{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:36:11Z","timestamp":1777437371060,"version":"3.51.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"15","license":[{"start":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T00:00:00Z","timestamp":1683849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sir Henry Wellcome Postdoctoral Fellowship","award":["210913\/Z\/18\/Z"],"award-info":[{"award-number":["210913\/Z\/18\/Z"]}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-15423"],"award-info":[{"award-number":["FDN-15423"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP133586"],"award-info":[{"award-number":["MOP133586"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP142398"],"award-info":[{"award-number":["MOP142398"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>ATRX is a chromatin remodelling ATPase that is involved in transcriptional regulation, DNA damage repair and heterochromatin maintenance. It has been widely studied for its role in ALT-positive cancers, but its role in neurological function remains elusive. Hypomorphic mutations in the X-linked ATRX gene cause a rare form of intellectual disability combined with alpha-thalassemia called ATR-X syndrome in hemizygous males. Clinical features also include facial dysmorphism, microcephaly, short stature, musculoskeletal defects and genital abnormalities. As complete deletion of ATRX in mice results in early embryonic lethality, the field has largely relied on conditional knockout models to assess the role of ATRX in multiple tissues. Given that null alleles are not found in patients, a more patient-relevant model was needed. Here, we have produced and characterized the first patient mutation knock-in model of ATR-X syndrome, carrying the most common causative mutation, R246C. This is one of a cluster of missense mutations located in the chromatin-binding domain and disrupts its function. The knock-in mice recapitulate several aspects of the patient disorder, including craniofacial defects, microcephaly, reduced body size and impaired neurological function. They provide a powerful model for understanding the molecular mechanisms underlying ATR-X syndrome and testing potential therapeutic strategies.<\/jats:p>","DOI":"10.1093\/hmg\/ddad075","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:11:08Z","timestamp":1683889868000},"page":"2485-2501","source":"Crossref","is-referenced-by-count":6,"title":["A new mouse model of ATR-X syndrome carrying a common patient mutation exhibits neurological and morphological defects"],"prefix":"10.1093","volume":"32","author":[{"given":"Rebekah","family":"Tillotson","sequence":"first","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"},{"name":"MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital\/Headley Way , Oxford OX3 9DS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keqin","family":"Yan","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Ruston","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor","family":"DeYoung","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre, The Hospital for Sick Children , Toronto, ON M5T 3H7 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"C\u00f3rdova","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Turcotte-Cardin","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 , Canada"},{"name":"Cellular & Molecular Medicine, University of Ottawa , Ottawa, ON K1H 8M5 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohan","family":"Yee","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre, The Hospital for Sick Children , Toronto, ON M5T 3H7 , Canada"},{"name":"Department of Medical Biophysics, University of Toronto , Toronto, ON M5G 1L7 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Taylor","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shagana","family":"Visuvanathan","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Babbs","sequence":"additional","affiliation":[{"name":"MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital\/Headley Way , Oxford OX3 9DS , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgueni A","family":"Ivakine","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"},{"name":"Department of Physiology, University of Toronto , Toronto, ON M5S 1A8 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G","family":"Sled","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre, The Hospital for Sick Children , Toronto, ON M5T 3H7 , Canada"},{"name":"Department of Medical Biophysics, University of Toronto , Toronto, ON M5G 1L7 , Canada"},{"name":"Translational Medicine Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian J","family":"Nieman","sequence":"additional","affiliation":[{"name":"Mouse Imaging Centre, The Hospital for Sick Children , Toronto, ON M5T 3H7 , Canada"},{"name":"Department of Medical Biophysics, University of Toronto , Toronto, ON M5G 1L7 , Canada"},{"name":"Translational Medicine Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"},{"name":"Ontario Institute for Cancer Research , Toronto, ON M5G 0A3 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Picketts","sequence":"additional","affiliation":[{"name":"Regenerative Medicine Program, Ottawa Hospital Research Institute , Ottawa, ON K1H 8L6 , Canada"},{"name":"Cellular & Molecular Medicine, University of Ottawa , Ottawa, ON K1H 8M5 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica J","family":"Justice","sequence":"additional","affiliation":[{"name":"Genetics and Genome Biology Program, The Hospital for Sick Children, The Peter Gilgan Centre for Research and Learning , Toronto, ON M5G 0A4 , Canada"},{"name":"Department of Molecular Genetics, University of Toronto , Toronto, ON M5S 1A1 , Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,5,12]]},"reference":[{"key":"2023111616032123800_ref1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0092-8674(95)90287-2","article-title":"Mutations in a putative global transcriptional regulator cause X-linked mental retardation with \u03b1-thalassemia (ATR-X syndrome)","volume":"80","author":"Gibbons","year":"1995","journal-title":"Cell"},{"key":"2023111616032123800_ref2","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3389\/fgene.2020.00885","article-title":"Neurodevelopmental disorders caused by defective chromatin Remodeling: phenotypic complexity is highlighted by a review of ATRX function","volume":"11","author":"Timpano","year":"2020","journal-title":"Front. Genet."