{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T05:26:23Z","timestamp":1790573183616,"version":"4.1.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T00:00:00Z","timestamp":1667001600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK062413"],"award-info":[{"award-number":["DK062413"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK087694"],"award-info":[{"award-number":["DK087694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK062431"],"award-info":[{"award-number":["DK062431"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,19]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammatory bowel disease (IBD) is an immune-mediated chronic intestinal disorder with major phenotypes: ulcerative colitis (UC) and Crohn\u2019s disease (CD). Multiple studies have identified over 240 IBD susceptibility loci. However, most studies have centered on European (EUR) and East Asian (EAS) populations. The prevalence of IBD in non-EUR, including African Americans (AAs), has risen in recent years. Here we present the first attempt to identify loci in AAs using a trans-ancestry Bayesian approach (MANTRA) accounting for heterogeneity between diverse ancestries while allowing for the similarity between closely related populations. We meta-analyzed genome-wide association studies (GWAS) and Immunochip data from a 2015 EUR meta-analysis of 38\u2009155 IBD cases and 48\u2009485 controls and EAS Immunochip study of 2824 IBD cases and 3719 controls, and our recent AA IBD GWAS of 2345 cases and 5002 controls. Across the major IBD phenotypes, we found significant evidence for 92% of 205 loci lead SNPs from the 2015 meta-analysis, but also for three IBD loci only established in latter studies. We detected 20 novel loci, all containing immunity-related genes or genes with other evidence for IBD or immune-mediated disease relevance: PLEKHG5;TNFSFR25 (encoding death receptor 3, receptor for TNFSF15 gene product TL1A), XKR6, ELMO1, BC021024;PI4KB;PSMD4 and APLP1 for IBD; AUTS2, XKR6, OSER1, TET2;AK094561, BCAP29 and APLP1 for CD; and GABBR1;MOG, DQ570892, SPDEF;ILRUN, SMARCE1;CCR7;KRT222;KRT24;KRT25, ANKS1A;TCP11, IL7, LRRC18;WDFY4, XKR6 and TNFSF4 for UC. Our study highlights the value of combining low-powered genomic studies from understudied populations of diverse ancestral backgrounds together with a high-powered study to enable novel locus discovery, including potentially important therapeutic IBD gene targets.<\/jats:p>","DOI":"10.1093\/hmg\/ddac269","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T13:37:45Z","timestamp":1667050665000},"page":"873-882","source":"Crossref","is-referenced-by-count":39,"title":["<i>Trans<\/i>-ancestry, Bayesian meta-analysis discovers 20 novel risk loci for inflammatory bowel disease in an African American, East Asian and European cohort"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4103-5181","authenticated-orcid":false,"given":"Roberto Y","family":"Cordero","sequence":"first","affiliation":[{"name":"Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center , Memphis, TN 38163 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-0522","authenticated-orcid":false,"given":"Jennifer B","family":"Cordero","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center , Memphis, TN 38163 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew B","family":"Stiemke","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center , Memphis, TN 38163 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa W","family":"Datta","sequence":"additional","affiliation":[{"name":"Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University , Baltimore, MD 21231 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8539-5416","authenticated-orcid":false,"given":"Steven","family":"Buyske","sequence":"additional","affiliation":[{"name":"Department of Statistics and Biostatistics, Rutgers University , Piscataway, NJ 08854 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subra","family":"Kugathasan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Department of Human Genetics, Emory University School of Medicine , Atlanta, GA 30322 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5621-759X","authenticated-orcid":false,"given":"Dermot P B","family":"McGovern","sequence":"additional","affiliation":[{"name":"F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center , Los Angeles, CA 90048 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3019-4240","authenticated-orcid":false,"given":"Steven R","family":"Brant","sequence":"additional","affiliation":[{"name":"Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University , Baltimore, MD 21231 , USA"},{"name":"Rutgers Crohn\u2019s and Colitis Center of New Jersey, Department of Medicine, Rutgers Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey , New Brunswick, NJ 08901 , USA"},{"name":"Human Genetics Institute of New Jersey and Department of Genetics, School of Arts and Sciences, Rutgers , The State University of New Jersey, Piscataway, NJ 08854 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2244-7690","authenticated-orcid":false,"given":"Claire L","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Genetics, Genomics, and Informatics, University of Tennessee Health Science Center , Memphis, TN 38163 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,29]]},"reference":[{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/ng.764","article-title":"Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47","volume":"43","author":"Anderson","year":"2011","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1053\/j.gastro.2016.09.032","article-title":"Genome-wide