{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:32:52Z","timestamp":1790379172178,"version":"4.1.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,1,15]]},"DOI":"10.1093\/hmg\/ddm301","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T20:34:26Z","timestamp":1192739666000},"page":"240-255","source":"Crossref","is-referenced-by-count":79,"title":["HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity"],"prefix":"10.1093","volume":"17","author":[{"given":"Swasti","family":"Raychaudhuri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mithun","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debashis","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitai P.","family":"Bhattacharyya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"key\n\t\t\t\t20170522164148_DDM301C1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"The Huntington\u2019s Disease Collaborative Research Group","year":"1993","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522164148_DDM301C2","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.1124514","article-title":"Progressive disruption of cellular protein folding in models of polyglutamine diseases","volume":"311","author":"Gidalevitz","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522164148_DDM301C3","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0896-6273(00)80405-5","article-title":"Intranuclear neuronal inclusions: a common pathogenic mechanism for glutamine-repeat neurodegenerative diseases?","volume":"19","author":"Ross","year":"1997","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522164148_DDM301C4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02998","article-title":"Inclusion body formation reduces levels of mutant Huntingtin and the risk of neuronal death","volume":"431","author":"Arrasate","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522164148_DDM301C5","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.tig.2004.01.008","article-title":"Huntingtin\u2013protein interactions and the pathogenesis of Huntington\u2019s disease","volume":"20","author":"Li","year":"2004","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C6","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/hmg\/7.9.1463","article-title":"Huntingtin interacts with a family of WW domain proteins","volume":"7","author":"Faber","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C7","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/hmg\/9.14.2175","article-title":"Huntingtin\u2019s WW domain partners in Huntington\u2019s disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington\u2019s disease pathogenesis","volume":"9","author":"Passani","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1006\/mcne.2001.1004","article-title":"Identification of the full-length Huntingtin-interacting protein p231HBP\/HYPB as a DNA-binding factor","volume":"18","author":"Rega","year":"2001","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C9","doi-asserted-by":"crossref","first-page":"34840","DOI":"10.1074\/jbc.M504508200","article-title":"Inhibition of metabotropic glutamate receptor signaling by the Huntingtin-binding protein optineurin","volume":"280","author":"Anborgh","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522164148_DDM301C10","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuron.2004.11.027","article-title":"Huntingtin-interacting protein HIP14 is a palmitoyl transferase involved in palmitoylation and trafficking of multiple neuronal proteins","volume":"44","author":"Huang","year":"2004","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522164148_DDM301C11","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nature750","article-title":"Comparative assessment of large-scale data sets of protein\u2013protein interactions","volume":"417","author":"Von Mering","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522164148_DDM301C12","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.mcn.2005.04.005","article-title":"Evidence for sequestration of polyglutamine inclusions by Drosophila myeloid leukemia factor","volume":"29","author":"Kim","year":"2005","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C13","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0092-8674(00)81369-0","article-title":"Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice","volume":"87","author":"Mangiarini","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522164148_DDM301C14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1097-2765(00)80142-2","article-title":"SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates","volume":"2","author":"Sittler","year":"1998","journal-title":"Mol. Cel."},{"key":"key\n\t\t\t\t20170522164148_DDM301C15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.nbd.2005.11.003","article-title":"Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein HIP1","volume":"22","author":"Majumder","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522164148_DDM301C16","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/ncb1478","article-title":"Cytosolic chaperonine prevents polyglutamine toxicity with altering the aggregation state","volume":"8","author":"Kitamura","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522164148_DDM301C17","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1073\/pnas.042681399","article-title":"Amyloid fibers are water-filled nanotubes","volume":"99","author":"Perutz","year":"2002","journal-title":"Proc. Natl. Acad. Sci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C18","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1073\/pnas.96.8.4604","article-title":"Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington\u2019s disease pathology","volume":"96","author":"Scherzinger","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C19","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/hmg\/ddl017","article-title":"Suppression of polyglutamine-induced toxicity in cell and animal models of Huntington\u2019s disease by ubiquilin","volume":"15","author":"Wang","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C20","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1093\/hmg\/11.21.2657","article-title":"Suppression of polyglutamine toxicity by a Drosophila homolog of myeloid leukemia factor 1","volume":"11","author":"Kazemi-Esfarjani","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0896-6273(02)00761-4","article-title":"Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?","volume":"35","author":"Muchowski","year":"2002","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522164148_DDM301C22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrn1587","article-title":"Modulation of neurodegeneration by molecular chaperones","volume":"6","author":"Muchowski","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C23","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/mt.sj.6300141","article-title":"Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington\u2019s disease","volume":"15","author":"Perrin","year":"2007","journal-title":"Mol. Ther."