},{"key":"2023111616032123800_ref3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1126\/science.1207313","article-title":"Altered telomeres in tumors with ATRX and DAXX mutations. Altered telomeres in tumors with ATRX and DAXX mutations","volume":"333","author":"Heaphy","year":"2011","journal-title":"Science"},{"key":"2023111616032123800_ref4","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.3390\/genes12111734","article-title":"Alternative lengthening of telomeres: lessons to be learned from Telomeric DNA double-strand break repair","volume":"12","author":"Kent","year":"2021","journal-title":"Genes (Basel)"},{"key":"2023111616032123800_ref5","volume-title":"GeneReviews\u00ae [Internet]","author":"Stevenson","year":"2020"},{"key":"2023111616032123800_ref6","doi-asserted-by":"crossref","first-page":"a011759","DOI":"10.1101\/cshperspect.a011759","article-title":"\u03b1-Thalassemia, mental retardation, and myelodysplastic syndrome","volume":"2","author":"Gibbons","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"2023111616032123800_ref7","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1371\/journal.pgen.0020058","article-title":"Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues","volume":"2","author":"Garrick","year":"2006","journal-title":"PLoS Genet."},{"key":"2023111616032123800_ref8","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1172\/JCI200522329","article-title":"The chromatin-remodeling protein ATRX is critical for neuronal survival during corticogenesis","volume":"115","author":"B\u00e9rub\u00e9","year":"2005","journal-title":"J. Clin. Investig."},{"key":"2023111616032123800_ref9","first-page":"119","article-title":"Mosaic expression of Atrx in the mouse central nervous system causes memory deficits","volume":"10","author":"Tamming","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"2023111616032123800_ref10","doi-asserted-by":"crossref","first-page":"107838","DOI":"10.1016\/j.celrep.2020.107838","article-title":"Atrx deletion in neurons leads to sexually dimorphic dysregulation of miR-137 and spatial learning and memory deficits","volume":"31","author":"Tamming","year":"2020","journal-title":"Cell Rep."},{"key":"2023111616032123800_ref11","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1093\/hmg\/ddn424","article-title":"Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome","volume":"18","author":"Medina","year":"2009","journal-title":"Hum. Mol. Genet."},{"key":"2023111616032123800_ref12","first-page":"4787","article-title":"Retinal interneuron survival requires non-cell-autonomous Atrx activity","volume":"25","author":"Lagali","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"2023111616032123800_ref13","doi-asserted-by":"crossref","first-page":"e7106","DOI":"10.1371\/journal.pone.0007106","article-title":"Loss of ATRX in chondrocytes has minimal effects on skeletal development","volume":"4","author":"Solomon","year":"2009","journal-title":"PLoS One"},{"key":"2023111616032123800_ref14","doi-asserted-by":"crossref","first-page":"4412","DOI":"10.1172\/JCI63765","article-title":"Compromised genomic integrity impedes muscle growth after Atrx inactivation","volume":"122","author":"Huh","year":"2012","journal-title":"J. Clin. Investig."},{"key":"2023111616032123800_ref15","doi-asserted-by":"crossref","first-page":"e0186989","DOI":"10.1371\/journal.pone.0186989","article-title":"Recovery from impaired muscle growth arises from prolonged postnatal accretion of myonuclei in Atrx mutant mice","volume":"12","author":"Huh","year":"2017","journal-title":"PLoS One"},{"key":"2023111616032123800_ref16","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1093\/hmg\/ddr109","article-title":"Defective survival of proliferating sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome","volume":"20","author":"Bagheri-fam","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2023111616032123800_ref17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1086\/518369","article-title":"Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model","volume":"80","author":"Muers","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"2023111616032123800_ref18","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1136\/jmg.2004.020248","article-title":"Attenuation of an amino-terminal premature stop codon mutation in the ATRX gene by an alternative mode of translational initiation","volume":"41","author":"Howard","year":"2004","journal-title":"J. Med. Genet."},{"key":"2023111616032123800_ref19","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1002\/humu.20734","article-title":"Mutations in the chromatin-associated protein ATRX","volume":"29","author":"Gibbons","year":"2008","journal-title":"Hum. Mutat."