{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:00:04Z","timestamp":1787504404369,"version":"build-2736575974"},"reference-count":137,"publisher":"Oxford University Press (OUP)","issue":"R1","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"NIAMS","doi-asserted-by":"publisher","award":["CORT P50AR070594"],"award-info":[{"award-number":["CORT P50AR070594"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center for Lupus Research"},{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","award":["U19 AI082715"],"award-info":[{"award-number":["U19 AI082715"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic Lupus Erythematosus (SLE) is a complex autoimmune disorder characterized by loss of self-tolerance to nucleic acids, resulting in multisystem inflammation and organ damage. The genetic underpinning of SLE spans from common risk variants with modest effect sizes to rare monogenic mutations with high penetrance. Recent advances in next-generation sequencing and transcriptomic profiling have illuminated the central role of innate immune pathways in disease pathogenesis. This review synthesizes emerging evidence regarding innate immunity in SLE, with emphasis on toll-like receptor (TLR) signaling and regulatory mechanisms, NLRP3 inflammasome activation, myeloid cell dysregulation, and microbiome-immune interactions. Understanding these pathways provides a foundation for developing targeted therapeutics that may offer precision medicine approaches for this heterogeneous disease.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf066","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T07:32:10Z","timestamp":1748935930000},"page":"R35-R44","source":"Crossref","is-referenced-by-count":6,"title":["Recent insights into the role of innate immunity in lupus"],"prefix":"10.1093","volume":"34","author":[{"given":"Lauren A","family":"Robinson","sequence":"first","affiliation":[{"name":"Drukier Institue for Children\u2019s Health, Weill Cornell Medical College , 513 East 69th Street, New York, NY 10021 ,","place":["United States"]},{"name":"Department of Pediatrics, Weill Cornell Medical College , 525 East 68th Street, New York, NY 10021 ,","place":["United States"]},{"name":"Hospital for Special Surgery , 535 East 70th Street, New York, NY 10021 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8806-8426","authenticated-orcid":false,"given":"Virginia","family":"Pascual","sequence":"additional","affiliation":[{"name":"Drukier Institue for Children\u2019s Health, Weill Cornell Medical College , 513 East 69th Street, New York, NY 10021 ,","place":["United States"]},{"name":"Department of Pediatrics, Weill Cornell Medical College , 525 East 68th Street, New York, NY 10021 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"2025100708213650300_ref1","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1056\/NEJMra1100359","article-title":"Systemic lupus erythematosus","volume":"365","author":"Tsokos","year":"2011","journal-title":"N Engl J 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