{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:55:11Z","timestamp":1791114911671,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,1,1]]},"DOI":"10.1093\/hmg\/ddi011","type":"journal-article","created":{"date-parts":[[2004,11,11]],"date-time":"2004-11-11T01:14:10Z","timestamp":1100135650000},"page":"113-123","source":"Crossref","is-referenced-by-count":60,"title":["Urogenital and caudal dysgenesis in adrenocortical dysplasia ( acd ) mice is caused by a splicing mutation in a novel telomeric regulator"],"prefix":"10.1093","volume":"14","author":[{"given":"Catherine E.","family":"Keegan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janna E.","family":"Hutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Else","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja","family":"Adamska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonalee P.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy E.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Howes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley G.","family":"Beamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary D.","family":"Hammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,11,10]]},"reference":[{"key":"key\n\t\t\t\t20171011134349_DDI011C1","doi-asserted-by":"crossref","unstructured":"Beamer, W.G., Sweet, H.O., Bronson, R.T., Shire, J.G., Orth, D.N. and Davisson, M.T. ( 1994 ) Adrenocortical dysplasia: a mouse model system for adrenocortical insufficiency. J. Endocrinol. , 141 , 33 \u201343.","DOI":"10.1677\/joe.0.1410033"},{"key":"key\n\t\t\t\t20171011134349_DDI011C2","doi-asserted-by":"crossref","unstructured":"Phelan, J.K. and McCabe, E.R. ( 2001 ) Mutations in NR0B1 (DAX1) and NR5A1 (SF1) responsible for adrenal hypoplasia congenita. Hum. Mutat. , 18 , 472 \u2013487.","DOI":"10.1002\/humu.1225"},{"key":"key\n\t\t\t\t20171011134349_DDI011C3","doi-asserted-by":"crossref","unstructured":"Keegan, C.E. and Hammer, G.D. ( 2002 ) Recent insights into organogenesis of the adrenal cortex. Trends Endocrinol. Metab. , 13 , 200 \u2013208.","DOI":"10.1016\/S1043-2760(02)00602-1"},{"key":"key\n\t\t\t\t20171011134349_DDI011C4","doi-asserted-by":"crossref","unstructured":"Pulichino, A.M., Vallette-Kasic, S., Couture, C., Gauthier, Y., Brue, T., David, M., Malpuech, G., Deal, C., Van Vliet, G., De Vroede, M. et\u00a0al. ( 2003 ) Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency. Genes Dev. , 17 , 711 \u2013716.","DOI":"10.1101\/gad.1065603"},{"key":"key\n\t\t\t\t20171011134349_DDI011C5","doi-asserted-by":"crossref","unstructured":"Clark, A.J., McLoughlin, L. and Grossman, A. ( 1993 ) Familial glucocorticoid deficiency associated with point mutation in the adrenocorticotropin receptor. Lancet,341 , 461 \u2013462.","DOI":"10.1016\/0140-6736(93)90208-X"},{"key":"key\n\t\t\t\t20171011134349_DDI011C6","doi-asserted-by":"crossref","unstructured":"Tsigos, C., Arai, K., Hung, W. and Chrousos, G.P. ( 1993 ) Hereditary isolated glucocorticoid deficiency is associated with abnormalities of the adrenocorticotropin receptor gene. J. Clin. Invest. , 92 , 2458 \u20132461.","DOI":"10.1172\/JCI116853"},{"key":"key\n\t\t\t\t20171011134349_DDI011C7","unstructured":"Kaufman, M. and Bard, J. ( 1999 ) The Anatomical Basis of Mouse Development. Academic Press, San Diego, CA."