{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:47:38Z","timestamp":1777448858938,"version":"3.51.4"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"24","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,15]]},"DOI":"10.1093\/hmg\/ddl425","type":"journal-article","created":{"date-parts":[[2006,11,10]],"date-time":"2006-11-10T01:13:39Z","timestamp":1163121219000},"page":"3485-3497","source":"Crossref","is-referenced-by-count":44,"title":["Itch genetically interacts with Notch1 in a mouse autoimmune disease model"],"prefix":"10.1093","volume":"15","author":[{"given":"Lydia E.","family":"Matesic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana C.","family":"Haines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal G.","family":"Copeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy A.","family":"Jenkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2006,11,9]]},"reference":[{"key":"key\n\t\t\t\t20171012083520_DDL425C1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/clin.1997.4412","article-title":"Epidemiology and estimated population burden of selected autoimmune diseases in the United States","volume":"84","author":"Jacobson","year":"1997","journal-title":"Clin. Immunol. Immunopathol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C2","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/genetics\/140.1.255","article-title":"Molecular genetic characterization of six recessive viable alleles of the mouse agouti locus","volume":"140","author":"Hustad","year":"1995","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20171012083520_DDL425C3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/ng0298-143","article-title":"The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice","volume":"18","author":"Perry","year":"1998","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20171012083520_DDL425C4","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1002\/pro.5560051201","article-title":"The C2 domain calcium-binding motif: structural and functional diversity","volume":"5","author":"Nalefski","year":"1996","journal-title":"Protein Sci."},{"key":"key\n\t\t\t\t20171012083520_DDL425C5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0079-6107(96)00008-9","article-title":"Structure and function of the WW domain","volume":"65","author":"Sudol","year":"1996","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev.biochem.67.1.425","article-title":"The ubiquitin system","volume":"67","author":"Hershko","year":"1998","journal-title":"Annu. Rev. Biochem."},{"key":"key\n\t\t\t\t20171012083520_DDL425C7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.cellbio.19.110701.154617","article-title":"Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins","volume":"19","author":"Hicke","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni763","article-title":"Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation","volume":"3","author":"Fang","year":"2002","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/ni1047","article-title":"Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins","volume":"5","author":"Heissmeyer","year":"2004","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1002\/(SICI)1097-4652(199912)181:3<393::AID-JCP3>3.0.CO;2-6","article-title":"Arbiter of differentiation and death: Notch signaling meets apoptosis","volume":"181","author":"Miele","year":"1999","journal-title":"J. Cell. Physiol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C11","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1126\/science.284.5415.770","article-title":"Notch signaling: cell fate control and signal integration in development","volume":"284","author":"Artavanis-Tsakonas","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012083520_DDL425C12","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni1045","article-title":"Notch regulation of lymphocyte development and function","volume":"5","author":"Radtke","year":"2004","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1242\/jcs.115.6.1095","article-title":"Notch: a membrane-bound transcription factor","volume":"115","author":"Kopan","year":"2002","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20171012083520_DDL425C14","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1016\/j.cub.2004.11.030","article-title":"Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins","volume":"14","author":"Wilkin","year":"2004","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C15","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1016\/j.cub.2004.12.028","article-title":"Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation","volume":"14","author":"Sakata","year":"2004","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C16","doi-asserted-by":"crossref","first-page":"35734","DOI":"10.1074\/jbc.M007300200","article-title":"Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase","volume":"275","author":"Qiu","year":"2000","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171012083520_DDL425C17","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0092-8674(00)81368-9","article-title":"An activated form of Notch influences the choice between CD4 and CD8 T cell lineages","volume":"87","author":"Robey","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20171012083520_DDL425C18","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/genetics\/150.4.1477","article-title":"Genetic characterization of the Drosophila melanogaster Suppressor of deltex gene: a regulator of notch signaling","volume":"150","author":"Fostier","year":"1998","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20171012083520_DDL425C19","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/S0952-7915(99)00067-9","article-title":"Notch signaling in T cell development","volume":"12","author":"Deftos","year":"2000","journal-title":"Curr. Opin. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C20","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.4049\/jimmunol.169.4.1817","article-title":"A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development","volume":"169","author":"Fowlkes","year":"2002","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S1535-6108(03)00137-5","article-title":"Perturbation of Ikaros isoform selection by MLV integration is a cooperative event in Notch(IC)-induced T cell leukemogenesis","volume":"3","author":"Beverly","year":"2003","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20171012083520_DDL425C22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1006\/dbio.2002.0606","article-title":"Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm","volume":"244","author":"Carmena","year":"2002","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C23","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.1128\/MCB.17.10.6057","article-title":"Isolation and functional analysis of a cDNA for human Jagged2, a gene encoding a ligand for the Notch1 receptor","volume":"17","author":"Luo","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C24","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1074-7613(00)00009-1","article-title":"Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes","volume":"13","author":"Deftos","year":"2000","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20171012083520_DDL425C25","doi-asserted-by":"crossref","first-page":"635","DOI":"10.4049\/jimmunol.162.2.635","article-title":"Cutting