{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:14:00Z","timestamp":1791036840520,"version":"4.1.0"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Rett syndrome (RTT) is an X-linked neurodevelopmental disorder linked to heterozygous de novo mutations in the MECP2 gene. MECP2 encodes methyl-CpG-binding protein 2 (MeCP2), which represses gene transcription by binding to 5-methylcytosine residues in symmetrically positioned CpG dinucleotides. Direct MeCP2 targets underlying RTT pathogenesis remain largely unknown. Here, we report that FXYD1, which encodes a transmembrane modulator of Na+,K+-ATPase activity, is elevated in frontal cortex (FC) neurons of RTT patients and Mecp2-null mice. Increasing neuronal FXDY1 expression is sufficient to reduce dendritic arborization and spine formation, hallmarks of RTT neuropathology. Mecp2-null mouse cortical neurons have diminished Na+,K+-ATPase activity, suggesting that aberrant FXYD1 expression contributes to abnormal neuronal activity in RTT. MeCP2 represses Fxyd1 transcription through direct interactions with sequences in the Fxyd1 promoter that are methylated in FC neurons. FXYD1 is therefore a MeCP2 target gene whose de-repression may directly contribute to RTT neuronal pathogenesis.<\/jats:p>","DOI":"10.1093\/hmg\/ddm007","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:05:16Z","timestamp":1171933516000},"page":"640-650","source":"Crossref","is-referenced-by-count":138,"title":["<i>FXYD1<\/i> is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and <i>Mecp2<\/i>-null mice"],"prefix":"10.1093","volume":"16","author":[{"given":"Vivianne","family":"Deng","sequence":"first","affiliation":[{"name":"Oregon National Primate Research Center 1 \u00a0 Division of Neuroscience , , Beaverton, OR , USA ,"},{"name":"School of Medicine Graduate Program 2 \u00a0 , Department of Cell and Developmental Biology ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Matagne","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center 1 \u00a0 Division of Neuroscience , , Beaverton, OR , USA ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Banine","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center 1 \u00a0 Division of Neuroscience , , Beaverton, OR , USA ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Frerking","sequence":"additional","affiliation":[{"name":"Neurological Sciences Institute 3 \u00a0 ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ohliger","sequence":"additional","affiliation":[{"name":"Neurological Sciences Institute 3 \u00a0 ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarojini","family":"Budden","sequence":"additional","affiliation":[{"name":"Oregon Health and Science University 4 \u00a0 Division of Developmental Pediatrics , , Portland, OR , USA ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Pevsner","sequence":"additional","affiliation":[{"name":"Kennedy Krieger Institute 5 \u00a0 Department of Neurology , and"},{"name":"Johns Hopkins School of Medicine 6 \u00a0 Department of Neuroscience , , Baltimore, MD , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Dissen","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center 1 \u00a0 Division of Neuroscience , , Beaverton, OR , USA ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry S.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center 1 \u00a0 Division of Neuroscience , , Beaverton, OR , USA ,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio R.","family":"Ojeda","sequence":"additional","affiliation":[{"name":"Oregon National Primate Research Center 1 \u00a0 Division of Neuroscience , , Beaverton, OR , USA ,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,2,19]]},"reference":[{"key":"2022053122003768400_DDM007C1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ana.410420104","article-title":"Rett syndrome: a disorder affecting early brain growth","volume":"42","author":"Naidu","year":"1997","journal-title":"Ann. Neurol."},{"key":"2022053122003768400_DDM007C2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg1878","article-title":"Molecular genetics of Rett syndrome: when DNA methylation goes unrecognized","volume":"7","author":"Bienvenu","year":"2006","journal-title":"Nat. Rev. Genet."},{"key":"2022053122003768400_DDM007C3","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/hmg\/9.9.1377","article-title":"MECP2 mutations account for most cases of typical forms of Rett syndrome","volume":"9","author":"Bienvenu","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"2022053122003768400_DDM007C4","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG binding protein 2","volume":"23","author":"Amir","year":"1999","journal-title":"Nat. Genet."},{"key":"2022053122003768400_DDM007C5","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1086\/302690","article-title":"Rett syndrome and beyond: recurrent spontaneous and familial MECP2 mutations at CpG hotspots","volume":"65","author":"Wan","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"2022053122003768400_DDM007C6","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1093\/hmg\/ddh282","article-title":"Mild overexpression of MeCP2 causes a progressive neurological disorder in mice","volume":"13","author":"Collins","year":"2004","journal-title":"Hum. Mol. Genet."