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<jats:p>American Indians and Hispanics\/Latinos have a high burden of chronic kidney disease (CKD) and they may share disease associated genetic variants. This study aims to identify loci for CKD and albuminuria that are shared between these populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed genome-wide association studies (GWAS) in 3157 American Indians and 12\u2009625 Hispanics\/Latinos for CKD (estimated glomerular filtration rate [eGFR] &amp;lt;\u200960\u00a0mL\/min\/1.73\u00a0m2) and albuminuria (urine albumin to creatinine ratio [uACR]) &amp;gt;\u200930\u00a0mg\/g). We examined significant associations across GWASs and the functional relevance of findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five low-frequency variants at chromosome 7 were significantly associated with albuminuria in American Indians (lead variant: rs4370473, intronic to KCND2, P\u00a0=\u20098.93 \u00d7 10\u22129), with evidence for a partly independent association driven by rs7791185 (p conditional on rs4370473\u2009=\u20093.8 \u00d7 10\u22125). A chromosome 11 variant (rs59232451, HBE1-HBB locus, P\u00a0=\u20094.9 \u00d7 10\u22128) was significantly associated with albuminuria in Hispanics\/Latinos when adjusting for diabetes, and the association was partially accounted for by the HBB rs344. The associations for albuminuria did not cross-replicate among studies. There were no significant associations with CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our study identified associations at KCND2 in American Indians and HBE1-HBB in Hispanics\/Latinos for albuminuria. Findings suggest differences in genetic architecture influencing albuminuria across these populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/hmg\/ddaf168","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T03:56:21Z","timestamp":1763006181000},"source":"Crossref","is-referenced-by-count":2,"title":["Genome-wide association of albuminuria and chronic kidney disease in American Indians and Hispanics\/Latinos"],"prefix":"10.1093","volume":"35","author":[{"given":"Kaylia M","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina , 123 W Franklin St, suite 410, Chapel Hill, NC 27516 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Pasteris","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina , 123 W Franklin St, suite 410, Chapel Hill, NC 27516 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyle G","family":"Best","sequence":"additional","affiliation":[{"name":"Missouri Breaks Industries Research Inc. , 505 So Willow St, Eagle Butte, SD 57625 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4945-6733","authenticated-orcid":false,"given":"Jiawen","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina , 123 W Franklin Street suite 450, Chapel Hill, NC 27516 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly J","family":"Kramer","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Loyola University Chicago , 2160 S First Ave, Maywood, Illinois, IL 60153 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James P","family":"Lash","sequence":"additional","affiliation":[{"name":"Division of Nephrology, University of Illinois Chicago , 840 South Wood Street, Suite 1020N, MC 787, Chicago, IL 60612 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Cole","sequence":"additional","affiliation":[{"name":"Texas Biomedical Research Institute , 8715 W. 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