","year":"1999","journal-title":"Genome Research","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"issue":"1","key":"46_10423162","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/sj.neo.7900011","volume":"1","author":"Zenklusen","year":"1999","journal-title":"Neoplasia (New York, N.Y.)","ISSN":"https:\/\/id.crossref.org\/issn\/1522-8002","issn-type":"print"},{"key":"47_37686762","first-page":"187","volume":"4","year":"1999","journal-title":"GENOME ANALYSIS A LABORATORY MANUAL"},{"issue":"3","key":"48_5528117","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1073\/pnas.87.3.1213","volume":"87","author":"Green","year":"1990","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"11","key":"49_5808158","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1101\/gr.7.11.1072","volume":"7","author":"Marra","year":"1997","journal-title":"Genome Research","ISSN":"https:\/\/id.crossref.org\/issn\/1088-9051","issn-type":"print"},{"key":"50_37686763","first-page":"241","volume":"16","year":"1994","journal-title":"Genetic engineering (Academic Press)","ISSN":"https:\/\/id.crossref.org\/issn\/0887-8307","issn-type":"print"},{"issue":"1","key":"51_16778796","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1006\/jmbi.1997.0951","volume":"268","author":"Burge","year":"1997","journal-title":"Journal of molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2836","issn-type":"print"},{"issue":"2","key":"52_16678437","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1073\/pnas.94.2.565","volume":"94","author":"Zhang","year":"1997","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"17","key":"53_37723758","doi-asserted-by":"publisher","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","year":"1997","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"},{"issue":"11","key":"54_6015177","doi-asserted-by":"publisher","first-page":"5857","DOI":"10.1073\/pnas.95.11.5857","volume":"95","author":"Schultz","year":"1998","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"55_37744975","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/nar\/27.1.229","volume":"27","year":"1999","journal-title":"Nucleic Acids Research","ISSN":"https:\/\/id.crossref.org\/issn\/0305-1048","issn-type":"print"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/8\/12\/2325\/1895268\/8-12-2325.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T03:28:31Z","timestamp":1682220511000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/8.12.2325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11,1]]},"references-count":55,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1999,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/8.12.2325","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11,1]]}}}