},{"key":"2022053122003768400_DDM007C7","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.gde.2006.04.009","article-title":"MeCP2 dysfunction in Rett syndrome and related disorders","volume":"16","author":"Moretti","year":"2006","journal-title":"Curr. Opin. Genet. Dev."},{"key":"2022053122003768400_DDM007C8","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/85480","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"327","author":"Chen","year":"2001","journal-title":"Nat. Genet."},{"key":"2022053122003768400_DDM007C9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"Guy","year":"2001","journal-title":"Nat. Genet."},{"key":"2022053122003768400_DDM007C10","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mcn.2004.07.006","article-title":"MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions","volume":"27","author":"Kishi","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"2022053122003768400_DDM007C11","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"key":"2022053122003768400_DDM007C12","doi-asserted-by":"crossref","first-page":"34115","DOI":"10.1074\/jbc.M105747200","article-title":"The Ski protein family is required for MeCP2-mediated transcriptional repression","volume":"276","author":"Kokura","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2022053122003768400_DDM007C13","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1093\/nar\/21.21.4886","article-title":"Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2","volume":"21","author":"Nan","year":"1993","journal-title":"Nucleic Acids Res."},{"key":"2022053122003768400_DDM007C14","doi-asserted-by":"crossref","first-page":"15536","DOI":"10.1073\/pnas.242566899","article-title":"Transcriptional profiling of a mouse model for Rett syndrome reveals subtle transcriptional changes in the brain","volume":"99","author":"Tudor","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022053122003768400_DDM007C15","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.0401626101","article-title":"Expression of MeCP2 in postmitotic neurons rescues Rett syndrome in mice","volume":"101","author":"Luikenhuis","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022053122003768400_DDM007C16","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1126\/science.1090842","article-title":"DNA methylation-related chromatin remodeling in activity-dependent Bdnf gene regulation","volume":"302","author":"Martinowich","year":"2003","journal-title":"Science"},{"key":"2022053122003768400_DDM007C17","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neuron.2005.12.027","article-title":"The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression","volume":"49","author":"Chang","year":"2006","journal-title":"Neuron"},{"key":"2022053122003768400_DDM007C18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/ng1491","article-title":"Loss of silent-chromatin looping and impaired imprinting of DLX5 in Rett syndrome","volume":"37","author":"Horike","year":"2005","journal-title":"Nat. Genet."},{"key":"2022053122003768400_DDM007C19","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1093\/hmg\/ddl124","article-title":"Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome","volume":"15","author":"Peddada","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"2022053122003768400_DDM007C20","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1093\/hmg\/ddi229","article-title":"Up-regulation of glucocorticoid-regulated genes in a mouse model of Rett syndrome","volume":"14","author":"Nuber","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"2022053122003768400_DDM007C21","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1128\/MCB.01665-05","article-title":"Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome","volume":"26","author":"Kriaucionis","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"2022053122003768400_DDM007C22","doi-asserted-by":"crossref","first-page":"18267","DOI":"10.1073\/pnas.0608702103","article-title":"Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome","volume":"103","author":"McGill","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022053122003768400_DDM007C23","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.tibs.2005.12.008","article-title":"Genomic DNA methylation: the mark and its mediators","volume":"31","author":"Klose","year":"2006","journal-title":"Trends Biochem. Sci."