{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T02:08:54Z","timestamp":1780452534800,"version":"3.54.1"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"17","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015194","name":"Feist-Weiller Cancer Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015194","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Caroll Feist Predoctoral Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The Parkinson\u2019s disease-associated protein, alpha-synuclein (\u03b1-syn; SNCA) is suspected of promoting melanoma progression. We recently knocked out SNCA in the human cutaneous melanoma cell line SK-MEL-28 to try to deduce the role of \u03b1-syn in melanoma progression. Compared to control cells, the SK-MEL-28 SNCA-knockout (KO) cells have significantly inhibited growth, invasion, and migration, and the levels of the neural adhesion protein L1CAM and the transferrin receptor (TFR1) are significantly reduced. In this study, using transmission electron microscopy and immunofluorescence we show that SK-MEL-28 SNCA-KO cells relative to control cells exhibit an (i) increased density of endolysosomes; (ii) increased perinuclear positioning of large (&amp;gt; 800\u00a0nm) endolysosomes; and (iii) decreased levels of the tetraspanins CD9 and CD81. Based on these results, we infer that \u03b1-syn disrupts the balance between anterograde and retrograde traffic; thus, we propose that \u03b1-syn is an accessory factor that that positively modulates the anterograde transport of endolysosomes and that loss of \u03b1-syn expression results events (i)-(iii). We infer that low levels of L1CAM and CD81 (and other membrane proteins) are likely the underlying reason for the significantly reduced invasiveness and migratory properties of SK-MEL-28 SNCA-KO cells.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf096","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T08:38:32Z","timestamp":1750063112000},"page":"1433-1445","source":"Crossref","is-referenced-by-count":3,"title":["Alpha-synuclein modulates the positioning of endolysosomes in melanoma cells"],"prefix":"10.1093","volume":"34","author":[{"given":"Nirjhar M","family":"Aloy","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center , 1501 Kings Highway, Shreveport, LA 71103 ,","place":["United States"]},{"name":"Feist-Weiller Cancer Center, LSU Health , 1405 Kings Highway, Shreveport, LA 71103 ,","place":["United 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