{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:25:56Z","timestamp":1791206756284,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1093\/hmg\/ddi161","type":"journal-article","created":{"date-parts":[[2005,4,20]],"date-time":"2005-04-20T20:13:39Z","timestamp":1114028019000},"page":"1529-1538","source":"Crossref","is-referenced-by-count":28,"title":["Sustained ERK1\/2 but not STAT1 or 3 activation is required for thanatophoric dysplasia phenotypes in PC12 cells"],"prefix":"10.1093","volume":"14","author":[{"given":"Nakisa","family":"Nowroozi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Raffioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara L.","family":"Apostol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph A.","family":"Bradshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie Michels","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,4,20]]},"reference":[{"key":"key\n\t\t\t\t20171012091504_DDI161C1","doi-asserted-by":"crossref","unstructured":"Shiang, R., Thompson, L.M., Zhu, Y.-Z., Church, D.M., Fielder, T.J., Bocian, M., Winokur, S.T. and Wasmuth, J.J. (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell, 78, 335\u2013342.","DOI":"10.1016\/0092-8674(94)90302-6"},{"key":"key\n\t\t\t\t20171012091504_DDI161C2","doi-asserted-by":"crossref","unstructured":"Rousseau, F., Bonaventure, J., Legeai-Mallet, L., Pelet, A., Rozet, J.-M., Maroteaux, P., Le Merrer, M. and Munnich, A. (1994) Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature, 371, 252\u2013254.","DOI":"10.1038\/371252a0"},{"key":"key\n\t\t\t\t20171012091504_DDI161C3","doi-asserted-by":"crossref","unstructured":"Bellus, G.A., Gaudenz, K., Zackai, E.H., Clarke, L.A., Szabo, J., Francomano, C.A. and Muenke, M. (1996) Identical mutations in three different fibroblast growth factor receptor genes in autosomal dominant craniosynostosis syndromes. Nat. Genet., 14, 174\u2013276.","DOI":"10.1038\/ng1096-174"},{"key":"key\n\t\t\t\t20171012091504_DDI161C4","doi-asserted-by":"crossref","unstructured":"Tavormina, P.L., Shiang, R., Thompson, L.M., Zhu, Y.-Z., Wilkin, D.J., Lachman, R.S., Wilcox, W.R., Rimoin, D.L., Cohn, D.H. and Wasmuth, J.J. (1995) Thanatophoric dysplasia (types I and II) caused by distinct mutations in fibroblast growth factor receptor 3. Nat. Genet., 9, 321\u2013328.","DOI":"10.1038\/ng0395-321"},{"key":"key\n\t\t\t\t20171012091504_DDI161C5","doi-asserted-by":"crossref","unstructured":"Meyer, A.N., Gastwirt, R.F., Schlaepfer, D.D. and Donoghue, D.J. (2004) The cytoplasmic tyrosine kinase Pyk2 as a novel effector of fibroblast growth factor receptor 3 activation. J. Biol. Chem., 279, 28450\u201328357.","DOI":"10.1074\/jbc.M403335200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C6","doi-asserted-by":"crossref","unstructured":"Boilly, B., Vercoutter-Edouart, A.S., Hondermarck, H., Nurcombe, V. and Le Bourhis, X. (2000) FGF signals for cell proliferation and migration through different pathways. Cytokine Growth Factor Rev., 11, 295\u2013302.","DOI":"10.1016\/S1359-6101(00)00014-9"},{"key":"key\n\t\t\t\t20171012091504_DDI161C7","doi-asserted-by":"crossref","unstructured":"Kreuger, J., Jemth, P., Sanders-Lindberg, E., Eliahu, L., Ron, D., Basilico, C., Salmivirta, M. and Lindahl, U. (2005) Fibroblast