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Individuals with ID exhibit deficits in intelligence, impaired adaptive behavior and often visual impairments. Cytoplasmic fragile X mental retardation 1 (FMR1)-interacting protein 2 (CYFIP2) is an interacting partner of the FMR protein, whose loss results in fragile X syndrome, the most common inherited cause of ID. Recently, CYFIP2 variants have been found in patients with early-onset epileptic encephalopathy, developmental delay and ID. Such individuals often exhibit visual impairments; however, the underlying mechanism is poorly understood. In the present study, we investigated the role of Cyfip2 in retinal and visual functions by generating and analyzing Cyfip2 conditional knockout (CKO) mice. While we found no major differences in the layer structures and cell compositions between the control and Cyfip2 CKO retinas, a subset of genes associated with the transporter and channel activities was differentially expressed in Cyfip2 CKO retinas than in the controls. Multi-electrode array recordings showed more sustained and stronger responses to positive flashes of the ON ganglion cells in the Cyfip2 CKO retina than in the controls, although electroretinogram analysis revealed that Cyfip2 deficiency unaffected the photoreceptor and ON bipolar cell functions. Furthermore, analysis of initial and late phase optokinetic responses demonstrated that Cyfip2 deficiency impaired the visual function at the organismal level. Together, our results shed light on the molecular mechanism underlying the visual impairments observed in individuals with CYFIP2 variants and, more generally, in patients with neurodevelopmental disorders, including ID.<\/jats:p>","DOI":"10.1093\/hmg\/ddab268","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T11:28:18Z","timestamp":1631100498000},"page":"535-547","source":"Crossref","is-referenced-by-count":19,"title":["Deficiency of the neurodevelopmental disorder-associated gene<i>Cyfip2<\/i>alters the retinal ganglion cell properties and visual acuity"],"prefix":"10.1093","volume":"31","author":[{"given":"Taro","family":"Chaya","sequence":"first","affiliation":[{"name":"Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishikane","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Human Sciences, Senshu University, Kawasaki 214-8580, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah R","family":"Varner","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Sugita","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamato","family":"Maeda","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryotaro","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Motooka","sequence":"additional","affiliation":[{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Okuzaki","sequence":"additional","affiliation":[{"name":"Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Furukawa","sequence":"additional","affiliation":[{"name":"Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, Osaka 565-0871, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,11]]},"reference":[{"key":"2022022310594668800_ref1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1352\/1934-9556-54.6.381","article-title":"The relation between intellectual functioning and adaptive behavior in the diagnosis of intellectual disability","volume":"54","author":"Tasse","year":"2016","journal-title":"Intellect. Dev. Disabil."},{"key":"2022022310594668800_ref2","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/jar.12728","article-title":"The relative influence of intellectual disabilities and autism on sensory impairments and physical disability: a whole-country cohort of 5.3 million children and adults","volume":"33","author":"Kinnear","year":"2020","journal-title":"J. Appl. Res. Intellect. Disabil."},{"key":"2022022310594668800_ref3","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/mrdd.10039","article-title":"The epidemiology of developmental disabilities in low-income countries","volume":"8","author":"Durkin","year":"2002","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"2022022310594668800_ref4","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/mrdd.10031","article-title":"The epidemiology of mental retardation: challenges and opportunities in the new millennium","volume":"8","author":"Leonard","year":"2002","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"2022022310594668800_ref5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jmg.2005.033043","article-title":"X linked mental retardation: a clinical guide","volume":"43","author":"Raymond","year":"2006","journal-title":"J. Med. Genet."