{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T16:12:02Z","timestamp":1762186322611,"version":"build-2065373602"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"22","license":[{"start":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T00:00:00Z","timestamp":1759363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Fragile X Syndrome is the most prevalent known genetic cause of intellectual disability (ID), affecting around 1 in 4\u2009000 individuals, and is also highly associated with autism spectrum disorder (ASD). Humans with the disorder and animal models display sleep and metabolic abnormalities. Given growing evidence of links between sleep and metabolism, we sought to determine if metabolic abnormalities underlie sleep deficits in mice lacking the Fragile X messenger ribonucleoprotein 1 (FMR1) gene. We found that metformin, a drug that targets metabolic pathways and has been shown to alleviate other symptoms in FXS, did not rescue sleep in mutant mice. Instead, metformin enhanced activity of Fmr1 knockout (KO) mice. As a way of exaggerating possible metabolic phenotypes, we treated mice with a high fat diet (HFD) and found that although this disrupted the sleep pattern in controls, it did not impact the sleep phenotype in Fmr1 KOs. Increased sleep during the dark phase, caused by HFD in wild type animals, was alleviated by metformin treatment. Metformin also decreased weight gain of wild type animals on a HFD, but the effect was delayed in Fmr1 KO mice. Fmr1 KO mice with or without metformin treatment displayed hyperphagia on a HFD, yet did not show higher weight gain than wild type. And, surprisingly, their glucose tolerance was equivalent to that of wild type mice on metformin. We suggest that Fmr1 KO mice are better able to metabolize fat and so are relatively resistant to its negative effects on sleep and metabolism.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf149","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T12:01:07Z","timestamp":1758283267000},"page":"1874-1883","source":"Crossref","is-referenced-by-count":0,"title":["Sleep in a mouse model of fragile X syndrome is resistant to metabolic manipulations"],"prefix":"10.1093","volume":"34","author":[{"given":"Mariela","family":"Lopez Valencia","sequence":"first","affiliation":[{"name":"Chronobiology and Sleep Institute, Perelman School of Medicine, University of Pennsylvania , Philadelphia , PA 19104,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A","family":"Vel\u00e1zquez Aponte","sequence":"additional","affiliation":[{"name":"Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A","family":"Baur","sequence":"additional","affiliation":[{"name":"Department of Physiology and Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas A","family":"Jongens","sequence":"additional","affiliation":[{"name":"Department of Genetics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104,","place":["United States"]},{"name":"Department of Autism Spectrum Program of Excellence, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA 19104,","place":["United 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