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Previously, we identified a dysregulated miR-486\/DOCK3 signaling cascade in dystrophin-deficient muscle, which resulted in the overexpression of DOCK3; however, little is known about the role of DOCK3 in muscle. Here, we characterize the functional role of DOCK3 in normal and dystrophic skeletal muscle. Utilizing Dock3 global knockout (Dock3 KO) mice, we found that the haploinsufficiency of Dock3 in Duchenne muscular dystrophy mice improved dystrophic muscle pathologies; however, complete loss of Dock3 worsened muscle function. Adult Dock3 KO mice have impaired muscle function and Dock3 KO myoblasts are defective for myogenic differentiation. Transcriptomic analyses of Dock3 KO muscles reveal a decrease in myogenic factors and pathways involved in muscle differentiation. These studies identify DOCK3 as a novel modulator of muscle health and may yield therapeutic targets for treating dystrophic muscle symptoms.<\/jats:p>","DOI":"10.1093\/hmg\/ddaa173","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T07:27:47Z","timestamp":1596180467000},"page":"2855-2871","source":"Crossref","is-referenced-by-count":14,"title":["DOCK3 is a dosage-sensitive regulator of skeletal muscle and Duchenne muscular dystrophy-associated pathologies"],"prefix":"10.1093","volume":"29","author":[{"given":"Andrea L","family":"Reid","sequence":"first","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The University of Alabama at Birmingham and Children\u2019s of Alabama, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimin","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The University of Alabama at Birmingham and Children\u2019s of Alabama, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Samani","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The University of Alabama at Birmingham and Children\u2019s of Alabama, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rylie M","family":"Hightower","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The University of Alabama at Birmingham and Children\u2019s of Alabama, Birmingham, AL 35294, USA"},{"name":"UAB Center for Exercise Medicine, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A","family":"Lopez","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The University of Alabama at Birmingham and Children\u2019s of Alabama, Birmingham, AL 35294, USA"},{"name":"UAB Center for Exercise Medicine, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn R","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Ianov","sequence":"additional","affiliation":[{"name":"Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K","family":"Crossman","sequence":"additional","affiliation":[{"name":"Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis J","family":"Dell\u2019Italia","sequence":"additional","affiliation":[{"name":"Birmingham Veteran Affairs Medical Center, Birmingham, AL 35233, USA"},{"name":"Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Department of Cell, Developmental, and Integrative Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas P","family":"Millay","sequence":"additional","affiliation":[{"name":"Division of Molecular Cardiovascular Biology, Cincinnati Children\u2019s Hospital Medical Center, Cincinnati, OH 45229, USA"},{"name":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"van Groen","sequence":"additional","affiliation":[{"name":"Department of Cell, Developmental, and Integrative Biology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesh V","family":"Halade","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Sciences, Department of Medicine, University of South Florida, Tampa, FL 33602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew S","family":"Alexander","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Pediatrics, The University of Alabama at Birmingham and Children\u2019s of Alabama, Birmingham, AL 35294, USA"},{"name":"UAB Center for Exercise Medicine, Birmingham, AL 35294, USA"},{"name":"Civitan International Research Center, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Department of Genetics, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"key":"2020101402144310700_ref1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1172\/JCI84419","article-title":"Non-coding RNAs in muscle differentiation and musculoskeletal disease","volume":"126","author":"Ballarino","year":"2016","journal-title":"J. Clin. Invest."},{"key":"2020101402144310700_ref2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/embor.2010.208","article-title":"miR-31 modulates dystrophin expression: new implications for Duchenne muscular dystrophy therapy","volume":"12","author":"Cacchiarelli","year":"2011","journal-title":"EMBO Rep."},{"key":"2020101402144310700_ref3","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.nmd.2017.11.007","article-title":"Low-level dystrophin expression attenuating the dystrophinopathy phenotype","volume":"28","author":"Waldrop","year":"2018","journal-title":"Neuromuscul Disord"},{"key":"2020101402144310700_ref4","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1016\/j.yexcr.2006.04.024","article-title":"Hypertrophic response of Duchenne and limb-girdle muscular dystrophies is associated with activation of Akt pathway","volume":"312","author":"Peter","year":"2006","journal-title":"Exp. 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Models Mech."},{"key":"2020101402144310700_ref24","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1440-1681.2004.04030.x","article-title":"Identification of a zebrafish model of muscular dystrophy","volume":"31","author":"Bassett","year":"2004","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"2020101402144310700_ref25","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1242\/dev.00799","article-title":"Dystrophin is required for the formation of stable muscle attachments in the zebrafish embryo","volume":"130","author":"Bassett","year":"2003","journal-title":"Development"},{"key":"2020101402144310700_ref26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2164-8-19","article-title":"The dystrotelin, dystrophin and dystrobrevin superfamily: new paralogues and old isoforms","volume":"8","author":"Jin","year":"2007","journal-title":"BMC Genomics"},{"key":"2020101402144310700_ref27","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1073\/pnas.1102116108","article-title":"Drug screening in a zebrafish model of Duchenne muscular dystrophy","volume":"108","author":"Kawahara","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2020101402144310700_ref28","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/hmg\/ddg071","article-title":"The