{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T06:11:06Z","timestamp":1778479866673,"version":"3.51.4"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Peripheral neuropathies are common neurological disorders affecting sensory, autonomic, and motor nerves, with an estimated prevalence exceeding 2% in the general population. Typical symptoms include numbness and distal limb muscle weakness, resulting from somatosensory nerve damage. Here, we investigate the genetic architecture of mono- and polyneuropathies and their relationships with comorbid traits using data from FinnGen and the UK Biobank. Our genome-wide association study (GWAS) and meta-analysis identified 48 genome-wide significant (P\u2009&amp;lt;\u20095\u2009\u00d7\u200910\u22128) independent loci and 66 fine-mapped credible sets. These included associations with genes involved in neurotransmitter signaling (HTR3A), immune function (HLA-DQB1, BCL11A), extracellular matrix remodeling (COL11A1, ADAMTS17, LOXL4), axon guidance and neural development (DCC, ETV1, NEGR1), and carpal tunnel syndrome (DIRC3). Public variant association data across cohorts, genetic correlation, and Mendelian randomization analyses supported shared genetic links of neuropathies with sleep problems, chronic pain, and psychiatric disorders. Together, our results highlight a strong polygenic basis for neuropathies and further confirm their genetic comorbid relationships with sleep, pain, psychiatric, and autoimmune traits.<\/jats:p>","DOI":"10.1093\/hmg\/ddaf200","type":"journal-article","created":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T12:40:03Z","timestamp":1766839203000},"source":"Crossref","is-referenced-by-count":0,"title":["Genome-wide meta-analysis identifies genetic risk loci for mono- and polyneuropathies in 983\u2009477 individuals"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-9479","authenticated-orcid":false,"given":"Martin","family":"Broberg","sequence":"first","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland"},{"name":"Stem Cells and Metabolism Research Program , Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, 00014, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finn","family":"Gen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eija","family":"Kalso","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology , Intensive Care and Pain Medicine, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, 00290, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna M","family":"Ollila","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine Finland (FIMM) , HiLIFE, University of Helsinki, Tukholmankatu 8, 00290 Helsinki, Finland"},{"name":"Center for Genomic Medicine , Massachusetts General Hospital and Program in Medical and Population Genetics, Broad Institute, 185 Cambridge Street, Boston, MA 02114, United States"},{"name":"Department of Anesthesia , Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, GRB 444, Boston, MA 02114, United States"},{"name":"Broad Institute of MIT and Harvard , Cambridge, MA , 415 Main Street, Cambridge, MA 02142,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,10]]},"reference":[{"key":"2026051101414736200_ref1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31820c3622","article-title":"The evaluation of polyneuropathies","volume":"76","author":"Burns","year":"2011","journal-title":"Neurology"},{"key":"2026051101414736200_ref2","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1212\/CON.0000000000000928","article-title":"Management of Neuropathic Pain in polyneuropathy","volume":"26","author":"Peltier","year":"2020","journal-title":"Contin Lifelong Learn Neurol"},{"key":"2026051101414736200_ref3","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s10654-015-0094-6","article-title":"The epidemiology and 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