{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:17:50Z","timestamp":1790651870744,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700901"],"award-info":[{"award-number":["2021YFC2700901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000584"],"award-info":[{"award-number":["32000584"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901541"],"award-info":[{"award-number":["81901541"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971441"],"award-info":[{"award-number":["81971441"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2208085Y31"],"award-info":[{"award-number":["2208085Y31"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["1908085QH313"],"award-info":[{"award-number":["1908085QH313"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Synergy Innovation Program of Anhui Province","award":["GXXT-2019-044"],"award-info":[{"award-number":["GXXT-2019-044"]}]},{"name":"Nonprofit Central Research Institute Fund of the Chinese Academy of Medical Sciences","award":["2019PT310002"],"award-info":[{"award-number":["2019PT310002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oligoasthenoteratozoospermia (OAT) can result in male infertility owing to reduced sperm motility and abnormal spermatozoan morphology. The Tektins are a family of highly conserved filamentous proteins expressed in the axoneme and associated structures in many different metazoan species. Earlier studies on mice identified Tektin3 (Tekt3) as a testis-enriched gene, and knockout of Tekt3 resulted in asthenozoospermia in the mice. Here, whole-exome sequencing of 100 males with asthenozoospermia from unrelated families was performed, followed by Sanger sequencing, leading to the identification of TEKT3 as a candidate gene in two of these patients and their associated family members. In total, three mutations in the TEKT3 gene were identified in both these patients, including one homozygous deletion\u2013insertion mutation (c.543_547delinsTTGAT: p.Glu182*) and one compound heterozygous mutation (c.[548G\u2009&amp;gt;\u2009A]; [752A\u2009&amp;gt;\u2009C], p.[Arg183Gln]; [Gln251Pro]). Both of these mutations resulted in the complete loss of TEKT3 expression. The patients were both found to produce sperm that, although those showed no apparent defects in the flagellar structure, had reduced progressive motility. In contrast to mice, most sperm from these two patients exhibited acrosomal hypoplasia, although this did not prevent the use of the sperm for in vitro fertilization through an ICSI approach. TEKT3 was found to bind to other TEKT proteins, suggesting that these proteins form a complex within human spermatozoa. Overall, these results suggest that a loss of TEKT3 function can contribute to OAT incidence in humans. TEKT3 deficiencies can reduce sperm motility and contribute to severe acrosomal hypoplasia in spermatozoa, compromising their normal function.<\/jats:p>","DOI":"10.1093\/hmg\/ddad013","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T05:13:26Z","timestamp":1674278006000},"page":"1730-1740","source":"Crossref","is-referenced-by-count":22,"title":["Bi-allelic human<i>TEKT3<\/i>mutations cause male infertility with oligoasthenoteratozoospermia owing to acrosomal hypoplasia and reduced progressive motility"],"prefix":"10.1093","volume":"32","author":[{"given":"Yiyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanlan","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University , Changsha, Hunan 410078 , China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya , Changsha, Hunan 410078 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuokuo","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingrong","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Anhui Provincial Institute of Translational Medicine , Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs , Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Anhui Provincial Institute of Translational Medicine , Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaolian","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"Anhui Provincial Engineering Research Center of Biopreservation and Artificial Organs , Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Anhui Provincial Institute of Translational Medicine , Anhui Medical University, No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunxia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0009-3839","authenticated-orcid":false,"given":"Huan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"The First Affiliated Hospital of Anhui Medical University , Reproductive Medicine Center, , No 218 Jixi Road, Hefei, Anhui 230022 , China"},{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8359-4654","authenticated-orcid":false,"given":"Yueqiu","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Basic Medical Science, Institute of Reproductive and Stem Cell Engineering, Central South University , Changsha, Hunan 410078 , China"},{"name":"Clinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive and Genetic Hospital of CITIC-Xiangya , Changsha, Hunan 410078 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9607-6605","authenticated-orcid":false,"given":"Rong","family":"Hua","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Ministry of Education of the People\u2019s Republic of China , No 81 Meishan Road, Hefei, Anhui 230032 , China"},{"name":"Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University , No 81 Meishan Road, Hefei, Anhui 230032 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"2023050516321775900_ref1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s40618-014-0053-1","article-title":"Relevance of genetic investigation in male infertility","volume":"37","author":"Asero","year":"2014","journal-title":"J. Endocrinol. Investig."