{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T23:15:46Z","timestamp":1788650146141,"version":"build-2803163510"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"20","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["101021500"],"award-info":[{"award-number":["101021500"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["863981"],"award-info":[{"award-number":["863981"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["874739"],"award-info":[{"award-number":["874739"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001828","name":"Erasmus University Rotterdam","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001828","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Netherlands Organization for Health Research and Development and the Ministry of Health, Welfare and Sport"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parental genetic variants can indirectly influence the traits of their child through the environment, a concept termed \u2018genetic nurture\u2019, or indirect genetic effects (IGE). This study estimated the direct genetic effects (DGE), via direct allelic transmission, and IGE shaping height, body mass index (BMI), and bone mineral density (BMD) in a multi-ethnic Dutch pediatric cohort, examining children with repeated measurements at ages six, nine, and thirteen. We imputed missing parental alleles from the phased haplotypes of 1\u2009931\u2009478 variants (MAF &amp;gt;\u20091%), utilizing snipar (single nucleotide imputation of parents). We constructed polygenic risk scores (PRSs) and jointly regressed the proband\u2019s trait on their own PRS, while controlling for the proband\u2019s maternal and paternal PRSs. A total of 4488 probands, with genetic data, underwent at least one of the three specified measurements. We found statistically significant DGE estimates for the three traits across ages six, nine and thirteen. For instance, 71%\u201377% of the BMI variance explained by the BMI-PRS can be attributed solely to the DGE. IGE estimates reached significance only for BMI measured at ages nine (Beta: 0.05, 95%CI: 0.01\u20130.09) and thirteen (Beta: 0.05, 95%CI: 0.01\u20130.09). Maternal and paternal IGE were of a similar magnitude in all our analyses. Our findings indicate that genetic nurture has limited influence on anthropometric traits during formative years. In addition, we do not observe differences between the maternal and paternal indirect contributions to these traits, opposite to the stronger maternal nurturing effect reported for other traits.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf117","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T07:53:57Z","timestamp":1751615637000},"page":"1744-1752","source":"Crossref","is-referenced-by-count":3,"title":["Genetic nurture: estimating the direct genetic effects of pediatric anthropometric traits"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8310-3448","authenticated-orcid":false,"given":"Samuel","family":"Ghatan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jard","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Pingault","sequence":"additional","affiliation":[{"name":"Department of Clinical, Educational and Health Psychology, University College London , Gower Street, London, WC1E 6BT,","place":["United Kingdom"]},{"name":"UCL Human Genomics, University College London , Gower Street, London, WC1E 6BT,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The Netherlands"]},{"name":"Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Cecil","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The Netherlands"]},{"name":"Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine F","family":"Felix","sequence":"additional","affiliation":[{"name":"The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The Netherlands"]},{"name":"Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam , Dr. Molewaterplein 40, 3015 GD, Rotterdam ,","place":["The 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