growth factors share binding sites in heparan sulfate. Biochem. J., published ahead of print (16 March 2005). doi: 10.1042\/BJ20042129.","DOI":"10.1042\/BJ20042129"},{"key":"key\n\t\t\t\t20171012091504_DDI161C8","doi-asserted-by":"crossref","unstructured":"Ornitz, D.M. (2000) FGFs, heparan sulfate and FGFRs: complex interactions essential for development. Bioessays, 22, 108\u2013112.","DOI":"10.1002\/(SICI)1521-1878(200002)22:2<108::AID-BIES2>3.0.CO;2-M"},{"key":"key\n\t\t\t\t20171012091504_DDI161C9","doi-asserted-by":"crossref","unstructured":"Murakami, S., Kan, M., McKeehan, W.L. and de Crombrugghe, B. (2000) Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway. Proc. Natl Acad. Sci. USA, 97, 1113\u20131118.","DOI":"10.1073\/pnas.97.3.1113"},{"key":"key\n\t\t\t\t20171012091504_DDI161C10","doi-asserted-by":"crossref","unstructured":"Peters, K., Ornitz, D., Werner, S. and Williams, L. (1994) Unique expression pattern of the FGF receptor 3 gene during mouse organogenesis. Dev. Biol., 155, 423\u2013430.","DOI":"10.1006\/dbio.1993.1040"},{"key":"key\n\t\t\t\t20171012091504_DDI161C11","doi-asserted-by":"crossref","unstructured":"Delezoide, A.L., Benoist-Lasselin, C., Legeai-Mallet, L., Le Merrer, M., Munnich, A., Vekemans, M. and Bonaventure, J. (1998) Spatio-temporal expression of FGFR 1, 2 and 3 genes during human embryo-fetal ossification. Mech. Dev., 77, 19\u201330.","DOI":"10.1016\/S0925-4773(98)00133-6"},{"key":"key\n\t\t\t\t20171012091504_DDI161C12","doi-asserted-by":"crossref","unstructured":"Naski, M.C. and Ornitz, D.M. (1998) FGF signaling in skeletal development. Front. Biosci., 3, D781\u2013D794.","DOI":"10.2741\/A321"},{"key":"key\n\t\t\t\t20171012091504_DDI161C13","doi-asserted-by":"crossref","unstructured":"Ohbayashi, N., Shibayama, M., Kurotaki, Y., Imanishi, M., Fujimori, T., Itoh, N. and Takada, S. (2002) FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis. Genes Dev., 16, 870\u2013879.","DOI":"10.1101\/gad.965702"},{"key":"key\n\t\t\t\t20171012091504_DDI161C14","doi-asserted-by":"crossref","unstructured":"Li, C., Chen, L., Iwata, T., Kitagawa, M., Fu, X.Y. and Deng, C.X. (1999) A Lys644Glu substitution in fibroblast growth factor receptor 3 (FGFR3) causes dwarfism in mice by activation of STATs and ink4 cell cycle inhibitors. Hum. Mol. Genet., 8, 35\u201344.","DOI":"10.1093\/hmg\/8.1.35"},{"key":"key\n\t\t\t\t20171012091504_DDI161C15","doi-asserted-by":"crossref","unstructured":"Wang, Y., Spatz, M.K., Kannan, K., Hayk, H., Avivi, A., Gorivodsky, M., Pines, M., Yayon, A., Lonai, P. and Givol, D. (1999) A mouse model for achondroplasia produced by targeting fibroblast growth factor receptor 3. Proc. Natl Acad. Sci. USA, 96, 4455\u20134460.","DOI":"10.1073\/pnas.96.8.4455"},{"key":"key\n\t\t\t\t20171012091504_DDI161C16","doi-asserted-by":"crossref","unstructured":"Iwata, T., Li, C.L., Deng, C.X. and Francomano, C.A. (2001) Highly activated Fgfr3 with the K644M mutation causes prolonged survival in severe dwarf mice. Hum. Mol. Genet., 10, 1255\u20131264.","DOI":"10.1093\/hmg\/10.12.1255"},{"key":"key\n\t\t\t\t20171012091504_DDI161C17","doi-asserted-by":"crossref","unstructured":"Iwata, T., Chen, L., Li, C., Ovchinnikov, D.A., Behringer, R.R., Francomano, C.A. and Deng, C.X. (2000) A