{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:57:02Z","timestamp":1789559822880,"version":"build-2803163510"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"DOI":"10.1093\/hmg\/ddl487","type":"journal-article","created":{"date-parts":[[2007,1,12]],"date-time":"2007-01-12T20:25:31Z","timestamp":1168633531000},"page":"600-608","source":"Crossref","is-referenced-by-count":66,"title":["The ongoing adaptive evolution of ASPM and Microcephalin is not explained by increased intelligence"],"prefix":"10.1093","volume":"16","author":[{"given":"Nitzan","family":"Mekel-Bobrov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Posthuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Lind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Florencia","family":"Gosso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Luciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinca J.C.","family":"Polderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence J.","family":"Whalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Starr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant W.","family":"Montgomery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Croydon","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Heutink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas G.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorret I.","family":"Boomsma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian J.","family":"Deary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret J.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eco J.C.","family":"de Geus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce T.","family":"Lahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,1,12]]},"reference":[{"key":"key\n\t\t\t\t20171012122714_DDL487C1","volume-title":"Evolution of the Brain and Intelligence","author":"Jerison","year":"1973"},{"key":"key\n\t\t\t\t20171012122714_DDL487C2","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1371\/journal.pgen.0020080","article-title":"The jewels of our genome: the search for the genomic changes underlying the evolutionarily unique capacities of the human brain","volume":"2","author":"Sikela","year":"2006","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrg1634","article-title":"Genetic links between brain development and brain evolution","volume":"6","author":"Gilbert","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ceb.2005.11.004","article-title":"Cytoskeletal genes regulating brain size","volume":"18","author":"Bond","year":"2006","journal-title":"Curr. Opin. Cell. Biol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.molmed.2006.06.006","article-title":"What primary microcephaly can tell us about brain growth","volume":"12","author":"Cox","year":"2006","journal-title":"Trends Mol. Med."},{"key":"key\n\t\t\t\t20171012122714_DDL487C6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.gde.2005.04.009","article-title":"Evolution of primary microcephaly genes and the enlargement of primate brains","volume":"15","author":"Ponting","year":"2005","journal-title":"Curr. Opin. Genet. Dev."},{"key":"key\n\t\t\t\t20171012122714_DDL487C7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1093\/hmg\/ddh126","article-title":"Reconstructing the evolutionary history of Microcephalin, a gene controlling human brain size","volume":"13","author":"Evans","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/hmg\/ddh055","article-title":"Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans","volume":"13","author":"Evans","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gene.2006.02.019","article-title":"Molecular evolution of the brain size regulator genes CDK5RAP2 and CENPJ","volume":"375","author":"Evans","year":"2006","journal-title":"Gene"},{"key":"key\n\t\t\t\t20171012122714_DDL487C10","doi-asserted-by":"crossref","first-page":"E126","DOI":"10.1371\/journal.pbio.0020126","article-title":"Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion","volume":"2","author":"Kouprina","year":"2004","journal-title":"PLoS Biol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C11","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/hmg\/ddh127","article-title":"Molecular evolution of microcephalin, a gene determining human brain size","volume":"13","author":"Wang","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C12","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1093\/genetics\/165.4.2063","article-title":"Evolution of the human ASPM gene, a major determinant of brain size","volume":"165","author":"Zhang","year":"2003","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20171012122714_DDL487C13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jez.b.21001","article-title":"Humans and primates: new model organisms for evolutionary developmental biology?","volume":"302","author":"Lieberman","year":"2004","journal-title":"J. Exp. Zoolog. B. Mol. Dev. Evol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C14","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.1116815","article-title":"Ongoing adaptive evolution of ASPM, a brain size determinant in Homo sapiens","volume":"309","author":"Mekel-Bobrov","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012122714_DDL487C15","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1126\/science.1113722","article-title":"Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans","volume":"309","author":"Evans","year":"2005","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012122714_DDL487C16","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1093\/hmg\/ddl126","article-title":"Normal variants of Microcephalin and ASPM do not account for brain size variability","volume":"15","author":"Woods","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C17","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1093\/cercor\/11.9.816","article-title":"Quantitative genetic modeling of variation in human brain morphology","volume":"11","author":"Baare","year":"2001","journal-title":"Cereb. Cortex"},{"key":"key\n\t\t\t\t20171012122714_DDL487C18","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nn758","article-title":"Genetic influences on brain structure","volume":"4","author":"Thompson","year":"2001","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20171012122714_DDL487C19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1019772628912","article-title":"Genetic and environmental influences on the development of intelligence","volume":"32","author":"Bartels","year":"2002","journal-title":"Behav. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1037\/10131-003","article-title":"Behavioral genetics of cognitive ability: a life-span perspective","volume-title":"Nature, Nurture, and Psychology","author":"McGue","year":"1993"},{"key":"key\n\t\t\t\t20171012122714_DDL487C21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2307\/2532296","article-title":"Performing the exact test of Hardy\u2013Weinberg proportion for multiple alleles","volume":"48","author":"Guo","year":"1992","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t20171012122714_DDL487C22","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/BF02985085","article-title":"An exact test for randomness of mating","volume":"52","author":"Haldane","year":"1954","journal-title":"J. