{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:27:23Z","timestamp":1792794443834,"version":"4.5.0"},"reference-count":97,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T00:00:00Z","timestamp":1660176000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Foundation pour la Recherche M\u00e9dicale","award":["DEQ20160334936"],"award-info":[{"award-number":["DEQ20160334936"]}],"id":[{"id":"https:\/\/ror.org\/04w6kn183","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE12-0008-01"],"award-info":[{"award-number":["ANR-18-CE12-0008-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002889","name":"Foundation for Prader-Willi Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002889","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The neuronal-specific SNORD115 has gathered interest because its deficiency may contribute to the pathophysiology of Prader-Willi syndrome (PWS), possibly by altering post-transcriptional regulation of the gene encoding the serotonin (HTR2C) receptor. Yet, Snord115-KO mice do not resume the main symptoms of PWS, and only subtle-altered A-to-I RNA editing of Htr2c mRNAs was uncovered. Because HTR2C signaling fine-tunes the activity of monoaminergic neurons, we addressed the hypothesis that lack of Snord115 alters monoaminergic systems. We first showed that Snord115 was expressed in both monoaminergic and non-monoaminergic cells of the ventral tegmental area (VTA) and the dorsal raphe nucleus (DRN) harboring cell bodies of dopaminergic and serotonergic neurons, respectively. Measuring the tissue level of monoamines and metabolites, we found very few differences except that the content of homovanillic acid\u2014a metabolite of dopamine\u2014was decreased in the orbitofrontal and prefrontal cortex of Snord115-KO mice. The latter effects were, however, associated with a few changes in monoamine tissue content connectivity across the 12 sampled brain regions. Using in vivo single-cell extracellular recordings, we reported that the firing rate of VTA dopaminergic neurons and DRN serotonergic neurons was significantly increased in Snord115-KO mice. These neural circuit dysfunctions were not, however, associated with apparent defects in binge eating, conditioned place preference to cocaine, cocaine-induced hyperlocomotion or compulsive behavior. Altogether, our multiscale study shows that the absence of Snord115 impacts central monoaminergic circuits to an extent that does not elicit gross behavioral abnormalities.<\/jats:p>","DOI":"10.1093\/hmg\/ddac139","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T10:58:21Z","timestamp":1660215501000},"page":"244-261","source":"Crossref","is-referenced-by-count":17,"title":["Deleting\n                    <i>Snord115<\/i>\n                    genes in mice remodels monoaminergic systems activity in the brain toward cortico-subcortical imbalances"],"prefix":"10.1093","volume":"32","author":[{"given":"Virginie","family":"Marty","sequence":"first","affiliation":[{"name":"Molecular , Cellular and Developmental Biology (MCD) unit, Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"},{"name":"University of Toulouse; CNRS, UPS , Cellular and Developmental Biology (MCD) unit, Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine J","family":"Butler","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine (INCIA) , CNRS-UMR 5287, 146 rue L\u00e9o Saignat, B.P.281, F-33000 Bordeaux Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Basile","family":"Coutens","sequence":"additional","affiliation":[{"name":"Research Center on Animal Cognition (CRCA) , Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"},{"name":"University of Toulouse; CNRS, UPS , Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumaima","family":"Chargui","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine (INCIA) , CNRS-UMR 5287, 146 rue L\u00e9o Saignat, B.P.281, F-33000 Bordeaux Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdeslam","family":"Chagraoui","sequence":"additional","affiliation":[{"name":"Diff\u00e9renciation et Communication Neuroendocrine , Endocrine et Germinale (NorDic), , 76 000 Rouen , France"},{"name":"INSERM U1239, IRIB, CHU Rouen , Endocrine et Germinale (NorDic), , 76 000 Rouen , France"},{"name":"Department of Medical Biochemistry, Rouen University Hospital , 76 000 Rouen , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno P","family":"Guiard","sequence":"additional","affiliation":[{"name":"Research Center on Animal Cognition (CRCA) , Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"},{"name":"University of Toulouse; CNRS, UPS , Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"De Deurwaerd\u00e8re","sequence":"additional","affiliation":[{"name":"Institut de Neurosciences Cognitives et Int\u00e9gratives d'Aquitaine (INCIA) , CNRS-UMR 5287, 146 rue L\u00e9o Saignat, B.P.281, F-33000 Bordeaux Cedex , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Cavaill\u00e9","sequence":"additional","affiliation":[{"name":"Molecular , Cellular and Developmental Biology (MCD) unit, Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"},{"name":"University