{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:26:47Z","timestamp":1791293207202,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"15","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"DOI":"10.1093\/hmg\/ddi229","type":"journal-article","created":{"date-parts":[[2005,7,8]],"date-time":"2005-07-08T00:33:05Z","timestamp":1120782785000},"page":"2247-2256","source":"Crossref","is-referenced-by-count":164,"title":["Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome"],"prefix":"10.1093","volume":"14","author":[{"given":"Ulrike A.","family":"Nuber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Skirmantas","family":"Kriaucionis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim C.","family":"Roloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Guy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Selfridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Steinhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Schulz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Lipkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Hilger","family":"Ropers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan C.","family":"Holmes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Bird","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,7,7]]},"reference":[{"key":"key\n\t\t\t\t20171012085512_DDI229C1","doi-asserted-by":"crossref","unstructured":"Amir, R.E., Van den Veyver, I.B., Wan, M., Tran, C.Q., Francke, U. and Zoghbi, H.Y. (1999) Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2. Nat. Genet., 23, 185\u2013188.","DOI":"10.1038\/13810"},{"key":"key\n\t\t\t\t20171012085512_DDI229C2","doi-asserted-by":"crossref","unstructured":"Hagberg, B., Aicardi, J., Dias, K. and Ramos, O. (1983) A progressive syndrome of autism, dementia, ataxia, and loss of purposeful hand use in girls: Rett's syndrome: report of 35 cases. Ann. Neurol., 14, 471\u2013479.","DOI":"10.1002\/ana.410140412"},{"key":"key\n\t\t\t\t20171012085512_DDI229C3","unstructured":"Rett, V.A. (1966) Uber ein eigenartiges hirnatrophisches Syndrom bei Hyperammonamie im Kindesalter. Weiner Medizinische Wochenschrift, 37, 723\u2013726."},{"key":"key\n\t\t\t\t20171012085512_DDI229C4","doi-asserted-by":"crossref","unstructured":"Guy, J., Hendrich, B., Holmes, M., Martin, J.E. and Bird, A. (2001) A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome. Nat. Genet., 27, 322\u2013326.","DOI":"10.1038\/85899"},{"key":"key\n\t\t\t\t20171012085512_DDI229C5","doi-asserted-by":"crossref","unstructured":"Chen, R.Z., Akbarian, S., Tudor, M. and Jaenisch, R. (2001) Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice. Nat. Genet., 27, 327\u2013331.","DOI":"10.1038\/85906"},{"key":"key\n\t\t\t\t20171012085512_DDI229C6","doi-asserted-by":"crossref","unstructured":"Shahbazian, M., Young, J., Yuva-Paylor, L., Spencer, C., Antalffy, B., Noebels, J., Armstrong, D., Paylor, R. and Zoghbi, H. (2002) Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron, 35, 243\u2013254.","DOI":"10.1016\/S0896-6273(02)00768-7"},{"key":"key\n\t\t\t\t20171012085512_DDI229C7","doi-asserted-by":"crossref","unstructured":"Shahbazian, M.D., Antalffy, B., Armstrong, D.L. and Zoghbi, H.Y. (2002) Insight into Rett syndrome: MeCP2 levels display tissue- and cell-specific differences and correlate with neuronal maturation. Hum. Mol. Genet., 11, 115\u2013124.","DOI":"10.1093\/hmg\/11.2.115"},{"key":"key\n\t\t\t\t20171012085512_DDI229C8","doi-asserted-by":"crossref","unstructured":"Kishi, N. and Macklis, J.D. (2004) MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions. Mol. Cell. Neurosci., 27, 306\u2013321.","DOI":"10.1016\/j.mcn.2004.07.006"},{"key":"key\n\t\t\t\t20171012085512_DDI229C9","doi-asserted-by":"crossref","unstructured":"Luikenhuis, S., Giacometti, E., Beard, C.F. and Jaenisch, R. (2004) Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice. Proc. Natl Acad. Sci. USA, 101, 6033\u20136038.","DOI":"10.1073\/pnas.0401626101"},{"key":"key\n\t\t\t\t20171012085512_DDI229C10","doi-asserted-by":"crossref","unstructured":"Jones, P.L., Veenstra, G.J., Wade, P.A., Vermaak, D., Kass, S.U., Landsberger, N., Strouboulis, J. and Wolffe, A.P. (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet., 19, 