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C23","volume-title":"Statistical Methods for Research Workers","author":"Fisher","year":"1970"},{"key":"key\n\t\t\t\t20171012122714_DDL487C24","volume-title":"Principles of Population Genetics","author":"Hartl","year":"2007"},{"key":"key\n\t\t\t\t20171012122714_DDL487C25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1086\/302698","article-title":"A general test of association for quantitative traits in nuclear families","volume":"66","author":"Abecasis","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/302193","article-title":"Combined linkage and association sib-pair analysis for quantitative traits","volume":"64","author":"Fulker","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.intell.2004.11.005","article-title":"Big-brained people are smarter: a meta-analysis of the relationship between in vivo brain volume and intelligence","volume":"33","author":"McDaniel","year":"2005","journal-title":"Intelligence"},{"key":"key\n\t\t\t\t20171012122714_DDL487C28","doi-asserted-by":"crossref","first-page":"10438","DOI":"10.1073\/pnas.0604066103","article-title":"Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells","volume":"103","author":"Fish","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"key\n\t\t\t\t20171012122714_DDL487C29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0166-2236(95)93934-P","article-title":"A small step for the cell, a giant leap for mankind: a hypothesis of neocortical expansion during evolution","volume":"18","author":"Rakic","year":"1995","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20171012122714_DDL487C30","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/j.1469-8749.1991.tb14813.x","article-title":"The predictive value of microcephaly during the first year of life for mental retardation at 7 years","volume":"33","author":"Dolk","year":"1991","journal-title":"Dev. Med. Child Neurol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature04103","article-title":"Molecular insights into human brain evolution","volume":"437","author":"Hill","year":"2005","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012122714_DDL487C32","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1101\/gr.3737405","article-title":"Comparing the human and chimpanzee genomes: searching for needles in a haystack","volume":"15","author":"Varki","year":"2005","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20171012122714_DDL487C33","doi-asserted-by":"crossref","first-page":"R283","DOI":"10.1016\/j.cub.2005.04.015","article-title":"Selection and the origin of species","volume":"15","author":"Albert","year":"2005","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C34","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/dvdy.20564","article-title":"Fishing for the secrets of vertebrate evolution in threespine sticklebacks","volume":"234","author":"Peichel","year":"2005","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20171012122714_DDL487C35","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1126\/science.1086807","article-title":"Gene expression profiles in the brain predict behavior in individual honey bees","volume":"302","author":"Whitfield","year":"2003","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012122714_DDL487C36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-294X.2004.02378.x","article-title":"Quantitative trait locus mapping in natural populations: progress, caveats and future directions","volume":"14","author":"Slate","year":"2005","journal-title":"Mol. Ecol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C37","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.intell.2006.03.010","article-title":"The phenotypic and genotypic relation between working memory speed and capacity","volume":"34","author":"Polderman","year":"2006","journal-title":"Intelligence"},{"key":"key\n\t\t\t\t20171012122714_DDL487C38","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1086\/432647","article-title":"A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p","volume":"77","author":"Posthuma","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20171012122714_DDL487C39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1375\/twin.4.1.48","article-title":"Genetics of cognition: outline of a collaborative twin study","volume":"4","author":"Wright","year":"2001","journal-title":"Twin Res."},{"key":"key\n\t\t\t\t20171012122714_DDL487C40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1037\/0022-3514.86.1.130","article-title":"The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947","volume":"86","author":"Deary","year":"2004","journal-title":"J. Pers. Soc. Psychol."},{"key":"key\n\t\t\t\t20171012122714_DDL487C41","volume-title":"Wechsler Intelligence Scale for Children-Revised. Dutch Version","author":"Van Haasen","year":"1986"},{"key":"key\n\t\t\t\t20171012122714_DDL487C42","volume-title":"WAIS-III Weschler Adult Intelligence Scale","author":"Wechsler","year":"1997"},{"key":"key\n\t\t\t\t20171012122714_DDL487C43","volume-title":"Multidimensional Aptitude Battery II","author":"Jackson","year":"1998"},{"key":"key\n\t\t\t\t20171012122714_DDL487C44","article-title":"The intelligence of Scottish children: a national survey of an age-group","author":"Scottish Council for Research in Education","year":"1933"},{"key":"key\n\t\t\t\t20171012122714_DDL487C45","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0160-2896(99)00031-8","article-title":"The stability of individual differences in mental ability from childhood to old age: follow-up of the 1932 Scottish Mental Survey","volume":"28","author":"Deary","year":"2000","journal-title":"Intelligence"},{"key":"key\n\t\t\t\t20171012122714_DDL487C46","volume-title":"Manual for Raven's Progressive Matrices and Vocabulary Scales","author":"Raven","year":"1977"},{"key":"key\n\t\t\t\t20171012122714_DDL487C47","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1017\/S0033291701003634","article-title":"The NART as an index of prior intellectual functioning: a retrospective validity study covering a 66-year interval","volume":"31","author":"Crawford","year":"2001","journal-title":"Psychol. Med."},{"key":"key\n\t\t\t\t20171012122714_DDL487C48","volume-title":"National Adult Reading Test (NART) test manual (Part 1)","author":"Nelson","year":"1982"},{"key":"key\n\t\t\t\t20171012122714_DDL487C49","volume-title":"National Adult Reading Test (NART) test manual (Part 2)","author":"Nelson","year":"1991"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/16\/6\/600\/1680080\/ddl487.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T11:55:32Z","timestamp":1628337332000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/hmg\/article\/16\/6\/600\/610971\/The-ongoing-adaptive-evolution-of-ASPM-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,12]]},"references-count":49,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,1,12]]},"published-print":{"date-parts":[[2007,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddl487","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1061848.513792","asserted-by":"object"}]},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,3,15]]},"published":{"date-parts":[[2007,1,12]]}}}