association study identifies African-specific susceptibility loci in African Americans with inflammatory bowel disease","volume":"152","author":"Brant","year":"2017","journal-title":"Gastroenterology"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002559","article-title":"A Genome-wide scan of Ashkenazi Jewish Crohn\u2019s disease suggests novel susceptibility loci","volume":"8","author":"Kenny","year":"2012","journal-title":"PLoS Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"979\u2013986","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/gepi.20630","article-title":"Transethnic meta-analysis of genomewide association studies","volume":"35","author":"Morris","year":"2011","journal-title":"Genet. Epidemiol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/ng2061","article-title":"Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn disease susceptibility","volume":"39","author":"Parkes","year":"2007","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1053\/j.gastro.2012.12.021","article-title":"A genome-wide association study identifies 2 susceptibility loci for Crohn\u2019s disease in a Japanese population","volume":"144","author":"Yamazaki","year":"2013","journal-title":"Gastroenterology"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1136\/gutjnl-2013-306625","article-title":"Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis","volume":"64","author":"Juyal","year":"2015","journal-title":"Gut"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/MIB.0000000000000584","article-title":"Identification of ten additional susceptibility loci for ulcerative colitis through Immunochip analysis in Koreans","volume":"22","author":"Ye","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/MIB.0000000000000268","article-title":"Immunochip analysis identification of 6 additional susceptibility loci for Crohn\u2019s disease in Koreans","volume":"21","author":"Yang","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/ecco-jcc\/jjy002","article-title":"Immunochip meta-analysis of inflammatory bowel disease identifies three novel loci and four novel associations in previously reported loci","volume":"12","author":"Hong","year":"2018","journal-title":"J. Crohns Colitis"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/ibd.21845","article-title":"Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis","volume":"18","author":"Ng","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng.3760","article-title":"Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease","volume":"49","author":"Lange","year":"2017","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/ng.3528","article-title":"Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci","volume":"48","author":"Ellinghaus","year":"2016","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1097\/MIB.0b013e318281f275","article-title":"Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn\u2019s disease","volume":"19","author":"Dubinsky","year":"2013","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/bcp.14187","article-title":"First-in-human, randomized dose-escalation study of the safety, tolerability, pharmacokinetics, pharmacodynamics and immunogenicity of PF-06480605 in healthy subjects","volume":"86","author":"Banfield","year":"2020","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1016\/j.cgh.2021.06.011","article-title":"Anti-TL1A antibody PF-06480605 safety and efficacy for ulcerative colitis: a phase 2a single-arm study","volume":"19","author":"Danese","year":"2021","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"760","DOI":"10.2174\/1389450122999210120205607","article-title":"TL1A: a new potential target in the treatment of inflammatory bowel disease","volume":"22","author":"Furfaro","year":"2021","journal-title":"Curr. Drug Targets"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1093\/hmg\/ddi379","article-title":"Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn\u2019s disease","volume":"14","author":"Yamazaki","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"4868","DOI":"10.4049\/jimmunol.171.9.4868","article-title":"Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel disease","volume":"171","author":"Bamias","year":"2003","journal-title":"J. Immunol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav7188","article-title":"Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility","volume":"365","author":"International Multiple Sclerosis Genetics Consortium","year":"2019","journal-title":"Science"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1172\/JCI118002","article-title":"Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes","volume":"95","author":"Watanabe","year":"1995","journal-title":"J. Clin. Invest."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1084\/jem.187.3.389","article-title":"Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa","volume":"187","author":"Watanabe","year":"1998","journal-title":"J. Exp. Med."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1172\/JCI59255","article-title":"Gene expression profiling of CD8+ T cells predicts prognosis in patients with Crohn disease and ulcerative colitis","volume":"121","author":"Lee","year":"2011","journal-title":"J. Clin. Invest."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1172\/JCI121668","article-title":"IL-7 receptor influences anti-TNF responsiveness and T cell gut homing in inflammatory bowel disease","volume":"129","author":"Belarif","year":"2019","journal-title":"J. Clin. Invest."