{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T22:33:40Z","timestamp":1776897220391,"version":"3.51.2"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"16","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Telomeres protect chromosome ends and control cell division and senescence. During organogenesis, telomeres need to be long enough to ensure the cell proliferation necessary at this stage of development. Previous studies have shown that telomere shortening is associated with growth retardation and congenital malformations. However, these studies were performed in newborns or postnatally, and data on telomere length (TL) during the prenatal period are still very limited. We measured TL using quantitative PCR in amniotic fluid (AF) and chorionic villi (CV) samples from 69 control fetuses with normal ultrasound (52 AF and 17 CV) and 213 fetuses (165 AF and 48 CV) with intrauterine growth retardation (IUGR) or congenital malformations diagnosed by ultrasound. The samples were collected by amniocentesis at the gestational age (GA) of 25.0\u2009\u00b1\u20095.4\u00a0weeks and by CV biopsy at 18.1\u2009\u00b1\u20096.3\u00a0weeks. In neither sample type was TL influenced by GA or fetal sex. In AF, a comparison of abnormal versus normal fetuses showed a significant telomere shortening in cases of IUGR (reduction of 34%, P\u2009&amp;lt;\u200910\u22126), single (29%, P\u2009&amp;lt;\u200910\u22126) and multiple (44%, P\u2009&amp;lt;\u200910\u22126) malformations. Similar TL shortening was also observed in CV from abnormal fetuses but to a lesser extent (25%, P\u2009=\u20090.0002; 18%, P\u2009=\u20090.016; 20%, P\u2009=\u20090.004, respectively). Telomere shortening was more pronounced in cases of multiple congenital anomalies than in fetuses with a single malformation, suggesting a correlation between TL and the severity of fetal phenotype. Thus, TL measurement in fetal samples during pregnancy could provide a novel predictive marker of pathological development.<\/jats:p>","DOI":"10.1093\/hmg\/ddac054","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T20:11:36Z","timestamp":1646251896000},"page":"2669-2677","source":"Crossref","is-referenced-by-count":9,"title":["Reduced telomere length in amniocytes: an early biomarker of abnormal fetal development?"],"prefix":"10.1093","volume":"31","author":[{"given":"Carole","family":"Goumy","sequence":"first","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"},{"name":"INSERM U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques, Universit\u00e9 Clermont Auvergne , Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Veronese","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"},{"name":"EA7453 CHELTER \u00ab Clonal Heterogeneity , Leukemic environment, Therapy Resistance of Chronic Leukemias \u00bb, , Clermont Ferrand, France"},{"name":"Universit\u00e9 Clermont Auvergne , Leukemic environment, Therapy Resistance of Chronic Leukemias \u00bb, , Clermont Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigue","family":"Stamm","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quentin","family":"Domas","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Hadjab","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Gallot","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine F\u0153tale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Laurichesse","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine F\u0153tale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Am\u00e9lie","family":"Delabaere","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de M\u00e9decine F\u0153tale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1891-4762","authenticated-orcid":false,"given":"Laetitia","family":"Gouas","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"},{"name":"INSERM U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques, Universit\u00e9 Clermont Auvergne , Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaelle","family":"Salaun","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"},{"name":"INSERM U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques, Universit\u00e9 Clermont Auvergne , Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Perbel-Richard","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Vago","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"},{"name":"INSERM U1240 Imagerie Mol\u00e9culaire et Strat\u00e9gies Th\u00e9ranostiques, Universit\u00e9 Clermont Auvergne , Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-498X","authenticated-orcid":false,"given":"Andrei","family":"Tchirkov","sequence":"additional","affiliation":[{"name":"Cytog\u00e9n\u00e9tique M\u00e9dicale, CHU Clermont-Ferrand, CHU Estaing , F-63000 Clermont-Ferrand, France"},{"name":"EA7453 CHELTER \u00ab Clonal Heterogeneity , Leukemic environment, Therapy Resistance of Chronic Leukemias \u00bb, , Clermont Ferrand, France"},{"name":"Universit\u00e9 Clermont Auvergne , Leukemic environment, Therapy Resistance of Chronic Leukemias \u00bb, , Clermont Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"2022082420082200200_ref1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jtbi.2004.12.016","article-title":"A mathematical model of cellular apoptosis and senescence through the dynamics of telomere loss","volume":"235","author":"Arkus","year":"2005","journal-title":"J. Theor. Biol."