},{"key":"key\n\t\t\t\t20171011134349_DDI011C8","doi-asserted-by":"crossref","unstructured":"Tam, P.P. and Tan, S.S. ( 1992 ) The somitogenetic potential of cells in the primitive streak and the tail bud of the organogenesis-stage mouse embryo. Development , 115 , 703 \u2013715.","DOI":"10.1242\/dev.115.3.703"},{"key":"key\n\t\t\t\t20171011134349_DDI011C9","doi-asserted-by":"crossref","unstructured":"Tam, P.P. ( 1984 ) The histogenetic capacity of tissues in the caudal end of the embryonic axis of the mouse. J. Embryol. Exp. Morphol. , 82 , 253 \u2013266.","DOI":"10.1242\/dev.82.1.253"},{"key":"key\n\t\t\t\t20171011134349_DDI011C10","doi-asserted-by":"crossref","unstructured":"Tam, P.P. ( 1986 ) A study of the pattern of prospective somites in the presomitic mesoderm of mouse embryos. J. Embryol. Exp. Morphol. , 92 , 269 \u2013285.","DOI":"10.1242\/dev.92.1.269"},{"key":"key\n\t\t\t\t20171011134349_DDI011C11","doi-asserted-by":"crossref","unstructured":"Catala, M. ( 2002 ) Genetic control of caudal development. Clin. Genet. , 61 , 89 \u201396.","DOI":"10.1034\/j.1399-0004.2002.610202.x"},{"key":"key\n\t\t\t\t20171011134349_DDI011C12","doi-asserted-by":"crossref","unstructured":"Gofflot, F., Hall, M. and Morriss-Kay, G.M. ( 1997 ) Genetic patterning of the developing mouse tail at the time of posterior neuropore closure. Dev. Dyn. , 210 , 431 \u2013445.","DOI":"10.1002\/(SICI)1097-0177(199712)210:4<431::AID-AJA7>3.0.CO;2-H"},{"key":"key\n\t\t\t\t20171011134349_DDI011C13","doi-asserted-by":"crossref","unstructured":"Bohring, A., Lewin, S.O., Reynolds, J.F., Voigtlander, T., Rittinger, O., Carey, J.C., Kopernik, M., Smith, R., Zackai, E.H., Leonard, N.J. et\u00a0al. ( 1999 ) Polytopic anomalies with agenesis of the lower vertebral column. Am. J. Med. Genet. , 87 , 99 \u2013114.","DOI":"10.1002\/(SICI)1096-8628(19991119)87:2<99::AID-AJMG1>3.0.CO;2-Q"},{"key":"key\n\t\t\t\t20171011134349_DDI011C14","doi-asserted-by":"crossref","unstructured":"Shum, A.S., Poon, L.L., Tang, W.W., Koide, T., Chan, B.W., Leung, Y.C., Shiroishi, T. and Copp, A.J. ( 1999 ) Retinoic acid induces down-regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo. Mech. Dev. , 84 , 17 \u201330.","DOI":"10.1016\/S0925-4773(99)00059-3"},{"key":"key\n\t\t\t\t20171011134349_DDI011C15","doi-asserted-by":"crossref","unstructured":"Takada, S., Stark, K.L., Shea, M.J., Vassileva, G., McMahon, J.A. and McMahon, A.P. ( 1994 ) Wnt-3a regulates somite and tailbud formation in the mouse embryo. Genes Dev. , 8 , 174 \u2013189.","DOI":"10.1101\/gad.8.2.174"},{"key":"key\n\t\t\t\t20171011134349_DDI011C16","doi-asserted-by":"crossref","unstructured":"Greco, T.L., Takada, S., Newhouse, M.M., McMahon, J.A., McMahon, A.P. and Camper, S.A. ( 1996 ) Analysis of the vestigial tail mutation demonstrates that Wnt-3a gene dosage regulates mouse axial development. Genes Dev. , 10 , 313 \u2013324.","DOI":"10.1101\/gad.10.3.313"},{"key":"key\n\t\t\t\t20171011134349_DDI011C17","doi-asserted-by":"crossref","unstructured":"Pinson, K.I., Brennan, J., Monkley, S., Avery, B.J. and Skarnes, W.C. ( 2000 ) An LDL-receptor-related protein mediates Wnt signalling in mice. Nature , 407 , 535 \u2013538.","DOI":"10.1038\/35035124"},{"key":"key\n\t\t\t\t20171011134349_DDI011C18","doi-asserted-by":"crossref","unstructured":"Liu, D., Safari, A., O'Connor, M.S., Chan, D.W., Laegeler, A., Qin, J. and Songyang, Z. ( 2004 ) PTOP interacts with POT1 and regulates its localization to telomeres. Nat. Cell Biol. , 6 , 673 \u2013680.","DOI":"10.1038\/ncb1142"},{"key":"key\n\t\t\t\t20171011134349_DDI011C19","doi-asserted-by":"crossref","unstructured":"Ye, J.Z., Hockemeyer, D., Krutchinsky, A.N., Loayza, D., Hooper, S.M., Chait, B.T. and de Lange, T. ( 2004 ) POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2\/TRF1 complex. Genes Dev. , 18 , 1649 \u20131654.","DOI":"10.1101\/gad.1215404"},{"key":"key\n\t\t\t\t20171011134349_DDI011C20","doi-asserted-by":"crossref","unstructured":"Nakai, K. and Sakamoto, H. ( 1994 ) Construction of a novel database containing aberrant splicing mutations of mammalian genes. Gene , 141 , 171 \u2013177.","DOI":"10.1016\/0378-1119(94)90567-3"},{"key":"key\n\t\t\t\t20171011134349_DDI011C21","doi-asserted-by":"crossref","unstructured":"Shapiro, M.B. and Senapathy, P. ( 1987 ) RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res. , 15 , 7155 \u20137174.","DOI":"10.1093\/nar\/15.17.7155"},{"key":"key\n\t\t\t\t20171011134349_DDI011C22","doi-asserted-by":"crossref","unstructured":"Zhuang, Y. and Weiner, A.M. ( 1986 ) A compensatory base change in U1 snRNA suppresses a 5\u2032 splice site mutation. Cell , 46 , 827 \u2013835.","DOI":"10.1016\/0092-8674(86)90064-4"},{"key":"key\n\t\t\t\t20171011134349_DDI011C23","doi-asserted-by":"crossref","unstructured":"Seraphin, B., Kretzner, L. and Rosbash, M. ( 1988 ) A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5\u2032 cleavage site. EMBO J. , 7 , 2533 \u20132538.","DOI":"10.1002\/j.1460-2075.1988.tb03101.x"},{"key":"key\n\t\t\t\t20171011134349_DDI011C24","doi-asserted-by":"crossref","unstructured":"Siliciano, P.G. and Guthrie, C. ( 1988 ) 5\u2032 splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev. , 2 , 1258 \u20131267.","DOI":"10.1101\/gad.2.10.1258"},{"key":"key\n\t\t\t\t20171011134349_DDI011C25","doi-asserted-by":"crossref","unstructured":"Chan, B.W., Chan, K.S., Koide, T., Yeung, S.M., Leung, M.B., Copp, A.J., Loeken, M.R., Shiroishi, T. and Shum, A.S. ( 2002 ) Maternal diabetes increases the risk of caudal regression caused by retinoic acid. Diabetes , 51 , 2811 \u20132816.","DOI":"10.2337\/diabetes.51.9.2811"},{"key":"key\n\t\t\t\t20171011134349_DDI011C26","doi-asserted-by":"crossref","unstructured":"Ross, A.J., Ruiz-Perez, V., Wang, Y., Hagan, D.M., Scherer, S., Lynch, S.A., Lindsay, S., Custard, E., Belloni, E., Wilson, D.I. et\u00a0al. ( 1998 ) A homeobox gene, HLXB9, is the major locus for dominantly inherited sacral agenesis. Nat. Genet. , 20 , 358 \u2013361.","DOI":"10.1038\/3828"},{"key":"key\n\t\t\t\t20171011134349_DDI011C27","doi-asserted-by":"crossref","unstructured":"Ding, H., Schertzer, M., Wu, X., Gertsenstein, M., Selig, S., Kammori, M., Pourvali, R., Poon, S., Vulto, I., Chavez, E. et\u00a0al. ( 2004 ) Regulation of murine telomere length by Rtel; an essential gene encoding a helicase-like protein. Cell , 117 , 873 \u2013886.","DOI":"10.1016\/j.cell.2004.05.026"},{"key":"key\n\t\t\t\t20171011134349_DDI011C28","doi-asserted-by":"crossref","unstructured":"Pani, L., Horal, M. and Loeken, M.R. ( 2002 ) Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3-dependent development and tumorigenesis. Genes Dev. , 16 , 676 \u2013680.","DOI":"10.1101\/gad.969302"},{"key":"key\n\t\t\t\t20171011134349_DDI011C29","doi-asserted-by":"crossref","unstructured":"Migliorini, D., Denchi, E.L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P.G. and Marine, J.C. ( 2002 ) Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development. Mol. Cell. Biol. , 22 , 5527 \u20135538.","DOI":"10.1128\/MCB.22.15.5527-5538.2002"},{"key":"key\n\t\t\t\t20171011134349_DDI011C30","doi-asserted-by":"crossref","unstructured":"Buchner, D.A., Trudeau, M. and Meisler, M.H. ( 2003 ) SCNM1, a putative RNA splicing factor that modifies disease severity in mice. Science , 301 , 967 \u2013969.","DOI":"10.1126\/science.1086187"},{"key":"key\n\t\t\t\t20171011134349_DDI011C31","doi-asserted-by":"crossref","unstructured":"Manning, E.L., Crossland, J., Dewey, M.J. and