{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:12:28Z","timestamp":1790856748710,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["RC2020-2756828"],"award-info":[{"award-number":["RC2020-2756828"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["GR2013-02356227"],"award-info":[{"award-number":["GR2013-02356227"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Epidermal development and maintenance are finely regulated events requiring a strict balance between proliferation and differentiation. Alterations in these processes give rise to human disorders such as cancer or syndromes with skin and annexes defects, known as ectodermal dysplasias (EDs). Here, we studied the functional effects of two novel receptor-interacting protein kinase 4 (RIPK4) missense mutations identified in siblings with an autosomal recessive ED with cutaneous syndactyly, palmoplantar hyperkeratosis and orofacial synechiae. Clinical overlap with distinct EDs caused by mutations in transcription factors (i.e. p63 and interferon regulatory factor 6, IRF6) or nectin adhesion molecules was noticed. Impaired activity of the RIPK4 kinase resulted both in altered epithelial differentiation and defective cell adhesion. We showed that mutant RIPK4 resulted in loss of PVRL4\/nectin-4 expression in patient epidermis and primary keratinocytes, and demonstrated that PVRL4 is transcriptionally regulated by IRF6, a RIPK4 phosphorylation target. In addition, defective RIPK4 altered desmosome morphology through modulation of plakophilin-1 and desmoplakin. In conclusion, this work implicates RIPK4 kinase function in the p63-IRF6 regulatory loop that controls the proliferation\/differentiation switch and cell adhesion, with implications in ectodermal development and cancer.<\/jats:p>","DOI":"10.1093\/hmg\/ddac046","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T12:10:30Z","timestamp":1645704630000},"page":"2535-2547","source":"Crossref","is-referenced-by-count":12,"title":["RIPK4 regulates cell\u2013cell adhesion in epidermal development and homeostasis"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-6477","authenticated-orcid":false,"given":"Paola","family":"Fortugno","sequence":"first","affiliation":[{"name":"Department of Life , Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"},{"name":"Human Functional Genomics , IRCCS San Raffaele Roma, 00163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosanna","family":"Monetta","sequence":"additional","affiliation":[{"name":"Department of Life , Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Belli","sequence":"additional","affiliation":[{"name":"MEBIC , IRCCS San Raffaele Roma, 00163 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta","family":"Botti","sequence":"additional","affiliation":[{"name":"Dermatology Unit , Department of Systems Medicine, Tor Vergata University of Rome, 00133 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Angelucci","sequence":"additional","affiliation":[{"name":"Department of Life , Health and Environmental Sciences, University of L\u2019Aquila, 67100 L\u2019Aquila, 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Dermatol."},{"key":"2022082311434328600_ref33","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/jid.2014.119","article-title":"Nectin-4 mutations causing ectodermal dysplasia with syndactyly perturb the rac1 pathway and the kinetics of adherens junction formation","volume":"134","author":"Fortugno","year":"2014","journal-title":"J. Invest. Dermatol."},{"key":"2022082311434328600_ref34","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.15252\/embj.201695679","article-title":"Phosphorylation of Pkp1 by RIPK 4 regulates epidermal differentiation and skin tumorigenesis","volume":"36","author":"Lee","year":"2017","journal-title":"EMBO J."},{"key":"2022082311434328600_ref35","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/ng1097-240","article-title":"Mutations in the Plakophilin 1 gene result in ectodermal dysplasia\/skin fragility syndrome","volume":"17","author":"McGrath","year":"1997","journal-title":"Nat. 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