{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:33:18Z","timestamp":1790929998605,"version":"4.1.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,15]]},"DOI":"10.1093\/hmg\/ddl145","type":"journal-article","created":{"date-parts":[[2006,6,2]],"date-time":"2006-06-02T00:36:55Z","timestamp":1149208615000},"page":"2200-2209","source":"Crossref","is-referenced-by-count":119,"title":["Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly"],"prefix":"10.1093","volume":"15","author":[{"given":"Svetlana","family":"Pidasheva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Canaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oya","family":"Ercan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ujendra","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey N.","family":"Hendy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,6,1]]},"reference":[{"key":"key\n\t\t\t\t20171011123706_DDL145C1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/366575a0","article-title":"Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid","volume":"366","author":"Brown","year":"1993","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011123706_DDL145C2","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/0092-8674(93)90617-Y","article-title":"Mutations in the human Ca\n              2+\n              -sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism","volume":"75","author":"Pollak","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171011123706_DDL145C3","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ng1194-303","article-title":"Autosomal dominant hypocalcaemia caused by a Ca(2+)-sensing receptor gene mutation","volume":"8","author":"Pollak","year":"1994","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20171011123706_DDL145C4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/1098-1004(200010)16:4<281::AID-HUMU1>3.0.CO;2-A","article-title":"Mutations of the calcium-sensing receptor (CASR) in familial hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia","volume":"16","author":"Hendy","year":"2000","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20171011123706_DDL145C5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00005792-198111000-00002","article-title":"The hypocalciuric or benign variant of familial hypercalcemia: clinical and biochemical features of fifteen families","volume":"60","author":"Marx","year":"1981","journal-title":"Medicine (Baltimore)"},{"key":"key\n\t\t\t\t20171011123706_DDL145C6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7326\/0003-4819-102-4-511","article-title":"Familial benign hypercalcemia (hypocalciuric hypercalcemia): clinical and pathogenetic study of 21 families","volume":"102","author":"Law","year":"1985","journal-title":"Ann. Intern. Med."},{"key":"key\n\t\t\t\t20171011123706_DDL145C7","first-page":"205","article-title":"Primary neonatal hyperparathyroidism: a devastating neurodevelopmental disorder if left untreated","volume":"10","author":"Cole","year":"1990","journal-title":"J. Craniofac. Genet. Dev. Biol."},{"key":"key\n\t\t\t\t20171011123706_DDL145C8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/humu.20067","article-title":"CASRdb: calcium-sensing receptor locus-specific database for mutations causing familial (benign) hypocalciuric hypercalcemia, neonatal severe hyperparathyroidism, and autosomal dominant hypocalcemia","volume":"24","author":"Pidasheva","year":"2004","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20171011123706_DDL145C9","doi-asserted-by":"crossref","first-page":"23605","DOI":"10.1074\/jbc.273.36.23605","article-title":"Dimerization of the extracellular calcium-sensing receptor (CaR) on the cell surface of CaR-transfected HEK293 cells","volume":"273","author":"Bai","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1172\/JCI117062","article-title":"Familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Effects of mutant gene dosage on phenotype","volume":"93","author":"Pollak","year":"1994","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20171011123706_DDL145C11","first-page":"1075","article-title":"Mutations in the human Ca\n              2+\n              sensing receptor gene that cause familial hypocalciuric hypercalcemia","volume":"56","author":"Chou","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171011123706_DDL145C12","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S1046-2023(02)00092-0","article-title":"Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes","volume":"27","author":"Patel","year":"2002","journal-title":"Methods"},{"key":"key\n\t\t\t\t20171011123706_DDL145C13","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1074\/jbc.275.11.7862","article-title":"Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers","volume":"275","author":"Rocheville","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C14","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.yfrne.2003.10.002","article-title":"G-protein coupled receptor oligomerization in neuroendocrine pathways","volume":"24","author":"Kroeger","year":"2003","journal-title":"Front. Neuroendocrinol."},{"key":"key\n\t\t\t\t20171011123706_DDL145C15","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ceca.2003.10.017","article-title":"Calcium receptor-mediated intracellular signaling","volume":"35","author":"Ward","year":"2004","journal-title":"Cell Calcium"},{"key":"key\n\t\t\t\t20171011123706_DDL145C16","first-page":"F291","article-title":"Regulation of MAP kinase by calcium-sensing receptor in bovine parathyroid and CaR-transfected HEK293 cells","volume":"280","author":"Kifor","year":"2001","journal-title":"Am. J. Physiol."