{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:38:08Z","timestamp":1792057088792,"version":"4.4.0"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,15]]},"DOI":"10.1093\/hmg\/ddm292","type":"journal-article","created":{"date-parts":[[2007,10,6]],"date-time":"2007-10-06T20:25:18Z","timestamp":1191702318000},"page":"159-169","source":"Crossref","is-referenced-by-count":121,"title":["The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment"],"prefix":"10.1093","volume":"17","author":[{"given":"Lut","family":"Van Laer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Els","family":"Van Eyken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Fransen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen R.","family":"Huyghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vedat","family":"Topsakal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Jaap","family":"Hendrickx","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuli","family":"Hannula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elina","family":"M\u00e4ki-Torkko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Demeester","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Baur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Bonaconsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Mazzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angeles","family":"Espeso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Verbruggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"Huyghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Huygen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Kunst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minna","family":"Manninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelies","family":"Konings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia N.","family":"Diaz-Lacava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Steffens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Wienker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilmari","family":"Pyykk\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cor W.R.J.","family":"Cremers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannie","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Dhooge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafydd","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Orzan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnete","family":"Parving","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martti","family":"Sorri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul H.","family":"Van de Heyning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Van Camp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,6]]},"reference":[{"key":"key\n\t\t\t\t20170522122608_DDM292C1","first-page":"43","article-title":"Prevalence of hearing impairment","volume-title":"Hearing in Adults","author":"Davis","year":"1994"},{"key":"key\n\t\t\t\t20170522122608_DDM292C2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00003446-199704000-00003","article-title":"Description and primary results from an audiometric study of male twins","volume":"18","author":"Karlsson","year":"1997","journal-title":"Ear Hear."},{"key":"key\n\t\t\t\t20170522122608_DDM292C3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/gerona\/62.4.447","article-title":"Genetic and environmental influences on hearing in older women","volume":"62","author":"Viljanen","year":"2007","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"key\n\t\t\t\t20170522122608_DDM292C4","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1046\/j.1532-5415.2001.4911245.x","article-title":"Genetic and environmental influences on self-reported reduced hearing in the old and oldest old","volume":"49","author":"Christensen","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"key\n\t\t\t\t20170522122608_DDM292C5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1001\/archotol.125.6.654","article-title":"Genetic associations in age-related hearing thresholds","volume":"125","author":"Gates","year":"1999","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"key\n\t\t\t\t20170522122608_DDM292C6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/00003446-199202000-00006","article-title":"The relative contributions of occupational noise and aging in individual cases of hearing loss","volume":"13","author":"Dobie","year":"1992","journal-title":"Ear Hear."},{"key":"key\n\t\t\t\t20170522122608_DDM292C7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/00206099209072911","article-title":"Support for Corso\u2019s hearing loss model. Relating aging and noise exposure","volume":"31","author":"Corso","year":"1992","journal-title":"Audiology"},{"key":"key\n\t\t\t\t20170522122608_DDM292C8","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0378-5955(95)00226-X","article-title":"Genetics of age-related hearing loss in mice. III. Susceptibility of inbred and F1 hybrid strains to noise-induced hearing loss","volume":"93","author":"Erway","year":"1996","journal-title":"Hear. Res."},{"key":"key\n\t\t\t\t20170522122608_DDM292C9","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3109\/00206099309072939","article-title":"Correlations between presbyacusis and extrinsic noxious factors","volume":"32","author":"Rosenhall","year":"1993","journal-title":"Audiology"},{"key":"key\n\t\t\t\t20170522122608_DDM292C10","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1749-6632.1999.tb08656.x","article-title":"Gender-specific effects of drugs on hearing levels of older persons","volume":"884","author":"Mills","year":"1999","journal-title":"Ann. NY Acad. Sci."},{"key":"key\n\t\t\t\t20170522122608_DDM292C11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1177\/019459989210600611","article-title":"Hearing: the effects of chemicals","volume":"106","author":"Rybak","year":"1992","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"key\n\t\t\t\t20170522122608_DDM292C12","first-page":"623","article-title":"Effects of industrial solvents on hearing","volume":"10","author":"Johnson","year":"1995","journal-title":"Occup. Med."