{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:25:58Z","timestamp":1791174358487,"version":"4.1.0"},"reference-count":61,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,10,15]]},"DOI":"10.1093\/hmg\/ddg290","type":"journal-article","created":{"date-parts":[[2003,10,2]],"date-time":"2003-10-02T16:28:21Z","timestamp":1065112101000},"page":"2577-2585","source":"Crossref","is-referenced-by-count":34,"title":["LD mapping of maternally and non-maternally derived alleles and atopy in Fc\u03b5RI-\u03b2"],"prefix":"10.1093","volume":"12","author":[{"given":"James A.","family":"Traherne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirro","family":"Hysi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"D'Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Broxholme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam F.","family":"Moffatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William O.C.M.","family":"Cookson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2003,10,15]]},"reference":[{"key":"key\n\t\t\t\t20170522154857_DDG290C1","doi-asserted-by":"crossref","unstructured":"Cookson, W. ( 1999 ) The alliance of genes and environment in asthma and allergy. Nature , 402 , B5 \u201311.","DOI":"10.1038\/35037002"},{"key":"key\n\t\t\t\t20170522154857_DDG290C2","doi-asserted-by":"crossref","unstructured":"Dizier, M.H., Hill, M., James, A., Faux, J., Ryan, G., le Souef, P., Lathrop, M., Musk, A.W., Demenais, F. and Cookson, W. ( 1995 ) Detection of a recessive major gene for high IgE levels acting independently of specific response to allergens. Genet. Epidemiol. , 12 , 93 \u2013105.","DOI":"10.1002\/gepi.1370120109"},{"key":"key\n\t\t\t\t20170522154857_DDG290C3","doi-asserted-by":"crossref","unstructured":"Palmer, L.J., Burton, P.R., Faux, J.A., James, A.L., Musk, A.W. and Cookson, W.O. ( 2000 ) Independent inheritance of serum immunoglobulin E concentrations and airway responsiveness. Am. J. Respir. Crit. Care Med. , 161 , 1836 \u20131843.","DOI":"10.1164\/ajrccm.161.6.9805104"},{"key":"key\n\t\t\t\t20170522154857_DDG290C4","doi-asserted-by":"crossref","unstructured":"Turner, H. and Kinet, J.P. ( 1999 ) Signalling through the high-affinity IgE receptor Fc epsilonRI. Nature , 402 , B24 \u201330.","DOI":"10.1038\/35037021"},{"key":"key\n\t\t\t\t20170522154857_DDG290C5","doi-asserted-by":"crossref","unstructured":"Sandford, A.J., Shirakawa, T., Moffatt, M.F., Daniels, S.E., Ra, C., Faux, J.A., Young, R.P., Nakamura, Y., Lathrop, G.M., Cookson, W.O. et al. ( 1993 ) Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q. Lancet , 341 , 332 \u2013334.","DOI":"10.1016\/0140-6736(93)90136-5"},{"key":"key\n\t\t\t\t20170522154857_DDG290C6","doi-asserted-by":"crossref","unstructured":"Young, R.P., Lynch, J., Sharp, P.A. et al. ( 1992 ) Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J. Med. Genet. , 29 , 236 \u2013238.","DOI":"10.1136\/jmg.29.4.236"},{"key":"key\n\t\t\t\t20170522154857_DDG290C7","doi-asserted-by":"crossref","unstructured":"Shirakawa, T., Hashimoto, T., Furuyama, J., Takeshita, T. and Morimoto, K. ( 1994 ) Linkage between severe atopy and chromosome 11q13 in Japanese families. Clin. Genet. , 46 , 228 \u2013232.","DOI":"10.1111\/j.1399-0004.1994.tb04231.