{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:38:41Z","timestamp":1772138321213,"version":"3.50.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,10,12]],"date-time":"2021-10-12T00:00:00Z","timestamp":1633996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019125","name":"Sorbonne University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019125","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Agence Nationale de la Recherche","award":["NEURON8-Full-815- 006"],"award-info":[{"award-number":["NEURON8-Full-815- 006"]}]},{"name":"French Fondation Bettencourt Schueller"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["60253"],"award-info":[{"award-number":["60253"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["CA16118"],"award-info":[{"award-number":["CA16118"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERA-Net for Research on Rare Diseases","award":["ERARE18-049"],"award-info":[{"award-number":["ERARE18-049"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Human cerebral cortical malformations are associated with progenitor proliferation and neuronal migration abnormalities. Progenitor cells include apical radial glia, intermediate progenitors and basal (or outer) radial glia (bRGs or oRGs). bRGs are few in number in lissencephalic species (e.g. the mouse) but abundant in gyrencephalic brains. The LIS1 gene coding for a dynein regulator, is mutated in human lissencephaly, associated also in some cases with microcephaly. LIS1 was shown to be important during cell division and neuronal migration. Here, we generated bRG-like cells in the mouse embryonic brain, investigating the role of Lis1 in their formation. This was achieved by in utero electroporation of a hominoid-specific gene TBC1D3 (coding for a RAB-GAP protein) at mouse embryonic day (E) 14.5. We first confirmed that TBC1D3 expression in wild-type (WT) brain generates numerous Pax6+ bRG-like cells that are basally localized. Second, using the same approach, we assessed the formation of these cells in heterozygote Lis1 mutant brains. Our novel results show that Lis1 depletion in the forebrain from E9.5 prevented subsequent TBC1D3-induced bRG-like cell amplification. Indeed, we observe perturbation of the ventricular zone (VZ) in the mutant. Lis1 depletion altered adhesion proteins and mitotic spindle orientations at the ventricular surface and increased the proportion of abventricular mitoses. Progenitor outcome could not be further altered by TBC1D3. We conclude that disruption of Lis1\/LIS1 dosage is likely to be detrimental for appropriate progenitor number and position, contributing to lissencephaly pathogenesis.<\/jats:p>","DOI":"10.1093\/hmg\/ddab295","type":"journal-article","created":{"date-parts":[[2021,10,7]],"date-time":"2021-10-07T08:19:04Z","timestamp":1633594744000},"page":"942-957","source":"Crossref","is-referenced-by-count":6,"title":["Lis1 mutation prevents basal radial glia-like cell production in the mouse"],"prefix":"10.1093","volume":"31","author":[{"given":"Maxime","family":"Penisson","sequence":"first","affiliation":[{"name":"INSERM U 1270, Paris F-75005, France"},{"name":"Sorbonne University, Paris F-75005, France"},{"name":"Institut du Fer \u00e0 Moulin, Paris 75005, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyue","family":"Jin","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine, Genetic Disease Research, Osaka, JP 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengming","family":"Wang","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine, Genetic Disease Research, Osaka, JP 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Hirotsune","sequence":"additional","affiliation":[{"name":"Osaka City University Graduate School of Medicine, Genetic Disease Research, Osaka, JP 545-8585, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8542-7537","authenticated-orcid":false,"given":"Fiona","family":"Francis","sequence":"additional","affiliation":[{"name":"INSERM U 1270, Paris F-75005, France"},{"name":"Sorbonne University, Paris F-75005, France"},{"name":"Institut du Fer \u00e0 Moulin, Paris 75005, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-9826","authenticated-orcid":false,"given":"Richard","family":"Belvindrah","sequence":"additional","affiliation":[{"name":"INSERM U 1270, Paris F-75005, France"},{"name":"Sorbonne University, Paris F-75005, France"},{"name":"Institut du Fer \u00e0 Moulin, Paris 75005, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,10,12]]},"reference":[{"key":"2022032516100257000_ref1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev-cellbio-101011-155801","article-title":"The cell biology of neurogenesis: toward an understanding of the development and evolution of the neocortex","volume":"30","author":"Taverna","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2022032516100257000_ref2","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","article-title":"The cell biology of neurogenesis","volume":"6","author":"G\u00f6tz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2022032516100257000_ref3","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1002\/1873-3468.12924","article-title":"Cerebral cortex development: an outside-in perspective","volume":"591","author":"Agirman","year":"2017","journal-title":"FEBS Lett."},{"key":"2022032516100257000_ref4","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/joa.12939","article-title":"Intermediate progenitors and Tbr2 in cortical development","volume":"235","author":"Hevner","year":"2019","journal-title":"J. Anat."