},{"key":"key\n\t\t\t\t20170522164148_DDM301C24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1471-4159.2005.03119.x","article-title":"Treatment with extracellular HSP70\/HSC70 protein can reduce polyglutamine toxicity and aggregation","volume":"94","author":"Novoselova","year":"2005","journal-title":"J. Neurochem."},{"key":"key\n\t\t\t\t20170522164148_DDM301C25","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neulet.2004.12.031","article-title":"BAG-1 associates with the polyglutamine-expanded huntingtin aggregates","volume":"22","author":"Jana","year":"2005","journal-title":"Neurosci. Lett."},{"key":"key\n\t\t\t\t20170522164148_DDM301C26","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/hmg\/11.9.1137","article-title":"Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin","volume":"11","author":"Wyttenbach","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C27","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1093\/hmg\/ddm057","article-title":"Hsp27 overexpression in the R6\/2 mouse model of Huntington\u2019s disease: chronic neurodegeneration does not induce hsp27 activation","volume":"16","author":"Zourlidou","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522164148_DDM301C28","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1523\/JNEUROSCI.5409-05.2006","article-title":"CA150 Expression delays striatal cell death in overexpression and knock-in conditions for mutant Huntingtin neurotoxicity","volume":"26","author":"Arango","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C29","doi-asserted-by":"crossref","first-page":"10261","DOI":"10.1073\/pnas.0503937102","article-title":"cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila","volume":"102","author":"Iijima-Ando","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mcn.2006.09.006","article-title":"Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death in polyglutamine diseases","volume":"34","author":"de Pril","year":"2007","journal-title":"Mol. Cell Neurosci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C31","doi-asserted-by":"crossref","first-page":"10064","DOI":"10.1073\/pnas.0504400102","article-title":"The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex","volume":"102","author":"Otto","year":"2005","journal-title":"Proc. Natl. Acad. Sci"},{"key":"key\n\t\t\t\t20170522164148_DDM301C32","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S1093-3263(00)00138-8","article-title":"Intrinsically disordered protein","volume":"19","author":"Dunker","year":"2001","journal-title":"J. Mol. Graph. Model."},{"key":"key\n\t\t\t\t20170522164148_DDM301C33","doi-asserted-by":"crossref","first-page":"D786","DOI":"10.1093\/nar\/gkl893","article-title":"DisProt: the database of disordered proteins","volume":"35","author":"Sickmeier","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170522164148_DDM301C34","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/ncb863","article-title":"Polyglutamine protein aggregates are dynamic","volume":"4","author":"Kim","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522164148_DDM301C35","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0896-6273(00)80716-3","article-title":"Caspase 8 is required for cell death induced by expanded polyglutamine repeats","volume":"22","author":"Sanchez","year":"1999","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522164148_DDM301C36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/sj.cdd.4401358","article-title":"Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington\u2019s disease","volume":"11","author":"Hermel","year":"2004","journal-title":"Cell Death Differ."},{"key":"key\n\t\t\t\t20170522164148_DDM301C37","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1523\/JNEUROSCI.4522-06.2007","article-title":"The induction levels of heat shock protein 70 differentiate the vulnerabilities to mutant Huntingtin among neuronal subtypes","volume":"27","author":"Tagawa","year":"2007","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522164148_DDM301C38","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1038\/sj.onc.1207529","article-title":"Molecular chaperones and the stress of oncogenesis","volume":"23","author":"Mosser","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170522164148_DDM301C39","doi-asserted-by":"crossref","first-page":"E145","DOI":"10.1038\/35078615","article-title":"From fixed to FRAP: measuring protein mobility and activity in living cells","volume":"3","author":"Reits","year":"2001","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170522164148_DDM301C40","doi-asserted-by":"crossref","first-page":"55080","DOI":"10.1074\/jbc.M406418200","article-title":"Chaperone activity and prodan binding at the self-associating domain of erythroid spectrin","volume":"279","author":"Bhattacharyya","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522164148_DDM301C41","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1111\/j.1432-1033.2004.04309.x","article-title":"Chaperone activity of recombinant maize chloroplast protein synthesis elongation factor, EF-Tu","volume":"271","author":"Rao","year":"2004","journal-title":"Eur. J. Biochem."},{"key":"key\n\t\t\t\t20170522164148_DDM301C42","doi-asserted-by":"crossref","first-page":"15505","DOI":"10.1074\/jbc.274.22.15505","article-title":"Molecular chaperone-like properties of an unfolded protein, \u03b1-casein","volume":"274","author":"Bhattacharyya","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522164148_DDM301C43","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/nar\/30.5.1278","article-title":"Mutations in domain V of the 23S ribosomal RNA of Bacillus subtilis that inactivate its protein folding property in vitro","volume":"30","author":"Chowdhury","year":"2002","journal-title":"Nucleic Acids Res."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/17\/2\/240\/17245338\/ddm301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T02:06:24Z","timestamp":1503453984000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddm301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,18]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,10,18]]},"published-print":{"date-parts":[[2008,1,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddm301","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1091626.546106","asserted-by":"object"}]},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10,18]]}}}