{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:26:29Z","timestamp":1776871589550,"version":"3.51.2"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"DOI":"10.1093\/hmg\/ddh293","type":"journal-article","created":{"date-parts":[[2004,9,15]],"date-time":"2004-09-15T03:25:06Z","timestamp":1095218706000},"page":"2607-2612","source":"Crossref","is-referenced-by-count":5,"title":["Reduced KIAA0471 mRNA expression in Alzheimer's patients: a new candidate gene product linked to the disease?"],"prefix":"10.1093","volume":"13","author":[{"given":"Llu\u00efsa","family":"de Yebra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Adroer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"de Gregorio-Rocasolano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Blesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon","family":"Trullas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Mahy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,9,14]]},"reference":[{"key":"key\n\t\t\t\t20171012082124_DDH293C1","doi-asserted-by":"crossref","unstructured":"Goate, A., Chartier-Harlin, M.C., Mullan, M., Brown, J., Crawford, F., Fidani, L., Giuffra, L., Haynes, A., Irving, N., James, L. et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature, 349, 704\u2013706.","DOI":"10.1038\/349704a0"},{"key":"key\n\t\t\t\t20171012082124_DDH293C2","doi-asserted-by":"crossref","unstructured":"Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, J., Holman, K. et al. (1995) Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature, 375, 754\u2013760.","DOI":"10.1038\/375754a0"},{"key":"key\n\t\t\t\t20171012082124_DDH293C3","doi-asserted-by":"crossref","unstructured":"Laws, S.M., Clarnette, R.M., Taddei, K., Martins, G., Paton, A., Almeida, O.P., Forstl, H. and Martins, R.N. (2002) Association between the presenilin-1 mutation Glu318Gly and complaints of memory impairment. Neurobiol. Aging, 23, 55\u201358.","DOI":"10.1016\/S0197-4580(01)00254-8"},{"key":"key\n\t\t\t\t20171012082124_DDH293C4","doi-asserted-by":"crossref","unstructured":"Lippa, C.F., Swearer, J.M., Kane, K.J., Nochlin, D., Bird, T.D., Ghetti, B., Nee, L.E., St George-Hyslop, P., Poleen, D.A. and Drachman, D.A. (2000) Familial Alzheimer's disease: site of mutation influences clinical phenotype. Ann. Neurol., 48, 376\u2013379.","DOI":"10.1002\/1531-8249(200009)48:3<376::AID-ANA13>3.0.CO;2-U"},{"key":"key\n\t\t\t\t20171012082124_DDH293C5","doi-asserted-by":"crossref","unstructured":"Rocchi, A., Pellegrini, S., Siciliano, G. and Murri, L. (2003) Causative and susceptibility genes for Alzheimer's disease: a review. Brain Res. Bull., 61, 1\u201324.","DOI":"10.1016\/S0361-9230(03)00067-4"},{"key":"key\n\t\t\t\t20171012082124_DDH293C6","doi-asserted-by":"crossref","unstructured":"Corder, E.H., Saunders, A.M., Strittmatter, W.J., Schmechel, D.E., Gaskell, P.C., Roses, A.D., Haines, J.L. and Pericak-Vance, M.A. (1993) Gene dose of apolipoprotein E type 4 allele and risk of Alzheimer's disease in late onset families. Science, 261, 921\u2013923.","DOI":"10.1126\/science.8346443"},{"key":"key\n\t\t\t\t20171012082124_DDH293C7","doi-asserted-by":"crossref","unstructured":"Everitt, B.J. and Robbins, T.W. (1997) Central cholinergic systems and cognition. Annu. Rev. Psychol., 48, 649\u2013684.","DOI":"10.1146\/annurev.psych.48.1.649"},{"key":"key\n\t\t\t\t20171012082124_DDH293C8","doi-asserted-by":"crossref","unstructured":"Callahan, L.M., Chow, N., Chetham, J.E., Cox, C. and