neonatal lethal mutation in FGFR3 uncouples proliferation and differentiation of growth plate chondrocytes in embryos. Hum. Mol. Genet., 9, 1603\u20131613.","DOI":"10.1093\/hmg\/9.11.1603"},{"key":"key\n\t\t\t\t20171012091504_DDI161C18","doi-asserted-by":"crossref","unstructured":"Segev, O., Chumakov, I., Nevo, Z., Givol, D., Madar-Shapiro, L., Sheinin, Y., Weinreb, M. and Yayon, A. (2000) Restrained chondrocyte proliferation and maturation with abnormal growth plate vascularization and ossification in human FGFR-3(G380R) transgenic mice. Hum. Mol. Genet., 9, 249\u2013258.","DOI":"10.1093\/hmg\/9.2.249"},{"key":"key\n\t\t\t\t20171012091504_DDI161C19","doi-asserted-by":"crossref","unstructured":"Chen, L., Li, C., Qiao, W., Xu, X. and Deng, C. (2001) A Ser(365)\u2192Cys mutation of fibroblast growth factor receptor 3 in mouse downregulates Ihh\/PTHrP signals and causes severe achondroplasia. Hum. Mol. Genet., 10, 457\u2013465.","DOI":"10.1093\/hmg\/10.5.457"},{"key":"key\n\t\t\t\t20171012091504_DDI161C20","doi-asserted-by":"crossref","unstructured":"Colvin, J.S., Bohne, B.A., Harding, G.W., McEwen, D.G. and Ornitz, D.M. (1996) Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat. Genet., 12, 290\u2013397.","DOI":"10.1038\/ng0496-390"},{"key":"key\n\t\t\t\t20171012091504_DDI161C21","doi-asserted-by":"crossref","unstructured":"Deng, C., Wynshaw-Boris, A., Zhou, F., Kuo, A. and Leder, P. (1996) Fibroblast growth factor receptor 3 is a negative regulator of bone growth. Cell, 84, 911\u2013921.","DOI":"10.1016\/S0092-8674(00)81069-7"},{"key":"key\n\t\t\t\t20171012091504_DDI161C22","doi-asserted-by":"crossref","unstructured":"Su, W.-C.S., Kitagawa, M., Xue, N., Xie, B., Garofalo, S., Cho, J., Deng, C., Horton, W.A. and Fu, X.-Y. (1997) Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism. Nature, 386, 288\u2013292.","DOI":"10.1038\/386288a0"},{"key":"key\n\t\t\t\t20171012091504_DDI161C23","doi-asserted-by":"crossref","unstructured":"Raucci, A., Laplantine, E., Mansukhani, A. and Basilico, C. (2004) Activation of the ERK1\/2 and p38 mitogen-activated protein kinase pathways mediates fibroblast growth factor-induced growth arrest of chondrocytes. J. Biol. Chem., 279, 1747\u20131756.","DOI":"10.1074\/jbc.M310384200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C24","doi-asserted-by":"crossref","unstructured":"Legeai-Mallet, L., Benoist-Lasselin, C., Munnich, A. and Bonaventure, J. (2004) Overexpression of FGFR3, Stat1, Stat5 and p21Cip1 correlates with phenotypic severity and defective chondrocyte differentiation in FGFR3-related chondrodysplasias. Bone, 34, 26\u201336.","DOI":"10.1016\/j.bone.2003.09.002"},{"key":"key\n\t\t\t\t20171012091504_DDI161C25","doi-asserted-by":"crossref","unstructured":"Sahni, M., Ambrosetti, D.C., Mansukhani, A., Gertner, R., Levy, D. and Basilico, C. (1999) FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. Genes Dev., 13, 1361\u20131366.","DOI":"10.1101\/gad.13.11.1361"},{"key":"key\n\t\t\t\t20171012091504_DDI161C26","doi-asserted-by":"crossref","unstructured":"Debiais, F., Lefevre, G., Lemonnier, J., Le Mee, S., Lasmoles, F., Mascarelli, F. and Marie, P.J. (2004) Fibroblast growth factor-2 induces osteoblast survival through a phosphatidylinositol 