},{"key":"2022082420082200200_ref2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ceb.2006.03.003","article-title":"Telomerase regulation and stem cell behaviour","volume":"18","author":"Flores","year":"2006","journal-title":"Curr. Opin. Cell Biol."},{"key":"2022082420082200200_ref3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3390\/jdb9040049","article-title":"Insights into the role of telomeres in human embryological parameters. Opinions regarding IVF","volume":"9","author":"Anifandis","year":"2021","journal-title":"J. Dev. Biol."},{"key":"2022082420082200200_ref4","doi-asserted-by":"crossref","DOI":"10.1111\/aji.12661","article-title":"Telomere length and fetal programming: a review of recent scientific advances","volume":"77","author":"Whiteman","year":"2017","journal-title":"Am. J. Reprod. Immunol."},{"key":"2022082420082200200_ref5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/molehr\/gat055","article-title":"Telomere length and telomerase activity during oocyte maturation and early embryo development in mammalian species","volume":"20","author":"Ozturk","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"2022082420082200200_ref6","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.placenta.2009.03.005","article-title":"Fetal growth restriction is associated with accelerated telomere shortening and increased expression of cell senescence markers in the placenta","volume":"30","author":"Davy","year":"2009","journal-title":"Placenta"},{"key":"2022082420082200200_ref7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.earlhumdev.2010.08.024","article-title":"TERC telomerase subunit gene copy number in placentas from pregnancies complicated with intrauterine growth restriction","volume":"87","author":"Biron-Shental","year":"2011","journal-title":"Early Hum. Dev."},{"key":"2022082420082200200_ref8","doi-asserted-by":"crossref","first-page":"e54013","DOI":"10.1371\/journal.pone.0054013","article-title":"Reduced placental telomere length during pregnancies complicated by intrauterine growth restriction","volume":"8","author":"Toutain","year":"2013","journal-title":"PLoS One"},{"key":"2022082420082200200_ref9","article-title":"Patients with congenital limb anomaly show short telomere, shutdown of telomerase and deregulated expression of various telomere-associated proteins in peripheral blood mononuclear cells: a case series","volume":"11","author":"Mazumdar","year":"2017","journal-title":"JCDR"},{"key":"2022082420082200200_ref10","first-page":"494","article-title":"Simultaneous decrease of telomere length and telomerase activity with ageing of human amniotic fluid cells","volume":"36","author":"Mosquera","year":"1999","journal-title":"J. Med. Genet."},{"key":"2022082420082200200_ref11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1159\/000329714","article-title":"Telomeres in trisomy 21 amniocytes","volume":"135","author":"Sukenik-Halevy","year":"2011","journal-title":"Cytogenet. Genome Res."},{"key":"2022082420082200200_ref12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.gene.2014.03.019","article-title":"Decreased telomere length in metaphase and interphase cells from newborns with trisomy 21","volume":"542","author":"Wenger","year":"2014","journal-title":"Gene"},{"key":"2022082420082200200_ref13","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.gene.2013.09.086","article-title":"Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH","volume":"533","author":"Nakamura","year":"2014","journal-title":"Gene"},{"key":"2022082420082200200_ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.mad.2017.03.006","article-title":"Telomere length analysis in Down syndrome birth","volume":"164","author":"Bhaumik","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"2022082420082200200_ref15","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1080\/15513815.2019.1661049","article-title":"Telomere length inheritance and shortening in trisomy 21","volume":"39","author":"Bhattacharya","year":"2020","journal-title":"Fetal Pediatr. Pathol."},{"key":"2022082420082200200_ref16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1159\/000381896","article-title":"Evaluation of quantitative fluorescence in situ hybridization for relative measurement of telomere length in placental mesenchymal core cells","volume":"81","author":"Toutain","year":"2016","journal-title":"Gynecol. Obstet. Investig."},{"key":"2022082420082200200_ref17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/molehr\/3.9.769","article-title":"Developmental regulation of telomerase activity in human fetal tissues during gestation","volume":"3","author":"Ulaner","year":"1997","journal-title":"Mol. Hum. Reprod."},{"key":"2022082420082200200_ref18","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1073\/pnas.92.11.4818","article-title":"Developmental and tissue-specific regulation of mouse telomerase and telomere length","volume":"92","author":"Prowse","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2022082420082200200_ref19","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/sj.onc.1201933","article-title":"Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation","volume":"16","author":"Greenberg","year":"1998","journal-title":"Oncogene"},{"key":"2022082420082200200_ref20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1071\/RD04112","article-title":"Telomere length regulation during cloning, embryogenesis and ageing","volume":"17","author":"Schaetzlein","year":"2005","journal-title":"Reprod. Fertil. Dev."