},{"key":"2022022310594668800_ref6","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ridd.2010.12.018","article-title":"Prevalence of intellectual disability: a meta-analysis of population-based studies","volume":"32","author":"Maulik","year":"2011","journal-title":"Res. Dev. 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Genet."},{"key":"2022022310594668800_ref24","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.3345\/kjp.2016.59.11.S19","article-title":"Interstitial deletion of 5q33.3q35.1 in a boy with severe mental retardation","volume":"59","author":"Lee","year":"2016","journal-title":"Korean J. Pediatr."},{"key":"2022022310594668800_ref25","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1002\/ana.25208","article-title":"De novo hotspot variants in CYFIP2 cause early-onset epileptic encephalopathy","volume":"83","author":"Nakashima","year":"2018","journal-title":"Ann. Neurol."},{"key":"2022022310594668800_ref26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/s41431-018-0331-z","article-title":"Spatially clustering de novo variants in CYFIP2, encoding the cytoplasmic FMRP interacting protein 2, cause intellectual disability and seizures","volume":"27","author":"Zweier","year":"2019","journal-title":"Eur. J. Hum. Genet."},{"key":"2022022310594668800_ref27","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/s41436-020-01011-x","article-title":"New insights into the clinical and molecular spectrum of the novel CYFIP2-related neurodevelopmental disorder and impairment of the WRC-mediated actin dynamics","volume":"23","author":"Begemann","year":"2021","journal-title":"Genet. Med."},{"key":"2022022310594668800_ref28","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1038\/nn.2897","article-title":"miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression","volume":"14","author":"Sanuki","year":"2011","journal-title":"Nat. Neurosci."},{"key":"2022022310594668800_ref29","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1038\/s41598-019-38910-2","article-title":"miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation","volume":"9","author":"Kozuka","year":"2019","journal-title":"Sci. Rep."},{"key":"2022022310594668800_ref30","doi-asserted-by":"crossref","first-page":"11883","DOI":"10.1523\/JNEUROSCI.4114-08.2008","article-title":"The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila","volume":"28","author":"Xu","year":"2008","journal-title":"J. Neurosci."},{"key":"2022022310594668800_ref31","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/dvg.20318","article-title":"Dkk3-Cre BAC transgenic mouse line: a tool for highly efficient gene deletion in retinal progenitor cells","volume":"45","author":"Sato","year":"2007","journal-title":"Genesis"},{"key":"2022022310594668800_ref32","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1016\/j.visres.2004.09.011","article-title":"Using eye movements to assess brain function in mice","volume":"44","author":"Stahl","year":"2004","journal-title":"Vis. Res."},{"key":"2022022310594668800_ref33","first-page":"13.1","article-title":"Initiation of the optokinetic response (OKR) in mice","volume":"10","author":"Tabata","year":"2010","journal-title":"J. Vis."},{"key":"2022022310594668800_ref34","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S0952523800000158","article-title":"Short latency ocular-following responses in man","volume":"5","author":"Gellman","year":"1990","journal-title":"Vis. Neurosci."},{"key":"2022022310594668800_ref35","doi-asserted-by":"crossref","first-page":"2823","DOI":"10.1111\/ejn.12284","article-title":"Contributions of retinal direction-selective ganglion cells to optokinetic responses in mice","volume":"38","author":"Sugita","year":"2013","journal-title":"Eur. J. 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Rep."},{"key":"2022022310594668800_ref38","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1016\/j.celrep.2018.03.007","article-title":"Lrit1, a retinal transmembrane protein, regulates selective synapse formation in cone photoreceptor cells and visual acuity","volume":"22","author":"Ueno","year":"2018","journal-title":"Cell Rep."