edge: protective effects of notch-1 on TCR-induced apoptosis","volume":"162","author":"Jehn","year":"1999","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C26","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1074\/jbc.M309924200","article-title":"The anti-apoptotic effect of Notch-1 requires p56lck-dependent, Akt\/PKB-mediated signaling in T cells","volume":"279","author":"Sade","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171012083520_DDL425C27","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/ni0901-793","article-title":"Autoimmunity and lymphoma: tribulations of B cells","volume":"2","author":"Mackay","year":"2001","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C28","doi-asserted-by":"crossref","first-page":"890","DOI":"10.4049\/jimmunol.174.2.890","article-title":"The Notch regulator Numb links the Notch and TCR signaling pathways","volume":"174","author":"Anderson","year":"2005","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C29","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/eji.200425562","article-title":"Notch1 co-localizes with CD4 on activated T cells and Notch signaling is required for IL-10 production","volume":"35","author":"Benson","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C30","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/JAD-2004-6107","article-title":"The role of the endosomal\/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective","volume":"6","author":"Pasternak","year":"2004","journal-title":"J. Alzheimers Dis."},{"key":"key\n\t\t\t\t20171012083520_DDL425C31","doi-asserted-by":"crossref","first-page":"7109","DOI":"10.4049\/jimmunol.173.12.7109","article-title":"Notch governing mature T cell differentiation","volume":"173","author":"Tsukumo","year":"2004","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C32","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/ni1209","article-title":"Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21","volume":"6","author":"Minter","year":"2005","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C33","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1084\/jem.20050923","article-title":"Notch signaling is an important regulator of type 2 immunity","volume":"202","author":"Tu","year":"2005","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20171012083520_DDL425C34","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/hmg\/ddh151","article-title":"Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice","volume":"13","author":"Tournoy","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171012083520_DDL425C35","doi-asserted-by":"crossref","first-page":"14967","DOI":"10.1073\/pnas.231467698","article-title":"Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus","volume":"98","author":"Malstrom","year":"2001","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20171012083520_DDL425C36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4049\/jimmunol.167.1.42","article-title":"Expression of active protein kinase B in T cells perturbs both T and B cell homeostasis and promotes inflammation","volume":"167","author":"Parsons","year":"2001","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C37","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1002\/eji.200324048","article-title":"Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma","volume":"33","author":"Rathmell","year":"2003","journal-title":"Eur. J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C38","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ni1234","article-title":"Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism","volume":"6","author":"Ciofani","year":"2005","journal-title":"Nat. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C39","doi-asserted-by":"crossref","first-page":"32799","DOI":"10.1074\/jbc.M105431200","article-title":"Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis","volume":"276","author":"Masuyama","year":"2001","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20171012083520_DDL425C40","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1084\/jem.191.10.1721","article-title":"Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo","volume":"191","author":"Jones","year":"2000","journal-title":"J. Exp. Med."},{"key":"key\n\t\t\t\t20171012083520_DDL425C41","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S1074-7613(01)00134-0","article-title":"T cell-specific loss of Pten leads to defects in central and peripheral tolerance","volume":"14","author":"Suzuki","year":"2001","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20171012083520_DDL425C42","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/1074-7613(95)90113-2","article-title":"A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection","volume":"3","author":"Calnan","year":"1995","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20171012083520_DDL425C43","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S0960-9822(00)00728-4","article-title":"Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1","volume":"10","author":"Dijkers","year":"2000","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C44","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/415922a","article-title":"BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes","volume":"415","author":"Bouillet","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012083520_DDL425C45","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1073\/pnas.88.9.3977","article-title":"Thymic tumorigenesis induced by overexpression of p56lck","volume":"88","author":"Abraham","year":"1991","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20171012083520_DDL425C46","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.4049\/jimmunol.166.4.2209","article-title":"Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes","volume":"166","author":"Sohn","year":"2001","journal-title":"J. Immunol."},{"key":"key\n\t\t\t\t20171012083520_DDL425C47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012083520_DDL425C48","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/sj.emboj.7600038","article-title":"Hematopoietic, angiogenic and eye defects in Meis1 mutant animals","volume":"23","author":"Hisa","year":"2004","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20171012083520_DDL425C49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1128\/JVI.43.1.26-36.1982","article-title":"Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus","volume":"43","author":"Jenkins","year":"1982","journal-title":"J. Virol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/15\/24\/3485\/17242884\/ddl425.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T18:11:05Z","timestamp":1683655865000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/15\/24\/3485\/597291\/Itch-genetically-interacts-with-Notch1-in-a-mouse"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,9]]},"references-count":49,"journal-issue":{"issue":"24","published-online":{"date-parts":[[2006,11,9]]},"published-print":{"date-parts":[[2006,12,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddl425","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,12,15]]},"published":{"date-parts":[[2006,11,9]]}}}