{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:22:47Z","timestamp":1790641367542,"version":"4.1.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"22","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,15]]},"DOI":"10.1093\/hmg\/ddh307","type":"journal-article","created":{"date-parts":[[2004,9,23]],"date-time":"2004-09-23T00:12:47Z","timestamp":1095898367000},"page":"2813-2821","source":"Crossref","is-referenced-by-count":38,"title":["Heightened susceptibility to chronic gastritis, hyperplasia and metaplasia in Kcnq1 mutant mice"],"prefix":"10.1093","volume":"13","author":[{"given":"Colleen M.","family":"Elso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cymbeline T.","family":"Culiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe C.","family":"Rutledge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nestor L.A.","family":"Cacheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walderico M.","family":"Generoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa J.","family":"Stubbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,9,22]]},"reference":[{"key":"key\n\t\t\t\t20171012085419_DDH307C1","unstructured":"McColl, K.E., el-Omar, E.M. and Gillen, D. (1997) Alterations in gastric physiology in Helicobacter pylori infection: causes of different diseases or all epiphenomena? Ital. J. Gastroenterol. Hepatol., 29, 459\u2013464."},{"key":"key\n\t\t\t\t20171012085419_DDH307C2","doi-asserted-by":"crossref","unstructured":"Peek, R.M., Jr and Blaser, M.J. (2002) Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat. Rev. Cancer, 2, 28\u201337.","DOI":"10.1038\/nrc703"},{"key":"key\n\t\t\t\t20171012085419_DDH307C3","doi-asserted-by":"crossref","unstructured":"Obst, B., Wagner, S., Sewing, K.F. and Beil, W. (2000) Helicobacter pylori causes DNA damage in gastric epithelial cells. Carcinogenesis, 21, 1111\u20131115.","DOI":"10.1093\/carcin\/21.6.1111"},{"key":"key\n\t\t\t\t20171012085419_DDH307C4","doi-asserted-by":"crossref","unstructured":"Naylor, G. and Axon, A. (2003) Role of bacterial overgrowth in the stomach as an additional risk factor for gastritis. Can. J. Gastroenterol., 17 (Suppl. B), 13B\u201317B.","DOI":"10.1155\/2003\/350347"},{"key":"key\n\t\t\t\t20171012085419_DDH307C5","doi-asserted-by":"crossref","unstructured":"Watanabe, T., Tada, M., Nagai, H., Sasaki, S. and Nakao, M. (1998) Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology, 115, 642\u2013648.","DOI":"10.1016\/S0016-5085(98)70143-X"},{"key":"key\n\t\t\t\t20171012085419_DDH307C6","doi-asserted-by":"crossref","unstructured":"Lee, A., Fox, J.G., Otto, G. and Murphy, J. (1990) A small animal model of human Helicobacter pylori active chronic gastritis. Gastroenterology, 99, 1315\u20131323.","DOI":"10.1016\/0016-5085(90)91156-Z"},{"key":"key\n\t\t\t\t20171012085419_DDH307C7","doi-asserted-by":"crossref","unstructured":"Marchetti, M., Arico, B., Burroni, D., Figura, N., Rappuoli, R. and Ghiara, P. (1995) Development of a mouse model of Helicobacter pylori infection that mimics human disease. Science, 267, 1655\u20131658.","DOI":"10.1126\/science.7886456"},{"key":"key\n\t\t\t\t20171012085419_DDH307C8","unstructured":"Enno, A., O'Rourke, J.L., Howlett, C.R., Jack, A., Dixon, M.F. and Lee, A. (1995) MALToma-like lesions in the murine gastric mucosa after long-term infection with Helicobacter felis. A mouse model of Helicobacter pylori-induced gastric lymphoma. Am. J. Pathol., 147, 217\u2013222."