3-kinase-dependent, -beta-catenin-independent signaling pathway. Exp. Cell Res., 297, 235\u2013246.","DOI":"10.1016\/j.yexcr.2004.03.032"},{"key":"key\n\t\t\t\t20171012091504_DDI161C27","doi-asserted-by":"crossref","unstructured":"Ronchetti, D., Greco, A., Compasso, S., Colombo, G., Dell'Era, P., Otsuki, T., Lombardi, L. and Neri, A. (2001) Deregulated FGFR3 mutants in multiple myeloma cell lines with t(4;14): comparative analysis of Y373C, K650E and the novel G384D mutations. Oncogene, 20, 3553\u20133562.","DOI":"10.1038\/sj.onc.1204465"},{"key":"key\n\t\t\t\t20171012091504_DDI161C28","doi-asserted-by":"crossref","unstructured":"Kong, M., Wang, C.S. and Donoghue, D.J. (2002) Interaction of fibroblast growth factor receptor 3 and the adapter protein SH2-B. A role in STAT5 activation. J. Biol. Chem., 277, 15962\u201315970.","DOI":"10.1074\/jbc.M102777200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C29","doi-asserted-by":"crossref","unstructured":"Shimoaka, T., Ogasawara, T., Yonamine, A., Chikazu, D., Kawano, H., Nakamura, K., Itoh, N. and Kawaguchi, H. (2002) Regulation of osteoblast, chondrocyte, and osteoclast functions by fibroblast growth factor (FGF)-18 in comparison with FGF-2 and FGF-10. J. Biol. Chem., 277, 7493\u20137500.","DOI":"10.1074\/jbc.M108653200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C30","doi-asserted-by":"crossref","unstructured":"Murakami, S., Balmes, G., McKinney, S., Zhang, Z., Givol, D. and de Crombrugghe, B. (2004) Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype. Genes Dev., 18, 290\u2013305.","DOI":"10.1101\/gad.1179104"},{"key":"key\n\t\t\t\t20171012091504_DDI161C31","doi-asserted-by":"crossref","unstructured":"Hart, K.C., Robertson, S.C., Kanemitsu, M.Y., Meyer, A.N., Tynan, J.A. and Donoghue, D.J. (2000) Transformation and Stat activation by derivatives of FGFR1, FGFR3 and FGFR4. Oncogene, 19, 3309\u20133320.","DOI":"10.1038\/sj.onc.1203650"},{"key":"key\n\t\t\t\t20171012091504_DDI161C32","doi-asserted-by":"crossref","unstructured":"Naski, M.C., Wang, Q., Xu, J. and Ornitz, D.M. (1996) Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thantophoric dysplasia. Nat. Genet., 13, 233\u2013237.","DOI":"10.1038\/ng0696-233"},{"key":"key\n\t\t\t\t20171012091504_DDI161C33","doi-asserted-by":"crossref","unstructured":"Raffioni, S., Zhu, Y.Z., Bradshaw, R.A. and Thompson, L.M. (1998) Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation. J. Biol. Chem., 273, 35250\u201335259.","DOI":"10.1074\/jbc.273.52.35250"},{"key":"key\n\t\t\t\t20171012091504_DDI161C34","doi-asserted-by":"crossref","unstructured":"Webster, M.K. and Donoghue, D.J. (1997) FGFR activation in skeletal disorders: too much of a good thing. Trends Genet., 13, 178\u2013182.","DOI":"10.1016\/S0168-9525(97)01131-1"},{"key":"key\n\t\t\t\t20171012091504_DDI161C35","doi-asserted-by":"crossref","unstructured":"Webster, M.K. and Donoghue, D.J. (1997) Enhanced signaling and morphological transformation by a membrane-localized derivative of the fibroblast growth factor receptor 3 kinase domain. Mol. Cell. Biol., 17, 5739\u20135747.","DOI":"10.1128\/MCB.17.10.5739"},{"key":"key\n\t\t\t\t20171012091504_DDI161C36","doi-asserted-by":"crossref","unstructured":"Cormier, S., Delezoide, A.L., Benoist-Lasselin, C., Legeai-Mallet, L., Bonaventure, J. and