{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:07:43Z","timestamp":1790885263663,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"20","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,15]]},"DOI":"10.1093\/hmg\/ddl227","type":"journal-article","created":{"date-parts":[[2006,8,24]],"date-time":"2006-08-24T00:34:57Z","timestamp":1156379697000},"page":"2975-2979","source":"Crossref","is-referenced-by-count":37,"title":["Genome-wide search for nevus density shows linkage to two melanoma loci on chromosome 9 and identifies a new QTL on 5q31 in an adult twin cohort"],"prefix":"10.1093","volume":"15","author":[{"given":"Mario","family":"Falchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim D.","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Perks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernet S.","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,8,23]]},"reference":[{"key":"key\n\t\t\t\t20171011130617_DDL227C1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1365-2133.1987.tb04109.x","article-title":"Melanocytic naevi and melanoma: an epidemiological perspective","volume":"117","author":"Swerdlow","year":"1987","journal-title":"Br. J. Dermatol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C2","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1086\/302494","article-title":"A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs","volume":"65","author":"Zhu","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/jnci\/92.6.457","article-title":"Genetics of risk factors for melanoma: an adult twin study of nevi and freckles","volume":"92","author":"Bataille","year":"2000","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20171011130617_DDL227C4","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.0022-202x.2001.01415.x","article-title":"Heritability and gene-environment interactions for melanocytic nevus density examined in a U.K. adolescent twin study","volume":"117","author":"Wachsmuth","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C5","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/jnci\/92.17.1436","article-title":"Development of melanocytic nevi in the first 3 years of life","volume":"92","author":"Harrison","year":"2000","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20171011130617_DDL227C6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1093\/oxfordjournals.aje.a117011","article-title":"Melanocytic nevi in children. I. Anatomic sites and demographic and host factors","volume":"139","author":"English","year":"1994","journal-title":"Am. J. Epidemiol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C7","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1093\/oxfordjournals.epirev.a036037","article-title":"Epidemiology of melanocytic nevi","volume":"11","author":"Green","year":"1989","journal-title":"Epidemiol. Rev."},{"key":"key\n\t\t\t\t20171011130617_DDL227C8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1524-4725.1978.tb00398.x","article-title":"Prevalence of nevocytic nevi on lateral and medial aspects of arms","volume":"4","author":"Kopf","year":"1978","journal-title":"J. Dermatol. Surg. Oncol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C9","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1093\/jnci\/84.18.1427","article-title":"Increasing incidence of cutaneous melanoma in Queensland, Australia","volume":"84","author":"MacLennan","year":"1992","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20171011130617_DDL227C10","first-page":"329","article-title":"Etiology of common acquired melanocytic nevi: constitutional variables, sun exposure, and diet","volume":"77","author":"Armstrong","year":"1986","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20171011130617_DDL227C11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/jid.1959.70","article-title":"Natural regression of the melanocytic nevus","volume":"32","author":"Stegmaier","year":"1959","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/bjc.1998.81","article-title":"The association between naevi and melanoma in populations with different levels of sun exposure: a joint case\u2013control study of melanoma in the UK and Australia","volume":"77","author":"Bataille","year":"1998","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20171011130617_DDL227C13","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/archderm.1980.01640290058011","article-title":"Nevi, lentigines, and melanomas in blacks","volume":"116","author":"Coleman","year":"1980","journal-title":"Arch. Dermatol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1126\/science.1439824","article-title":"Assignment of a locus for familial melanoma, MLM, to chromosome 9p13\u2013p22","volume":"258","author":"Cannon-Albright","year":"1992","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011130617_DDL227C15","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1126\/science.8153634","article-title":"A cell cycle regulator potentially involved in genesis of many tumor types","volume":"264","author":"Kamb","year":"1994","journal-title":"Science"},{"key":"key\n\t\t\t\t20171011130617_DDL227C16","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/375694a0","article-title":"Interaction between the retinoblastoma protein and the oncoprotein MDM2","volume":"375","author":"Xiao","year":"1995","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011130617_DDL227C17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/8991","article-title":"Nucleolar Arf sequesters Mdm2 and activates p53","volume":"1","author":"Weber","year":"1999","journal-title":"Nat. Cell. Biol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C18","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1093\/jnci\/94.12.894","article-title":"Geographical variation in the penetrance of CDKN2A mutations for melanoma","volume":"94","author":"Bishop","year":"2002","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20171011130617_DDL227C19","doi-asserted-by":"crossref","first-page":"5543","DOI":"10.1038\/sj.onc.1204728","article-title":"A melanoma-associated germline mutation in exon 1beta inactivates p14ARF","volume":"20","author":"Rizos","year":"2001","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20171011130617_DDL227C20","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/hmg\/11.11.1273","article-title":"Germline mutation of ARF in a melanoma kindred","volume":"11","author":"Hewitt","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C21","first-page":"395","article-title":"Chromosome 9p deletions in cutaneous malignant melanoma tumors: the minimal deleted region involves markers outside the p16 (CDKN2) gene","volume":"57","author":"Puig","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C22","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1054\/bjoc.2000.1513","article-title":"Melanoma Cooperative Group. Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases. The Melanoma Cooperative Group","volume":"83","author":"Palmieri","year":"2000","journal-title":"Br. J. Cancer."},{"key":"key\n\t\t\t\t20171011130617_DDL227C23","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJM198905253202102","article-title":"Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p","volume":"320","author":"Bale","year":"1989","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20171011130617_DDL227C24","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/(SICI)1098-2264(199708)19:4<241::AID-GCC6>3.0.CO;2-X","article-title":"Linkage analysis of familial melanoma and chromosome 6 in 14 Australian kindreds","volume":"19","author":"Holland","year":"1997","journal-title":"Genes Chromosomes Cancer"},{"key":"key\n\t\t\t\t20171011130617_DDL227C25","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1086\/377140","article-title":"Localization of a novel melanoma susceptibility locus to 1p22","volume":"73","author":"Gillanders","year":"2003","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C26","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/jnci\/dji280","article-title":"Mapping of a novel ocular and cutaneous malignant melanoma susceptibility locus to chromosome 9q21.32","volume":"97","author":"Jonsson","year":"2005","journal-title":"J. Natl Cancer Inst."},{"key":"key\n\t\t\t\t20171011130617_DDL227C27","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1038\/sj.bjc.6600904","article-title":"Linkage and association analysis of nevus density and the region containing the melanoma gene CDKN2A in UK twins","volume":"88","author":"Barrett","year":"2003","journal-title":"Br. J. Cancer"},{"key":"key\n\t\t\t\t20171011130617_DDL227C28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1007\/978-3-642-82641-2_6","article-title":"Risk factors for cutaneous melanoma in Queensland","volume":"102","author":"Green","year":"1986","journal-title":"Recent Results Cancer Res."},{"key":"key\n\t\t\t\t20171011130617_DDL227C29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/003130299105052","article-title":"Expression of catenins and p120cas in melanocytic nevi and cutaneous melanoma: deficient alpha-catenin expression is associated with melanoma progression","volume":"31","author":"Zhang","year":"1999","journal-title":"Pathology"},{"key":"key\n\t\t\t\t20171011130617_DDL227C30","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1111\/1523-1747.ep12292703","article-title":"Identification of novel cadherins expressed in human melanoma cells","volume":"108","author":"Matsuyoshi","year":"1997","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20171011130617_DDL227C31","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/geno.1994.1374","article-title":"Assignment of a human melanoma associated gene MG50 (D2S448) to chromosome 2p25.3 by fluorescence \n              in situ\n               hybridization","volume":"22","author":"Weiler","year":"1994","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20171011130617_DDL227C32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1375\/136905202320906246","article-title":"The St Thomas' UK adult twin registry","volume":"5","author":"Spector","year":"2002","journal-title":"Twin Res."},{"key":"key\n\t\t\t\t20171011130617_DDL227C33","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM198710223171717","article-title":"Simplified calculation of body-surface area","volume":"317","author":"Mosteller","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"key\n\t\t\t\t20171011130617_DDL227C34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/hmg\/4.2.197","article-title":"Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping","volume":"4","author":"Pritchard","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/380152a0","article-title":"A comprehensive genetic map of the human genome based on 5,264 microsatellites","volume":"380","author":"Dib","year":"1996","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171011130617_DDL227C36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/bioinformatics\/bti024","article-title":"MAP-O-MAT: internet-based linkage mapping","volume":"21","author":"Kong","year":"2005","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20171011130617_DDL227C37","first-page":"A435","article-title":"MAP-O-MAT: marker-based linkage mapping on the World Wide Web","volume":"65","author":"Matise","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C38","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1073\/pnas.84.8.2363","article-title":"Construction of multilocus genetic linkage maps in humans","volume":"84","author":"Lander","year":"1987","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20171011130617_DDL227C39","first-page":"309","article-title":"Local regression models","volume-title":"Statistical Models in S","author":"Cleveland","year":"1992"},{"key":"key\n\t\t\t\t20171011130617_DDL227C40","volume-title":"Mx: Statistical Modelling","author":"Neale","edition":"4th edn."},{"key":"key\n\t\t\t\t20171011130617_DDL227C41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1469-1809.1976.tb00156.x","article-title":"Extensions to pedigree analysis. III. Variance components by the scoring method","volume":"39","author":"Lange","year":"1976","journal-title":"Ann. Hum. Genet."},{"key":"key\n\t\t\t\t20171011130617_DDL227C42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"Abecasis","journal-title":"Nat. Genet."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/15\/20\/2975\/6949940\/ddl227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T17:08:46Z","timestamp":1507741726000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/15\/20\/2975\/2355914\/Genomewide-search-for-nevus-density-shows-linkage"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,23]]},"references-count":42,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2006,8,23]]},"published-print":{"date-parts":[[2006,10,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddl227","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,10,15]]},"published":{"date-parts":[[2006,8,23]]}}}