{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:28:52Z","timestamp":1789532932598,"version":"build-2803163510"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["#16GRNT26700008"],"award-info":[{"award-number":["#16GRNT26700008"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hertz Family Foundation"},{"name":"Rady Children\u2019s Hospital Foundation"},{"name":"11q Research and Resource Group"},{"name":"Chloe Duyck Memorial Fund"},{"DOI":"10.13039\/100012424","name":"UCSD School of Medicine","doi-asserted-by":"publisher","award":["NINDS P30 NS047101"],"award-info":[{"award-number":["NINDS P30 NS047101"]}],"id":[{"id":"10.13039\/100012424","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ets1 deletion in some mouse strains causes septal defects and has been implicated in human congenital heart defects in Jacobsen syndrome, in which one copy of the Ets1 gene is missing. Here, we demonstrate that loss of Ets1 in mice results in a decrease in neural crest (NC) cells migrating into the proximal outflow tract cushions during early heart development, with subsequent malalignment of the cushions relative to the muscular ventricular septum, resembling double outlet right ventricle (DORV) defects in humans. Consistent with this, we find that cultured cardiac NC cells from Ets1 mutant mice or derived from iPS cells from Jacobsen patients exhibit decreased migration speed and impaired cell-to-cell interactions. Together, our studies demonstrate a critical role for ETS1 for cell migration in cardiac NC cells that are required for proper formation of the proximal outflow tracts. These data provide further insights into the molecular and cellular basis for development of the outflow tracts, and how perturbation of NC cells can lead to DORV.<\/jats:p>","DOI":"10.1093\/hmg\/ddac174","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T05:39:10Z","timestamp":1658986750000},"page":"4217-4227","source":"Crossref","is-referenced-by-count":14,"title":["ETS1 loss in mice impairs cardiac outflow tract septation via a cell migration defect autonomous to the neural crest"],"prefix":"10.1093","volume":"31","author":[{"given":"Lizhu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Pediatrics, UCSD School of Medicine , La Jolla, CA 92093 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Pinto","sequence":"additional","affiliation":[{"name":"Department of Biology, Sanford-Burnham-Prebys Institute of Medical Discovery , La Jolla, CA 92037 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSD School of Medicine , La Jolla, CA 92093 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazumi","family":"Fukatsu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSD School of Medicine , La Jolla, CA 92093 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSD School of Medicine , La Jolla, CA 92093 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon D","family":"Bamforth","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University , Newcastle upon Tyne NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne E","family":"Bronner","sequence":"additional","affiliation":[{"name":"Department of Biology, California Institute of Technology , Pasadena, CA 91125 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia M","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD , La Jolla, CA 92093 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyi","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgia Institute of Technology , Atlanta, GA 30332 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H","family":"Anderson","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Centre, Institute of Genetic Medicine, Newcastle University , Newcastle upon Tyne NE1 3BZ ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey V","family":"Terskikh","sequence":"additional","affiliation":[{"name":"Department of Biology, Sanford-Burnham-Prebys Institute of Medical Discovery , La Jolla, CA 92037 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7215-3821","authenticated-orcid":false,"given":"Paul D","family":"Grossfeld","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, UCSD School of Medicine , La Jolla, CA 92093 ,","place":["USA"]},{"name":"Division of Cardiology, Rady Children\u2019s Hospital , San Diego, CA 92123 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"2026041420030259700_ref1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1146\/annurev.physiol.60.1.267","article-title":"Role of cardiac neural crest cells in cardiovascular development","volume":"60","author":"Creazzo","year":"1998","journal-title":"Annu. 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