of Toulouse; CNRS, UPS , Cellular and Developmental Biology (MCD) unit, Center of Integrative Biology (CBI), CNRS - , 31 062 Toulouse , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,11]]},"reference":[{"key":"2023011411264958100_ref1","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/nar\/gkz1140","article-title":"Functional diversity of small nucleolar RNAs","volume":"48","author":"Bratkovic","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"2023011411264958100_ref2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.pharmthera.2015.11.009","article-title":"New therapeutic opportunities for 5-HT2C receptor ligands in neuropsychiatric disorders","volume":"157","author":"Di Giovanni","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"2023011411264958100_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2004.01.036","article-title":"Contributions of 5-HT(2C) receptors to multiple actions of central serotonin systems","volume":"488","author":"Giorgetti","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"2023011411264958100_ref4","doi-asserted-by":"crossref","first-page":"14311","DOI":"10.1073\/pnas.250426397","article-title":"Identification of brain-specific and imprinted small nucleolar RNA genes exhibiting an unusual genomic organization","volume":"97","author":"Cavaille","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023011411264958100_ref5","doi-asserted-by":"crossref","first-page":"e1417","DOI":"10.1002\/wrna.1417","article-title":"Box C\/D small nucleolar RNA genes and the Prader-Willi syndrome: a complex interplay","volume":"8","author":"Cavaill\u00e9","year":"2017","journal-title":"Wiley Interdiscip Rev. RNA"},{"key":"2023011411264958100_ref6","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1126\/science.1118265","article-title":"The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C","volume":"311","author":"Kishore","year":"2006","journal-title":"Science"},{"key":"2023011411264958100_ref7","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00439-017-1826-3","article-title":"The activity of the serotonin receptor 2C is regulated by alternative splicing","volume":"136","author":"Stamm","year":"2017","journal-title":"Hum. Genet."},{"key":"2023011411264958100_ref8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1083\/jcb.200411129","article-title":"ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C\/D small nucleolar RNAs","volume":"169","author":"Vitali","year":"2005","journal-title":"J. Cell Biol."},{"key":"2023011411264958100_ref9","first-page":"10","article-title":"Prader-Willi syndrome","volume":"14","author":"Cassidy","year":"2012","journal-title":"Genet. med official J. Am. C.Med. Genet."},{"key":"2023011411264958100_ref10","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ijo.2010.139","article-title":"Development of the eating behaviour in Prader-Willi syndrome: advances in our understanding","volume":"35","author":"McAllister","year":"2011","journal-title":"Int. J. Obes."},{"key":"2023011411264958100_ref11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S2213-8587(21)00002-4","article-title":"Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction","volume":"9","author":"Tauber","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2023011411264958100_ref12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00439-004-1219-2","article-title":"Exclusion of the C\/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome","volume":"116","author":"Runte","year":"2005","journal-title":"Hum. Genet."},{"key":"2023011411264958100_ref13","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1093\/hmg\/ddz100","article-title":"Prader-Willi syndrome imprinting Centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition","volume":"28","author":"Davies","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"2023011411264958100_ref14","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1093\/hmg\/ddp137","article-title":"Loss of the imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT2CR-mediated behaviour","volume":"18","author":"Doe","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2023011411264958100_ref15","article-title":"Reassessment of the involvement of Snord115 in the serotonin 2c receptor pathway in a genetically relevant mouse model","volume":"9","author":"Hebras","year":"2020","journal-title":"elife"},{"key":"2023011411264958100_ref16","doi-asserted-by":"crossref","first-page":"4300","DOI":"10.1038\/s41598-019-39940-6","article-title":"Ectopic expression of Snord115 in choroid plexus interferes with editing but not splicing of 5-Ht2c receptor pre-mRNA in mice","volume":"9","author":"Raabe","year":"2019","journal-title":"Sci. Rep."},{"key":"2023011411264958100_ref17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051649","article-title":"Serotonin in animal cognition and behavior","volume":"21","author":"Bacque-Cazenave","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2023011411264958100_ref18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1152\/physrev.1991.71.1.155","article-title":"Mesocorticolimbic dopaminergic network: functional and regulatory roles","volume":"71","author":"Le Moal","year":"1991","journal-title":"Physiol. Rev."