{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:55:46Z","timestamp":1790207746335,"version":"4.1.0"},"reference-count":88,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T00:00:00Z","timestamp":1590019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Navigator research grant from the Huntington Society of Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Olfactory dysfunction and altered neurogenesis are observed in several neurodegenerative disorders including Huntington disease (HD). These deficits occur early and correlate with a decline in global cognitive performance, depression and structural abnormalities of the olfactory system including the olfactory epithelium, bulb and cortices. However, the role of olfactory system dysfunction in the pathogenesis of HD remains poorly understood and the mechanisms underlying this dysfunction are unknown. We show that deficits in odour identification, discrimination and memory occur in HD individuals. Assessment of the olfactory system in an HD murine model demonstrates structural abnormalities in the olfactory bulb (OB) and piriform cortex, the primary cortical recipient of OB projections. Furthermore, a decrease in piriform neuronal counts and altered expression levels of neuronal nuclei and tyrosine hydroxylase in the OB are observed in the YAC128 HD model. Similar to the human HD condition, olfactory dysfunction is an early phenotype in the YAC128 mice and concurrent with caspase activation in the murine HD OB. These data provide a link between the structural olfactory brain region atrophy and olfactory dysfunction in HD and suggest that cell proliferation and cell death pathways are compromised and may contribute to the olfactory deficits in HD.<\/jats:p>","DOI":"10.1093\/hmg\/ddaa099","type":"journal-article","created":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T20:32:06Z","timestamp":1589920326000},"page":"2134-2147","source":"Crossref","is-referenced-by-count":14,"title":["Early deficits in olfaction are associated with structural and molecular alterations in the olfactory system of a Huntington disease mouse model"],"prefix":"10.1093","volume":"29","author":[{"given":"M","family":"Laroche","sequence":"first","affiliation":[{"name":"Research Center on Aging, CIUSSS-IUGS de l\u2019Estrie-CHUS, FMSS, Department of Pharmacology and Physiology, University of Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lessard-Beaudoin","sequence":"additional","affiliation":[{"name":"Research Center on Aging, CIUSSS-IUGS de l\u2019Estrie-CHUS, FMSS, Department of Pharmacology and Physiology, University of Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Garcia-Miralles","sequence":"additional","affiliation":[{"name":"Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore 138632"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Kreidy","sequence":"additional","affiliation":[{"name":"Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore 138632"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Peachey","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B R","family":"Leavitt","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Vancouver V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Pouladi","sequence":"additional","affiliation":[{"name":"Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research (ASTAR), Singapore 138632"},{"name":"Departments of Medicine and Physiology, National University of Singapore, Singapore 119077"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R K","family":"Graham","sequence":"additional","affiliation":[{"name":"Research Center on Aging, CIUSSS-IUGS de l\u2019Estrie-CHUS, FMSS, Department of Pharmacology and Physiology, University of Sherbrooke, Quebec J1K 2R1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,21]]},"reference":[{"key":"2020080403103432300_ref1","doi-asserted-by":"crossref","first-page":"541259","DOI":"10.1155\/2013\/541259","article-title":"The role of the immune system in Huntington's disease","volume":"2013","author":"Ellrichmann","year":"2013","journal-title":"Clin. 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