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C8","doi-asserted-by":"crossref","unstructured":"Daniels, S.E., Bhattacharrya, S., James, A., Leaves, N.I., Young, A., Hill, M.R., Faux, J.A., Ryan, G.F., le Souef, P.N., Lathrop, G.M. et al. ( 1996 ) A genome-wide search for quantitative trait loci underlying asthma. Nature , 383 , 247 \u2013250.","DOI":"10.1038\/383247a0"},{"key":"key\n\t\t\t\t20170522154857_DDG290C9","doi-asserted-by":"crossref","unstructured":"Folster-Holst, R., Moises, H., Yang, L., Fritsch, W., Weissenbach, J. and Christophers, E. ( 1998 ) Linkage between atopy and the IgE high-affinity receptor gene at 11q13 in atopic dermatitis families. Hum. Genet. , 102 , 236 \u2013239.","DOI":"10.1007\/s004390050685"},{"key":"key\n\t\t\t\t20170522154857_DDG290C10","doi-asserted-by":"crossref","unstructured":"Moffatt, M. and Cookson, W. ( 1998 ) The genetics of asthma. Maternal effects in atopic disease. Clin. Exp. Allergy , 28 (Suppl. 1), 56 \u201361.","DOI":"10.1046\/j.1365-2222.1998.0280s1056.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C11","doi-asserted-by":"crossref","unstructured":"Cookson, W.O., Young, R.P., Sandford, A.J., Moffatt, M.F., Shirakawa, T., Sharp, P.A., Faux, J.A., Julier, C., Nakumuura, Y., Nakumura, Y. et al. ( 1992 ) Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet , 340 , 381 \u2013384.","DOI":"10.1016\/0140-6736(92)91468-N"},{"key":"key\n\t\t\t\t20170522154857_DDG290C12","doi-asserted-by":"crossref","unstructured":"Lin, S., Cicala, C., Scharenberg, A. and Kinet, J. ( 1996 ) The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals. Cell , 85 , 985 \u2013995.","DOI":"10.1016\/S0092-8674(00)81300-8"},{"key":"key\n\t\t\t\t20170522154857_DDG290C13","doi-asserted-by":"crossref","unstructured":"Kuster, H., Zhang, L. and Brini, A.T. ( 1992 ) The gene and cDNA for the human high affinity immunoglobulin E receptor \u03b2 chain and expression of the complete human receptor. J. Biol. Chem. , 267 , 12782 \u201312787.","DOI":"10.1016\/S0021-9258(18)42344-7"},{"key":"key\n\t\t\t\t20170522154857_DDG290C14","doi-asserted-by":"crossref","unstructured":"Shirakawa, T., Li, A., Dubowitz, M. et al. ( 1994 ) Association between atopy and variants of the \u03b2 subunit of the high affinity immunoglobulin E receptor. Nat. Genet. , 7 , 125 \u2013129.","DOI":"10.1038\/ng0694-125"},{"key":"key\n\t\t\t\t20170522154857_DDG290C15","doi-asserted-by":"crossref","unstructured":"Hijazi, Z., Haider, M.Z., Khan, M.R. and Al-Dowaisan, A.A. ( 1998 ) High frequency of IgE receptor Fc epsilonRIbeta variant (Leu181\/Leu183) in Kuwaiti Arabs and its association with asthma. Clin. Genet. , 53 , 149 \u2013152.","DOI":"10.1111\/j.1399-0004.1998.tb02664.