Coleman, P.D. (1998) Analysis of message expression in single neurons of Alzheimer's disease brain. Neurobiol. Aging, 19, 99\u2013105.","DOI":"10.1016\/S0197-4580(98)00044-X"},{"key":"key\n\t\t\t\t20171012082124_DDH293C9","doi-asserted-by":"crossref","unstructured":"Pasinetti, G.M. (2001) Use of cDNA microarray in the search for molecular markers involved in the onset of Alzheimer's disease dementia. J. Neurosci. Res., 65, 471\u2013476.","DOI":"10.1002\/jnr.1176"},{"key":"key\n\t\t\t\t20171012082124_DDH293C10","unstructured":"Pasinetti, G.M. and Ho, L. (2001) From cDNA microarrays to high-throughput proteomics. Implications in the search for preventive initiatives to slow the clinical progression of Alzheimer's disease dementia. Restor. Neurol. Neurosci., 18, 137\u2013142."},{"key":"key\n\t\t\t\t20171012082124_DDH293C11","doi-asserted-by":"crossref","unstructured":"Liang, P. and Pardee, A.B. (1992) Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science, 257, 967\u2013971.","DOI":"10.1126\/science.1354393"},{"key":"key\n\t\t\t\t20171012082124_DDH293C12","doi-asserted-by":"crossref","unstructured":"Liang, P., Bauer, D., Averboukh, L., Warthoe, P., Rohrwild, M., Muller, H., Strauss, M. and Pardee, A.B. (1995) Analysis of altered gene expression by differential display. Methods Enzymol., 254, 304\u2013321.","DOI":"10.1016\/0076-6879(95)54022-9"},{"key":"key\n\t\t\t\t20171012082124_DDH293C13","doi-asserted-by":"crossref","unstructured":"Kikuno, R., Nagase, T., Waki, M. and Ohara, O. (2002) HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project. Nucleic Acids Res., 30, 166\u2013168.","DOI":"10.1093\/nar\/30.1.166"},{"key":"key\n\t\t\t\t20171012082124_DDH293C14","doi-asserted-by":"crossref","unstructured":"Ohara, O., Nagase, T., Ishikawa, K., Nakayima, D., Ohira, M., Seki, N. and Nomura, N. (1997) Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. DNA Res., 4, 53\u201359.","DOI":"10.1093\/dnares\/4.1.53"},{"key":"key\n\t\t\t\t20171012082124_DDH293C15","doi-asserted-by":"crossref","unstructured":"DeGregorio-Rocasolano, N., Gasull, T., and Trull\u00e0s, R. (2001) Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K+ in cerebellar granule cells. J. Biol. Chem., 276, 796\u2013803.","DOI":"10.1074\/jbc.M007967200"},{"key":"key\n\t\t\t\t20171012082124_DDH293C16","doi-asserted-by":"crossref","unstructured":"Li, J.Z., Vawter, M.P., Walsh, D.M., Tomita, H., Evans, S.J., Choudary, P.V., Lopez, J.F., Avelar, A., Shokoohi, V., Chung, T. et al. (2004) Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum. Mol. Genet., 13, 609\u2013616.","DOI":"10.1093\/hmg\/ddh065"},{"key":"key\n\t\t\t\t20171012082124_DDH293C17","doi-asserted-by":"crossref","unstructured":"Colantuoni, C., Purcell, A.E., Bouton, C.M. and Pevsner, J. (2000) High throughput analysis of gene expression in the human brain. J. Neurosci. Res., 59, 1\u201310.","DOI":"10.1002\/(SICI)1097-4547(20000101)59:1<1::AID-JNR1>3.0.CO;2-2"},{"key":"key\n\t\t\t\t20171012082124_DDH293C18","doi-asserted-by":"crossref","unstructured":"Babity, J.M., Newton, R.A., Guido, M.E. and Robertson, H.A. (1997) The application of differential display to the brain. In Liang, P. and Pardee, A.B. (eds), Differential Display Methods and Protocols. Humana Press Inc., Totowa, NJ, pp. 285\u2013295.","DOI":"10.1385\/0-89603-489-5:285"},{"key":"key\n\t\t\t\t20171012082124_DDH293C19","doi-asserted-by":"crossref","unstructured":"Roschier, M., Kuusisto, E. and Salminen, A. (2000) A differential display protocol to identify