{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:58:48Z","timestamp":1790855928165,"version":"4.1.0"},"reference-count":59,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Martin Carver Chair in Ocular Cell Biology"},{"name":"Elmer and Sylvia Sramek Charitable Foundation"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["GM007337"],"award-info":[{"award-number":["GM007337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY031923"],"award-info":[{"award-number":["EY031923"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY025580"],"award-info":[{"award-number":["EY025580"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["EY024605"],"award-info":[{"award-number":["EY024605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The human neural retina is a light sensitive tissue with remarkable spatial and cellular organization. Compared with the periphery, the central retina contains more densely packed cone photoreceptor cells with unique morphologies and synaptic wiring. Some regions of the central retina exhibit selective degeneration or preservation in response to retinal disease and the basis for this variation is unknown. In this study, we used both bulk and single-cell RNA sequencing to compare gene expression within concentric regions of the central retina. We identified unique gene expression patterns of foveal cone photoreceptor cells, including many foveal-enriched transcription factors. In addition, we found that the genes RORB1, PPFIA1 and KCNAB2 are differentially spliced in the foveal, parafoveal and macular regions. These results provide a highly detailed spatial characterization of the retinal transcriptome and highlight unique molecular features of different retinal regions.<\/jats:p>","DOI":"10.1093\/hmg\/ddab140","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T03:15:28Z","timestamp":1621307728000},"page":"1543-1558","source":"Crossref","is-referenced-by-count":44,"title":["Human photoreceptor cells from different macular subregions have distinct transcriptional profiles"],"prefix":"10.1093","volume":"30","author":[{"given":"Andrew P","family":"Voigt","sequence":"first","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel K","family":"Mullin","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Scott","family":"Whitmore","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P","family":"DeLuca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin R","family":"Burnight","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budd A","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E","family":"Scheetz","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M","family":"Stone","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"Mullins","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, the University of Iowa Carver College of Medicine, Iowa City, IA 52242, USA"},{"name":"Institute for Vision Research, the University of Iowa, Iowa City, IA 52242, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"2021080317203272800_ref1","first-page":"1","volume-title":"Macular Degeneration","author":"Hendrickson","year":"2005"},{"key":"2021080317203272800_ref2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archopht.1969.00990020153002","article-title":"Some structural features of the fovea centralis in the human retina","volume":"82","author":"Yamada","year":"1969","journal-title":"Arch. 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