},{"key":"key\n\t\t\t\t20170522122608_DDM292C13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1017\/S0022215100108345","article-title":"Hearing threshold in patients with diabetes mellitus","volume":"103","author":"Kurien","year":"1989","journal-title":"J. Laryngol. Otol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1001\/archotol.1993.01880140038006","article-title":"The relation of hearing in the elderly to the presence of cardiovascular disease and cardiovascular risk factors","volume":"119","author":"Gates","year":"1993","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"key\n\t\t\t\t20170522122608_DDM292C15","first-page":"54","article-title":"Audiological findings in elderly patients with chronic renal failure","volume":"476","author":"Antonelli","year":"1990","journal-title":"Acta Otolaryngol. Suppl."},{"key":"key\n\t\t\t\t20170522122608_DDM292C16","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0378-5955(95)00107-F","article-title":"Genetics of age-related hearing loss in mice. II. Strain differences and effects of caloric restriction on cochlear pathology and evoked response thresholds","volume":"88","author":"Willott","year":"1995","journal-title":"Hear. Res."},{"key":"key\n\t\t\t\t20170522122608_DDM292C17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/ajcn\/69.3.564","article-title":"Age-related hearing loss, vitamin B-12, and folate in elderly women","volume":"69","author":"Houston","year":"1999","journal-title":"Am. J. Clin. Nutr."},{"key":"key\n\t\t\t\t20170522122608_DDM292C18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00005537-200005000-00003","article-title":"Effects of dietary restriction and antioxidants on presbyacusis","volume":"110","author":"Seidman","year":"2000","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20170522122608_DDM292C19","first-page":"192","article-title":"Smoking and drinking habits as risk factors for hearing loss in the elderly: epidemiological study of subjects undergoing routine health checks in Aichi, Japan","volume":"115","author":"Itoh","year":"2001","journal-title":"Public Health"},{"key":"key\n\t\t\t\t20170522122608_DDM292C20","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1001\/jama.279.21.1715","article-title":"Cigarette smoking and hearing loss: the epidemiology of hearing loss study","volume":"279","author":"Cruickshanks","year":"1998","journal-title":"J. Am. Med. Assoc."},{"key":"key\n\t\t\t\t20170522122608_DDM292C21","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1532-5415.2000.tb02601.x","article-title":"Moderate alcohol consumption and hearing loss: a protective effect","volume":"48","author":"Popelka","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"key\n\t\t\t\t20170522122608_DDM292C22","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1007\/s00198-005-1902-8","article-title":"Hearing sensitivity and bone mineral density in older adults: the health, aging and body composition study","volume":"16","author":"Helzner","year":"2005","journal-title":"Osteoporos. Int."},{"key":"key\n\t\t\t\t20170522122608_DDM292C23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/1047-2797(94)00035-R","article-title":"Age-related hearing loss and bone mass in a population of rural women aged 60 to 85 years","volume":"5","author":"Clark","year":"1995","journal-title":"Ann. Epidemiol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C24","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.annepidem.2003.09.008","article-title":"Hearing sensitivity and the risk of incident falls and fracture in older women: the study of osteoporotic fractures","volume":"14","author":"Purchase-Helzner","year":"2004","journal-title":"Ann. Epidemiol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1001\/archotol.132.5.506","article-title":"Hearing impairment susceptibility in elderly men and the DFNA18 locus","volume":"132","author":"Garringer","year":"2006","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"key\n\t\t\t\t20170522122608_DDM292C26","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/archotol.129.3.285","article-title":"Genomewide linkage analysis to presbycusis in the Framingham heart study","volume":"129","author":"DeStefano","year":"2003","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"key\n\t\t\t\t20170522122608_DDM292C27","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/01.mao.0000169774.23668.f1","article-title":"Glutathione S-transferase gene polymorphisms in presbycusis","volume":"26","author":"Ates","year":"2005","journal-title":"Otol. Neurotol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C28","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.ejhg.5200878","article-title":"Is DFNA5 a susceptibility gene for age-related hearing impairment?","volume":"10","author":"Van Laer","year":"2002","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522122608_DDM292C29","first-page":"970","article-title":"The contribution of GJB2 (Connexin 26) 35delG to age-related hearing impairment and noise-induced hearing loss","volume":"28","author":"Van Eyken","year":"2007","journal-title":"Otol. Neurotol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C30","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1097\/01.mlg.0000183694.10583.12","article-title":"N-acetyltransferase 2 gene polymorphism and presbycusis","volume":"115","author":"Unal","year":"2005","journal-title":"Laryngoscope"},{"key":"key\n\t\t\t\t20170522122608_DDM292C31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jmg.2007.049205","article-title":"The N-acetyltransferase 2 polymorphism NAT2*6A is a causative factor for age related hearing impairment","volume":"44","author":"Van Eyken","year":"2007","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170522122608_DDM292C32","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/humu.20375","article-title":"KCNQ4: a gene for age-related hearing impairment?","volume":"27","author":"Van Eyken","year":"2006","journal-title":"Hum. Mutat."