differentially expressed mRNAs in potassium-deprived cerebellar granule cells. Brain Res. Prot., 5, 121\u2013131.","DOI":"10.1016\/S1385-299X(00)00002-7"},{"key":"key\n\t\t\t\t20171012082124_DDH293C20","doi-asserted-by":"crossref","unstructured":"Seki, N., Ohira, M., Nagase, T., Ishikawa, K., Miyajima, N., Nakajima, D., Nomura, N. and Ohara, O. (1997) Characterization of cDNA clones in size-fractioned cDNA libraries from human brain. DNA Res., 4, 345\u2013349.","DOI":"10.1093\/dnares\/4.5.345"},{"key":"key\n\t\t\t\t20171012082124_DDH293C21","doi-asserted-by":"crossref","unstructured":"Sharma, R., Samantaray, S., Shukla, N.K. and Ralhan, R. (2003) Transcriptional gene expression profile of human esophageal squamous cell carcinoma. Genomics, 81, 481\u2013488.","DOI":"10.1016\/S0888-7543(03)00023-5"},{"key":"key\n\t\t\t\t20171012082124_DDH293C22","doi-asserted-by":"crossref","unstructured":"Nakayama, M., Kikuno, R. and Ohara, O. (2002) Protein\u2013protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Genome Res., 12, 1773\u20131784.","DOI":"10.1101\/gr.406902"},{"key":"key\n\t\t\t\t20171012082124_DDH293C23","doi-asserted-by":"crossref","unstructured":"Hara, Y., Shimada, K., Kohga, H., Ohara, O. and Koga, H. (2003) High-throughput production of recombinant antigens for mouse KIAA proteins in Escherichia coli: computational allocation of possible antigenic regions, and construction of expression plasmids of glutathione-S-transferase-fused antigens by in vitro of recombinant-assisted method. DNA Res., 10, 129\u2013136.","DOI":"10.1093\/dnares\/10.3.129"},{"key":"key\n\t\t\t\t20171012082124_DDH293C24","doi-asserted-by":"crossref","unstructured":"Bird, T.D., Levy-Lahad, E., Poorkaj, P., Sharma, V., Nemens, E., Lahad, A., Lampe, T.H. and Schellenberg, G.D. (1996) Wide range in age of onset for chromosome 1-related familial Alzheimer's disease. Ann. Neurol., 40, 932\u2013936.","DOI":"10.1002\/ana.410400619"},{"key":"key\n\t\t\t\t20171012082124_DDH293C25","doi-asserted-by":"crossref","unstructured":"Debiec-Rychter, M., Alwasiak, J., Liberski, P.P., Nedoszytko, B., Babinska, M., Mrozek, K., Imielinski, B., Borowska-Lehman, J. and Limon, J. (1995) Accumulation of chromosomal changes in human glioma progression. A cytogenetic study of 50 cases. Cancer Genet. Cytogenet., 85, 61\u201367.","DOI":"10.1016\/0165-4608(95)00129-8"},{"key":"key\n\t\t\t\t20171012082124_DDH293C26","doi-asserted-by":"crossref","unstructured":"Carter, M., Nicholson, J., Ross, F., Crolla, J., Allibone, R., Balaji, V., Perry, R., Walker, D., Gilberston, R. and Ellison, D.W. (2002) Genetic abnormalities detected in ependymomas by comparative genomic hybridization. Br. J. Cancer, 86, 929\u2013939.","DOI":"10.1038\/sj.bjc.6600180"},{"key":"key\n\t\t\t\t20171012082124_DDH293C27","unstructured":"Wiltshire, S., Hattersley, A.T., Hitman, G.A., Walker, M., Levy, J.C., Sampson, M., O'Rahilly, S., Frayling, T.M., Bell, J.I., Lathrop, G.M. et al. (2002) A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Hum. Genet., 70, 1075."