{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T17:39:51Z","timestamp":1785173991492,"version":"3.55.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100016401","name":"Jan Kornelis de Cock Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001721","name":"University of Groningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001721","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Long non-coding RNAs (lncRNAs) are involved in many normal and oncogenic pathways through a diverse repertoire of transcriptional and posttranscriptional regulatory mechanisms. LncRNAs that are under tight regulation of well-known oncogenic transcription factors such as c-Myc (Myc) are likely to be functionally involved in their disease-promoting mechanisms. Myc is a major driver of many subsets of B cell lymphoma and to date remains an undruggable target. We identified three Myc-induced and four Myc-repressed lncRNAs by use of multiple in vitro models of Myc-driven Burkitt lymphoma and detailed analysis of Myc binding profiles. We show that the top Myc-induced lncRNA KTN1-AS1 is strongly upregulated in different types of B cell lymphoma compared with their normal counterparts. We used CRISPR-mediated genome editing to confirm that the direct induction of KTN1-AS1 by Myc is dependent on the presence of a Myc E-box-binding motif. Knockdown of KTN1-AS1 revealed a strong negative effect on the growth of three BL cell lines. Global gene expression analysis upon KTN1-AS1 depletion shows a strong enrichment of key genes in the cholesterol biosynthesis pathway as well as co-regulation of many Myc-target genes, including a moderate negative effect on the levels of Myc itself. Our study suggests a critical role for KTN1-AS1 in supporting BL cell growth by mediating co-regulation of a variety of Myc-target genes and co-activating key genes involved in cholesterol biosynthesis. Therefore, KTN1-AS1 may represent a putative novel therapeutic target in lymphoma.<\/jats:p>","DOI":"10.1093\/hmg\/ddac159","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T11:28:27Z","timestamp":1658489307000},"page":"4193-4206","source":"Crossref","is-referenced-by-count":15,"title":["The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells"],"prefix":"10.1093","volume":"31","author":[{"given":"Melanie","family":"Winkle","sequence":"first","affiliation":[{"name":"Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"},{"name":"Department of Translational Molecular Biology , University of Texas MD Anderson Cancer Center, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina M","family":"Tayari","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"},{"name":"Department of Human Genetics , University of Miami, Sylvester Comprehensive Cancer Center, Miami, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas","family":"Kok","sequence":"additional","affiliation":[{"name":"Department of Genetics , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerben","family":"Duns","sequence":"additional","affiliation":[{"name":"Department of Lymphoid Cancer Research , BC Cancer Center, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Grot","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics , Polish Academy of Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Kazimierska","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics , Polish Academy of Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora","family":"de Jong","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Koerts","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Diepstra","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology , University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Dzikiewicz-Krawczyk","sequence":"additional","affiliation":[{"name":"Institute of Human Genetics , Polish Academy of Sciences, Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Steidl","sequence":"additional","affiliation":[{"name":"Department of Lymphoid Cancer Research , BC Cancer Center, Vancouver, BC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Kluiver","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Biology , University 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