},{"key":"2023011411264958100_ref19","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, compulsivity, and top-down cognitive control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"key":"2023011411264958100_ref20","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.pbb.2007.12.021","article-title":"Neurobehavioral mechanisms of impulsivity: fronto-striatal systems and functional neurochemistry","volume":"90","author":"Dalley","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"2023011411264958100_ref21","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1017\/S1461145707008383","article-title":"Functional interactions between dopamine, serotonin and norepinephrine neurons: an in-vivo electrophysiological study in rats with monoaminergic lesions","volume":"11","author":"Guiard","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"2023011411264958100_ref22","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1523\/JNEUROSCI.0112-04.2004","article-title":"Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens","volume":"24","author":"De Deurwaerdere","year":"2004","journal-title":"J. Neurosci."},{"key":"2023011411264958100_ref23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0306-4522(98)00655-1","article-title":"Selective blockade of serotonin-2C\/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study","volume":"91","author":"Di Giovanni","year":"1999","journal-title":"Neuroscience"},{"key":"2023011411264958100_ref24","first-page":"83","article-title":"Serotonin-dopamine interaction in the rat ventral tegmental area: an electrophysiological study in vivo","volume":"271","author":"Prisco","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023011411264958100_ref25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1242\/jcs.054957","article-title":"Long nuclear-retained non-coding RNAs and allele-specific higher-order chromatin organization at imprinted snoRNA gene arrays","volume":"123","author":"Vitali","year":"2010","journal-title":"J. Cell Sci."},{"key":"2023011411264958100_ref26","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jneumeth.2017.01.020","article-title":"Correlative analysis of dopaminergic and serotonergic metabolism across the brain to study monoaminergic function and interaction","volume":"280","author":"Dellu-Hagedorn","year":"2017","journal-title":"J. Neurosci. Methods"},{"key":"2023011411264958100_ref27","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuroscience.2013.09.059","article-title":"Monoamines tissue content analysis reveals restricted and site-specific correlations in brain regions involved in cognition","volume":"255","author":"Fitoussi","year":"2013","journal-title":"Neuroscience"},{"key":"2023011411264958100_ref28","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0006-2952(85)90484-8","article-title":"Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity","volume":"34","author":"Commissiong","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"2023011411264958100_ref29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0165-0270(93)90097-B","article-title":"Quantitative microdialysis of neurotransmitters","volume":"48","author":"Justice","year":"1993","journal-title":"J. Neurosci. Methods"},{"key":"2023011411264958100_ref30","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1111\/j.1471-4159.1986.tb00704.x","article-title":"A comparison of biochemical indices of 5-hydroxytryptaminergic neuronal activity following electrical stimulation of the dorsal raphe nucleus","volume":"47","author":"Shannon","year":"1986","journal-title":"J. Neurochem."},{"key":"2023011411264958100_ref31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuint.2019.01.019","article-title":"Neurochemical impact of the 5-HT2C receptor agonist WAY-163909 on monoamine tissue content in the rat brain","volume":"124","author":"Chagraoui","year":"2019","journal-title":"Neurochem. Int."},{"key":"2023011411264958100_ref32","doi-asserted-by":"crossref","first-page":"107915","DOI":"10.1016\/j.neuropharm.2019.107915","article-title":"Lorcaserin bidirectionally regulates dopaminergic function site-dependently and disrupts dopamine brain area correlations in rats","volume":"166","author":"De Deurwaerdere","year":"2020","journal-title":"Neuropharmacology"},{"key":"2023011411264958100_ref33","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.neuint.2019.05.001","article-title":"Early neurochemical modifications of monoaminergic systems in the R6\/1 mouse model of Huntington's disease","volume":"128","author":"Puginier","year":"2019","journal-title":"Neurochem. Int."},{"key":"2023011411264958100_ref34","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/jnc.14929","article-title":"Old neurochemical markers, new functional directions?: an editorial for 'Distinct gradients of various neurotransmitter markers in caudate nucleus and putamen of the human brain' on page 650","volume":"152","author":"De Deurwaerdere","year":"2020","journal-title":"J. Neurochem."