},{"key":"2023111616032123800_ref20","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/1096-8628(200023)97:3<204::AID-AJMG1038>3.0.CO;2-X","article-title":"Molecular\u2014clinical spectrum of the ATR-X syndrome","volume":"97","author":"Gibbons","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"2023111616032123800_ref21","doi-asserted-by":"crossref","first-page":"11939","DOI":"10.1073\/pnas.0704057104","article-title":"Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX","volume":"104","author":"Argentaro","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023111616032123800_ref22","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1093\/hmg\/ddr163","article-title":"Functional significance of mutations in the Snf2 domain of ATRX","volume":"20","author":"Mitson","year":"2011","journal-title":"Hum. Mol. Genet."},{"key":"2023111616032123800_ref23","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/nsmb.2062","article-title":"ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome","volume":"18","author":"Iwase","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2023111616032123800_ref24","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/hipo.20782","article-title":"Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice","volume":"21","author":"Nogami","year":"2011","journal-title":"Hippocampus"},{"key":"2023111616032123800_ref25","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1523\/JNEUROSCI.4816-10.2011","article-title":"Aberrant calcium\/Calmodulin-dependent protein kinase II (CaMKII) activity is associated with abnormal dendritic spine morphology in the ATRX mutant mouse brain","volume":"31","author":"Shioda","year":"2011","journal-title":"J. Neurosci."},{"key":"2023111616032123800_ref26","doi-asserted-by":"crossref","first-page":"12570","DOI":"10.1523\/JNEUROSCI.4048-08.2008","article-title":"Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53","volume":"28","author":"Seah","year":"2008","journal-title":"J. Neurosci."},{"key":"2023111616032123800_ref27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1750-1172-1-15","article-title":"Alpha thalassaemia-mental retardation, X linked","volume":"1","author":"Gibbons","year":"2006","journal-title":"Orphanet. J. Rare. Dis."},{"key":"2023111616032123800_ref28","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.3390\/genes13101792","article-title":"Phenotypic Spectrum and molecular findings in 17 ATR-X syndrome Italian patients: some new insights","volume":"13","author":"Vaisfeld","year":"2022","journal-title":"Genes (Basel)"},{"key":"2023111616032123800_ref29","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.cell.2010.09.023","article-title":"ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner","volume":"143","author":"Law","year":"2010","journal-title":"Cell"},{"key":"2023111616032123800_ref30","doi-asserted-by":"crossref","first-page":"e2220","DOI":"10.1038\/cddis.2016.121","article-title":"Stalled replication forks within heterochromatin require ATRX for protection","volume":"7","author":"Huh","year":"2016","journal-title":"Cell Death Dis."},{"key":"2023111616032123800_ref31","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.3174\/ajnr.A3560","article-title":"Neuroradiologic features in \u03b1-linked \u03b1-thalassemia\/mental retardation syndrome","volume":"34","author":"Wada","year":"2013","journal-title":"Am. J. Neuroradiol."},{"key":"2023111616032123800_ref32","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.gene.2015.04.075","article-title":"Alpha-thalassemia X-linked intellectual disability syndrome identified by whole exome sequencing in two boys with white matter changes and developmental retardation","volume":"569","author":"Lee","year":"2015","journal-title":"Gene"},{"key":"2023111616032123800_ref33","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1038\/sj.ejhg.5201878","article-title":"Partial duplications of the ATRX gene cause the ATR-X syndrome","volume":"15","author":"Thienpont","year":"2007","journal-title":"Eur. J. Hum. Genet."},{"key":"2023111616032123800_ref34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s12311-015-0724-2","article-title":"Consensus paper: cerebellar development. Consensus paper: cerebellar development","volume":"15","author":"Leto","year":"2016","journal-title":"Cerebellum"},{"key":"2023111616032123800_ref35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/sj.ejhg.5201303","article-title":"Mutation in the 5\u2019 alternatively spliced region of the XNP\/ATR-X gene causes Chudley-Lowry syndrome","volume":"13","author":"Abidi","year":"2005","journal-title":"Eur. J. Hum. Genet."},{"key":"2023111616032123800_ref36","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/hmg\/11.3.253","article-title":"Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice","volume":"11","author":"B\u00e9rub\u00e9","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"2023111616032123800_ref37","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.2353\/ajpath.2010.090887","article-title":"Genetic background affects properties of satellite cells and mdx phenotypes","volume":"176","author":"Fukada","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2023111616032123800_ref38","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.045369","article-title":"A novel mouse model of Duchenne muscular dystrophy carrying a multi-exonic DMD deletion exhibits progressive muscular dystrophy and early-onset cardiomyopathy","volume":"13","author":"Wong","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"2023111616032123800_ref39","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1038\/s41467-022-31194-7","article-title":"The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin","volume":"13","author":"Truch","year":"2022","journal-title":"Nat. Commun."},{"key":"2023111616032123800_ref40","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1093\/nar\/gkac683","article-title":"ATRX histone binding and helicase activities have distinct roles in neuronal differentiation","volume":"50","author":"Bieluszewska","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"2023111616032123800_ref41","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1172\/JCI65634","article-title":"Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span","volume":"123","author":"Watson","year":"2013","journal-title":"J. Clin. Investig."