{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T21:53:34Z","timestamp":1783547614019,"version":"3.55.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"13","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271633"],"award-info":[{"award-number":["82271633"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qinglan Project of Jiangsu Province of China, Fund of Xuzhou Science and Technology","award":["KC23189"],"award-info":[{"award-number":["KC23189"]}]},{"name":"Qinglan Project of Jiangsu Province of China, Fund of Xuzhou Science and Technology","award":["KC20092"],"award-info":[{"award-number":["KC20092"]}]},{"name":"Qinglan Project of Jiangsu Province of China, Fund of Xuzhou Science and Technology","award":["KC22038"],"award-info":[{"award-number":["KC22038"]}]},{"name":"Open Fund of Jiangsu Key Laboratory for New Drug Research and Clinical Pharmacy, Xuzhou Pengcheng Talents\u2014Medical young reserve talents","award":["XWRCH20220011"],"award-info":[{"award-number":["XWRCH20220011"]}]},{"name":"Xuzhou Municipal Health Commission General Program Project","award":["XWKYHT20240081"],"award-info":[{"award-number":["XWKYHT20240081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Mesenchymal cells constitute the primary structural support elements within endometriotic lesions, yet their pivotal roles in endometriotic pathogenesis remain largely uncharted. This study aimed to construct a single-cell atlas of endometriosis using samples from three ovarian tissues affected by endometriosis and three normal ovarian tissues. Through the utilization of scRNA-seq, we have unveiled six distinct mesenchymal subclusters in normal and endometriosis-afflicted ovaries, elucidating the diverse functions of mesenchymal populations in endometriosis. Our comprehensive analysis has revealed that mesenchymal cells predominantly engage in three key functions: ribosome-mediated protein synthesis and processing, cell adhesion facilitating intercellular support and communication, and a range of metabolic processes. Furthermore, our findings have identified several pivotal differentially expressed genes (e.g. C3, FN1, COL3A1, COL1A1, NRXN3), primarily associated with the complement and coagulation cascades, extracellular matrix (ECM) regulation, ECM receptor interactions, and cell adhesion molecules. In essence, our study provides a comprehensive transcriptomic dataset and novel insights into adhesive molecule and integrin networks within mesenchymal subclusters in endometriosis. This, in effect, has deepened the understanding of the pathomechanisms governing this condition.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf065","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T07:34:48Z","timestamp":1745998488000},"page":"1146-1156","source":"Crossref","is-referenced-by-count":4,"title":["Single-cell transcriptome unveils mesenchymal cell diversity in endometriosis"],"prefix":"10.1093","volume":"34","author":[{"given":"Xia","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Affiliated Hospital of Nantong University , 20# Xisi Road, Nantong 226001 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengkun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics, Xuzhou Central Hospital, Southeast University Affiliated Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University , 199# Jiefang South Road, Xuzhou 221000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Qi","sequence":"additional","affiliation":[{"name":"Clinical Center of Reproductive Medicine, Xuzhou Central Hospital, Xuzhou Clinical School of Xuzhou Medical University , 199# Jiefang South Road, Xuzhou 221000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine and Offspring Health, Center for Reproduction and Genetics, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University , 16# Baita West Road, Suzhou 215002 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuru","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Reproductive 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