Silve, C. (2002) Parathyroid hormone receptor type 1\/Indian hedgehog expression is preserved in the growth plate of human fetuses affected with fibroblast growth factor receptor type 3 activating mutations. Am. J. Pathol., 161, 1325\u20131335.","DOI":"10.1016\/S0002-9440(10)64409-4"},{"key":"key\n\t\t\t\t20171012091504_DDI161C37","doi-asserted-by":"crossref","unstructured":"Legeai-Mallet, L., Benoist-Lasselin, C., Delezoide, A.L., Munnich, A. and Bonaventure, J. (1998) Fibroblast growth factor receptor 3 mutations promote apoptosis but do not alter chondrocyte proliferation in thanatophoric dysplasia. J. Biol. Chem., 273, 13007\u201313014.","DOI":"10.1074\/jbc.273.21.13007"},{"key":"key\n\t\t\t\t20171012091504_DDI161C38","doi-asserted-by":"crossref","unstructured":"Lievens, P.M. and Liboi, E. (2003) The thanatophoric dysplasia type II mutation hampers complete maturation of fibroblast growth factor receptor 3 (FGFR3), which activates signal transducer and activator of transcription 1 (STAT1) from the endoplasmic reticulum. J. Biol. Chem., 278, 17344\u201317349.","DOI":"10.1074\/jbc.M212710200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C39","doi-asserted-by":"crossref","unstructured":"Lievens, P.M., Mutinelli, C., Baynes, D. and Liboi, E. (2004) The kinase activity of fibroblast growth factor receptor 3 with activation loop mutations affects receptor trafficking and signaling. J. Biol. Chem., 279, 43254\u201343260.","DOI":"10.1074\/jbc.M405247200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C40","doi-asserted-by":"crossref","unstructured":"Krejci, P., Bryja, V., Pachernik, J., Hampl, A., Pogue, R., Mekikian, P. and Wilcox, W.R. (2004) FGF2 inhibits proliferation and alters the cartilage-like phenotype of RCS cells. Exp. Cell Res., 297, 152\u2013164.","DOI":"10.1016\/j.yexcr.2004.03.011"},{"key":"key\n\t\t\t\t20171012091504_DDI161C41","doi-asserted-by":"crossref","unstructured":"Yasoda, A., Komatsu, Y., Chusho, H., Miyazawa, T., Ozasa, A., Miura, M., Kurihara, T., Rogi, T., Tanaka, S., Suda, M. et\u00a0al. (2004) Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway. Nat. Med., 10, 80\u201386.","DOI":"10.1038\/nm971"},{"key":"key\n\t\t\t\t20171012091504_DDI161C42","doi-asserted-by":"crossref","unstructured":"Ornitz, D.M. and Marie, P.J. (2002) FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease. Genes Dev., 16, 1446\u20131465.","DOI":"10.1101\/gad.990702"},{"key":"key\n\t\t\t\t20171012091504_DDI161C43","doi-asserted-by":"crossref","unstructured":"Dailey, L., Laplantine, E., Priore, R. and Basilico, C. (2003) A network of transcriptional and signaling events is activated by FGF to induce chondrocyte growth arrest and differentiation. J. Cell Biol., 161, 1053\u20131066.","DOI":"10.1083\/jcb.200302075"},{"key":"key\n\t\t\t\t20171012091504_DDI161C44","doi-asserted-by":"crossref","unstructured":"Vaudry, D., Stork, P.J., Lazarovici, P. and Eiden, L.E. (2002) Signaling pathways for PC12 cell differentiation: making the right connections. Science, 296, 1648\u20131649.","DOI":"10.1126\/science.1071552"},{"key":"key\n\t\t\t\t20171012091504_DDI161C45","doi-asserted-by":"crossref","unstructured":"Favata, M.F., Horiuchi, K.Y., Manos, E.J., Daulerio, A.J., Stradley, D.A., Feeser, W.S., Van