},{"key":"key\n\t\t\t\t20171012085419_DDH307C9","doi-asserted-by":"crossref","unstructured":"Han, S.U., Kim, Y.B., Joo, H.J., Hahm, K.B., Lee, W.H., Cho, Y.K., Kim, D.Y. and Kim, M.W. (2002) Helicobacter pylori infection promotes gastric carcinogenesis in a mice model. J. Gastroenterol. Hepatol., 17, 253\u2013261.","DOI":"10.1046\/j.1440-1746.2002.02684.x"},{"key":"key\n\t\t\t\t20171012085419_DDH307C10","doi-asserted-by":"crossref","unstructured":"Mahler, M., Janke, C., Wagner, S. and Hedrich, H.J. (2002) Differential susceptibility of inbred mouse strains to Helicobacter pylori infection. Scand. J. Gastroenterol., 37, 267\u2013278.","DOI":"10.1080\/003655202317284165"},{"key":"key\n\t\t\t\t20171012085419_DDH307C11","doi-asserted-by":"crossref","unstructured":"Gonzalez, C.A., Sala, N. and Capella, G. (2002) Genetic susceptibility and gastric cancer risk. Int. J. Cancer, 100, 249\u2013260.","DOI":"10.1002\/ijc.10466"},{"key":"key\n\t\t\t\t20171012085419_DDH307C12","doi-asserted-by":"crossref","unstructured":"Nardone, G. (2003) Review article: molecular basis of gastric carcinogenesis. Aliment. Pharmacol. Ther., 17 (Suppl. 2), 75\u201381.","DOI":"10.1046\/j.1365-2036.17.s2.10.x"},{"key":"key\n\t\t\t\t20171012085419_DDH307C13","doi-asserted-by":"crossref","unstructured":"Sundt, T.M., III, Compton, C.C. and Malt, R.A. (1988) Menetrier's disease. A trivalent gastropathy. Ann. Surg., 208, 694\u2013701.","DOI":"10.1097\/00000658-198812000-00004"},{"key":"key\n\t\t\t\t20171012085419_DDH307C14","doi-asserted-by":"crossref","unstructured":"Reinhardt, J.D., McCloy, R.M. and Blackwell, C.F. (1976) Autoimmune atrophic gastritis with hypergastrinemia. South Med. J., 69, 1551\u20131553.","DOI":"10.1097\/00007611-197612000-00010"},{"key":"key\n\t\t\t\t20171012085419_DDH307C15","doi-asserted-by":"crossref","unstructured":"Lee, M.P., Ravenel, J.D., Hu, R.J., Lustig, L.R., Tomaselli, G., Berger, R.D., Brandenburg, S.A., Litzi, T.J., Bunton, T.E., Limb, C. et al. (2000) Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. J. Clin. Invest., 106, 1447\u20131455.","DOI":"10.1172\/JCI10897"},{"key":"key\n\t\t\t\t20171012085419_DDH307C16","doi-asserted-by":"crossref","unstructured":"Dedek, K. and Waldegger, S. (2001) Colocalization of KCNQ1\/KCNE channel subunits in the mouse gastrointestinal tract. Pflugers Arch., 442, 896\u2013902.","DOI":"10.1007\/s004240100609"},{"key":"key\n\t\t\t\t20171012085419_DDH307C17","doi-asserted-by":"crossref","unstructured":"Grahammer, F., Herling, A.W., Lang, H.J., Schmitt-Graff, A., Wittekindt, O.H., Nitschke, R., Bleich, M., Barhanin, J. and Warth, R. (2001) The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Gastroenterology, 120, 1363\u20131371.","DOI":"10.1053\/gast.2001.24053"},{"key":"key\n\t\t\t\t20171012085419_DDH307C18","doi-asserted-by":"crossref","unstructured":"Neyroud, N., Tesson, F., Denjoy, I., Leibovici, M., Donger, C., Barhanin, J., Faure, S., Gary, F., Coumel, P., Petit, C. et al. (1997) A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange\u2013Nielsen cardioauditory syndrome. Nat. Genet., 15, 186\u2013189.","DOI":"10.1038\/ng0297-186"},{"key":"key\n\t\t\t\t20171012085419_DDH307C19","doi-asserted-by":"crossref","unstructured":"Splawski, I., Timothy, K.W., Vincent, G.M., Atkinson, D.L. and Keating, M.T. (1997) Molecular basis of the long-QT syndrome associated with deafness. N. Engl. J. Med., 336, 1562\u20131567.","DOI":"10.1056\/NEJM199705293362204"},{"key":"key\n\t\t\t\t20171012085419_DDH307C20","doi-asserted-by":"crossref","unstructured":"Wang, Q., Curran, M.E., Splawski, I., Burn, T.C., Millholland, J.M., VanRaay, T.J., Shen, J., Timothy, K.W., Vincent, G.M., de Jager, T. et al. (1996) Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat. Genet., 12, 