},{"key":"2023011411264958100_ref35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1124\/pr.56.3.1","article-title":"Catecholamine metabolism: a contemporary view with implications for physiology and medicine","volume":"56","author":"Eisenhofer","year":"2004","journal-title":"Pharmacol. Rev."},{"key":"2023011411264958100_ref36","volume-title":"The Biochemical Basis of Neuropharmacology","author":"Cooper","year":"2003"},{"key":"2023011411264958100_ref37","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neubiorev.2021.06.022","article-title":"Serotonergic regulation of the dopaminergic system: implications for reward-related functions","volume":"128","author":"Courtiol","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"2023011411264958100_ref38","doi-asserted-by":"crossref","first-page":"7211","DOI":"10.1038\/s41380-021-01220-z","article-title":"5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding","volume":"26","author":"He","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"2023011411264958100_ref39","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1523\/JNEUROSCI.02-12-01786.1982","article-title":"Intracellular identification of central noradrenergic and serotonergic neurons by a new double labeling procedure","volume":"2","author":"Aghajanian","year":"1982","journal-title":"J. Neurosci."},{"key":"2023011411264958100_ref40","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3109\/00207458808985756","article-title":"Functional properties of presumed dopamine-containing and other ventral tegmental area neurons in conscious rats","volume":"42","author":"Kiaytkin","year":"1988","journal-title":"Int. J. Neurosci."},{"key":"2023011411264958100_ref41","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00221-013-3593-2","article-title":"Serotonin2C receptors and drug addiction: focus on cocaine","volume":"230","author":"Devroye","year":"2013","journal-title":"Exp. Brain Res."},{"key":"2023011411264958100_ref42","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1124\/pr.114.009514","article-title":"Serotonin 5-HT2 receptor interactions with dopamine function: implications for therapeutics in cocaine use disorder","volume":"67","author":"Howell","year":"2015","journal-title":"Pharmacol. Rev."},{"key":"2023011411264958100_ref43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbr.2012.10.034","article-title":"Serotonin (2C) receptor regulation of cocaine-induced conditioned place preference and locomotor sensitization","volume":"238","author":"Craige","year":"2013","journal-title":"Behav. Brain Res."},{"key":"2023011411264958100_ref44","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.biopsych.2016.06.005","article-title":"Activation of serotonin 2C receptors in dopamine neurons inhibits binge-like eating in mice","volume":"81","author":"Xu","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"2023011411264958100_ref45","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/S0031-9384(03)00047-7","article-title":"Compulsive behavior in the 5-HT2C receptor knockout mouse","volume":"78","author":"Chou-Green","year":"2003","journal-title":"Physiol. Behav."},{"key":"2023011411264958100_ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3758\/s13415-018-00653-4","article-title":"A critical inquiry into marble-burying as a preclinical screening paradigm of relevance for anxiety and obsessive-compulsive disorder: mapping the way forward","volume":"19","author":"Brouwer","year":"2019","journal-title":"Cogn. Affect. Behav. Ne."},{"key":"2023011411264958100_ref47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fnbeh.2020.00073","article-title":"Inhibition of catechol-O-methyltransferase does not Alter effort-related choice behavior in a fixed ratio\/concurrent chow task in male mice","volume":"14","author":"DeBrosse","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"2023011411264958100_ref48","first-page":"231s","article-title":"Heterologous monoamine reuptake: lack of transmitter specificity of neuron-specific carriers","volume":"20","author":"Di Chiara","year":"1992","journal-title":"Neurochem. Int."},{"key":"2023011411264958100_ref49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF02246048","article-title":"Local 5HT3 receptors mediate fluoxetine but not desipramine-induced increase of extracellular dopamine in the prefrontal cortex","volume":"119","author":"Tanda","year":"1995","journal-title":"Psychopharmacology"},{"key":"2023011411264958100_ref50","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/cns.12275","article-title":"Noradrenergic terminals regulate L-DOPA-derived dopamine extracellular levels in a region-dependent manner in parkinsonian rats","volume":"20","author":"Navailles","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"2023011411264958100_ref51","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1111\/j.1476-5381.2009.00494.x","article-title":"Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice","volume":"158","author":"Kaenmaki","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"2023011411264958100_ref52","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1111\/j.1471-4159.2010.06723.x","article-title":"Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice","volume":"113","author":"Myohanen","year":"2010","journal-title":"J. Neurochem."