},{"issue":"1","key":"2023050516321775900_ref2","first-page":"12","article-title":"Disorders of spermatogenesis","volume":"30","author":"T\u00fcttelmann","year":"2018","journal-title":"Med. Genet."},{"issue":"3","key":"2023050516321775900_ref3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1086\/303061","article-title":"Male sperm motility dictated by mother's mtDNA","volume":"67","author":"Moore","year":"2000","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"2023050516321775900_ref4","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1093\/humrep\/dev003","article-title":"Aged men share the sperm protein PATE1 defect with young asthenozoospermia patients","volume":"30","author":"Liu","year":"2015","journal-title":"Hum. Reprod."},{"issue":"6","key":"2023050516321775900_ref5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/s41431-022-01095-w","article-title":"Bi-allelic variants in human TCTE1\/DRC5 cause asthenospermia and male infertility","volume":"30","author":"Zhou","year":"2022","journal-title":"Eur. J. Hum. Genet."},{"issue":"2","key":"2023050516321775900_ref6","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ajhg.2018.12.013","article-title":"Bi-allelic mutations in ARMC2 lead to severe astheno-teratozoospermia due to sperm flagellum malformations in humans and mice","volume":"104","author":"Coutton","year":"2019","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"2023050516321775900_ref7","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1136\/jmedgenet-2018-105486","article-title":"Novel homozygous CFAP69 mutations in humans and mice cause severe asthenoteratospermia with multiple morphological abnormalities of the sperm flagella","volume":"56","author":"He","year":"2019","journal-title":"J. Med. Genet."},{"issue":"3","key":"2023050516321775900_ref8","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.ajhg.2020.07.010","article-title":"Bi-allelic loss-of-function variants in CFAP58 cause flagellar axoneme and mitochondrial sheath defects and asthenoteratozoospermia in humans and mice","volume":"107","author":"He","year":"2020","journal-title":"Am. J. Hum. Genet."},{"key":"2023050516321775900_ref9","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1016\/j.ajhg.2019.10.010","article-title":"Bi-allelic mutations in TTC29 cause male subfertility with asthenoteratospermia in humans and mice","volume":"105","author":"Liu","year":"2019","journal-title":"Am. J. Hum. Genet."},{"issue":"2","key":"2023050516321775900_ref10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ajhg.2020.06.004","article-title":"Bi-allelic DNAH8 variants lead to multiple morphological abnormalities of the sperm flagella and primary male infertility","volume":"107","author":"Liu","year":"2020","journal-title":"Am. J. Hum. Genet."},{"issue":"4","key":"2023050516321775900_ref11","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.ajhg.2019.02.020","article-title":"Bi-allelic mutations in TTC21A induce asthenoteratospermia in humans and mice","volume":"104","author":"Liu","year":"2019","journal-title":"Am. J. Hum. Genet."},{"issue":"7","key":"2023050516321775900_ref12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/jmedgenet-2019-106479","article-title":"Homozygous mutations in DZIP1 can induce asthenoteratospermia with severe MMAF","volume":"57","author":"Lv","year":"2020","journal-title":"J. Med. Genet."},{"issue":"6","key":"2023050516321775900_ref13","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.ajhg.2017.04.012","article-title":"Biallelic mutations in CFAP43 and CFAP44 cause male infertility with multiple morphological abnormalities of the sperm flagella","volume":"100","author":"Tang","year":"2017","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"2023050516321775900_ref14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s10038-018-0520-1","article-title":"Biallelic mutations of CFAP251 cause sperm flagellar defects and human male infertility","volume":"64","author":"Li","year":"2019","journal-title":"J. Hum. Genet."},{"issue":"1","key":"2023050516321775900_ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/jcs.58.1.1","article-title":"Structure and chemical composition of insoluble filamentous components of sperm flagellar microtubules","volume":"58","author":"Linck","year":"1982","journal-title":"J. Cell Sci."