},{"key":"2022082420082200200_ref21","doi-asserted-by":"crossref","first-page":"8034","DOI":"10.1073\/pnas.0402400101","article-title":"Telomere length is reset during early mammalian embryogenesis","volume":"101","author":"Schaetzlein","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2022082420082200200_ref22","doi-asserted-by":"crossref","first-page":"e1002161","DOI":"10.1371\/journal.pgen.1002161","article-title":"Telomere DNA deficiency is associated with development of human embryonic aneuploidy","volume":"7","author":"Treff","year":"2011","journal-title":"PLoS Genet."},{"key":"2022082420082200200_ref23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00018-006-6466-z","article-title":"Telomeres and meiosis in health and disease: telomeres and aging-related meiotic dysfunction in women","volume":"64","author":"Keefe","year":"2007","journal-title":"Cell. Mol. Life Sci."},{"key":"2022082420082200200_ref24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13039-018-0361-9","article-title":"Can telomere shortening be the main indicator of non-viable fetus elimination?","volume":"11","author":"Huleyuk","year":"2018","journal-title":"Mol. Cytogenet."},{"key":"2022082420082200200_ref25","article-title":"Etiology and clinical presentation of birth defects: population based study","volume":"357","author":"Feldkamp","year":"2017","journal-title":"BMJ"},{"key":"2022082420082200200_ref26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1006\/bbrc.1997.7767","article-title":"Expression of telomerase activity in human chorion","volume":"241","author":"Kyo","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2022082420082200200_ref27","first-page":"81","article-title":"Comparison of telomerase activity in normal chorionic villi to trophoblastic diseases","volume":"12","author":"Nishi","year":"1998","journal-title":"Int. J. Oncol."},{"key":"2022082420082200200_ref28","first-page":"124","article-title":"Telomerase and proliferative activity in placenta from women with and without fetal growth restriction","volume":"93","author":"Izutsu","year":"1999","journal-title":"Obstet. Gynecol."},{"key":"2022082420082200200_ref29","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/humrep\/17.2.463","article-title":"Telomerase activity in gestational trophoblastic disease and placental tissue from early and late human pregnancies","volume":"17","author":"Chen","year":"2002","journal-title":"Hum. Reprod."},{"key":"2022082420082200200_ref30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nbt1274","article-title":"Isolation of amniotic stem cell lines with potential for therapy","volume":"25","author":"De Coppi","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"2022082420082200200_ref31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12272-012-0207-7","article-title":"Amniotic fluid-derived stem cells in regenerative medicine research","volume":"35","author":"Joo","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"2022082420082200200_ref32","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1007\/s004390050755","article-title":"Synchrony in telomere length of the human fetus","volume":"102","author":"Youngren","year":"1998","journal-title":"Hum. Genet."},{"key":"2022082420082200200_ref33","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1474-9726.2011.00741.x","article-title":"Sex differences in telomeres and lifespan","volume":"10","author":"Barrett","year":"2011","journal-title":"Aging Cell"},{"key":"2022082420082200200_ref34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.placenta.2017.09.007","article-title":"Telomere length heterogeneity in placenta revealed with high-resolution telomere length analysis","volume":"59","author":"Garcia-Martin","year":"2017","journal-title":"Placenta"},{"key":"2022082420082200200_ref35","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1203\/00006450-200209000-00012","article-title":"Telomere length in the newborn","volume":"52","author":"Okuda","year":"2002","journal-title":"Pediatr. Res."},{"key":"2022082420082200200_ref36","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3927","article-title":"Leukocyte telomere length in newborns: implications for the role of telomeres in human disease","volume":"137","author":"Factor-Litvak","year":"2016","journal-title":"Pediatrics"},{"key":"2022082420082200200_ref37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.placenta.2016.10.001","article-title":"Placental telomere length decline with gestational age differs by sex and TERT, DNMT1, and DNMT3A DNA methylation","volume":"48","author":"Wilson","year":"2016","journal-title":"Placenta"},{"key":"2022082420082200200_ref38","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1002\/pd.483","article-title":"Origin of amnion and implications for evaluation of the fetal genotype in cases of mosaicism","volume":"22","author":"Robinson","year":"2002","journal-title":"Prenat. Diagn."