},{"key":"key\n\t\t\t\t20170522122608_DDM292C33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/14992020601145294","article-title":"Apolipoprotein E alleles and sensorineural hearing loss","volume":"46","author":"O\u2019Grady","year":"2007","journal-title":"Int. J. Audiol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C34","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0925-4773(02)00046-1","article-title":"A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead","volume":"114","author":"Wilanowski","year":"2002","journal-title":"Mech. Dev."},{"key":"key\n\t\t\t\t20170522122608_DDM292C35","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1093\/hmg\/11.23.2877","article-title":"Mutation of a transcription factor, TFCP2L3, causes progressive autosomal dominant hearing loss, DFNA28","volume":"11","author":"Peters","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122608_DDM292C36","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1042\/bj20021476","article-title":"The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors","volume":"370","author":"Ting","year":"2003","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170522122608_DDM292C37","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.modgep.2006.03.011","article-title":"Spatial and temporal expression of the Grainyhead-like transcription factor family during murine development","volume":"6","author":"Auden","year":"2006","journal-title":"Gene Expr. Patterns"},{"key":"key\n\t\t\t\t20170522122608_DDM292C38","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/hmg\/10.3.195","article-title":"Mutations in the transcriptional activator EYA4 cause late-onset deafness at the DFNA10 locus","volume":"10","author":"Wayne","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522122608_DDM292C39","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1126\/science.279.5358.1950","article-title":"Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans","volume":"279","author":"Vahava","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522122608_DDM292C40","article-title":"Audiometric characteristics of a Dutch DFNA15 family with a novel mutation in POU4F3, p.L289F","author":"Pauw","year":"2007","journal-title":"Arch. Otolaryngol. Head Neck Surg,"},{"key":"key\n\t\t\t\t20170522122608_DDM292C41","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/ng1732","article-title":"Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes","volume":"38","author":"Grant","year":"2006","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522122608_DDM292C42","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.2337\/db06-0355","article-title":"Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk","volume":"55","author":"Groves","year":"2006","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20170522122608_DDM292C43","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/dbio.1995.8050","article-title":"Developmental role of transcription factor isoforms generated by alternative splicing","volume":"172","author":"Lopez","year":"1995","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522122608_DDM292C44","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/01.AUD.0000120362.69077.0B","article-title":"A novel Z-score-based method to analyze candidate genes for age-related hearing impairment","volume":"25","author":"Fransen","year":"2004","journal-title":"Ear Hear."},{"key":"key\n\t\t\t\t20170522122608_DDM292C45","article-title":"Acoustics \u2013 Statistical distribution of hearing thresholds as a function of age","volume-title":"International Standard","author":"International Organization for Standardization","year":"2000"},{"key":"key\n\t\t\t\t20170522122608_DDM292C46","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1101\/gr.142200","article-title":"Active conservation of noncoding sequences revealed by three-way species comparisons","volume":"10","author":"Dubchak","year":"2000","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170522122608_DDM292C47","doi-asserted-by":"crossref","first-page":"W273","DOI":"10.1093\/nar\/gkh458","article-title":"VISTA: computational tools for comparative genomics","volume":"32","author":"Frazer","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170522122608_DDM292C48","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1469-1809.2002.00109.x","article-title":"A quick and simple method for detecting subjects with abnormal genetic background in case-control samples","volume":"66","author":"Curtis","year":"2002","journal-title":"Ann. Hum. Genet."},{"key":"key\n\t\t\t\t20170522122608_DDM292C49","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1093\/bioinformatics\/17.8.742","article-title":"GRR: graphical representation of relationship errors","volume":"17","author":"Abecasis","year":"2001","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20170522122608_DDM292C50","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000095850","article-title":"SNP-based analysis of genetic substructure in the German population","volume":"62","author":"Steffens","year":"2006","journal-title":"Hum. Hered."},{"key":"key\n\t\t\t\t20170522122608_DDM292C51","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"Storey","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522122608_DDM292C52","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat. Genet."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/17\/2\/159\/17245099\/ddm292.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T11:40:17Z","timestamp":1556883617000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddm292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,6]]},"references-count":52,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,10,6]]},"published-print":{"date-parts":[[2008,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddm292","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10,6]]}}}