187\u2013191.","DOI":"10.1038\/561"},{"key":"key\n\t\t\t\t20171012085512_DDI229C11","doi-asserted-by":"crossref","unstructured":"Lewis, J.D., Meehan, R.R., Henzel, W.J., Maurer-Fogy, I., Jeppesen, P., Klein, F. and Bird, A. (1992) Purification, sequence and cellular localisation of a novel chromosomal protein that binds to methylated DNA. Cell, 69, 905\u2013914.","DOI":"10.1016\/0092-8674(92)90610-O"},{"key":"key\n\t\t\t\t20171012085512_DDI229C12","doi-asserted-by":"crossref","unstructured":"Nan, X., Campoy, J. and Bird, A. (1997) MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin. Cell, 88, 471\u2013481.","DOI":"10.1016\/S0092-8674(00)81887-5"},{"key":"key\n\t\t\t\t20171012085512_DDI229C13","doi-asserted-by":"crossref","unstructured":"Nan, X., Ng, H.-H., Johnson, C.A., Laherty, C.D., Turner, B.M., Eisenman, R.N. and Bird, A. (1998) Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature, 393, 386\u2013389.","DOI":"10.1038\/30764"},{"key":"key\n\t\t\t\t20171012085512_DDI229C14","doi-asserted-by":"crossref","unstructured":"Tudor, M., Akbarian, S., Chen, R.Z. and Jaenisch, R. (2002) Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain. Proc. Natl Acad. Sci. USA, 99, 15\u2005536\u201315\u2005541.","DOI":"10.1073\/pnas.242566899"},{"key":"key\n\t\t\t\t20171012085512_DDI229C15","doi-asserted-by":"crossref","unstructured":"Chen, W.G., Chang, Q., Lin, Y., Meissner, A., West, A.E., Griffith, E.C., Jaenisch, R. and Greenberg, M.E. (2003) Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science, 302, 885\u2013889.","DOI":"10.1126\/science.1086446"},{"key":"key\n\t\t\t\t20171012085512_DDI229C16","doi-asserted-by":"crossref","unstructured":"Martinowich, K., Hattori, D., Wu, H., Fouse, S., He, F., Hu, Y., Fan, G. and Sun, Y.E. (2003) DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science, 302, 890\u2013893.","DOI":"10.1126\/science.1090842"},{"key":"key\n\t\t\t\t20171012085512_DDI229C17","doi-asserted-by":"crossref","unstructured":"Samaco, R.C., Hogart, A. and LaSalle, J.M. (2005) Epigenetic overlap in autism-spectrum neurodevelopmental disorders: MECP2 deficiency causes reduced expression of UBE3A and GABRB3. Hum. Mol. Genet., 14, 483\u2013492.","DOI":"10.1093\/hmg\/ddi045"},{"key":"key\n\t\t\t\t20171012085512_DDI229C18","doi-asserted-by":"crossref","unstructured":"Horike, S., Cai, S., Miyano, M., Cheng, J.F. and Kohwi-Shigematsu, T. (2005) Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome. Nat. Genet., 37, 31\u201340.","DOI":"10.1038\/ng1491"},{"key":"key\n\t\t\t\t20171012085512_DDI229C19","doi-asserted-by":"crossref","unstructured":"Reichardt, H.M. and Schutz, G. (1998) Glucocorticoid signalling\u2014multiple variations of a common theme. Mol. Cell. Endocrinol., 146, 1\u20136.","DOI":"10.1016\/S0303-7207(98)00208-1"},{"key":"key\n\t\t\t\t20171012085512_DDI229C20","unstructured":"Duanmu, Z., Kocarek, T.A. and Runge-Morris, M. (2001) Transcriptional regulation of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by glucocorticoids. Drug Metab. Dispos., 29, 1130\u20131135."},{"key":"key\n\t\t\t\t20171012085512_DDI229C21","doi-asserted-by":"crossref","unstructured":"Lang, F. and Cohen, P. (2001) Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms. Sci. STKE, 2001, RE17.","DOI":"10.1126\/stke.2001.108.re17"},{"key":"key\n\t\t\t\t20171012085512_DDI229C22","doi-asserted-by":"crossref","unstructured":"Wadekar, S.A., Li, D., Periyasamy, S. and Sanchez, E.R. (2001) Inhibition of heat shock transcription factor by GR. Mol. Endocrinol., 15, 1396\u20131410.","DOI":"10.1210\/mend.15.8.0674"},{"key":"key\n\t\t\t\t20171012085512_DDI229C23","doi-asserted-by":"crossref","unstructured":"Wellmann, S., Buhrer, C., Moderegger, E., Zelmer, A., Kirschner, R., Koehne, P., Fujita, J. and Seeger, K. (2004) Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism. J. Cell Sci., 117, 1785\u20131794.","DOI":"10.1242\/jcs.01026"},{"key":"key\n\t\t\t\t20171012085512_DDI229C24","doi-asserted-by":"crossref","unstructured":"Reynolds, P.D., Ruan, Y., Smith, D.F. and Scammell, J.G. (1999) Glucocorticoid resistance in the squirrel monkey is associated with overexpression of the immunophilin FKBP51. J. Clin. Endocrinol. Metab., 84, 