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C16","doi-asserted-by":"crossref","unstructured":"Green, S., Gaillard, M., Song, E., Dewar, J. and Halkas, A. ( 1998 ) Polymorphisms of the beta chain of the high-affinity immunoglobulin E receptor (Fcepsilon RI-beta) in South African black and white asthmatic and nonasthmatic individuals. Am. J. Respir. Crit. Care Med. , 158 , 1487 \u20131492.","DOI":"10.1164\/ajrccm.158.5.9707099"},{"key":"key\n\t\t\t\t20170522154857_DDG290C17","doi-asserted-by":"crossref","unstructured":"Rigoli, L., Salpietro, D.C., Lavalle, R., Cafiero, G., Zuccarello, D. and Barberi, I. ( 2000 ) Allelic association of gene markers on chromosome 11q in Italian families with atopy. Acta Paediatr. , 89 , 1056 \u20131061.","DOI":"10.1111\/j.1651-2227.2000.tb03350.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C18","doi-asserted-by":"crossref","unstructured":"Hill, M.R. and Cookson, W.O.C.M. ( 1996 ) A new variant of the \u03b2 subunit of the high affinity receptor for Immunoglobulin E (Fc\u03b5RI-E237G): associations with measures of atopy and bronchial hyper-responsiveness. Hum. Mol. Genet. , 5 , 959 \u2013962.","DOI":"10.1093\/hmg\/5.7.959"},{"key":"key\n\t\t\t\t20170522154857_DDG290C19","doi-asserted-by":"crossref","unstructured":"Nagata, H., Mutoh, H., Kumahara, K., Arimoto, Y., Tomemori, T., Sakurai, D., Arase, K., Ohno, K., Yamakoshi, T., Nakano, K. et al. ( 2001 ) Association between nasal allergy and a coding variant of the Fc epsilon RI beta gene Glu237Gly in a Japanese population. Hum. Genet. , 109 , 262 \u2013266.","DOI":"10.1007\/s004390100561"},{"key":"key\n\t\t\t\t20170522154857_DDG290C20","doi-asserted-by":"crossref","unstructured":"Shirakawa, T., Mao, X.Q., Sasaki, S., Enomoto, T., Kawai, M., Morimoto, K. and Hopkin, J. ( 1996 ) Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population. Hum. Mol. Genet. , 5 , 1129 \u20131130.","DOI":"10.1093\/hmg\/5.8.1129"},{"key":"key\n\t\t\t\t20170522154857_DDG290C21","doi-asserted-by":"crossref","unstructured":"Laprise, C., Boulet, L.P., Morissette, J., Winstall, E. and Raymond, V. ( 2000 ) Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population. Immunogenetics , 51 , 695 \u2013702.","DOI":"10.1007\/s002510000185"},{"key":"key\n\t\t\t\t20170522154857_DDG290C22","doi-asserted-by":"crossref","unstructured":"Donnadieu, E., Cookson, W.O., Jouvin, M.H. and Kinet, J.P. ( 2000 ) Allergy-associated polymorphisms of the FcepsilonRIbeta subunit do not impact its two amplification functions. J. Immunol. , 165 , 3917 \u20133922.","DOI":"10.4049\/jimmunol.165.7.3917"},{"key":"key\n\t\t\t\t20170522154857_DDG290C23","doi-asserted-by":"crossref","unstructured":"Furumoto, Y., Hiraoka, S., Kawamoto, K., Masaki, S., Kitamura, T., Okumura, K. and Ra, C. ( 2000 ) Polymorphisms in FcepsilonRI beta chain do not affect IgE-mediated mast cell activation. Biochem. Biophys. Res. Commun. , 273 , 765 \u2013771.","DOI":"10.1006\/bbrc.2000.2989"},{"key":"key\n\t\t\t\t20170522154857_DDG290C24","doi-asserted-by":"crossref","unstructured":"Adra, C.N., Mao, X.Q., Kawada, H., Gao, P.S., Korzycka, B., Donate, J.L., Shaldon, S.R., Coull, P., Dubowitz, M., Enomoto, T. et al. ( 1999 ) Chromosome 11q13 and atopic asthma. Clin. Genet. , 55 , 431 \u2013437.","DOI":"10.1034\/j.1399-0004.1999.550606.