},{"key":"key\n\t\t\t\t20171012082124_DDH293C28","doi-asserted-by":"crossref","unstructured":"Takei, T., Iida, A., Nitta, K., Tanaka, T., Ohnishi, Y., Yamada, R., Maeda, S., Tsunoda, T., Takeoka, S., Ito, K. et al. (2002) Association between single-nucleotide polymorphisms in selectine genes and inmunoglobulin A nephropathy. Am. J. Hum. Genet., 70, 781\u2013786.","DOI":"10.1086\/339077"},{"key":"key\n\t\t\t\t20171012082124_DDH293C29","doi-asserted-by":"crossref","unstructured":"Xu, J., Zheng, S.L., Chang, B., Smith, J.R., Carpten, J.D., Stine, O.C., Isaacs, S.D., Wiley, K.D., Henning, L., Ewing, C. et al. (2001) Linkage of prostate cancer susceptibility loci to chromosome 1. Hum. Genet., 108, 335\u2013345.","DOI":"10.1007\/s004390100488"},{"key":"key\n\t\t\t\t20171012082124_DDH293C30","doi-asserted-by":"crossref","unstructured":"Leibson, C.L., Rocca, W.A., Hanson, V.A., Cha, R., Kokmen, E., O'Brien, P.C. and Palumbo, P.J. (1997) The risk of dementia among persons with diabetes mellitus: a population based-cohort. Ann. NY Acad. Sci., 826, 422\u2013427.","DOI":"10.1111\/j.1749-6632.1997.tb48496.x"},{"key":"key\n\t\t\t\t20171012082124_DDH293C31","doi-asserted-by":"crossref","unstructured":"Vekrellis, K., Ye, Z., Qiu, W.Q., Walsh, D., Hartley, D., Chesneau, V., Rosner, M.R. and Selkoe, D.J. (2000) Neurons regulate extracellular levels of amyloid \u03b2-protein via proteolysis by insulin-degrading enzyme. J. Neurosci., 20, 1657\u20131665.","DOI":"10.1523\/JNEUROSCI.20-05-01657.2000"},{"key":"key\n\t\t\t\t20171012082124_DDH293C32","doi-asserted-by":"crossref","unstructured":"Xie, L., Helmerhorst, E., Taddei, K., Plewright, B., van Bronswijk, W. and Martins, R. (2002) Alzheimer's \u03b2-amyloid peptides compete for insulin binding to the insulin receptor. J. Neurosci., 22, 1\u20135.","DOI":"10.1523\/JNEUROSCI.22-10-j0001.2002"},{"key":"key\n\t\t\t\t20171012082124_DDH293C33","doi-asserted-by":"crossref","unstructured":"Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E.A., Frosch, M.P., Eckman, C.B., Tanzi, R.E., Selkoe, D.J. and Guenette, S. (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo. Proc. Natl Acad. Sci. USA, 100, 4162\u20134167.","DOI":"10.1073\/pnas.0230450100"},{"key":"key\n\t\t\t\t20171012082124_DDH293C34","doi-asserted-by":"crossref","unstructured":"Braak, H. and Braak, E. (1991) Neuropathological staging of Alzheimer-related changes. Acta Neuropathol., 82, 235\u2013259.","DOI":"10.1007\/BF00308809"},{"key":"key\n\t\t\t\t20171012082124_DDH293C35","doi-asserted-by":"crossref","unstructured":"Newel, K.L., Hyman, B.T., Growdon, J.H. and Hedley-Whyle, E.T. (1999) Application of the National Institute of Aging (NIA)\u2013Regan Institute for the neuropathological diagnosis of Alzheimer Disease. J. Neuropathol. Exp. Neurol., 58, 1147\u20131155.","DOI":"10.1097\/00005072-199911000-00004"},{"key":"key\n\t\t\t\t20171012082124_DDH293C36","doi-asserted-by":"crossref","unstructured":"Queralt, R., Ezquerra, M., Lle\u00f3, A., Castellv\u00ed, M., Gelp\u00ed, J., Ferrer, I., Acar\u00edn, N., Pasar\u00edn, L., Blesa, R. and Oliva, R. (2002) A novel mutation (V89L) in the presenilin 1 gene in a family with early onset Alzheimer's disease and marked behavioural disturbances. J. Neurol. Neurosurg. Psychiatry, 72, 266\u2013269.","DOI":"10.1136\/jnnp.72.2.266"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/13\/21\/2607\/1582377\/ddh293.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T04:47:21Z","timestamp":1533012441000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/13\/21\/2607\/587494\/Reduced-KIAA0471-mRNA-expression-in-Alzheimers"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,14]]},"references-count":36,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2004,9,14]]},"published-print":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddh293","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,11,1]]},"published":{"date-parts":[[2004,9,14]]}}}