663\u2013669.","DOI":"10.1210\/jc.84.2.663"},{"key":"key\n\t\t\t\t20171012085512_DDI229C25","doi-asserted-by":"crossref","unstructured":"Binder, E.B., Salyakina, D., Lichtner, P., Wochnik, G.M., Ising, M., Putz, B., Papiol, S., Seaman, S., Lucae, S., Kohli, M.A. et\u00a0al. (2004) Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat. Genet., 36, 1319\u20131325.","DOI":"10.1038\/ng1479"},{"key":"key\n\t\t\t\t20171012085512_DDI229C26","doi-asserted-by":"crossref","unstructured":"De Kloet, E.R., Rosenfeld, P., Van Eekelen, J.A., Sutanto, W. and Levine, S. (1988) Stress, glucocorticoids and development. Prog. Brain Res., 73, 101\u2013120.","DOI":"10.1016\/S0079-6123(08)60500-2"},{"key":"key\n\t\t\t\t20171012085512_DDI229C27","doi-asserted-by":"crossref","unstructured":"Welberg, L.A., Seckl, J.R. and Holmes, M.C. (2001) Prenatal glucocorticoid programming of brain corticosteroid receptors and corticotrophin-releasing hormone: possible implications for behaviour. Neuroscience, 104, 71\u201379.","DOI":"10.1016\/S0306-4522(01)00065-3"},{"key":"key\n\t\t\t\t20171012085512_DDI229C28","doi-asserted-by":"crossref","unstructured":"Yeh, T.F., Lin, Y.J., Lin, H.C., Huang, C.C., Hsieh, W.S., Lin, C.H. and Tsai, C.H. (2004) Outcomes at school age after postnatal dexamethasone therapy for lung disease of prematurity. N. Engl. J. Med., 350, 1304\u20131313.","DOI":"10.1056\/NEJMoa032089"},{"key":"key\n\t\t\t\t20171012085512_DDI229C29","doi-asserted-by":"crossref","unstructured":"Bohn, M.C. and Lauder, J.M. (1980) Cerebellar granule cell genesis in the hydrocortisone-treated rats. Dev. Neurosci., 3, 81\u201389.","DOI":"10.1159\/000112380"},{"key":"key\n\t\t\t\t20171012085512_DDI229C30","doi-asserted-by":"crossref","unstructured":"Armstrong, D.D. (2002) Neuropathology of Rett syndrome. Ment. Retard. Dev. Disabil. Res. Rev., 8, 72\u201376.","DOI":"10.1002\/mrdd.10027"},{"key":"key\n\t\t\t\t20171012085512_DDI229C31","doi-asserted-by":"crossref","unstructured":"Budden, S.S. and Gunness, M.E. (2001) Bone histomorphometry in three females with Rett syndrome. Brain Dev., 23 (Suppl. 1), S133\u2013S137.","DOI":"10.1016\/S0387-7604(01)00338-2"},{"key":"key\n\t\t\t\t20171012085512_DDI229C32","doi-asserted-by":"crossref","unstructured":"Haas, R.H., Dixon, S.D., Sartoris, D.J. and Hennessy, M.J. (1997) Osteopenia in Rett syndrome. J. Pediatr., 131, 771\u2013774.","DOI":"10.1016\/S0022-3476(97)70113-6"},{"key":"key\n\t\t\t\t20171012085512_DDI229C33","doi-asserted-by":"crossref","unstructured":"Leonard, H., Thomson, M.R., Glasson, E.J., Fyfe, S., Leonard, S., Bower, C., Christodoulou, J. and Ellaway, C. (1999) A population-based approach to the investigation of osteopenia in Rett syndrome. Dev. Med. Child Neurol., 41, 323\u2013328.","DOI":"10.1017\/S0012162299000717"},{"key":"key\n\t\t\t\t20171012085512_DDI229C34","doi-asserted-by":"crossref","unstructured":"Wellman, C.L. (2001) Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J. Neurobiol., 49, 245\u2013253.","DOI":"10.1002\/neu.1079"},{"key":"key\n\t\t\t\t20171012085512_DDI229C35","doi-asserted-by":"crossref","unstructured":"Holmes, M.C., French, K.L. and Seckl, J.R. (1997) Dysregulation of diurnal rhythms of serotonin 5-HT2C and corticosteroid receptor gene expression in the hippocampus with food restriction and glucocorticoids. J. Neurosci., 17, 4056\u20134065.","DOI":"10.1523\/JNEUROSCI.17-11-04056.1997"},{"key":"key\n\t\t\t\t20171012085512_DDI229C36","doi-asserted-by":"crossref","unstructured":"Gurok, U., Steinhoff, C., Lipkowitz, B., Ropers, H.H., Scharff, C. and Nuber, U.A. (2004) Gene expression changes in the course of neural progenitor cell differentiation. J. Neurosci., 24, 5982\u20136002.","DOI":"10.1523\/JNEUROSCI.0809-04.2004"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/14\/15\/2247\/1463867\/ddi229.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T18:23:53Z","timestamp":1683138233000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/14\/15\/2247\/551741\/Upregulation-of-glucocorticoidregulated-genes-in-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,7]]},"references-count":36,"journal-issue":{"issue":"15","published-online":{"date-parts":[[2005,7,7]]},"published-print":{"date-parts":[[2005,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddi229","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,8,1]]},"published":{"date-parts":[[2005,7,7]]}}}