17\u201323.","DOI":"10.1038\/ng0196-17"},{"key":"key\n\t\t\t\t20171012085419_DDH307C21","doi-asserted-by":"crossref","unstructured":"Scarff, K.L., Judd, L.M., Toh, B.H., Gleeson, P.A. and Van Driel, I.R. (1999) Gastric H(+),K(+)-adenosine triphosphatase beta subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology, 117, 605\u2013618.","DOI":"10.1016\/S0016-5085(99)70453-1"},{"key":"key\n\t\t\t\t20171012085419_DDH307C22","doi-asserted-by":"crossref","unstructured":"Spicer, Z., Miller, M.L., Andringa, A., Riddle, T.M., Duffy, J.J., Doetschman, T. and Shull, G.E. (2000) Stomachs of mice lacking the gastric H,K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J. Biol. Chem., 275, 21555\u201321565.","DOI":"10.1074\/jbc.M001558200"},{"key":"key\n\t\t\t\t20171012085419_DDH307C23","doi-asserted-by":"crossref","unstructured":"Franic, T.V., Judd, L.M., Robinson, D., Barrett, S.P., Scarff, K.L., Gleeson, P.A., Samuelson, L.C. and Van Driel, I.R. (2001) Regulation of gastric epithelial cell development revealed in H(+)\/K(+)-ATPase beta-subunit- and gastrin-deficient mice. Am. J. Physiol. Gastrointest. Liver Physiol., 281, G1502\u2013G1511.","DOI":"10.1152\/ajpgi.2001.281.6.G1502"},{"key":"key\n\t\t\t\t20171012085419_DDH307C24","doi-asserted-by":"crossref","unstructured":"Sharp, R., Babyatsky, M.W., Takagi, H., Tagerud, S., Wang, T.C., Bockman, D.E., Brand, S.J. and Merlino, G. (1995) Transforming growth factor alpha disrupts the normal program of cellular differentiation in the gastric mucosa of transgenic mice. Development, 121, 149\u2013161.","DOI":"10.1242\/dev.121.1.149"},{"key":"key\n\t\t\t\t20171012085419_DDH307C25","doi-asserted-by":"crossref","unstructured":"Gut, M.O., Parkkila, S., Vernerova, Z., Rohde, E., Zavada, J., Hocker, M., Pastorek, J., Karttunen, T., Gibadulinova, A., Zavadova, Z. et al. (2002) Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology, 123, 1889\u20131903.","DOI":"10.1053\/gast.2002.37052"},{"key":"key\n\t\t\t\t20171012085419_DDH307C26","doi-asserted-by":"crossref","unstructured":"Aly, A., Shulkes, A. and Baldwin, G.S. (2004) Gastrins, cholecystokinins and gastrointestinal cancer. Biochim. Biophys. Acta, 1704, 1\u201310.","DOI":"10.1016\/j.bbcan.2004.01.004"},{"key":"key\n\t\t\t\t20171012085419_DDH307C27","doi-asserted-by":"crossref","unstructured":"Baldus, S.E., Monig, S.P., Arkenau, V., Hanisch, F.G., Schneider, P.M., Thiele, J., Holscher, A.H. and Dienes, H.P. (2002) Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma. Ann. Surg. Oncol., 9, 887\u2013893.","DOI":"10.1007\/BF02557526"},{"key":"key\n\t\t\t\t20171012085419_DDH307C28","doi-asserted-by":"crossref","unstructured":"Velcich, A., Yang, W., Heyer, J., Fragale, A., Nicholas, C., Viani, S., Kucherlapati, R., Lipkin, M., Yang, K. and Augenlicht, L. (2002) Colorectal cancer in mice genetically deficient in the mucin Muc2. Science, 295, 1726\u20131729.","DOI":"10.1126\/science.1069094"},{"key":"key\n\t\t\t\t20171012085419_DDH307C29","doi-asserted-by":"crossref","unstructured":"Byrd, J.C., Yunker, C.K., Xu, Q.S., Sternberg, L.R. and Bresalier, R.S. (2000) Inhibition of gastric mucin synthesis by Helicobacter pylori. Gastroenterology, 118, 1072\u20131079.","DOI":"10.1016\/S0016-5085(00)70360-X"},{"key":"key\n\t\t\t\t20171012085419_DDH307C30","doi-asserted-by":"crossref","unstructured":"Morgenstern, S., Koren, R., Moss, S.F., Fraser, G., Okon, E. and Niv, Y. (2001) Does Helicobacter pylori affect gastric mucin expression? Relationship between gastric antral mucin expression and H. pylori colonization. Eur. J. Gastroenterol. Hepatol., 13, 19\u201323.","DOI":"10.1097\/00042737-200101000-00004"},{"key":"key\n\t\t\t\t20171012085419_DDH307C31","doi-asserted-by":"crossref","unstructured":"Stubbs, L., Carver, E.A., Cacheiro, N.L., Shelby, M. and