},{"key":"2022053122003768400_DDM007C24","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1006\/nbdi.2001.0428","article-title":"Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification","volume":"8","author":"Colantuoni","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"2022053122003768400_DDM007C25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00005072-199503000-00006","article-title":"Selective dendritic alterations in the cortex of Rett syndrome","volume":"54","author":"Armstrong","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2022053122003768400_DDM007C26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00005072-199811000-00003","article-title":"Decreased dendritic branching in frontal, motor and limbic cortex in Rett syndrome compared with trisomy 21","volume":"57","author":"Armstrong","year":"1998","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"2022053122003768400_DDM007C27","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s004010050582","article-title":"Morphological study of neocortical areas in Rett syndrome","volume":"93","author":"Belichenko","year":"1997","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"2022053122003768400_DDM007C28","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)00125-Z","article-title":"Studies on the 3-dimensional architecture of dendritic spines and varicosities in human cortex by confocal laser scanning microscopy and Lucifer yellow microinjections","volume":"57","author":"Belichenko","year":"1995","journal-title":"J. Neurosci. Methods"},{"key":"2022053122003768400_DDM007C29","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neuroscience.2003.11.025","article-title":"Developmental expression of methyl-CpG binding protein 2 is dynamically regulated in the rodent brain","volume":"123","author":"Mullaney","year":"2004","journal-title":"Neuroscience"},{"key":"2022053122003768400_DDM007C30","doi-asserted-by":"crossref","first-page":"11476","DOI":"10.1073\/pnas.182267299","article-title":"Phospholemman (FXYD1) associates with Na,K-ATPase and regulates its transport properties","volume":"99","author":"Crambert","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022053122003768400_DDM007C31","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1523\/JNEUROSCI.23-06-02161.2003","article-title":"Phospholemman, a single-span membrane protein, is an accessory protein of Na,K-ATPase in cerebellum and choroid plexus","volume":"23","author":"Feschenko","year":"2003","journal-title":"J. Neurosci."},{"key":"2022053122003768400_DDM007C32","doi-asserted-by":"crossref","first-page":"re 1","DOI":"10.1126\/stke.2003.166.re1","article-title":"FXYD proteins: new tissue-specific regulators of the ubiquitous Na,K-ATPase","volume":"2003","author":"Crambert","year":"2003","journal-title":"Sci. STKE"},{"key":"2022053122003768400_DDM007C33","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1006\/geno.1997.4665","article-title":"Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1","volume":"41","author":"Chen","year":"1997","journal-title":"Genomics"},{"key":"2022053122003768400_DDM007C34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"2022053122003768400_DDM007C35","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1177\/08830738050200091001","article-title":"Dissecting MECP2 function in the central nervous system","volume":"20","author":"Kishi","year":"2005","journal-title":"J. Child Neurol."},{"key":"2022053122003768400_DDM007C36","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1152\/japplphysiol.00757.2005","article-title":"Phospholemman overexpression inhibits Na+-K+-ATPase in adult rat cardiac myocytes: relevance to decreased Na+ pump activity in postinfarction myocytes","volume":"100","author":"Zhang","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"2022053122003768400_DDM007C37","doi-asserted-by":"crossref","first-page":"H1982","DOI":"10.1152\/ajpheart.00142.2004","article-title":"Hypertrophy, increased ejection fraction, and reduced Na,K-ATPase activity in phospholemman-deficient mice","volume":"288","author":"Jia","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2022053122003768400_DDM007C38","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1152\/jn.00244.2002","article-title":"Mechanisms of neuronal hyperexcitability caused by partial inhibition of Na + -K + -ATPases in the rat CA1 hippocampal region","volume":"88","author":"Vaillend","year":"2002","journal-title":"J. Neurophysiol."},{"key":"2022053122003768400_DDM007C39","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1152\/jn.1987.57.2.496","article-title":"Sodium-potassium pump inhibitors increase neuronal excitability in the rat hippocampal slice: role of a Ca2 + -dependent conductance","volume":"57","author":"McCarren","year":"1987","journal-title":"J. Neurophysiol."},{"key":"2022053122003768400_DDM007C40","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1528-1157.1995.tb01012.x","article-title":"Regional distributions of hippocampal Na +,K(+)-ATPase, cytochrome oxidase, and total protein in temporal lobe epilepsy","volume":"36","author":"Brines","year":"1995","journal-title":"Epilepsia"},{"key":"2022053122003768400_DDM007C41","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.1073\/pnas.0506071102","article-title":"Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome","volume":"102","author":"Dani","year":"2005","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022053122003768400_DDM007C42","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1523\/JNEUROSCI.2623-05.2006","article-title":"Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome","volume":"26","author":"Moretti","year":"2006","journal-title":"J. Neurosci."