},{"issue":"1","key":"2023050516321775900_ref16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1083\/jcb.100.1.126","article-title":"Localization of tektin filaments in microtubules of sea urchin sperm flagella by immunoelectron microscopy","volume":"100","author":"Linck","year":"1985","journal-title":"J. Cell Biol."},{"issue":"10","key":"2023050516321775900_ref17","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/j.yexcr.2007.04.009","article-title":"Towards a molecular description of intermediate filament structure and assembly","volume":"313","author":"Parry","year":"2007","journal-title":"Exp. Cell Res."},{"issue":"3","key":"2023050516321775900_ref18","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.jsb.2006.12.007","article-title":"Dissecting the 3-D structure of vimentin intermediate filaments by cryo-electron tomography","volume":"158","author":"Goldie","year":"2007","journal-title":"J. Struct. Biol."},{"issue":"21","key":"2023050516321775900_ref19","doi-asserted-by":"crossref","first-page":"8912","DOI":"10.1523\/JNEUROSCI.18-21-08912.1998","article-title":"Expression of ciliary tektins in brain and sensory development","volume":"18","author":"Norrander","year":"1998","journal-title":"J. Neurosci."},{"issue":"2","key":"2023050516321775900_ref20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0014-5793(99)00967-9","article-title":"Molecular cloning of haploid germ cell-specific tektin cDNA and analysis of the protein in mouse testis","volume":"456","author":"Iguchi","year":"1999","journal-title":"FEBS Lett."},{"issue":"3","key":"2023050516321775900_ref21","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/mrd.20025","article-title":"Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells","volume":"67","author":"Roy","year":"2004","journal-title":"Mol. Reprod. Dev."},{"issue":"4","key":"2023050516321775900_ref22","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1096\/fj.06-7035com","article-title":"Absence of tektin 4 causes asthenozoospermia and subfertility in male mice","volume":"21","author":"Roy","year":"2007","journal-title":"FASEB J."},{"issue":"5","key":"2023050516321775900_ref23","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1074\/mcp.M500322-MCP200","article-title":"Proteomic profiling of accessory structures from the mouse sperm flagellum","volume":"5","author":"Cao","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"issue":"18","key":"2023050516321775900_ref24","doi-asserted-by":"crossref","first-page":"7958","DOI":"10.1128\/MCB.24.18.7958-7964.2004","article-title":"Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function","volume":"24","author":"Tanaka","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"23","key":"2023050516321775900_ref25","doi-asserted-by":"crossref","first-page":"5791","DOI":"10.1016\/j.cell.2021.10.007","article-title":"De novo identification of mammalian ciliary motility proteins using cryo-EM","volume":"184","author":"Gui","year":"2021","journal-title":"Cell"},{"issue":"5","key":"2023050516321775900_ref26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/mrd.20957","article-title":"Tektin 3 is required for progressive sperm motility in mice","volume":"76","author":"Roy","year":"2009","journal-title":"Mol. Reprod. Dev."},{"issue":"8","key":"2023050516321775900_ref27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/mrd.21352","article-title":"Characterization and subcellular localization of Tektin 3 in rat spermatozoa","volume":"78","author":"Takiguchi","year":"2011","journal-title":"Mol. Reprod. Dev."},{"issue":"1","key":"2023050516321775900_ref28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/mrd.22763","article-title":"Translocation of Tektin 3 to the equatorial segment of heads in bull spermatozoa exposed to dibutyryl cAMP and calyculin A","volume":"84","author":"Tsukamoto","year":"2017","journal-title":"Mol. Reprod. Dev."},{"key":"2023050516321775900_ref29","doi-asserted-by":"crossref","first-page":"E5370","DOI":"10.1073\/pnas.1621279114","article-title":"TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa","volume":"114","author":"Castaneda","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"7","key":"2023050516321775900_ref30","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.fertnstert.2011.03.059","article-title":"Mitochondrial membrane potential profile and its correlation with increasing sperm motility","volume":"95","author":"Paoli","year":"2011","journal-title":"Fertil. Steril."},{"key":"2023050516321775900_ref31","first-page":"650","article-title":"Tektin5, a new Tektin family member, is a component of the middle piece of flagella in rat spermatozoa","volume-title":"Mol Reprod Dev.,","author":"Murayama","year":"2008"},{"key":"2023050516321775900_ref32","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1242\/dev.152413","article-title":"Unraveling transcriptome dynamics in human spermatogenesis","volume":"144","author":"Jan","year":"2017","journal-title":"Development"},{"issue":"6","key":"2023050516321775900_ref33","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41585-018-0003-3","article-title":"Genetics of male infertility","volume":"15","author":"Krausz","year":"2018","journal-title":"Nat. Rev. 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