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However, the molecular links between T2DM and AD remain obscure. Here, we reported that serum-\/glucocorticoid-regulated kinase 1 (SGK1) is activated by administering a chronic high-fat diet (HFD), which increases the risk of T2DM, and thus promotes Tau pathology via the phosphorylation of tau at Ser214 and the activation of a key tau kinase, namely, GSK-3\u00df, forming SGK1-GSK-3\u00df-tau complex. SGK1 was activated under conditions of elevated glucocorticoid and hyperglycemia associated with HFD, but not of fatty acid\u2013mediated insulin resistance. Elevated expression of SGK1 in the mouse hippocampus led to neurodegeneration and impairments in learning and memory. Upregulation and activation of SGK1, SGK1-GSK-3\u00df-tau complex were also observed in the hippocampi of AD cases. Our results suggest that SGK1 is a key modifier of tau pathology in AD, linking AD to corticosteroid effects and T2DM.<\/jats:p>","DOI":"10.1093\/hmg\/ddab115","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T10:09:18Z","timestamp":1618826958000},"page":"1693-1710","source":"Crossref","is-referenced-by-count":51,"title":["High-fat diet\u2013induced activation of SGK1 promotes Alzheimer\u2019s disease\u2013associated tau pathology"],"prefix":"10.1093","volume":"30","author":[{"given":"Montasir","family":"Elahi","sequence":"first","affiliation":[{"name":"Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University Graduate of Medicine, Tokyo, Japan"},{"name":"Department of Neurology, Juntendo University Graduate of Medicine, Tokyo, Japan"},{"name":"Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Motoi","sequence":"additional","affiliation":[{"name":"Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University Graduate of Medicine, Tokyo, Japan"},{"name":"Department of Neurology, Juntendo University Graduate of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Shimonaka","sequence":"additional","affiliation":[{"name":"Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University Graduate of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Juntendo University Graduate of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hioki","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Neuroscience, Juntendo University Graduate of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Takanashi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Juntendo University Graduate of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Department of Neurology, Juntendo University Graduate of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzuru","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Juntendo University Graduate of Medicine, Tokyo, Japan"},{"name":"Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Diagnosis, Prevention and Treatment of Dementia, Juntendo University Graduate of Medicine, Tokyo, Japan"},{"name":"Department of Neurology, Juntendo University Graduate of Medicine, Tokyo, Japan"},{"name":"Department of Research for Parkinson's Disease, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,4,22]]},"reference":[{"key":"2021090214223381700_ref1","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","article-title":"Global, regional, and national burden of Alzheimer's disease and other dementias, 1990\u20132016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"18","author":"GBD 2016 Dementia Collaborators","year":"2019","journal-title":"Lancet Neurol."},{"key":"2021090214223381700_ref2","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. 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