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On average, twins have a lower BW than singletons as a result of a different pattern of fetal growth and shorter gestational duration. Therefore, investigations into the genetics of BW often exclude data from twins, leading to a reduction in sample size and remaining ambiguities concerning the genetic contribution to BW in twins. In this study, we carried out a genome-wide association meta-analysis of BW in 42\u2009212 twin individuals and found a positive correlation of beta values (Pearson\u2019s r\u2009=\u20090.66, 95% confidence interval [CI]: 0.47\u20130.77) with 150 previously reported genome-wide significant variants for singleton BW. We identified strong positive genetic correlations between BW in twins and numerous anthropometric traits, most notably with BW in singletons (genetic correlation [rg]\u2009=\u20090.92, 95% CI: 0.66\u20131.18). Genetic correlations of BW in twins with a series of health-related traits closely resembled those previously observed for BW in singletons. Polygenic scores constructed from a genome-wide association study on BW in the UK Biobank demonstrated strong predictive power in a target sample of Dutch twins and singletons. Together, our results indicate that a similar genetic architecture underlies BW in twins and singletons and that future genome-wide studies might benefit from including data from large twin registers.<\/jats:p>","DOI":"10.1093\/hmg\/ddab121","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T03:20:29Z","timestamp":1619580029000},"page":"1894-1905","source":"Crossref","is-referenced-by-count":17,"title":["Genetic meta-analysis of twin birth weight shows high genetic correlation with singleton birth weight"],"prefix":"10.1093","volume":"30","author":[{"given":"Jeffrey J","family":"Beck","sequence":"first","affiliation":[{"name":"Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57108, USA"},{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9","family":"Pool","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot","family":"van de Weijer","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Krapohl","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott D","family":"Gordon","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Laboratory, QIMR Berghofer, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Nygaard","sequence":"additional","affiliation":[{"name":"The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Debrabant","sequence":"additional","affiliation":[{"name":"The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teemu","family":"Palviainen","sequence":"additional","affiliation":[{"name":"University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthijs D","family":"van der Zee","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Baselmans","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"},{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey T","family":"Finnicum","sequence":"additional","affiliation":[{"name":"Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Lundstr\u00f6m","sequence":"additional","affiliation":[{"name":"Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toos","family":"van Beijsterveldt","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Christiansen","sequence":"additional","affiliation":[{"name":"The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kauko","family":"Heikkil\u00e4","sequence":"additional","affiliation":[{"name":"University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Kittelsrud","sequence":"additional","affiliation":[{"name":"Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anu","family":"Loukola","sequence":"additional","affiliation":[{"name":"University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miina","family":"Ollikainen","sequence":"additional","affiliation":[{"name":"University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaare","family":"Christensen","sequence":"additional","affiliation":[{"name":"The Danish Twin Registry, Department of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G","family":"Martin","sequence":"additional","affiliation":[{"name":"Genetic Epidemiology Laboratory, QIMR Berghofer, Brisbane, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Plomin","sequence":"additional","affiliation":[{"name":"MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Nivard","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meike","family":"Bartels","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Dolan","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonneke","family":"Willemsen","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eco","family":"de Geus","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catarina","family":"Almqvist","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrik K E","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Mbarek","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A","family":"Ehli","sequence":"additional","affiliation":[{"name":"Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57108, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorret I","family":"Boomsma","sequence":"additional","affiliation":[{"name":"Avera Institute for Human Genetics, Avera McKennan Hospital and University Health Center, Sioux Falls, SD 57108, USA"},{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke-Jan","family":"Hottenga","sequence":"additional","affiliation":[{"name":"Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,6]]},"reference":[{"key":"2021091611513720200_ref1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/ije\/30.6.1233","article-title":"On the importance--and the unimportance--of birthweight","volume":"30","author":"Wilcox","year":"2001","journal-title":"Int. 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Epidemiol."},{"key":"2021091611513720200_ref11","first-page":"1008","article-title":"Evidence for genetic factors explaining the birth weight-blood pressure relation","volume":"36","author":"RG","year":"2000","journal-title":"Analysis in twins. Hypertension"},{"key":"2021091611513720200_ref12","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1097\/00004872-199608000-00002","article-title":"Is blood pressure inversely related to birth weight? The strength of evidence from a systematic review of the literature","volume":"14","author":"Law","year":"1996","journal-title":"J. Hypertens."},{"key":"2021091611513720200_ref13","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1651-2227.2004.tb02697.x","article-title":"Birthweight and psychological distress in adult twins: a longitudinal study","volume":"93","author":"Cheung","year":"2004","journal-title":"Acta Paediatr."},{"key":"2021091611513720200_ref14","first-page":"663","article-title":"Determinants of low birth weight: methodological assessment and meta-analysis","volume":"65","author":"Kramer","year":"1987","journal-title":"Bull. World Health Organ."},{"key":"2021091611513720200_ref15","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/j.1365-3016.1997.tb00007.x","article-title":"Ecological and individual predictors of birthweight in a northern Finland birth cohort 1986","volume":"11","author":"Jarvelin","year":"1997","journal-title":"Paediatr. Perinat. Epidemiol."},{"key":"2021091611513720200_ref16","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1093\/humrep\/deq160","article-title":"Secular trends in gestational age and birthweight in twins","volume":"25","author":"Gielen","year":"2010","journal-title":"Hum. Reprod."},{"key":"2021091611513720200_ref17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1375\/twin.8.6.638","article-title":"A comparison of twin birthweight data from Australia, the Netherlands, the United States, Japan, and South Korea: are genetic and environmental variations in birthweight similar in Caucasians and east Asians?","volume":"8","author":"Hur","year":"2005","journal-title":"Twin Res. Hum. 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