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Thus, there is a need for early, functional biomarker to better understand disease progression and to evaluate treatment efficacy far from onset. Recent studies have shown that white matter may be affected early in mutant HTT gene carriers. A previous study performed on 12 months old Ki140CAG mice showed reduced glutamate level measured by Chemical Exchange Saturation Transfer of glutamate (gluCEST), especially in the corpus callosum. In this study, we scanned longitudinally Ki140CAG mice with structural MRI, diffusion tensor imaging, gluCEST and magnetization transfer imaging, in order to assess white matter integrity over the life of this mouse model characterized by slow progression of symptoms. Our results show early defects of diffusion properties in the anterior part of the corpus callosum at 5\u00a0months of age, preceding gluCEST defects in the same region at 8 and 12\u00a0months that spread to adjacent regions. At 12\u00a0months, frontal and piriform cortices showed reduced gluCEST, as well as the pallidum. MT imaging showed reduced signal in the septum at 12\u00a0months. Cortical and striatal atrophy then appear at 18\u00a0months. Vulnerability of the striatum and motor cortex, combined with alterations of anterior corpus callosum, seems to point out the potential role of white matter in the brain dysfunction that characterizes HD and the pertinence of gluCEST and DTI as biomarkers in HD.<\/jats:p>","DOI":"10.1093\/hmg\/ddac036","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T20:11:23Z","timestamp":1644351083000},"page":"3581-3596","source":"Crossref","is-referenced-by-count":24,"title":["Longitudinal multimodal MRI characterization of a knock-in mouse model of Huntington\u2019s disease reveals early gray and white matter alterations"],"prefix":"10.1093","volume":"31","author":[{"given":"Jean-Baptiste","family":"P\u00e9rot","sequence":"first","affiliation":[{"name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives , Molecular Imaging Research Center (MIRCen), Universit\u00e9 Paris-Saclay, Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Fontenay -aux-Roses 92260, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"C\u00e9lestine","sequence":"additional","affiliation":[{"name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives , Molecular Imaging Research Center (MIRCen), Universit\u00e9 Paris-Saclay, Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Fontenay -aux-Roses 92260, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Palombo","sequence":"additional","affiliation":[{"name":"Department of Computer Science , Centre for Medical Image Computing, University College London, London WC1E 6BT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dhenain","sequence":"additional","affiliation":[{"name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives , Molecular Imaging Research Center (MIRCen), Universit\u00e9 Paris-Saclay, Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Fontenay -aux-Roses 92260, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Humbert","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes , INSERM, U1216, Grenoble Institut Neurosciences, Grenoble 38000 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Brouillet","sequence":"additional","affiliation":[{"name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives , Molecular Imaging Research Center (MIRCen), Universit\u00e9 Paris-Saclay, Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Fontenay -aux-Roses 92260, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6412-3427","authenticated-orcid":false,"given":"Julien","family":"Flament","sequence":"additional","affiliation":[{"name":"Laboratoire des Maladies Neurod\u00e9g\u00e9n\u00e9ratives , Molecular Imaging Research Center (MIRCen), Universit\u00e9 Paris-Saclay, Commissariat \u00e0 l\u2019Energie Atomique et aux Energies Alternatives (CEA), Centre National de la Recherche Scientifique (CNRS), Fontenay -aux-Roses 92260, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"2022102819593644600_ref1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","article-title":"Huntington\u2019s disease","volume":"369","author":"Walker","year":"2007","journal-title":"Lancet Lond. 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