{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:00:34Z","timestamp":1780340434778,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":151,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","award":["202208440079"],"award-info":[{"award-number":["202208440079"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sleep disorder is associated with risk of osteoarthritis, yet their causal association has not been fully understood. This study aims to evaluate the causal association between sleep traits and osteoarthritis, by performing two sample Mendelian randomization (MR) leveraging the currently largest genome-wide association study (GWAS) summary statistics for sleep traits and osteoarthritis traits. We demonstrate that insomnia has a risk-increasing causal effect on osteoarthritis at any site, hip osteoarthritis, and hip and\/or knee osteoarthritis, corresponding to approximately 60%, 100%, and 50% higher odds of disease, respectively, with the strongest effect observed for hip osteoarthritis. Conversely, genetic predisposition to osteoarthritis at any site was associated with a modest 4% increase in the odds of insomnia. These findings reveal a bidirectional causal relationship between insomnia and osteoarthritis-related traits, underscoring the critical interplay between sleep health and joint disease, and suggesting opportunities for preventive and therapeutic strategies that align with the body\u2019s intrinsic timing systems.<\/jats:p>","DOI":"10.1093\/hmg\/ddag043","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:45:17Z","timestamp":1778845517000},"source":"Crossref","is-referenced-by-count":0,"title":["The causal association between sleep traits and osteoarthritis traits: evidence from bidirectional mendelian randomization"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1895-3657","authenticated-orcid":false,"given":"Shibo","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Translational Genomics, Computational Health Center, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health , Ingolst\u00e4dter Landstra\u00dfe 1, Bavaria, Neuherberg 85764 ,","place":["Germany"]},{"name":"Munich Medical Research School (MMRS), Faculty of Medicine, Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen , Geschwister-Scholl-Platz 1, Bavaria, Munich 80539 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorraine","family":"Southam","sequence":"additional","affiliation":[{"name":"Institute of Translational Genomics, Computational Health Center, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health , Ingolst\u00e4dter Landstra\u00dfe 1, Bavaria, Neuherberg 85764 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Arruda","sequence":"additional","affiliation":[{"name":"Institute of Translational Genomics, Computational Health Center, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health , Ingolst\u00e4dter Landstra\u00dfe 1, Bavaria, Neuherberg 85764 ,","place":["Germany"]},{"name":"Institute of Metabolic Science (IMS) Epidemiology , University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ ,","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleftheria","family":"Zeggini","sequence":"additional","affiliation":[{"name":"Institute of Translational Genomics, Computational Health Center, Helmholtz Zentrum M\u00fcnchen \u2013 German Research Center for Environmental Health , Ingolst\u00e4dter Landstra\u00dfe 1, Bavaria, Neuherberg 85764 ,","place":["Germany"]},{"name":"Technical University of Munich (TUM), TUM University Hospital, TUM School of Medicine and Health , Ismaninger Str. 22, Bavaria, 81675 Munich 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