{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:11:52Z","timestamp":1791205912026,"version":"4.1.0"},"reference-count":118,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Educational and Teaching Reform Projects of Wenzhou Medical University","award":["JG2023107"],"award-info":[{"award-number":["JG2023107"]}]},{"name":"Science and Technology Planning Project of Wenzhou","award":["ZY2023032 and ZY2021025"],"award-info":[{"award-number":["ZY2023032 and ZY2021025"]}]},{"name":"Zhejiang Provincial Science and Technology Bureau Foundation","award":["LGF22H040010"],"award-info":[{"award-number":["LGF22H040010"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LQ21H040007 and LQ21H040008"],"award-info":[{"award-number":["LQ21H040007 and LQ21H040008"]}]},{"name":"Open Fund Project of Key Laboratory of Structural Malformations in Children of Zhejiang Province","award":["ZJET2305Z"],"award-info":[{"award-number":["ZJET2305Z"]}]},{"name":"ShangDa TranslationalI Medicine Funding supported by Wenzhou Institute of Shanghai University","award":["SDTMF2023EP07 and SDTMF2022EP03"],"award-info":[{"award-number":["SDTMF2023EP07 and SDTMF2022EP03"]}]},{"name":"Medical Health Science and Technology Project of Zhejiang Provincial","award":["2024KY394 and WKJ-ZJ-2555"],"award-info":[{"award-number":["2024KY394 and WKJ-ZJ-2555"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The occurrence of preterm premature rupture of membranes (PPROM) significantly impacts maternal and fetal health due to its association with the cellular composition and genetic changes of the fetal membrane. However, the specific cell type responsible for triggering PPROM and the underlying mechanisms are still largely unexplored. We employed single-cell RNA sequencing (scRNA-seq) analysis on fetal membrane along with adjacent placental tissues about two centimeters from the umbilical cord obtained from women who delivered full-term in labor (FTIL), preterm premature without rupture of membrane (PPWROM), as well as PPROM\uff0cimmunofluorescence were used to verify the findings. Our result s highlighted notable differences in cell type composition and interactions among these three groups. Of particular significance, we have identified a previously unrecognized subtype of trophoblast cells known as FABP7+Tb, a transitional state cell between cytotrophoblasts (CTB) and extravillous trophoblasts (EVT) cells, which appears to have some impact on PPWROM. Additionally, up-regulated expression of MMP11 in EVT-1 may serve as a promising biomarker for PPROM diagnosis. Furthermore, our study unveiled distinct interaction patterns among different trophoblast subtypes under varying pathological conditions, as well as significant variations in the interactions of trophoblast cells with other cell types, especially the pathways that are orchestrated by cell\u2013cell cross-talk. Our study offers a comprehensive cell type and interaction map for the human fetal membrane along with adjacent placental tissues about two centimeters from the umbilical cord, providing insights into the molecular mechanisms that drive PPROM and uncovering potential targets for the early prediction of this condition.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf143","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:12:22Z","timestamp":1764249142000},"source":"Crossref","is-referenced-by-count":2,"title":["Single-cell analysis reveals the diversity of human fetal membrane and adjacent placental cells with preterm premature rupture of membranes"],"prefix":"10.1093","volume":"35","author":[{"given":"Congcong","family":"Sun","sequence":"first","affiliation":[{"name":"Research and Experiment Center, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1580-5004","authenticated-orcid":false,"given":"Mao","family":"Wu","sequence":"additional","affiliation":[{"name":"Children\u2019s Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , No.1111, Wenzhou Avenue, Longwan District, Wenzhou, Zhejiang Province 325000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Children\u2019s Heart Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , No.1111, Wenzhou Avenue, Longwan District, Wenzhou, Zhejiang Province 325000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Xu","sequence":"additional","affiliation":[{"name":"Research and Experiment Center, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingdiao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University, Wenzhou People\u2019s Hospital, Wenzhou Maternal and Child Health Care Hospital , No.299, Guan Road, Ouhai District, Wenzhou, Zhejiang Province 325006 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