},{"key":"key\n\t\t\t\t20171011123706_DDL145C17","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1210\/jcem.87.5.8492","article-title":"Mitogen-activated protein kinase cascade in human normal and tumoral parathyroid cells","volume":"87","author":"Corbetta","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20171011123706_DDL145C18","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1210\/jc.87.3.1309","article-title":"Identification and functional characterization of novel calcium-sensing receptor mutations in familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia","volume":"87","author":"D'Souza-Li","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20171011123706_DDL145C19","doi-asserted-by":"crossref","first-page":"34558","DOI":"10.1074\/jbc.273.51.34558","article-title":"Identification of the sites of N-linked glycosylation on the human calcium receptor and assessment of their role in cell surface expression and signal transduction","volume":"273","author":"Ray","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C20","doi-asserted-by":"crossref","first-page":"19537","DOI":"10.1074\/jbc.271.32.19537","article-title":"Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor","volume":"271","author":"Bai","year":"1996","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C21","doi-asserted-by":"crossref","first-page":"27642","DOI":"10.1074\/jbc.274.39.27642","article-title":"Identification of the cysteine residues in the amino-terminal extracellular domain of the human Ca\n              2+\n               receptor critical for dimerization. Implications for the function of monomeric Ca\n              2+\n               receptor","volume":"274","author":"Ray","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C22","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1074\/jbc.M005958200","article-title":"The extracellular calcium-sensing receptor dimerizes through multiple types of intermolecular interactions","volume":"276","author":"Zhang","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C23","doi-asserted-by":"crossref","first-page":"14147","DOI":"10.1074\/jbc.M307422200","article-title":"Modulation of interprotomer relationships is important for activation of dimeric calcium-sensing receptor","volume":"279","author":"Jiang","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C24","doi-asserted-by":"crossref","first-page":"11629","DOI":"10.1074\/jbc.274.17.11629","article-title":"Dimerization of the calcium-sensing receptor occurs within the extracellular domain and is eliminated by Cys \u2212> Ser mutations at Cys\n              101\n               and Cys\n              236","volume":"274","author":"Pace","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C25","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S1043-2760(03)00104-8","article-title":"Naturally occurring mutations of the extracellular Ca\n              2+\n              -sensing receptor: implications for its structure and function","volume":"14","author":"Hu","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"key\n\t\t\t\t20171011123706_DDL145C26","doi-asserted-by":"crossref","first-page":"14476","DOI":"10.1074\/jbc.273.23.14476","article-title":"Disulfide bonds in the extracellular calcium-polyvalent cation-sensing receptor correlate with dimer formation and its response to divalent cations \n              in vitro","volume":"273","author":"Ward","year":"1998","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C27","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1046\/j.1432-1033.2002.03218.x","article-title":"Probing intermolecular protein\u2013protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET)","volume":"269","author":"Jensen","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C28","doi-asserted-by":"crossref","first-page":"9852","DOI":"10.1073\/pnas.152621799","article-title":"Association of calnexin with mutant peripheral myelin protein-22 \n              ex vivo\n              : a basis for \u2018gain-of-function\u2019 ER diseases","volume":"99","author":"Dickson","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20171011123706_DDL145C29","doi-asserted-by":"crossref","first-page":"26308","DOI":"10.1074\/jbc.M102514200","article-title":"A conserved alpha-helix at the amino terminus of prosomatostatin serves as a sorting signal for the regulated secretory pathway","volume":"276","author":"Mouchantaf","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1210\/jc.2002-020081","article-title":"Autosomal dominant hypocalcemia: a novel activating mutation (E604K) in the cysteine-rich domain of the calcium-sensing receptor","volume":"88","author":"Tan","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20171011123706_DDL145C31","doi-asserted-by":"crossref","first-page":"53288","DOI":"10.1074\/jbc.M410098200","article-title":"cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated carboxyterminal tail from the mozambique tilapia (\n              Oreochromis mossambicus\n              )","volume":"279","author":"Loretz","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C32","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1210\/jc.2003-030409","article-title":"Recurrent familial hypocalcemia due to germline mosaicism for an activating mutation of the calcium-sensing receptor gene","volume":"88","author":"Hendy","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key\n\t\t\t\t20171011123706_DDL145C33","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1093\/hmg\/ddi176","article-title":"Impaired cotranslational processing of the calcium-sensing receptor due to signal peptide missense mutations in familial hypocalciuric hypercalcemia","volume":"14","author":"Pidasheva","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171011123706_DDL145C34","doi-asserted-by":"crossref","first-page":"16382","DOI":"10.1074\/jbc.M000277200","article-title":"Human Ca2+ receptor cysteine-rich domain. Analysis of function of mutant and chimeric receptors","volume":"275","author":"Hu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171011123706_DDL145C35","doi-asserted-by":"crossref","first-page":"38636","DOI":"10.1074\/jbc.M406276200","article-title":"The role of subtype-specific ligand binding and the C-tail domain in dimer formation of human somatostatin receptors","volume":"279","author":"Grant","year":"2004","journal-title":"J. Biol. Chem."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/15\/14\/2200\/6949996\/ddl145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T16:39:47Z","timestamp":1507739987000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/15\/14\/2200\/2355925\/Calciumsensing-receptor-dimerizes-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,1]]},"references-count":35,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2006,6,1]]},"published-print":{"date-parts":[[2006,7,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddl145","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,7,15]]},"published":{"date-parts":[[2006,6,1]]}}}