dystrophin associated protein complex in zebrafish","volume":"12","author":"Guyon","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"2020101402144310700_ref29","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.bbrc.2012.06.040","article-title":"Quantification of birefringence readily measures the level of muscle damage in zebrafish","volume":"423","author":"Berger","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2020101402144310700_ref30","doi-asserted-by":"crossref","first-page":"4856","DOI":"10.1073\/pnas.80.15.4856","article-title":"Defective myoblasts identified in Duchenne muscular dystrophy","volume":"80","author":"Blau","year":"1983","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2020101402144310700_ref31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0014-4827(83)90431-7","article-title":"Differentiation properties of pure populations of human dystrophic muscle cells","volume":"144","author":"Blau","year":"1983","journal-title":"Exp. Cell Res."},{"key":"2020101402144310700_ref32","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1016\/B978-0-323-18907-1.00099-8","volume-title":"Endocrinology: Adult and Pediatric (Seventh Edition)","author":"Chrousos","year":"2016"},{"key":"2020101402144310700_ref33","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/(SICI)1097-4598(199910)22:10<1367::AID-MUS5>3.0.CO;2-H","article-title":"Quantitative magnetic resonance imaging of the mdx mouse model of Duchenne muscular dystrophy","volume":"22","author":"Dunn","year":"1999","journal-title":"Muscle Nerve"},{"key":"2020101402144310700_ref34","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/1756-0500-6-262","article-title":"Temporal changes in magnetic resonance imaging in the mdx mouse","volume":"6","author":"Pratt","year":"2013","journal-title":"BMC Res. Notes"},{"key":"2020101402144310700_ref35","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.3390\/nu10121947","article-title":"Impaired glucose tolerance in adults with Duchenne and Becker muscular dystrophy","volume":"10","author":"Bostock","year":"2018","journal-title":"Nutrients"},{"key":"2020101402144310700_ref36","first-page":"179","article-title":"Serum and organ indices of the mdx dystrophic mouse","volume":"77","author":"Brazeau","year":"1992","journal-title":"Res. Commun. Chem. Pathol. Pharmacol."},{"key":"2020101402144310700_ref37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0091514","article-title":"Dysfunctional muscle and liver glycogen metabolism in mdx dystrophic mice","volume":"9","author":"Stapleton","year":"2014","journal-title":"PLoS One"},{"key":"2020101402144310700_ref38","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-12-127","article-title":"Use of imaging biomarkers to assess perfusion and glucose metabolism in the skeletal muscle of dystrophic mice","volume":"12","author":"Ahmad","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"key":"2020101402144310700_ref39","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s004240050148","article-title":"Effect of intraperitoneal injection of glucose on glucose oxidation and energy expenditure in the mdx mouse model of Duchenne muscular dystrophy","volume":"432","author":"Mokhtarian","year":"1996","journal-title":"Pflugers Arch."},{"key":"2020101402144310700_ref40","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1042\/bj3040649","article-title":"Defective regulation of energy metabolism in mdx mouse skeletal muscles","volume":"304","author":"Even","year":"1994","journal-title":"Biochem. J."},{"key":"2020101402144310700_ref41","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1242\/jcs.113860","article-title":"Dock mediates scar- and WASp-dependent actin polymerization through interaction with cell adhesion molecules in founder cells and fusion-competent myoblasts","volume":"126","author":"Kaipa","year":"2013","journal-title":"J. Cell Sci."},{"key":"2020101402144310700_ref42","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1073\/pnas.0914514107","article-title":"Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex","volume":"107","author":"Namekata","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2020101402144310700_ref43","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/dgd.12290","article-title":"Low Six4 and Six5 gene dosage improves dystrophic phenotype and prolongs life span of mdx mice","volume":"58","author":"Yajima","year":"2016","journal-title":"Develop. Growth Differ."},{"key":"2020101402144310700_ref44","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0472-7","article-title":"Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function","author":"Guo","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"2020101402144310700_ref45","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1074\/jbc.M311275200","article-title":"MOCA induces membrane spreading by activating Rac1","volume":"279","author":"Namekata","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2020101402144310700_ref46","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1523\/JNEUROSCI.4884-11.2012","article-title":"Dock3 stimulates axonal outgrowth via GSK-3\u03b2-mediated microtubule assembly","volume":"32","author":"Namekata","year":"2012","journal-title":"J. Neurosci."},{"key":"2020101402144310700_ref47","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ncb2455","article-title":"RAC1 activation mediates Twist1-induced cancer cell migration","volume":"14","author":"Yang","year":"2012","journal-title":"Nat. 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Cell Physiol."},{"key":"2020101402144310700_ref51","doi-asserted-by":"crossref","first-page":"37307","DOI":"10.1074\/jbc.M103195200","article-title":"Rac1 inhibits myogenic differentiation by preventing the complete withdrawal of myoblasts from the cell cycle","volume":"276","author":"Heller","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2020101402144310700_ref52","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.215251","article-title":"Balanced Rac1 activity controls formation and maintenance of neuromuscular acetylcholine receptor clusters","volume":"131","author":"Bai","year":"2018","journal-title":"J. Cell Sci."},{"key":"2020101402144310700_ref53","doi-asserted-by":"crossref","first-page":"15730","DOI":"10.1074\/jbc.M611197200","article-title":"Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain \u03b17A and influences myoblast differentiation","volume":"282","author":"Samson","year":"2007","journal-title":"J. Biol. 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