},{"key":"2022053122003768400_DDM007C43","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.cub.2006.02.062","article-title":"MeCP2-dependent transcriptional repression regulates excitatory neurotransmission","volume":"16","author":"Nelson","year":"2006","journal-title":"Curr. Biol."},{"key":"2022053122003768400_DDM007C44","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.nbd.2005.07.005","article-title":"Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome","volume":"21","author":"Asaka","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"2022053122003768400_DDM007C45","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neuron.2006.09.037","article-title":"Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation","volume":"52","author":"Zhou","year":"2006","journal-title":"Neuron"},{"key":"2022053122003768400_DDM007C46","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.10674","article-title":"Novel mutations in the Na +, K + -ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions","volume":"54","author":"Vanmolkot","year":"2003","journal-title":"Ann. Neurol."},{"key":"2022053122003768400_DDM007C47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuron.2004.06.028","article-title":"Mutations in the Na + \/K + -ATPase alpha3 gene ATP1A3 are associated with rapid-onset dystonia parkinsonism","volume":"43","author":"de Carvalho Aguiar","year":"2004","journal-title":"Neuron"},{"key":"2022053122003768400_DDM007C48","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1074\/jbc.M211315200","article-title":"The Na,K-ATPase alpha 2 isoform is expressed in neurons, and its absence disrupts neuronal activity in newborn mice","volume":"278","author":"Moseley","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2022053122003768400_DDM007C49","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1001\/archpsyc.59.7.631","article-title":"Gene expression profile for schizophrenia: discrete neuron transcription patterns in the entorhinal cortex","volume":"59","author":"Hemby","year":"2002","journal-title":"Arch. Gen. Psychiatry"},{"key":"2022053122003768400_DDM007C50","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1523\/JNEUROSCI.23-09-03807.2003","article-title":"Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment","volume":"23","author":"Blalock","year":"2003","journal-title":"J. Neurosci."},{"key":"2022053122003768400_DDM007C51","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1210\/endo.143.4.8711","article-title":"Nerve growth factor induces the expression of functional FSH receptors in newly formed follicles of the rat ovary","volume":"143","author":"Romero","year":"2002","journal-title":"Endocrinology"},{"key":"2022053122003768400_DDM007C52","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0006-8993(01)03367-4","article-title":"Apolipoprotein E4 inhibits, and apolipoprotein E3 promotes neurite outgrowth in cultured adult mouse cortical neurons through the low-density lipoprotein receptor-related protein","volume":"928","author":"Nathan","year":"2002","journal-title":"Brain Res."},{"key":"2022053122003768400_DDM007C53","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1074\/jbc.M007096200","article-title":"Evidence that silencing of the HPRT promoter by DNA methylation is mediated by critical CpG sites","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"2022053122003768400_DDM007C54","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.89.5.1827","article-title":"A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands","volume":"89","author":"Frommer","year":"1992","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2022053122003768400_DDM007C55","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/2194","article-title":"Synaptic activation of kainate receptors on hippocampal interneurons","volume":"1","author":"Frerking","year":"1998","journal-title":"Nat. Neurosci."},{"key":"2022053122003768400_DDM007C56","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1152\/jn.1990.63.2.225","article-title":"Role of Na-K pump potassium regulation and IPSPs in seizures and spreading depression in immature rabbit hippocampal slices","volume":"63","author":"Haglund","year":"1990","journal-title":"J. Neurophysiol."},{"key":"2022053122003768400_DDM007C57","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1152\/jn.2000.84.3.1355","article-title":"Hyperthermic spreading depressions in the immature rat hippocampal slice","volume":"84","author":"Wu","year":"2000","journal-title":"J. Neurophysiol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/16\/6\/640\/43890190\/hmg_16_6_640.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/hmg\/article-pdf\/16\/6\/640\/43890190\/hmg_16_6_640.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,31]],"date-time":"2022-05-31T22:01:14Z","timestamp":1654034474000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article\/16\/6\/640\/611806"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,19]]},"references-count":57,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,2,19]]},"published-print":{"date-parts":[[2007,3,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddm007","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,3,15]]},"published":{"date-parts":[[2007,2,19]]}}}