},{"key":"2023111616032123800_ref42","doi-asserted-by":"crossref","first-page":"a026567","DOI":"10.1101\/cshperspect.a026567","article-title":"ATRX and DAXX: mechanisms and mutations","volume":"7","author":"Dyer","year":"2017","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"2023111616032123800_ref43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ymeth.2021.01.005","article-title":"Production of knockout mouse lines with Cas9","volume":"191","author":"Gertsenstein","year":"2021","journal-title":"Methods"},{"key":"2023111616032123800_ref44","doi-asserted-by":"crossref","first-page":"100114","DOI":"10.1016\/j.xpro.2020.100114","article-title":"Protocol for evaluating neuronal polarity in murine models","volume":"1","author":"Wilson","year":"2020","journal-title":"STAR Protoc."},{"key":"2023111616032123800_ref45","doi-asserted-by":"crossref","first-page":"13983","DOI":"10.1073\/pnas.96.24.13983","article-title":"Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes","volume":"96","author":"McDowell","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023111616032123800_ref46","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1002\/cpmo.44","article-title":"MRI to assess neurological function","volume":"8","author":"Nieman","year":"2018","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"2023111616032123800_ref47","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119008","article-title":"Multiple-mouse magnetic resonance imaging with cryogenic radiofrequency probes for evaluation of brain development","volume":"252","author":"Arbabi","year":"2022","journal-title":"NeuroImage"},{"key":"2023111616032123800_ref48","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1002\/mrm.21945","article-title":"Three-dimensional, in vivo MRI with self-gating and image coregistration in the mouse","volume":"61","author":"Nieman","year":"2009","journal-title":"Magn. Reason. Med."},{"key":"2023111616032123800_ref49","doi-asserted-by":"crossref","first-page":"e3802","DOI":"10.1002\/nbm.3802","article-title":"Partitioning k-space for cylindrical three-dimensional rapid acquisition with relaxation enhancement imaging in the mouse brain","volume":"30","author":"Spencer Noakes","year":"2017","journal-title":"NMR Biomed."},{"key":"2023111616032123800_ref50","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3389\/fninf.2014.00067","article-title":"Pydpiper: a flexible toolkit for constructing novel registration pipelines","volume":"8","author":"Friedel","year":"2014","journal-title":"Front. Neuroinform."},{"key":"2023111616032123800_ref51","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroimage.2008.03.037","article-title":"High resolution three-dimensional brain atlas using an average magnetic resonance image of 40 adult C57Bl\/6J mice","volume":"42","author":"Dorr","year":"2008","journal-title":"NeuroImage"},{"key":"2023111616032123800_ref52","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.neuroimage.2013.04.008","article-title":"A segmentation protocol and MRI atlas of the C57BL\/6J mouse neocortex","volume":"78","author":"Ullmann","year":"2013","journal-title":"NeuroImage"},{"key":"2023111616032123800_ref53","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/aur.1344","article-title":"Genetic effects on cerebellar structure across mouse models of autism using a magnetic resonance imaging atlas","volume":"7","author":"Steadman","year":"2014","journal-title":"Autism Res."},{"key":"2023111616032123800_ref54","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.neuroimage.2011.06.025","article-title":"Segmentation of the mouse hippocampal formation in magnetic resonance images","volume":"58","author":"Richards","year":"2011","journal-title":"NeuroImage"},{"key":"2023111616032123800_ref55","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1002\/hbm.22092","article-title":"Performing label-fusion-based segmentation using multiple automatically generated templates","volume":"34","author":"Chakravarty","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"2023111616032123800_ref56","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuroimage.2008.02.019","article-title":"Cortical thickness measured from MRI in the YAC128 mouse model of Huntington\u2019s disease","volume":"41","author":"Lerch","year":"2008","journal-title":"NeuroImage"},{"key":"2023111616032123800_ref57","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1152\/japplphysiol.01357.2003","article-title":"Progression of kyphosis in mdx mice","volume":"97","author":"Laws","year":"2004","journal-title":"J. Appl. Physiol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/advance-article-pdf\/doi\/10.1093\/hmg\/ddad075\/50573120\/ddad075.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/32\/15\/2485\/53473230\/ddad075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/32\/15\/2485\/53473230\/ddad075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T11:54:26Z","timestamp":1700135666000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/32\/15\/2485\/7160870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,12]]},"references-count":57,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2023,5,12]]},"published-print":{"date-parts":[[2023,7,20]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddad075","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.01.25.525394","asserted-by":"object"}]},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,8,1]]},"published":{"date-parts":[[2023,5,12]]}}}