Dyk, D.E., Pitts, W.J., Earl, R.A., Hobbs, F. et\u00a0al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J. Biol. Chem., 273, 18623\u201318632.","DOI":"10.1074\/jbc.273.29.18623"},{"key":"key\n\t\t\t\t20171012091504_DDI161C46","doi-asserted-by":"crossref","unstructured":"Aletsee, C., Brors, D., Palacios, S., Pak, K., Mullen, L., Dazert, S. and Ryan, A.F. (2002) The effects of laminin-1 on spiral ganglion neurons are dependent on the MEK\/ERK signaling pathway and are partially independent of Ras. Hear Res., 164, 1\u201311.","DOI":"10.1016\/S0378-5955(01)00364-1"},{"key":"key\n\t\t\t\t20171012091504_DDI161C47","doi-asserted-by":"crossref","unstructured":"Schmitt, J.M., Wayman, G.A., Nozaki, N. and Soderling, T.R. (2004) Calcium activation of ERK mediated by calmodulin kinase I. J. Biol. Chem., 279, 24064\u201324072.","DOI":"10.1074\/jbc.M401501200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C48","doi-asserted-by":"crossref","unstructured":"Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R. and Lee, J.C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364, 229\u2013233.","DOI":"10.1016\/0014-5793(95)00357-F"},{"key":"key\n\t\t\t\t20171012091504_DDI161C49","doi-asserted-by":"crossref","unstructured":"Walter, M.J., Look, D.C., Tidwell, R.M., Roswit, W.T. and Holtzman, M.J. (1997) Targeted inhibition of interferon-gamma-dependent intercellular adhesion molecule-1 (ICAM-1) expression using dominant-negative Stat1. J. Biol. Chem., 272, 28582\u201328589.","DOI":"10.1074\/jbc.272.45.28582"},{"key":"key\n\t\t\t\t20171012091504_DDI161C50","doi-asserted-by":"crossref","unstructured":"Sandberg, E.M., Ma, X., VonDerLinden, D., Godeny, M.D. and Sayeski, P.P. (2004) Jak2 tyrosine kinase mediates angiotensin II-dependent inactivation of ERK2 via induction of mitogen-activated protein kinase phosphatase 1. J. Biol. Chem., 279, 1956\u20131967.","DOI":"10.1074\/jbc.M303540200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C51","doi-asserted-by":"crossref","unstructured":"Wilkie, A.O., Patey, S.J., Kan, S.H., van den Ouweland, A.M. and Hamel, B.C. (2002) FGFs, their receptors, and human limb malformations: clinical and molecular correlations. Am. J. Med. Genet., 112, 266\u2013278.","DOI":"10.1002\/ajmg.10775"},{"key":"key\n\t\t\t\t20171012091504_DDI161C52","doi-asserted-by":"crossref","unstructured":"Aviezer, D., Golembo, M. and Yayon, A. (2003) Fibroblast growth factor receptor-3 as a therapeutic target for Achondroplasia\u2014genetic short limbed dwarfism. Curr. Drug Targets, 4, 353\u2013365.","DOI":"10.2174\/1389450033490993"},{"key":"key\n\t\t\t\t20171012091504_DDI161C53","doi-asserted-by":"crossref","unstructured":"Dreyer, S.D., Zhou, G. and Lee, B. (1998) The long and the short of it: developmental genetics of the skeletal dysplasias. Clin. Genet., 54, 464\u2013473.","DOI":"10.1111\/j.1399-0004.1998.tb03766.x"},{"key":"key\n\t\t\t\t20171012091504_DDI161C54","doi-asserted-by":"crossref","unstructured":"Minina, E., Kreschel, C., Naski, M.C., Ornitz, D.M. and Vortkamp, A. (2002) Interaction of FGF, Ihh\/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev. Cell, 3, 