Van Zant, G. ( 2002 ) Influences of inbreeding and genetics on telomere length in mice. Mamm. Genome , 13 , 234 \u2013238.","DOI":"10.1007\/s003350020027"},{"key":"key\n\t\t\t\t20171011134349_DDI011C32","doi-asserted-by":"crossref","unstructured":"Martin-Rivera, L., Herrera, E., Albar, J.P. and Blasco, M.A. ( 1998 ) Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc. Natl Acad. Sci. USA , 95 , 10471 \u201310476.","DOI":"10.1073\/pnas.95.18.10471"},{"key":"key\n\t\t\t\t20171011134349_DDI011C33","unstructured":"Yashima, K., Maitra, A., Rogers, B.B., Timmons, C.F., Rathi, A., Pinar, H., Wright, W.E., Shay, J.W. and Gazdar, A.F. ( 1998 ) Expression of the RNA component of telomerase during human development and differentiation. Cell Growth Differ. , 9 , 805 \u2013813."},{"key":"key\n\t\t\t\t20171011134349_DDI011C34","doi-asserted-by":"crossref","unstructured":"Lee, H.W., Blasco, M.A., Gottlieb, G.J., Horner, J.W., II, Greider, C.W. and DePinho, R.A. ( 1998 ) Essential role of mouse telomerase in highly proliferative organs. Nature , 392 , 569 \u2013574.","DOI":"10.1038\/33345"},{"key":"key\n\t\t\t\t20171011134349_DDI011C35","doi-asserted-by":"crossref","unstructured":"Herrera, E., Samper, E. and Blasco, M.A. ( 1999 ) Telomere shortening in mTR\u2212\/\u2212 embryos is associated with failure to close the neural tube. EMBO J. , 18 , 1172 \u20131181.","DOI":"10.1093\/emboj\/18.5.1172"},{"key":"key\n\t\t\t\t20171011134349_DDI011C36","doi-asserted-by":"crossref","unstructured":"Cheong, C., Hong, K.U. and Lee, H.W. ( 2003 ) Mouse models for telomere and telomerase biology. Exp. Mol. Med. , 35 , 141 \u2013153.","DOI":"10.1038\/emm.2003.20"},{"key":"key\n\t\t\t\t20171011134349_DDI011C37","doi-asserted-by":"crossref","unstructured":"Vulliamy, T., Marrone, A., Goldman, F., Dearlove, A., Bessler, M., Mason, P.J. and Dokal, I. ( 2001 ) The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature , 413 , 432 \u2013435.","DOI":"10.1038\/35096585"},{"key":"key\n\t\t\t\t20171011134349_DDI011C38","doi-asserted-by":"crossref","unstructured":"Thompson, L.H. and Schild, D. ( 2002 ) Recombinational DNA repair and human disease. Mutat. Res. , 509 , 49 \u201378.","DOI":"10.1016\/S0027-5107(02)00224-5"},{"key":"key\n\t\t\t\t20171011134349_DDI011C39","unstructured":"Zantour, B., Messaoud, R., Zouali, M., Ladjimi, A., Braham, H., Hamza, H., Zebidi, A. and Sfar, M.H. ( 2003 ) Werner's syndrome and endocrine disorders. Ann. Endocrinol. , 64 , 205 \u2013209."},{"key":"key\n\t\t\t\t20171011134349_DDI011C40","doi-asserted-by":"crossref","unstructured":"Artandi, S.E., Alson, S., Tietze, M.K., Sharpless, N.E., Ye, S., Greenberg, R.A., Castrillon, D.H., Horner, J.W., Weiler, S.R., Carrasco, R.D. et\u00a0al. ( 2002 ) Constitutive telomerase expression promotes mammary carcinomas in aging mice. Proc. Natl Acad. Sci. USA , 99 , 8191 \u20138196.","DOI":"10.1073\/pnas.112515399"},{"key":"key\n\t\t\t\t20171011134349_DDI011C41","doi-asserted-by":"crossref","unstructured":"Karlseder, J., Kachatrian, L., Takai, H., Mercer, K., Hingorani, S., Jacks, T. and de Lange, T. ( 2003 ) Targeted deletion reveals an essential function for the telomere length regulator Trf1. Mol. Cell. Biol. , 23 , 6533 \u20136541.","DOI":"10.1128\/MCB.23.18.6533-6541.2003"},{"key":"key\n\t\t\t\t20171011134349_DDI011C42","doi-asserted-by":"crossref","unstructured":"Goytisolo, F.A. and Blasco, M.A. ( 2002 ) Many ways to telomere dysfunction: in vivo studies using mouse models. Oncogene , 21 , 584 \u2013591.","DOI":"10.1038\/sj.onc.1205085"},{"key":"key\n\t\t\t\t20171011134349_DDI011C43","doi-asserted-by":"crossref","unstructured":"Yashiro, K., Zhao, X., Uehara, M., Yamashita, K., Nishijima, M., Nishino, J., Saijoh, Y., Sakai, Y. and Hamada, H. ( 2004 ) Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev. Cell , 6 , 411 \u2013422.","DOI":"10.1016\/S1534-5807(04)00062-0"},{"key":"key\n\t\t\t\t20171011134349_DDI011C44","doi-asserted-by":"crossref","unstructured":"Pendino, F., Flexor, M., Delhommeau, F., Buet, D., Lanotte, M. and Segal-Bendirdjian, E. ( 2001 ) Retinoids down-regulate telomerase and telomere length in a pathway distinct from leukemia cell differentiation. Proc. Natl Acad. Sci. USA , 98 , 6662 \u20136667.","DOI":"10.1073\/pnas.111464998"},{"key":"key\n\t\t\t\t20171011134349_DDI011C45","doi-asserted-by":"crossref","unstructured":"Bober, E., Franz, T., Arnold, H.H., Gruss, P. and Tremblay, P. ( 1994 ) Pax-3 is required for the development of limb muscles: a possible role for the migration of dermomyotomal muscle progenitor cells. Development , 120 , 603 \u2013612.","DOI":"10.1242\/dev.120.3.603"},{"key":"key\n\t\t\t\t20171011134349_DDI011C46","doi-asserted-by":"crossref","unstructured":"Crossley, P.H. and Martin, G.R. ( 1995 ) The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development , 121 , 439 \u2013451.","DOI":"10.1242\/dev.121.2.439"},{"key":"key\n\t\t\t\t20171011134349_DDI011C47","doi-asserted-by":"crossref","unstructured":"Echelard, Y., Epstein, D.J., St-Jacques, B., Shen, L., Mohler, J., McMahon, J.A. and McMahon, A.P. ( 1993 ) Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell , 75 , 1417 \u20131430.","DOI":"10.1016\/0092-8674(93)90627-3"},{"key":"key\n\t\t\t\t20171011134349_DDI011C48","doi-asserted-by":"crossref","unstructured":"Krebs, L.T., Iwai, N., Nonaka, S., Welsh, I.C., Lan, Y., Jiang, R., Saijoh, Y., O'Brien, T.P., Hamada, H. and Gridley, T. ( 2003 ) Notch signaling regulates left\u2013right asymmetry determination by inducing Nodal expression. Genes Dev. , 17 , 1207 \u20131212.","DOI":"10.1101\/gad.1084703"},{"key":"key\n\t\t\t\t20171011134349_DDI011C49","doi-asserted-by":"crossref","unstructured":"Roelink, H. and Nusse, R. ( 1991 ) Expression of two members of the Wnt family during mouse development\u2014restricted temporal and spatial patterns in the developing neural tube. Genes Dev. , 5 , 381 \u2013388.","DOI":"10.1101\/gad.5.3.381"},{"key":"key\n\t\t\t\t20171011134349_DDI011C50","doi-asserted-by":"crossref","unstructured":"Kimmel, C.A. and Trammell, C. ( 1981 ) A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. Stain Technol. , 56 , 271 \u2013273.","DOI":"10.3109\/10520298109067325"},{"key":"key\n\t\t\t\t20171011134349_DDI011C51","doi-asserted-by":"crossref","unstructured":"Niwa, H., Yamamura, K. and Miyazaki, J. ( 1991 ) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene , 108 , 193 \u2013199.","DOI":"10.1016\/0378-1119(91)90434-D"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/14\/1\/113\/17242071\/ddi011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T03:38:37Z","timestamp":1624851517000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/14\/1\/113\/2355791\/Urogenital-and-caudal-dysgenesis-in-adrenocortical"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,10]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2004,11,10]]},"published-print":{"date-parts":[[2005,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddi011","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,1,1]]},"published":{"date-parts":[[2004,11,10]]}}}