},{"key":"2023011411264958100_ref53","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00213-010-1944-2","article-title":"Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice","volume":"211","author":"Tammimaki","year":"2010","journal-title":"Psychopharmacology"},{"key":"2023011411264958100_ref54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21010294","article-title":"L-DOPA in Parkinson's disease: looking at the \"false\" neurotransmitters and their meaning","volume":"21","author":"Chagraoui","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2023011411264958100_ref55","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1126\/science.7792602","article-title":"Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA","volume":"268","author":"Cases","year":"1995","journal-title":"Science"},{"key":"2023011411264958100_ref56","doi-asserted-by":"crossref","first-page":"14835","DOI":"10.1073\/pnas.1616515114","article-title":"Dopamine release from the locus coeruleus to the dorsal hippocampus promotes spatial learning and memory","volume":"113","author":"Kempadoo","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023011411264958100_ref57","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/adb.12026","article-title":"The dopamine beta-hydroxylase inhibitor nepicastat increases dopamine release and potentiates psychostimulant-induced dopamine release in the prefrontal cortex","volume":"19","author":"Devoto","year":"2014","journal-title":"Addict. Biol."},{"key":"2023011411264958100_ref58","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2202-6-31","article-title":"Co-release of noradrenaline and dopamine in the cerebral cortex elicited by single train and repeated train stimulation of the locus coeruleus","volume":"6","author":"Devoto","year":"2005","journal-title":"BMC Neurosci."},{"key":"2023011411264958100_ref59","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pnpbp.2018.11.015","article-title":"Noradrenergic terminals are the primary source of \u03b1(2)-adrenoceptor mediated dopamine release in the medial prefrontal cortex","volume":"90","author":"Devoto","year":"2019","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"2023011411264958100_ref60","doi-asserted-by":"crossref","first-page":"11759","DOI":"10.3390\/ijms222111759","article-title":"Simulated microgravity subtlety changes monoamine function across the rat brain","volume":"22","author":"Gros","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023011411264958100_ref61","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/B978-0-12-411512-5.00009-9","article-title":"Catecholamine\/serotonin interactions: systems thinking for brain function and disease","volume":"68","author":"Hensler","year":"2013","journal-title":"Adv. Pharmacol."},{"key":"2023011411264958100_ref62","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1046\/j.1471-4159.1996.66020589.x","article-title":"The prefrontal cortex regulates the basal release of dopamine in the limbic striatum: an effect mediated by ventral tegmental area","volume":"66","author":"Karreman","year":"1996","journal-title":"J. Neurochem."},{"key":"2023011411264958100_ref63","doi-asserted-by":"crossref","first-page":"108309","DOI":"10.1016\/j.neuropharm.2020.108309","article-title":"Serotonin2B receptor blockade in the rat dorsal raphe nucleus suppresses cocaine-induced hyperlocomotion through an opposite control of mesocortical and mesoaccumbens dopamine pathways","volume":"180","author":"Cathala","year":"2020","journal-title":"Neuropharmacology"},{"key":"2023011411264958100_ref64","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1471-4159.1989.tb07319.x","article-title":"In vivo measurement of extracellular 5-hydroxytryptamine in hippocampus of the anaesthetized rat using microdialysis: changes in relation to 5-hydroxytryptaminergic neuronal activity","volume":"53","author":"Sharp","year":"1989","journal-title":"J. Neurochem."},{"key":"2023011411264958100_ref65","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.3390\/ijms20122925","article-title":"Effect of the 5-HT2C receptor agonist WAY-163909 on serotonin and dopamine metabolism across the rat brain: a quantitative and qualitative neurochemical study","volume":"20","author":"Whitestone","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2023011411264958100_ref66","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1111\/j.1476-5381.2009.00406.x","article-title":"Further pharmacological characterization of 5-HT(2C) receptor agonist-induced inhibition of 5-HT neuronal activity in the dorsal raphe nucleus in vivo","volume":"158","author":"Queree","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"2023011411264958100_ref67","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.bjp.0706935","article-title":"In vivo evidence