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1053\/j.gastro.2015.07.065","article-title":"Characterization of genetic loci that affect susceptibility to inflammatory bowel diseases in African Americans","volume":"149","author":"Huang","year":"2015","journal-title":"Gastroenterology"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1189\/jlb.3HI0614-303R","article-title":"Chemokine receptor CCR7 regulates the intestinal TH1\/TH17\/Treg balance during Crohn\u2019s-like murine ileitis","volume":"97","author":"McNamee","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1189\/jlb.5CE0215037RR","article-title":"Editorial: CCR7 is required for leukocyte egression in an experimental model of Crohn\u2019s disease-like ileitis","volume":"97","author":"Genua","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/s41588-022-01156-2","article-title":"Large-scale sequencing identifies multiple genes and rare variants associated with Crohn\u2019s disease susceptibility","volume":"54","author":"Sazonovs","year":"2022","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"16583","DOI":"10.1038\/s41598-018-34815-8","article-title":"Assessment of coding region variants in Kuwaiti population: implications for medical genetics and population genomics","volume":"8","author":"John","year":"2018","journal-title":"Sci. Rep."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1158\/1078-0432.CCR-06-1633","article-title":"A susceptibility gene set for early onset colorectal cancer that integrates diverse signaling pathways: implication for tumorigenesis","volume":"13","author":"Hong","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127660","article-title":"Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production","volume":"4","author":"Kakoki","year":"2019","journal-title":"JCI Insight"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1111\/febs.15236","article-title":"Host engulfment pathway controls inflammation in inflammatory bowel disease","volume":"287","author":"Sayed","year":"2020","journal-title":"FEBS J."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.2337\/diabetes.54.4.1171","article-title":"Genetic variations in the gene encoding ELMO1 are associated with susceptibility to diabetic nephropathy","volume":"54","author":"Shimazaki","year":"2005","journal-title":"Diabetes"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/gene.2012.21","article-title":"Association of celiac disease genes with inflammatory bowel disease in Finnish and Swedish patients","volume":"13","author":"Parmar","year":"2012","journal-title":"Genes Immun."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045356","article-title":"Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study","volume":"7","author":"Alonso-Perez","year":"2012","journal-title":"PLoS One"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"9962","DOI":"10.1038\/s41598-018-28128-z","article-title":"Genetic variants in systemic lupus erythematosus susceptibility loci, XKR6 and GLT1D1 are associated with childhood-onset SLE in a Korean cohort","volume":"8","author":"Joo","year":"2018","journal-title":"Sci. Rep."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ng.3033","article-title":"Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease","volume":"46","author":"Kottyan","year":"2014","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJMoa0707865","article-title":"Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX","volume":"358","author":"Hom","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng.395","article-title":"REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis","volume":"41","author":"Gregersen","year":"2009","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1038\/ng.2792","article-title":"Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sj\u00f6gren\u2019s syndrome","volume":"45","author":"Lessard","year":"2013","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1097\/MIB.0000000000000340","article-title":"Blood-based biomarkers used to predict disease activity in Crohn\u2019s disease and ulcerative colitis","volume":"21","author":"Burakoff","year":"2015","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1126\/science.1058783","article-title":"A transcriptionally (correction of transcriptively) active complex of APP with Fe65 and histone acetyltransferase Tip60","volume":"293","author":"Cao","year":"2001","journal-title":"Science"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"14979","DOI":"10.1073\/pnas.261463298","article-title":"The gamma-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus","volume":"98","author":"Gao","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00054725-200401000-00001","article-title":"Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays","volume":"10","author":"Dooley","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1677\/ERC-07-0145","article-title":"Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract","volume":"15","author":"Arvidsson","year":"2008","journal-title":"Endocr. Relat. Cancer"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"790","DOI":"10.7150\/jca.9794","article-title":"Amplification of chromosome 1q genes encoding the phosphoinositide signalling enzymes PI4KB, AKT3, PIP5K1A and PI3KC2B in breast cancer","volume":"5","author":"Waugh","year":"2014","journal-title":"J. Cancer"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2017.04.023","article-title":"The logic of the 26S proteasome","volume":"169","author":"Collins","year":"2017","journal-title":"Cell"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1097\/MIB.0000000000000925","article-title":"Colonic lamina propria inflammatory cells from patients with IBD Induce the nuclear factor-E2 related factor-2 thereby leading to greater proteasome activity and apoptosis protection in human colonocytes","volume":"22","author":"Kruse","year":"2016","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/ibd.20110","article-title":"Genome-wide gene expression differences in Crohn\u2019s disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis","volume":"13","author":"Wu","year":"2007","journal-title":"Inflamm. Bowel Dis."