Generoso, W. (1997) Generation and characterization of heritable reciprocal translocations in mice. Methods, 13, 397\u2013408.","DOI":"10.1006\/meth.1997.0546"},{"key":"key\n\t\t\t\t20171012085419_DDH307C32","doi-asserted-by":"crossref","unstructured":"Frohman, M.A. (1993) Rapid amplification of complementary DNA ends for generation of full-length complementary DNAs: thermal RACE. Methods Enzymol., 218, 340\u2013356.","DOI":"10.1016\/0076-6879(93)18026-9"},{"key":"key\n\t\t\t\t20171012085419_DDH307C33","doi-asserted-by":"crossref","unstructured":"Casimiro, M.C., Knollmann, B.C., Ebert, S.N., Vary, J.C., Jr, Greene, A.E., Franz, M.R., Grinberg, A., Huang, S.P. and Pfeifer, K. (2001) Targeted disruption of the Kcnq1 gene produces a mouse model of Jervell and Lange\u2013Nielsen Syndrome. Proc. Natl Acad. Sci. USA, 98, 2526\u20132531.","DOI":"10.1073\/pnas.041398998"},{"key":"key\n\t\t\t\t20171012085419_DDH307C34","doi-asserted-by":"crossref","unstructured":"Schmitt, N., Schwarz, M., Peretz, A., Abitbol, I., Attali, B. and Pongs, O. (2000) A recessive C-terminal Jervell and Lange\u2013Nielsen mutation of the KCNQ1 channel impairs subunit assembly. EMBO J., 19, 332\u2013340.","DOI":"10.1093\/emboj\/19.3.332"},{"key":"key\n\t\t\t\t20171012085419_DDH307C35","doi-asserted-by":"crossref","unstructured":"Tyson, J., Tranebjaerg, L., McEntagart, M., Larsen, L.A., Christiansen, M., Whiteford, M.L., Bathen, J., Aslaksen, B., Sorland, S.J., Lund, O. et al. (2000) Mutational spectrum in the cardioauditory syndrome of Jervell and Lange\u2013Nielsen. Hum. Genet., 107, 499\u2013503.","DOI":"10.1007\/s004390000402"},{"key":"key\n\t\t\t\t20171012085419_DDH307C36","doi-asserted-by":"crossref","unstructured":"Stolte, M. and Eidt, S. (1989) Lymphoid follicles in antral mucosa: immune response to Campylobacter pylori? J. Clin. Pathol., 42, 1269\u20131271.","DOI":"10.1136\/jcp.42.12.1269"},{"key":"key\n\t\t\t\t20171012085419_DDH307C37","doi-asserted-by":"crossref","unstructured":"Gut, M.O., Parkkila, S., Vernerova, Z., Rohde, E., Zavada, J., Hocker, M., Pastorek, J., Karttunen, T., Gibadulinova, A., Zavadova, Z., Knobeloch, K.P., Wiedenmann, B., Svoboda, J., Horak, I., Pastorekova, S. (2002) Gastric hyperplasia in mice with targeted disruption of the carbonic anhydrase gene Car9. Gastroenterology, 123, 1889\u20131903.","DOI":"10.1053\/gast.2002.37052"},{"key":"key\n\t\t\t\t20171012085419_DDH307C38","doi-asserted-by":"crossref","unstructured":"Chittenden, L., Lu, X., Cacheiro, N.L., Cain, K.T., Generoso, W., Bryda, E.C. and Stubbs, L. (2002) A new mouse model for autosomal recessive polycystic kidney disease. Genomics, 79, 499\u2013504.","DOI":"10.1006\/geno.2002.6731"},{"key":"key\n\t\t\t\t20171012085419_DDH307C39","unstructured":"Riley, L.K., Franklin, C.L., Hook, R.R., Jr and Besch-Williford, C. (1996) Identification of murine helicobacters by PCR and restriction enzyme analyses. J Clin. Microbiol., 34, 942\u2013946."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/13\/22\/2813\/1676963\/ddh307.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T21:29:44Z","timestamp":1624656584000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/13\/22\/2813\/610264\/Heightened-susceptibility-to-chronic-gastritis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,22]]},"references-count":39,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2004,9,22]]},"published-print":{"date-parts":[[2004,11,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddh307","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,11,15]]},"published":{"date-parts":[[2004,9,22]]}}}