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Herein, we report prominent developmental defects in the hippocampus of a conditional knockout mouse lacking the conserved exons 11 and 12 of Talpid3. At early postnatal stages, the Talpid3 mutants exhibit a reduction in proliferation in the dentate gyrus and a disrupted glial scaffold. The occurrence of mis-localized progenitors in the granule cell layer suggests a role for the disrupted glial scaffold in cell migration resulting in defective subpial neurogenic zone-to-hilar transition. Neurospheres derived from the hippocampus of Talpid3fl\/flUbcCre mouse, in which Talpid3 was conditionally deleted, lacked primary cilia and were smaller in size. In addition, neurosphere cells showed a disrupted actin cytoskeleton and defective migration. Our findings suggest a link between the hippocampal defects and the learning\/memory deficits seen in JS patients.<\/jats:p>","DOI":"10.1093\/hmg\/ddac095","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T19:16:26Z","timestamp":1650568586000},"page":"3245-3265","source":"Crossref","is-referenced-by-count":5,"title":["Hippocampals neurogenesis is impaired in mice with a deletion in the coiled coil domain of Talpid3\u2014implications for Joubert syndrome"],"prefix":"10.1093","volume":"31","author":[{"given":"Andrew L","family":"Bashford","sequence":"first","affiliation":[{"name":"Department of Biology and Biochemistry, University of Bath , Bath BA2 7AY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1969-7333","authenticated-orcid":false,"given":"Vasanta","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Biology and Biochemistry, University of Bath , Bath BA2 7AY , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"2022093009404744900_ref1","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrg2774","article-title":"The primary cilium: a signalling centre during vertebrate development","volume":"11","author":"Goetz","year":"2010","journal-title":"Nat. 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