},{"key":"2022032516100257000_ref5","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/nn.2553","article-title":"OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling","volume":"13","author":"Fietz","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2022032516100257000_ref6","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1126\/science.aaa1975","article-title":"Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion","volume":"347","author":"Florio","year":"2015","journal-title":"Science"},{"key":"2022032516100257000_ref7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature08845","article-title":"Neurogenic radial glia in the outer subventricular zone of human neocortex","volume":"464","author":"Hansen","year":"2010","journal-title":"Nature"},{"key":"2022032516100257000_ref8","first-page":"1","article-title":"Genes and mechanisms involved in the generation and amplification of basal radial glial cells","volume":"13","author":"Penisson","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"2022032516100257000_ref9","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/cercor\/bhq238","article-title":"A role for intermediate radial glia in the tangential expansion of the mammalian cerebral cortex","volume":"21","author":"Reillo","year":"2011","journal-title":"Cereb. Cortex"},{"key":"2022032516100257000_ref10","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/nn.2807","article-title":"A new subtype of progenitor cell in the mouse embryonic neocortex","volume":"14","author":"Wang","year":"2011","journal-title":"Nat. Neurosci."},{"key":"2022032516100257000_ref11","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.neuron.2013.09.032","article-title":"Precursor diversity and complexity of lineage relationships in the outer subventricular zone of the primate","volume":"80","author":"Betizeau","year":"2013","journal-title":"Neuron"},{"key":"2022032516100257000_ref12","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.conb.2012.03.006","article-title":"OSVZ progenitors in the human cortex: an updated perspective on neurodevelopmental disease","volume":"22","author":"LaMonica","year":"2012","journal-title":"Curr. Opin. Neurobiol."},{"key":"2022032516100257000_ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms11812","article-title":"A restricted period for formation of outer subventricular zone defined by Cdh1 and Trnp1 levels","volume":"7","author":"Mart\u00ednez-Mart\u00ednez","year":"2016","journal-title":"Nat. Commun."},{"key":"2022032516100257000_ref14","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1038\/ncomms3125","article-title":"Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type","volume":"4","author":"Pilz","year":"2013","journal-title":"Nat. Commun."},{"key":"2022032516100257000_ref15","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/ana.24793","article-title":"Malformations of cortical development","volume":"80","author":"Desikan","year":"2016","journal-title":"Ann. Neurol."},{"key":"2022032516100257000_ref16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.semcdb.2017.09.031","article-title":"Genetics and mechanisms leading to human cortical malformations","volume":"76","author":"Romero","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"2022032516100257000_ref17","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1093\/brain\/aws019","article-title":"A developmental and genetic classification for malformations of cortical development: update 2012","volume":"135","author":"Barkovich","year":"2012","journal-title":"Brain"},{"key":"2022032516100257000_ref18","doi-asserted-by":"crossref","first-page":"308","DOI":"10.5005\/jp-journals-10009-1538","article-title":"Malformations of cortical development","volume":"11","author":"Capuano","year":"2017","journal-title":"Donald School J. Ultrasound Obstet Gynecol."},{"key":"2022032516100257000_ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2019.00576","article-title":"Cortical malformations: lessons in human brain development","volume":"13","author":"Subramanian","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"2022032516100257000_ref20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev-cellbio-100814-125438","article-title":"Mechanism and regulation of cytoplasmic dynein","volume":"31","author":"Cianfrocco","year":"2015","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2022032516100257000_ref21","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1001\/jama.1993.03510230076039","article-title":"Lissencephaly: a human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13","volume":"270","author":"Dobyns","year":"1993","journal-title":"JAMA"},{"key":"2022032516100257000_ref22","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.conb.2013.08.001","article-title":"LIS1 functions in normal development and disease","volume":"23","author":"Reiner","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"2022032516100257000_ref23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/hmg\/6.2.157","article-title":"Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome","volume":"6","author":"Lo Nigro","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"2022032516100257000_ref24","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1086\/378096","article-title":"Miller-Dieker syndrome: analysis of a human contiguous gene syndrome in the mouse","volume":"73","author":"Yingling","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"2022032516100257000_ref25","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1523\/JNEUROSCI.23-05-01719.2003","article-title":"Multiple dose-dependent effects of Lis1 on cerebral cortical development","volume":"23","author":"Gambello","year":"2003","journal-title":"J. Neurosci."},{"key":"2022032516100257000_ref26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/1221","article-title":"Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality","volume":"19","author":"Hirotsune","year":"1998","journal-title":"Nat. Genet."},{"key":"2022032516100257000_ref27","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1083\/jcb.200505166","article-title":"LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages","volume":"170","author":"Tsai","year":"2005","journal-title":"J. Cell Biol."