{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:26:55Z","timestamp":1790342815985,"version":"4.1.0"},"reference-count":96,"publisher":"Oxford University Press (OUP)","issue":"24","license":[{"start":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T00:00:00Z","timestamp":1693267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This year is a milestone anniversary of the discovery that Huntington\u2019s disease is caused by the presence of expanded polyglutamine repeats in the huntingtin gene leading to the formation of huntingtin aggregates. 30\u00a0years have elapsed and there is still no cure and the only FDA-approved treatment to alleviate the debilitating locomotor impairments presents several adverse effects. It has long been neglected that the huntingtin gene is almost ubiquitously expressed in many tissues outside of the nervous system. Growing evidence indicates that these peripheral tissues can contribute to the symptoms of the disease. New findings in Drosophila have shown that the selective expression of mutant huntingtin in muscle or fat is sufficient to cause detrimental effects in the absence of any neurodegeneration. In addition, it was discovered that a completely different tissue distribution of Htt aggregates in Drosophila muscles is responsible for a drastic aggravation of the detrimental effects. This review examines the peripheral tissues that express huntingtin with an added focus on the nature and distribution of the aggregates, if any.<\/jats:p>","DOI":"10.1093\/hmg\/ddad138","type":"journal-article","created":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T16:43:59Z","timestamp":1692895439000},"page":"3303-3311","source":"Crossref","is-referenced-by-count":4,"title":["Polyglutamine disease in peripheral tissues"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0301-1170","authenticated-orcid":false,"given":"Taylor","family":"Barwell","sequence":"first","affiliation":[{"name":"Department of Biology, Queen\u2019s University , 116 Barrie St, Kingston, ON K7L 3N6 , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4785-3890","authenticated-orcid":false,"given":"Laurent","family":"Seroude","sequence":"additional","affiliation":[{"name":"Department of Biology, Queen\u2019s University , 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