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.yexcr.2009.09.020","article-title":"SAM pointed domain ETS factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells","volume":"316","author":"Noah","year":"2010","journal-title":"Exp. Cell Res."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1007\/s00535-018-01540-y","article-title":"Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids","volume":"54","author":"Nishimura","year":"2019","journal-title":"J. Gastroenterol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"12799","DOI":"10.1038\/ncomms12799","article-title":"Anks1a regulates COPII-mediated anterograde transport of receptor tyrosine kinases critical for tumorigenesis","volume":"7","author":"Lee","year":"2016","journal-title":"Nat. Commun."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1478-811X-6-7","article-title":"Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells","volume":"6","author":"Emaduddin","year":"2008","journal-title":"Cell Commun. Signal."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"e04115","DOI":"10.1016\/j.heliyon.2020.e04115","article-title":"Molecular characterisation of ILRUN, a novel inhibitor of proinflammatory and antimicrobial cytokines","volume":"6","author":"Ambrose","year":"2020","journal-title":"Heliyon"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/j.gastro.2017.05.010","article-title":"Genetic factors interact with tobacco smoke to modify risk for inflammatory bowel disease in humans and mice","volume":"153","author":"Yadav","year":"2017","journal-title":"Gastroenterology"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1023\/A:1011031014433","article-title":"Immune responses against the myelin\/oligodendrocyte glycoprotein in experimental autoimmune demyelination","volume":"21","author":"B\u00fcdingen","year":"2001","journal-title":"J. Clin. Immunol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ng.2007.47","article-title":"Polymorphism at the TNF superfamily gene TNFSF4 confers susceptibility to systemic lupus erythematosus","volume":"40","author":"Cunninghame Graham","year":"2008","journal-title":"Nat. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/gene.2010.44","article-title":"Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sj\u00f6gren\u2019s syndrome","volume":"12","author":"Nordmark","year":"2011","journal-title":"Genes Immun."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.4049\/jimmunol.1800399","article-title":"WDFY4 is involved in symptoms of systemic lupus erythematosus by modulating B cell fate via noncanonical autophagy","volume":"201","author":"Yuan","year":"2018","journal-title":"J. Immunol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/gepi.22103","article-title":"Properties of global- and local-ancestry adjustments in genetic association tests in admixed populations","volume":"42","author":"Martin","year":"2018","journal-title":"Genet. Epidemiol."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/jmedgenet-2012-100918","article-title":"wANNOVAR: annotating genetic variants for personal genomes via the web","volume":"49","author":"Chang","year":"2012","journal-title":"J. Med. Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"Aguet","year":"2017","journal-title":"Nature"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/biostatistics\/kxx048","article-title":"An empirical Bayes approach for multiple tissue eQTL analysis","volume":"19","author":"Li","year":"2018","journal-title":"Biostatistics"},{"key":"2023022108391361000_","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003486","article-title":"A statistical framework for joint eQTL analysis in multiple tissues","volume":"9","author":"Flutre","year":"2013","journal-title":"PLoS Genet."},{"key":"2023022108391361000_","doi-asserted-by":"crossref","first-page":"e1003491","DOI":"10.1371\/journal.pgen.1003491","article-title":"Effectively identifying eQTLs from multiple tissues by combining mixed model and meta-analytic approaches","volume":"9","author":"Sul","year":"2013","journal-title":"PLoS Genet."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddac269\/47772720\/ddac269.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/32\/5\/873\/49283203\/ddac269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/32\/5\/873\/49283203\/ddac269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T09:32:22Z","timestamp":1678440742000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/32\/5\/873\/6779977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,29]]},"references-count":68,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,10,29]]},"published-print":{"date-parts":[[2023,2,19]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddac269","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,3,1]]},"published":{"date-parts":[[2022,10,29]]}}}