},{"key":"2022032516100257000_ref28","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cell.2008.01.026","article-title":"Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division","volume":"132","author":"Yingling","year":"2008","journal-title":"Cell"},{"key":"2022032516100257000_ref29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.celrep.2017.03.047","article-title":"An organoid-based model of cortical development identifies non-cell-autonomous defects in Wnt Signaling contributing to Miller-Dieker syndrome","volume":"19","author":"Iefremova","year":"2017","journal-title":"Cell Rep."},{"key":"2022032516100257000_ref30","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1523\/JNEUROSCI.4851-09.2010","article-title":"Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction","volume":"30","author":"Pramparo","year":"2010","journal-title":"J. Neurosci."},{"key":"2022032516100257000_ref31","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.stem.2016.12.007","article-title":"Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia","volume":"20","author":"Bershteyn","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2022032516100257000_ref32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.23253","article-title":"Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia","volume":"6","author":"Heng","year":"2017","journal-title":"Elife"},{"key":"2022032516100257000_ref33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.18197","article-title":"The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice","volume":"5","author":"Ju","year":"2016","journal-title":"Elife"},{"key":"2022032516100257000_ref34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.stem.2017.08.013","article-title":"The primate-specific gene TMEM14B marks outer radial glia cells and promotes cortical expansion and folding","volume":"21","author":"Liu","year":"2017","journal-title":"Cell Stem Cell"},{"key":"2022032516100257000_ref35","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nature13973","article-title":"Radial glia require PDGFD\u2013PDGFRb signalling in human but not mouse neocortex","volume":"515","author":"Lui","year":"2014","journal-title":"Nature"},{"key":"2022032516100257000_ref36","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.cell.2013.03.027","article-title":"Trnp1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate","volume":"153","author":"Stahl","year":"2013","journal-title":"Cell"},{"key":"2022032516100257000_ref37","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.neuron.2018.01.052","article-title":"Insm1 induces neural progenitor delamination in developing neocortex via downregulation of the Adherens Junction Belt-Specific Protein Plekha7","volume":"97","author":"Tavano","year":"2018","journal-title":"Neuron"},{"key":"2022032516100257000_ref38","doi-asserted-by":"publisher","first-page":"e1002217","DOI":"10.1371\/journal.pbio.1002217","article-title":"Sustained Pax6 expression generates primate-like basal radial glia in developing mouse neocortex","volume":"13","author":"Wong","year":"2015","journal-title":"PLoS Biol."},{"key":"2022032516100257000_ref39","doi-asserted-by":"crossref","first-page":"6309","DOI":"10.1523\/JNEUROSCI.22-15-06309.2002","article-title":"Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage","volume":"22","author":"Gorski","year":"2002","journal-title":"J. Neurosci."},{"key":"2022032516100257000_ref40","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1523\/JNEUROSCI.4773-10.2011","article-title":"Oblique radial glial divisions in the developing mouse neocortex induce self-renewing progenitors outside the germinal zone that resemble primate outer subventricular zone progenitors","volume":"31","author":"Shitamukai","year":"2011","journal-title":"J. Neurosci."},{"key":"2022032516100257000_ref41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.4161\/cam.5.4.17432","article-title":"Interkinetic nuclear migration: reciprocal activities of dynein and kinesin","volume":"5","author":"Kulikova","year":"2011","journal-title":"Cell Adhes. Migr."},{"key":"2022032516100257000_ref42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cercor\/bhp038","article-title":"Characterization of Nkx6-2-derived neocortical interneuron lineages","volume":"19","author":"Sousa","year":"2009","journal-title":"Cereb. Cortex"},{"key":"2022032516100257000_ref43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-3806(99)00104-2","article-title":"Pax-2 regulatory sequences that direct transgene expression in the developing neural plate and external granule cell layer of the cerebellum","volume":"20","author":"Rowitch","year":"1999","journal-title":"Brain Res. Dev. Brain Res."},{"key":"2022032516100257000_ref44","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1006\/meth.1996.0113","article-title":"GFAP transgenic mice","volume":"10","author":"Brenner","year":"1996","journal-title":"Methods"},{"key":"2022032516100257000_ref45","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1212\/WNL.57.3.416","article-title":"LIS1 missense mutations cause milder lissencephaly phenotypes including a child with normal IQ","volume":"57","author":"Leventer","year":"2001","journal-title":"Neurology"},{"key":"2022032516100257000_ref46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1399-0004.2007.00888.x","article-title":"Lissencephaly and LIS1: insights into the molecular mechanisms of neuronal migration and development","volume":"72","author":"Wynshaw-Boris","year":"2007","journal-title":"Clin. Genet."