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C25","doi-asserted-by":"crossref","unstructured":"Kim, Y.K., Cho, S.H., Koh, Y.Y., Son, J.W., Lee, B.J., Min, K.U. and Kim, Y.Y. ( 1999 ) Linkage between IgE receptor-mediated histamine releasability from basophils and gene marker of chromosome 11q13. J. Allergy Clin. Immunol. , 104 , 618 \u2013622.","DOI":"10.1016\/S0091-6749(99)70333-7"},{"key":"key\n\t\t\t\t20170522154857_DDG290C26","doi-asserted-by":"crossref","unstructured":"van Herwerden, L., Harrap, S.B., Wong, Z.Y., Abramson, M.J., Kutin, J.J., Forbes, A.B., Raven, J., Lanigan, A. and Walters, E.H. ( 1995 ) Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. Lancet , 346 , 1262 \u20131265.","DOI":"10.1016\/S0140-6736(95)91863-9"},{"key":"key\n\t\t\t\t20170522154857_DDG290C27","doi-asserted-by":"crossref","unstructured":"Cox, H.E., Moffatt, M.F., Faux, J.A., Walley, A.J., Coleman, R., Trembath, R.C., Cookson, W.O. and Harper, J.I. ( 1998 ) Association of atopic dermatitis to the beta subunit of the high affinity immunoglobulin E receptor. Br. J. Dermatol. , 138 , 182 \u2013187.","DOI":"10.1046\/j.1365-2133.1998.02108.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C28","doi-asserted-by":"crossref","unstructured":"Palmer, L.J., Pare, P.D., Faux, J.A., Moffatt, M.F., Daniels, S.E., LeSouef, P.N., Bremner, P.R., Mockford, E., Gracey, M., Spargo, R. et al. ( 1997 ) Fc epsilon R1-beta polymorphism and total serum IgE levels in endemically parasitized Australian aborigines. Am. J. Hum. Genet. , 61 , 182 \u2013188.","DOI":"10.1086\/513888"},{"key":"key\n\t\t\t\t20170522154857_DDG290C29","unstructured":"Cockcroft, D.W., Murdock, K.Y., Kirby, J. and Hargreave, F. ( 1987 ) Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. Am. Rev. Respir. Dis. , 135 , 264 \u2013267."},{"key":"key\n\t\t\t\t20170522154857_DDG290C30","doi-asserted-by":"crossref","unstructured":"Hill, M.R., James, A.L., Faux, J.A., Ryan, G., Hopkin, J.M., le Souef, P., Musk, A.W. and Cookson, W.O. ( 1995 ) Fc epsilon RI-beta polymorphism and risk of atopy in a general population sample. Br. Med. J. , 311 , 776 \u2013779.","DOI":"10.1136\/bmj.311.7008.776"},{"key":"key\n\t\t\t\t20170522154857_DDG290C31","doi-asserted-by":"crossref","unstructured":"Shirakawa, T., Mao, X.Q., Sasaki, S., Kawai, M., Morimoto, K. and Hopkin, J.M. ( 1996 ) Association between Fc epsilon RI beta and atopic disorder in a Japanese population. Lancet , 347 , 394 \u2013395.","DOI":"10.1016\/S0140-6736(96)90570-X"},{"key":"key\n\t\t\t\t20170522154857_DDG290C32","doi-asserted-by":"crossref","unstructured":"Martinati, L., Trabetti, E., Casartelli, A., Boner, A. and Pignatti, P. ( 1996 ) Affected sib-pair and mutation analyses of the high affinity IgE receptor beta chain locus in Italian families with atopic asthmatic children. Am. J. Respir. Crit. Care Med. , 153 , 1682 \u20131685.","DOI":"10.1164\/ajrccm.153.5.8630620"},{"key":"key\n\t\t\t\t20170522154857_DDG290C33","doi-asserted-by":"crossref","unstructured":"Dickson, P., Wong, Z., Harrap, S., Abramson, M. and Walters, E. ( 1999 ) Mutational analysis of the high affinity immunoglobulin E receptor beta subunit gene in asthma. Thorax , 54 , 409 \u2013412.","DOI":"10.1136\/thx.54.5.409"},{"key":"key\n\t\t\t\t20170522154857_DDG290C34","doi-asserted-by":"crossref","unstructured":"Rohrbach, M., Kraemer, R. and Liechti-Gallati, S. ( 1998 ) Screening of the Fc epsilon RI-beta-gene