that 5-HT(2C) receptors inhibit 5-HT neuronal activity via a GABAergic mechanism","volume":"149","author":"Boothman","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"2023011411264958100_ref68","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/(SICI)1098-2396(200001)35:1<53::AID-SYN7>3.0.CO;2-2","article-title":"Preferential modulation of mesolimbic vs. nigrostriatal dopaminergic function by serotonin(2C\/2B) receptor agonists: a combined in vivo electrophysiological and microdialysis study","volume":"35","author":"Di Giovanni","year":"2000","journal-title":"Synapse"},{"key":"2023011411264958100_ref69","doi-asserted-by":"crossref","first-page":"6479","DOI":"10.1073\/pnas.1321576111","article-title":"Gq\/5-HT2c receptor signals activate a local GABAergic inhibitory feedback circuit to modulate serotonergic firing and anxiety in mice","volume":"111","author":"Spoida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023011411264958100_ref70","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.neuroscience.2006.12.071","article-title":"Distribution of serotonin 5-HT2C receptors in the ventral tegmental area","volume":"146","author":"Bubar","year":"2007","journal-title":"Neuroscience"},{"key":"2023011411264958100_ref71","doi-asserted-by":"crossref","first-page":"e20508","DOI":"10.1371\/journal.pone.0020508","article-title":"5-HT(2C) receptors localize to dopamine and GABA neurons in the rat mesoaccumbens pathway","volume":"6","author":"Bubar","year":"2011","journal-title":"PLoS One"},{"key":"2023011411264958100_ref72","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/npp.2016.264","article-title":"Activation of ventral tegmental area 5-HT2C receptors reduces incentive motivation","volume":"42","author":"Valencia-Torres","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2023011411264958100_ref73","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuropharm.2015.01.021","article-title":"Dorsal raphe 5-HT(2C) receptor and GABA networks regulate anxiety produced by cocaine withdrawal","volume":"93","author":"Craige","year":"2015","journal-title":"Neuropharmacology"},{"key":"2023011411264958100_ref74","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jchemneu.2004.03.010","article-title":"Expression of serotonin 5-HT2C receptors in GABAergic cells of the anterior raphe nuclei","volume":"29","author":"Serrats","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"2023011411264958100_ref75","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/(SICI)1098-2396(20000601)36:3<205::AID-SYN5>3.0.CO;2-D","article-title":"Serotonin(2C) receptors tonically suppress the activity of mesocortical dopaminergic and adrenergic, but not serotonergic, pathways: a combined dialysis and electrophysiological analysis in the rat","volume":"36","author":"Gobert","year":"2000","journal-title":"Synapse"},{"key":"2023011411264958100_ref76","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1471-4159.2002.00947.x","article-title":"Stimulation of 5-hydroxytryptamine (5-HT(2C)) receptors in the ventrotegmental area inhibits stress-induced but not basal dopamine release in the rat prefrontal cortex","volume":"82","author":"Pozzi","year":"2002","journal-title":"J. Neurochem."},{"key":"2023011411264958100_ref77","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/S0028-3908(99)00047-7","article-title":"SB 242084, a selective serotonin2C receptor antagonist, increases dopaminergic transmission in the mesolimbic system","volume":"38","author":"Di Matteo","year":"1999","journal-title":"Neuropharmacology"},{"key":"2023011411264958100_ref78","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1124\/jpet.106.111690","article-title":"D2-like dopamine receptors depolarize dorsal raphe serotonin neurons through the activation of nonselective cationic conductance","volume":"320","author":"Aman","year":"2007","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2023011411264958100_ref79","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.0953-816x.2001.01616.x","article-title":"D2-like dopamine receptor activation excites rat dorsal raphe 5-HT neurons in vitro","volume":"14","author":"Haj-Dahmane","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"2023011411264958100_ref80","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.pneurobio.2016.03.004","article-title":"Serotonergic modulation of the activity of mesencephalic dopaminergic systems: therapeutic implications","volume":"151","author":"De Deurwaerdere","year":"2017","journal-title":"Prog. Neurobiol."},{"key":"2023011411264958100_ref81","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1037\/bne0000150","article-title":"Dopamine pathway imbalance in mice lacking Magel2, a Prader-Willi syndrome candidate gene","volume":"130","author":"Luck","year":"2016","journal-title":"Behav. Neurosci."