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Glia, 49, 430\u2013444.","DOI":"10.1002\/glia.20123"},{"key":"key\n\t\t\t\t20171012080719_DDI446C55","doi-asserted-by":"crossref","unstructured":"Weiss, S., Dunne, C., Hewson, J., Wohl, C., Wheatley, M., Peterson, A.C. and Reynolds, B.A. (1996) Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis. J. Neurosci., 16, 7599\u20137609.","DOI":"10.1523\/JNEUROSCI.16-23-07599.1996"},{"key":"key\n\t\t\t\t20171012080719_DDI446C56","doi-asserted-by":"crossref","unstructured":"Kalyani, A., Hobson, K. and Rao, M.S. (1997) Neuroepithelial stem cells from the embryonic spinal cord: isolation, characterization, and clonal analysis. Dev. Biol., 186, 202\u2013223.","DOI":"10.1006\/dbio.1997.8592"},{"key":"key\n\t\t\t\t20171012080719_DDI446C57","doi-asserted-by":"crossref","unstructured":"Feng, G., Mellor, R.H., Bernstein, M., Keller-Peck, C., Nguyen, Q.T., Wallace, M., Nerbonne, J.M., Lichtman, J.W. and Sanes, J.R. (2000) Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron, 28, 41\u201351.","DOI":"10.1016\/S0896-6273(00)00084-2"},{"key":"key\n\t\t\t\t20171012080719_DDI446C58","doi-asserted-by":"crossref","unstructured":"Elliger, S.S., Elliger, C.A., Aguilar, C.P., Raju, N.R. and Watson, G.L. (1999) Elimination of lysosomal storage in brains of MPS VII mice treated by intrathecal administration of an adeno-associated virus vector. Gene Ther., 6, 1175\u20131178.","DOI":"10.1038\/sj.gt.3300931"},{"key":"key\n\t\t\t\t20171012080719_DDI446C59","doi-asserted-by":"crossref","unstructured":"Li, M., Ona, V.O., Guegan, C., Chen, M., Jackson-Lewis, V., Andrews, L.J., Olszewski, A.J., Stieg, P.E., Lee, J.P., Przedborski, S. et\u00a0al. (2000) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science, 288, 335\u2013339.","DOI":"10.1126\/science.288.5464.335"},{"key":"key\n\t\t\t\t20171012080719_DDI446C60","doi-asserted-by":"crossref","unstructured":"Jablonka, S., Schrank, B., Kralewski, M., Rossoll, W. and Sendtner, M. (2000) Reduced survival motor neuron (Smn) gene dose in mice leads to motor neuron degeneration: an animal model for spinal muscular atrophy type III. Hum. Mol. Genet., 9, 341\u2013346.","DOI":"10.1093\/hmg\/9.3.341"},{"key":"key\n\t\t\t\t20171012080719_DDI446C61","doi-asserted-by":"crossref","unstructured":"Gundersen, H.J., Bagger, P., Bendtsen, T.F., Evans, S.M., Korbo, L., Marcussen, N., Moller, A., Nielsen, K., Nyengaard, J.R., Pakkenberg, B. et\u00a0al. (1988) The new stereological tools: dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS, 96, 857\u2013881.","DOI":"10.1111\/j.1699-0463.1988.tb00954.x"},{"key":"key\n\t\t\t\t20171012080719_DDI446C62","doi-asserted-by":"crossref","unstructured":"Messina, A., Sangster, C.L., Morrison, W.A. and Galea, M.P. (2000) Requirements for obtaining unbiased estimates of neuronal numbers in frozen sections. J. Neurosci. Methods, 97, 133\u2013137.","DOI":"10.1016\/S0165-0270(00)00177-1"},{"key":"key\n\t\t\t\t20171012080719_DDI446C63","doi-asserted-by":"crossref","unstructured":"Corti, S., Locatelli, F., Donadoni, C., Guglieri, M., Papadimitriou, D., Strazzer, S., Del Bo, R. and Comi, G.P. (2004) Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues. Brain, 127, 2518\u20132532.","DOI":"10.1093\/brain\/awh273"},{"key":"key\n\t\t\t\t20171012080719_DDI446C64","doi-asserted-by":"crossref","unstructured":"Hoffmann, R. and Valencia, A. (2004) A gene network for navigating the literature. Nat. 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