},{"key":"2022082420082200200_ref39","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1212\/NXG.0000000000000370","article-title":"CNS manifestations in patients with telomere biology disorders","volume":"5","author":"Bhala","year":"2019","journal-title":"Neurol Genet"},{"key":"2022082420082200200_ref40","doi-asserted-by":"crossref","first-page":"E503","DOI":"10.3390\/cells9020503","article-title":"Telomeres and telomerase in heart ontogenesis, aging and regeneration","volume":"9","author":"Nalobin","year":"2020","journal-title":"Cell"},{"key":"2022082420082200200_ref41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1083\/jcb.201510091","article-title":"Postnatal telomere dysfunction induces cardiomyocyte cell-cycle arrest through p21 activation","volume":"213","author":"Aix","year":"2016","journal-title":"J. Cell Biol."},{"key":"2022082420082200200_ref42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/bdra.23240","article-title":"Epidemiology of multiple congenital anomalies in Europe: a EUROCAT population-based registry study","volume":"100","author":"Calzolari","year":"2014","journal-title":"Birth Defects Res. A Clin. Mol. Teratol."},{"key":"2022082420082200200_ref43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.5665\/sleep.4570","article-title":"Association between maternal symptoms of sleep disordered breathing and fetal telomere length","volume":"38","author":"Salihu","year":"2015","journal-title":"Sleep"},{"key":"2022082420082200200_ref44","doi-asserted-by":"crossref","first-page":"205.e1","DOI":"10.1016\/j.ajog.2014.08.026","article-title":"Impact of intrauterine tobacco exposure on fetal telomere length","volume":"212","author":"Salihu","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2022082420082200200_ref45","doi-asserted-by":"crossref","first-page":"767","DOI":"10.14423\/SMJ.0000000000000567","article-title":"Association between maternal-perceived psychological stress and Fetal telomere length","volume":"109","author":"Salihu","year":"2016","journal-title":"South. Med. J."},{"key":"2022082420082200200_ref46","doi-asserted-by":"crossref","first-page":"283.e1","DOI":"10.1016\/j.ajog.2015.08.050","article-title":"Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia","volume":"214","author":"Sukenik-Halevy","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2022082420082200200_ref47","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2017.0463","article-title":"Does oxidative stress shorten telomeres in vivo? A Review","volume":"13","author":"Reichert","year":"2017","journal-title":"Biol. Lett."},{"key":"2022082420082200200_ref48","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1196\/annals.1297.047","article-title":"Mechanism of telomere shortening by oxidative stress","volume":"1019","author":"Kawanishi","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"2022082420082200200_ref49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/358375","article-title":"Oxidative stress-mediated aging during the fetal and perinatal periods","volume":"2014","author":"Marseglia","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"2022082420082200200_ref50","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/bdr2.1682","article-title":"Preconception telomere length as a novel maternal biomarker to assess the risk of spina bifida in the offspring","volume":"112","author":"Aoulad Fares","year":"2020","journal-title":"Birth Defects Res."},{"key":"2022082420082200200_ref51","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.atherosclerosis.2009.09.070","article-title":"Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation","volume":"209","author":"Salpea","year":"2010","journal-title":"Atherosclerosis"},{"key":"2022082420082200200_ref52","doi-asserted-by":"crossref","first-page":"21491","DOI":"10.1038\/srep21491","article-title":"Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin","volume":"6","author":"Cao","year":"2016","journal-title":"Sci. Rep."},{"key":"2022082420082200200_ref53","doi-asserted-by":"crossref","first-page":"237.e1","DOI":"10.1016\/j.ajog.2008.06.028","article-title":"Diabetes mellitus and birth defects","volume":"199","author":"Correa","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2022082420082200200_ref54","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1480-9222-13-3","article-title":"A quantitative PCR method for measuring absolute telomere length","volume":"13","author":"O\u2019Callaghan","year":"2011","journal-title":"Biol. Proced. Online"},{"key":"2022082420082200200_ref55","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/leu.2012.194","article-title":"Telomeres and chromosomal instability in chronic lymphocytic leukemia","volume":"27","author":"V\u00e9ron\u00e8se","year":"2013","journal-title":"Leukemia"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddac054\/43289391\/ddac054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/31\/16\/2669\/45499290\/ddac054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/31\/16\/2669\/45499290\/ddac054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T20:09:16Z","timestamp":1661371756000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/31\/16\/2669\/6542340"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":55,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2022,3,4]]},"published-print":{"date-parts":[[2022,8,23]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddac054","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,8,15]]},"published":{"date-parts":[[2022,3,4]]}}}