},{"key":"2022022310594668800_ref39","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/j.cell.2008.07.031","article-title":"The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP","volume":"134","author":"Napoli","year":"2008","journal-title":"Cell"},{"key":"2022022310594668800_ref40","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1016\/j.neuron.2018.01.027","article-title":"Axon-axon interactions regulate topographic optic tract sorting via CYFIP2-dependent WAVE complex function","volume":"97","author":"Cioni","year":"2018","journal-title":"Neuron"},{"key":"2022022310594668800_ref41","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2017.07.033","article-title":"Excess translation of epigenetic regulators contributes to fragile X syndrome and is alleviated by Brd4 inhibition","volume":"170","author":"Korb","year":"2017","journal-title":"Cell"},{"key":"2022022310594668800_ref42","doi-asserted-by":"crossref","first-page":"e105996","DOI":"10.1371\/journal.pone.0105996","article-title":"Visual sensorial impairments in neurodevelopmental disorders: evidence for a retinal phenotype in fragile X syndrome","volume":"9","author":"Rossignol","year":"2014","journal-title":"PLoS One"},{"key":"2022022310594668800_ref43","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3389\/fncel.2018.00096","article-title":"Early retinal defects in Fmr1(\u2212\/y) mice: toward a critical role of visual dys-sensitivity in the fragile X syndrome phenotype?","volume":"12","author":"Perche","year":"2018","journal-title":"Front. Cell. Neurosci."},{"key":"2022022310594668800_ref44","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ydbio.2010.05.512","article-title":"nev (cyfip2) is required for retinal lamination and axon guidance in the zebrafish retinotectal system","volume":"344","author":"Pittman","year":"2010","journal-title":"Dev. Biol."},{"key":"2022022310594668800_ref45","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3389\/fnmol.2018.00482","article-title":"Smaller body size, early postnatal lethality, and cortical extracellular matrix-related gene expression changes of Cyfip2-null embryonic mice","volume":"11","author":"Zhang","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"2022022310594668800_ref46","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gep.2018.04.005","article-title":"Enriched expression of the ciliopathy gene ick in cell proliferating regions of adult mice","volume":"29","author":"Tsutsumi","year":"2018","journal-title":"Gene Expr. Patterns"},{"key":"2022022310594668800_ref47","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/embj.201488175","article-title":"ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport","volume":"33","author":"Chaya","year":"2014","journal-title":"EMBO J."},{"key":"2022022310594668800_ref48","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1523\/JNEUROSCI.3067-16.2017","article-title":"Ick ciliary kinase is essential for planar cell polarity formation in inner ear hair cells and hearing function","volume":"37","author":"Okamoto","year":"2017","journal-title":"J. Neurosci."},{"key":"2022022310594668800_ref49","doi-asserted-by":"crossref","first-page":"e101409","DOI":"10.15252\/embj.2018101409","article-title":"Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation","volume":"38","author":"Chaya","year":"2019","journal-title":"EMBO J."},{"key":"2022022310594668800_ref50","doi-asserted-by":"crossref","first-page":"22671","DOI":"10.1073\/pnas.1009437108","article-title":"Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival","volume":"107","author":"Omori","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2022022310594668800_ref51","doi-asserted-by":"crossref","first-page":"8318","DOI":"10.1128\/MCB.01209-07","article-title":"Functional roles of Otx2 transcription factor in postnatal mouse retinal development","volume":"27","author":"Koike","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"2022022310594668800_ref52","doi-asserted-by":"crossref","first-page":"21450","DOI":"10.1038\/s41598-020-78452-6","article-title":"The potential role of Arhgef33 RhoGEF in foveal development in the zebra finch retina","volume":"10","author":"Sugiyama","year":"2020","journal-title":"Sci. Rep."},{"key":"2022022310594668800_ref53","doi-asserted-by":"crossref","first-page":"W566","DOI":"10.1093\/nar\/gkv468","article-title":"ClustVis: a web tool for visualizing clustering of multivariate data using principal component analysis and heatmap","volume":"43","author":"Metsalu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"2022022310594668800_ref54","doi-asserted-by":"crossref","first-page":"W305","DOI":"10.1093\/nar\/gkp427","article-title":"ToppGene suite for gene list enrichment analysis and candidate gene prioritization","volume":"37","author":"Chen","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"2022022310594668800_ref55","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1128\/MCB.00048-15","article-title":"Rax homeoprotein regulates photoreceptor cell maturation and survival in association with Crx in the postnatal mouse retina","volume":"35","author":"Irie","year":"2015","journal-title":"Mol. Cell. 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