439\u2013449.","DOI":"10.1016\/S1534-5807(02)00261-7"},{"key":"key\n\t\t\t\t20171012091504_DDI161C55","doi-asserted-by":"crossref","unstructured":"Coffin, J.D., Florkiewicz, R.Z., Neumann, J., Mort-Hopkins, T., Dorn, G.W., II, Lightfoot, P., German, R., Howles, P.N., Kier, A., O'Toole, B.A. et\u00a0al. (1995) Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice. Mol. Biol. Cell, 6, 1861\u20131873.","DOI":"10.1091\/mbc.6.12.1861"},{"key":"key\n\t\t\t\t20171012091504_DDI161C56","doi-asserted-by":"crossref","unstructured":"Sahni, M., Raz, R., Coffin, J.D., Levy, D. and Basilico, C. (2001) STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2. Development, 128, 2119\u20132129.","DOI":"10.1242\/dev.128.11.2119"},{"key":"key\n\t\t\t\t20171012091504_DDI161C57","doi-asserted-by":"crossref","unstructured":"Aikawa, T., Segre, G.V. and Lee, K. (2001) Fibroblast growth factor inhibits chondrocytic growth through induction of p21 and subsequent inactivation of cyclin E-Cdk2. J. Biol. Chem., 276, 29347\u201329352.","DOI":"10.1074\/jbc.M101859200"},{"key":"key\n\t\t\t\t20171012091504_DDI161C58","doi-asserted-by":"crossref","unstructured":"Tsukada, Y., Tanaka, T., Miyazawa, K. and Kitamura, N. (2004) Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human Hepatocellular carcinoma cell line HepG2. J. Biochem. (Tokyo), 136, 701\u2013709.","DOI":"10.1093\/jb\/mvh177"},{"key":"key\n\t\t\t\t20171012091504_DDI161C59","doi-asserted-by":"crossref","unstructured":"Venkatasubbarao, K., Choudary, A. and Freeman, J.W. (2005) Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases. Cancer Res., 65, 2861\u20132871.","DOI":"10.1158\/0008-5472.CAN-04-2396"},{"key":"key\n\t\t\t\t20171012091504_DDI161C60","doi-asserted-by":"crossref","unstructured":"Wu, Y.Y. and Bradshaw, R.A. (1996) Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12 cell (E2) line. J. Biol. Chem., 271, 13023\u201313032.","DOI":"10.1074\/jbc.271.22.13023"},{"key":"key\n\t\t\t\t20171012091504_DDI161C61","doi-asserted-by":"crossref","unstructured":"Deng, C., Zhang, P., Harper, J.W., Elledge, S.J. and Leder, P. (1995) Mice lacking p21CIP1\/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell, 82, 675\u2013684.","DOI":"10.1016\/0092-8674(95)90039-X"},{"key":"key\n\t\t\t\t20171012091504_DDI161C62","unstructured":"Ausubel, F.M., Brent, R.H., Myers Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.S. and Struhl, K. (1998) Current Protocols in Molecular Biology. Wiley, New York."},{"key":"key\n\t\t\t\t20171012091504_DDI161C63","doi-asserted-by":"crossref","unstructured":"Feinberg, A.P. and Vogelstein, B. (1984) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Addendum. Anal.Biochem., 137, 266\u2013267.","DOI":"10.1016\/0003-2697(84)90381-6"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/14\/11\/1529\/17241370\/ddi161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T08:27:12Z","timestamp":1625819232000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/14\/11\/1529\/605498\/Sustained-ERK12-but-not-STAT1-or-3-activation-is"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,20]]},"references-count":63,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2005,4,20]]},"published-print":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddi161","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,6,1]]},"published":{"date-parts":[[2005,4,20]]}}}