},{"key":"2023011411264958100_ref82","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32640","article-title":"Necdin shapes serotonergic development and SERT activity modulating breathing in a mouse model for Prader-Willi syndrome","volume":"6","author":"Matarazzo","year":"2017","journal-title":"elife"},{"key":"2023011411264958100_ref83","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1002\/ajmg.b.30934","article-title":"Regionally reduced brain volume, altered serotonin neurochemistry, and abnormal behavior in mice null for the circadian rhythm output gene Magel2","volume":"150B","author":"Mercer","year":"2009","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"2023011411264958100_ref84","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1523\/JNEUROSCI.4334-07.2008","article-title":"Necdin plays a role in the serotonergic modulation of the mouse respiratory network: implication for Prader-Willi syndrome","volume":"28","author":"Zanella","year":"2008","journal-title":"J. Neurosci."},{"key":"2023011411264958100_ref85","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13041-016-0277-4","article-title":"Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite","volume":"9","author":"Garfield","year":"2016","journal-title":"Mol. Brain"},{"key":"2023011411264958100_ref86","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.3390\/ijms21165711","article-title":"Chronic administration of fipronil heterogeneously alters the neurochemistry of monoaminergic systems in the rat brain","volume":"21","author":"Bharatiya","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2023011411264958100_ref87","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2004.10.004","article-title":"Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment","volume":"119","author":"Ango","year":"2004","journal-title":"Cell"},{"key":"2023011411264958100_ref88","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-009-1466-y","article-title":"Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety","volume":"204","author":"Thomas","year":"2009","journal-title":"Psychopharmacology"},{"key":"2023011411264958100_ref89","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/ejhg.2014.103","article-title":"Highly restricted deletion of the SNORD116 region is implicated in Prader-Willi syndrome","volume":"23","author":"Bieth","year":"2015","journal-title":"EJHG"},{"key":"2023011411264958100_ref90","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1093\/hmg\/ddp263","article-title":"A deletion of the HBII-85 class of small nucleolar RNAs (snoRNAs) is associated with hyperphagia, obesity and hypogonadism","volume":"18","author":"Smith","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2023011411264958100_ref91","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/ejhg.2010.102","article-title":"Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C\/D box snoRNA cluster in Prader-Willi syndrome","volume":"18","author":"Duker","year":"2010","journal-title":"EJHG"},{"key":"2023011411264958100_ref92","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/ng.158","article-title":"Prader-Willi phenotype caused by paternal deficiency for the HBII-85 C\/D box small nucleolar RNA cluster","volume":"40","author":"Sahoo","year":"2008","journal-title":"Nat. Genet."},{"key":"2023011411264958100_ref93","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/cge.13005","article-title":"SNORD116 deletions cause Prader-Willi syndrome with a mild phenotype and macrocephaly","volume":"92","author":"Fontana","year":"2017","journal-title":"Clin. Genet."},{"key":"2023011411264958100_ref94","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/genes11020128","article-title":"Prader-Willi-like phenotype caused by an atypical 15q11.2 microdeletion","volume":"11","author":"Tan","year":"2020","journal-title":"Genes"},{"key":"2023011411264958100_ref95","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.omtm.2019.03.001","article-title":"Preclinical testing in translational animal models of Prader-Willi syndrome: overview and gap analysis","volume":"13","author":"Carias","year":"2019","journal-title":"Mol. Ther. Methods Clin. Dev."},{"key":"2023011411264958100_ref96","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.3390\/ijms22073613","article-title":"A comprehensive review of genetically engineered mouse models for Prader-Willi syndrome research","volume":"22","author":"Kummerfeld","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2023011411264958100_ref97","first-page":"256","author":"Franklin","year":"2007"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddac139\/46555366\/ddac139.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/32\/2\/244\/48520251\/ddac139.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/32\/2\/244\/48520251\/ddac139.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,25]],"date-time":"2023-11-25T09:29:54Z","timestamp":1700904594000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/32\/2\/244\/6661271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,11]]},"references-count":97,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,8,11]]},"published-print":{"date-parts":[[2023,1,6]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddac139","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,15]]},"published":{"date-parts":[[2022,8,11]]}}}