{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:02:04Z","timestamp":1767924124280,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"23","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology of Taiwan","doi-asserted-by":"publisher","award":["109-2634-F-075-001"],"award-info":[{"award-number":["109-2634-F-075-001"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V108D44-001-MY3-1"],"award-info":[{"award-number":["V108D44-001-MY3-1"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Numerous genome-wide association studies (GWASs) have been conducted for the identification of genetic variants involved with human height. The vast majority of these studies, however, have been conducted in populations of European ancestry. Here, we report the first GWAS of adult height in the Taiwan Biobank using a discovery sample of 14\u2009571 individuals and an independent replication sample of 20\u2009506 individuals. From our analysis, we generalize to the Taiwanese population genome-wide significant associations with height and 18 previously identified genes in European and non-Taiwanese East Asian populations. We also identify and replicate, at the genome-wide significance level, associated variants for height in four novel genes at two loci that have not previously been reported: RASA2 on chromosome 3 and NABP2, RNF41 and SLC39A5 at 12q13.3 on chromosome 12. RASA2 and RNF41 are strong candidates for having a role in height with copy number and loss of function variants in RASA2 previously found to be associated with short stature disorders, and decreased expression of the RNF41 gene resulting in insulin resistance in skeletal muscle. The results from our analysis of the Taiwan Biobank underscore the potential for the identification of novel genetic discoveries in underrepresented worldwide populations, even for traits, such as height, that have been extensively investigated in large-scale studies of European ancestry populations.<\/jats:p>","DOI":"10.1093\/hmg\/ddab202","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T11:11:20Z","timestamp":1626174680000},"page":"2362-2369","source":"Crossref","is-referenced-by-count":16,"title":["Genome-wide association study in the Taiwan Biobank identifies four novel genes for human height:<i>NABP2, R<\/i>A<i>SA2, RNF41<\/i>and<i>SLC39A5<\/i>"],"prefix":"10.1093","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6984-2159","authenticated-orcid":false,"given":"Eugene","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA 98195, USA"},{"name":"Department of Electrical & Computer Engineering, University of Washington, Seattle, WA 98195, USA"},{"name":"Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9987-022X","authenticated-orcid":false,"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Taipei Veterans General Hospital, Taipei 11217, Taiwan"},{"name":"Division of Psychiatry, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Hsiu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli County 35053, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert C","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Brain Science, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan"},{"name":"Division of Interdisciplinary Medicine and Biotechnology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew P","family":"Conomos","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA 98195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy A","family":"Thornton","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Washington, Seattle, WA 98195, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"2021111806110895400_ref1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.2307\/2841583","article-title":"Regression towards mediocrity in hereditary stature","volume":"15","author":"Galton","year":"1886","journal-title":"J. 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