},{"key":"2022032516100257000_ref47","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1002\/ajmg.a.38245","article-title":"Lissencephaly: expanded imaging and clinical classification","volume":"173","author":"Di Donato","year":"2017","journal-title":"Am. J. Med. Genet. A"},{"key":"2022032516100257000_ref48","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1093\/hmg\/ddn144","article-title":"Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination","volume":"17","author":"Pawlisz","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"2022032516100257000_ref49","first-page":"1","article-title":"Recent advances in understanding neocortical development","volume":"23","author":"Borrell","year":"2019","journal-title":"F1000 Res."},{"key":"2022032516100257000_ref50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.ygeno.2006.05.009","article-title":"TBC1D3 , a hominoid oncoprotein , is encoded by a cluster of paralogues located on chromosome 17q12","volume":"88","author":"Hodzic","year":"2006","journal-title":"Genomics"},{"key":"2022032516100257000_ref51","doi-asserted-by":"publisher","first-page":"395830","DOI":"10.7554\/eLife.41241","article-title":"Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex","volume":"7","author":"Kalebic","year":"2018","journal-title":"Elife"},{"key":"2022032516100257000_ref52","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1038\/nn.4307","article-title":"Hedgehog signaling promotes basal progenitor expansion and the growth and folding of the neocortex","volume":"19","author":"Wang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"2022032516100257000_ref53","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.isci.2018.05.014","article-title":"Chromatin remodeling BAF155 subunit regulates the genesis of basal progenitors in developing cortex","volume":"4","author":"Narayanan","year":"2018","journal-title":"iScience"},{"key":"2022032516100257000_ref54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms2647","article-title":"Mitotic spindle orientation predicts outer radial glial cell generation in human neocortex","volume":"4","author":"LaMonica","year":"2013","journal-title":"Nat. Commun."},{"key":"2022032516100257000_ref55","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1128\/MCB.22.9.3089-3102.2002","article-title":"LIS1, CLIP-170's key to the dynein\/dynactin pathway","volume":"22","author":"Coquelle","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"2022032516100257000_ref56","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/s41556-020-0506-z","article-title":"LIS1 promotes the formation of activated cytoplasmic dynein-1 complexes","volume":"22","author":"Htet","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"2022032516100257000_ref57","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1091\/mbc.e13-05-0283","article-title":"Nudel\/NudE and Lis1 promote dynein and dynactin interaction in the context of spindle morphogenesis","volume":"24","author":"Wang","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"2022032516100257000_ref58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.51512","article-title":"LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility","volume":"9","author":"Moon","year":"2020","journal-title":"Elife"},{"key":"2022032516100257000_ref59","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1242\/dev.140764","article-title":"Spindle orientation: a question of complex positioning","volume":"144","author":"Bergstralh","year":"2017","journal-title":"Development"},{"key":"2022032516100257000_ref60","doi-asserted-by":"publisher","first-page":"e1001172","DOI":"10.1371\/journal.pbio.1001172","article-title":"Three-dimensional regulation of radial glial functions by lis1-nde1 and dystrophin glycoprotein complexes","volume":"9","author":"Pawlisz","year":"2011","journal-title":"PLoS Biol."},{"key":"2022032516100257000_ref61","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/nn.2665","article-title":"Kinesin 3 and cytoplasmic dynein mediate interkinetic nuclear migration in neural stem cells","volume":"13","author":"Tsai","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2022032516100257000_ref62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2008.03.018","article-title":"Lis1\/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts","volume":"319","author":"Siller","year":"2008","journal-title":"Dev. Biol."},{"key":"2022032516100257000_ref63","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1091\/mbc.e05-04-0338","article-title":"Live imaging of Drosophila brain neuroblasts reveals a role for Lis1\/dynactin in spindle assembly and mitotic checkpoint control","volume":"16","author":"Siller","year":"2005","journal-title":"Mol. Biol. Cell"},{"key":"2022032516100257000_ref64","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/hmg\/ddt436","article-title":"LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex","volume":"15","author":"Moon","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"2022032516100257000_ref65","doi-asserted-by":"crossref","first-page":"17308","DOI":"10.1038\/s41598-017-15253-4","article-title":"Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex","volume":"7","author":"Bizzotto","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddab295\/41074541\/ddab295.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/31\/6\/942\/42993592\/ddab295.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/31\/6\/942\/42993592\/ddab295.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,25]],"date-time":"2022-03-25T16:39:03Z","timestamp":1648226343000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/31\/6\/942\/6390037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,12]]},"references-count":65,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2021,10,12]]},"published-print":{"date-parts":[[2022,3,21]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddab295","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.10.10.334508","asserted-by":"object"}]},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,15]]},"published":{"date-parts":[[2021,10,12]]}}}