in a Swiss population of asthmatic children: no association with E237G and identification of new sequence variations. Dis. Markers , 14 , 177 \u2013186.","DOI":"10.1155\/1998\/940356"},{"key":"key\n\t\t\t\t20170522154857_DDG290C35","doi-asserted-by":"crossref","unstructured":"Frech, K., Herrmann, G. and Werner, T. ( 1993 ) Computer-assisted prediction, classification, and delimitation of protein binding sites in nucleic acids. Nucl. Acids Res. , 21 , 1655 \u20131664.","DOI":"10.1093\/nar\/21.7.1655"},{"key":"key\n\t\t\t\t20170522154857_DDG290C36","doi-asserted-by":"crossref","unstructured":"Kruglyak, L. and Nickerson, D.A. ( 2001 ) Variation is the spice of life. Nat. Genet. , 27 , 234 \u2013236.","DOI":"10.1038\/85776"},{"key":"key\n\t\t\t\t20170522154857_DDG290C37","doi-asserted-by":"crossref","unstructured":"Moffatt, M.F., Traherne, J.A., Abecasis, G.R. and Cookson, W.O. ( 2000 ) Single nucleotide polymorphism and linkage disequilibrium within the TCR alpha\/delta locus. Hum. Mol. Genet. , 9 , 1011 \u20131019.","DOI":"10.1093\/hmg\/9.7.1011"},{"key":"key\n\t\t\t\t20170522154857_DDG290C38","doi-asserted-by":"crossref","unstructured":"Abecasis, G.R., Noguchi, E., Heinzmann, A., Traherne, J.A., Bhattacharyya, S., Leaves, N.I., Anderson, G.G., Zhang, Y., Lench, N.J., Carey, A. et al. ( 2001 ) Extent and distribution of linkage disequilibrium in three genomic regions. Am. J. Hum. Genet. , 68 , 191 \u2013197.","DOI":"10.1086\/316944"},{"key":"key\n\t\t\t\t20170522154857_DDG290C39","doi-asserted-by":"crossref","unstructured":"Daly, M.J., Rioux, J.D., Schaffner, S.F., Hudson, T.J. and Lander, E.S. ( 2001 ) High-resolution haplotype structure in the human genome. Nat. Genet. , 29 , 229 \u2013232.","DOI":"10.1038\/ng1001-229"},{"key":"key\n\t\t\t\t20170522154857_DDG290C40","doi-asserted-by":"crossref","unstructured":"Gabriel, S.B., Schaffner, S.F., Nguyen, H., Moore, J.M., Roy, J., Blumenstiel, B., Higgins, J., DeFelice, M., Lochner, A., Faggart, M. et al. ( 2002 ) The structure of haplotype blocks in the human genome. Science , 296 , 2225 \u20132229.","DOI":"10.1126\/science.1069424"},{"key":"key\n\t\t\t\t20170522154857_DDG290C41","doi-asserted-by":"crossref","unstructured":"Dombrowicz, D., Lin, S., Flamand, V., Brini, A.T., Koller, B.H. and Kinet, J.P. ( 1998 ) Allergy-associated FcRbeta is a molecular amplifier of IgE- and IgG-mediated in vivo responses. Immunity , 8 , 517 \u2013529.","DOI":"10.1016\/S1074-7613(00)80556-7"},{"key":"key\n\t\t\t\t20170522154857_DDG290C42","doi-asserted-by":"crossref","unstructured":"Donnadieu, E., Jouvin, M.H., Rana, S., Moffatt, M.F., Mockford, E.H., Cookson, W.O. and Kinet, J.P. ( 2003 ) Competing functions encoded in the allergy-associated Fc RI gene. Immunity , 18 , 665 \u2013674.","DOI":"10.1016\/S1074-7613(03)00115-8"},{"key":"key\n\t\t\t\t20170522154857_DDG290C43","doi-asserted-by":"crossref","unstructured":"Udalova, I.A., Mott, R., Field, D. and Kwiatkowski, D. ( 2002 ) Quantitative prediction of NF-kappa B DNA-protein interactions. Proc. Natl Acad. Sci. USA , 99 , 8167 \u20138172.","DOI":"10.1073\/pnas.102674699"},{"key":"key\n\t\t\t\t20170522154857_DDG290C44","doi-asserted-by":"crossref","unstructured":"Nishio, Y., Noguchi, E., Ito, S., Ichikawa, E., Umebayashi, Y., Otsuka, F. and Arinami, T. ( 2001 ) Mutation and association analysis of the interferon regulatory factor 2 gene (IRF2) with atopic dermatitis. J. Hum. Genet. , 46 , 664 \u2013667.","DOI":"10.1007\/s100380170018"},{"key":"key\n\t\t\t\t20170522154857_DDG290C45","doi-asserted-by":"crossref","unstructured":"Hida, S., Ogasawara, K., Sato, K., Abe, M., Takayanagi, H., Yokochi, T., Sato, T., Hirose, S., Shirai, T., Taki, S. et al. ( 2000 ) CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha\/beta signaling. Immunity , 13 , 643 \u2013655.","DOI":"10.1016\/S1074-7613(00)00064-9"},{"key":"key\n\t\t\t\t20170522154857_DDG290C46","doi-asserted-by":"crossref","unstructured":"Deichmann, K., Heinzmann, A., Forster, J., Dischinger, S., Mehl, C., Brueggenolte, E., Hildebrandt, F., Moseler, M. and Kuehr, J. ( 1998 ) Linkage and allelic association of atopy and markers flanking the IL4-receptor gene. Clin. Exp. Allergy , 28 , 151 \u2013155.","DOI":"10.1046\/j.1365-2222.1998.00159.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C47","doi-asserted-by":"crossref","unstructured":"Walley, A.J., Chavanas, S., Moffatt, M.F., Esnouf, R.M., Ubhi, B., Lawrence, R., Wong, K., Abecasis, G.R., Jones, E.Y., Harper, J.I. et al. ( 2001 ) Gene polymorphism in Netherton and common atopic disease. Nat. Genet. , 29 , 175 \u2013178.","DOI":"10.1038\/ng728"},{"key":"key\n\t\t\t\t20170522154857_DDG290C48","doi-asserted-by":"crossref","unstructured":"Warram, J.H., Krolewski, A.S., Gottlieb, M.S. and Kahn, C.R. ( 1984 ) Differences in risk of insulin-dependent diabetes in offspring of diabetic mothers and diabetic fathers. New Engl. J. Med. , 311 , 149 \u2013152.","DOI":"10.1056\/NEJM198407193110304"},{"key":"key\n\t\t\t\t20170522154857_DDG290C49","unstructured":"Akolkar, P.N., Gulwani-Akolkar, B., Heresbach, D., Lin, X.Y., Fisher, S., Katz, S. and Silver, J. ( 1997 ) Differences in risk of Crohn's disease in offspring of mothers and fathers with inflammatory bowel disease. Am. J. Gastroenterol. , 92 , 2241 \u20132244."},{"key":"key\n\t\t\t\t20170522154857_DDG290C50","unstructured":"Koumantaki, Y., Giziaki, E., Linos, A., Kontomerkos, A., Kaklamanis, P., Vaiopoulos, G., Mandas, J. and Kaklamani, E. ( 1997 ) Family history as a risk factor for rheumatoid arthritis: a case\u2013control study. J. Rheumatol. , 24 , 1522 \u20131526."},{"key":"key\n\t\t\t\t20170522154857_DDG290C51","doi-asserted-by":"crossref","unstructured":"Vorechovsky, I., Webster, A.D., Plebani, A. and Hammarstrom, L. ( 1999 ) Genetic linkage of IgA deficiency to the major histocompatibility complex: evidence for allele segregation distortion, parent-of-origin penetrance differences, and the role of anti-IgA antibodies in disease predisposition. Am. J. Hum. Genet. , 64 , 1096 \u20131109.","DOI":"10.1086\/302326"},{"key":"key\n\t\t\t\t20170522154857_DDG290C52","doi-asserted-by":"crossref","unstructured":"Bennett, S. and Todd, J. ( 1996 ) Human type 1 diabetes and the insulin gene: principles of mapping polygenes. A. Rev. Genet. , 30 , 343 \u2013370.","DOI":"10.1146\/annurev.genet.30.1.343"},{"key":"key\n\t\t\t\t20170522154857_DDG290C53","doi-asserted-by":"crossref","unstructured":"Cookson, W. ( 2002 ) Genetics and genomics of asthma and allergic diseases. Immunol. Rev. , 190 , 195 \u2013206.","DOI":"10.1034\/j.1600-065X.2002.19015.x"},{"key":"key\n\t\t\t\t20170522154857_DDG290C54","doi-asserted-by":"crossref","unstructured":"Munroe, D.J., Haas, M., Bric, E., Whitton, T., Aburatani, H., Hunter, K., Ward, D. and Housman, D.E. ( 1994 ) IRE-bubble PCR: a rapid method for efficient and representative amplification of human genomic DNA sequences from complex sources. Genomics , 19 , 506 \u2013514.","DOI":"10.1006\/geno.1994.1100"},{"key":"key\n\t\t\t\t20170522154857_DDG290C55","doi-asserted-by":"crossref","unstructured":"Sandford, A.J., Moffatt, M.F., Daniels, S.E., Nakamura, Y., Lathrop, G.M., Hopkin, J.M. and Cookson, W.O. ( 1995 ) A genetic map of chromosome 11q, including the atopy locus. Eur. J. Hum. Genet. , 3 , 188 \u2013194.","DOI":"10.1159\/000472294"},{"key":"key\n\t\t\t\t20170522154857_DDG290C56","doi-asserted-by":"crossref","unstructured":"Abecasis, G.R., Cardon, L.R. and Cookson, W.O. ( 2000 ) A general test of association for quantitative traits in nuclear families. Am. J. Hum. Genet. , 66 , 279 \u2013292.","DOI":"10.1086\/302698"},{"key":"key\n\t\t\t\t20170522154857_DDG290C57","doi-asserted-by":"crossref","unstructured":"Weinberg, C.R. ( 1999 ) Methods for detection of parent-of-origin effects in genetic studies of case\u2013parents triads. Am. J. Hum. Genet. , 65 , 229 \u2013235.","DOI":"10.1086\/302466"},{"key":"key\n\t\t\t\t20170522154857_DDG290C58","doi-asserted-by":"crossref","unstructured":"Abecasis, G.R., Cherny, S.S., Cookson, W.O. and Cardon, L.R. ( 2002 ) Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. , 30 , 97 \u2013101.","DOI":"10.1038\/ng786"},{"key":"key\n\t\t\t\t20170522154857_DDG290C59","doi-asserted-by":"crossref","unstructured":"Abecasis, G.R. and Cookson, W.O. ( 2000 ) GOLD\u2014graphical overview of linkage disequilibrium. Bioinformatics , 16 , 182 \u2013183.","DOI":"10.1093\/bioinformatics\/16.2.182"},{"key":"key\n\t\t\t\t20170522154857_DDG290C60","doi-asserted-by":"crossref","unstructured":"Smith, T.F. and Waterman, M.S. ( 1981 ) Identification of common molecular subsequences. J. Mol. Biol. , 147 , 195 \u2013197.","DOI":"10.1016\/0022-2836(81)90087-5"},{"key":"key\n\t\t\t\t20170522154857_DDG290C61","doi-asserted-by":"crossref","unstructured":"Karlin, S. and Altschul, S.F. ( 1990 ) Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes. Proc. Natl Acad. Sci. USA , 87 , 2264 \u20132268.","DOI":"10.1073\/pnas.87.6.2264"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/12\/20\/2577\/17240557\/ddg290.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T16:51:52Z","timestamp":1623430312000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddg290"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10,15]]},"references-count":61,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2003,10,15]]},"published-print":{"date-parts":[[2003,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddg290","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10,15]]}}}