{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T13:42:36Z","timestamp":1791034956850,"version":"4.1.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,15]]},"DOI":"10.1093\/hmg\/ddp136","type":"journal-article","created":{"date-parts":[[2009,3,21]],"date-time":"2009-03-21T00:45:34Z","timestamp":1237596334000},"page":"2127-2139","source":"Crossref","is-referenced-by-count":19,"title":["Astrocytic protection of spinal motor neurons but not cortical neurons against loss of Als2\/alsin function"],"prefix":"10.1093","volume":"18","author":[{"given":"A.","family":"Jacquier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bellouze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Blanchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Bohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Haase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,3,20]]},"reference":[{"key":"key\n\t\t\t\t20170522145942_DDP136C1","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn1971","article-title":"Molecular biology of amyotrophic lateral sclerosis: insights from genetics","volume":"7","author":"Pasinelli","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2006.09.018","article-title":"ALS: a disease of motor neurons and their nonneuronal neighbors","volume":"52","author":"Boillee","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522145942_DDP136C3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuint.2007.04.010","article-title":"Molecular and cellular function of ALS2\/alsin: implication of membrane dynamics in neuronal development and degeneration","volume":"51","author":"Hadano","year":"2007","journal-title":"Neurochem. Int."},{"key":"key\n\t\t\t\t20170522145942_DDP136C4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/s12035-007-0034-x","article-title":"Alsin and the molecular pathways of amyotrophic lateral sclerosis","volume":"36","author":"Chandran","year":"2007","journal-title":"Mol. Neurobiol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C5","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1212\/01.WNL.0000048207.28790.25","article-title":"Infantile ascending hereditary spastic paralysis (IAHSP): clinical features in 11 families","volume":"60","author":"Lesca","year":"2003","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522145942_DDP136C6","doi-asserted-by":"crossref","first-page":"16041","DOI":"10.1073\/pnas.2635267100","article-title":"Unstable mutants in the peripheral endosomal membrane component ALS2 cause early-onset motor neuron disease","volume":"100","author":"Yamanaka","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145942_DDP136C7","doi-asserted-by":"crossref","first-page":"38626","DOI":"10.1074\/jbc.M406120200","article-title":"Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking","volume":"279","author":"Kunita","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145942_DDP136C8","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1093\/hmg\/ddg184","article-title":"ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics","volume":"12","author":"Otomo","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C9","doi-asserted-by":"crossref","first-page":"4532","DOI":"10.1074\/jbc.M410508200","article-title":"A Rac1\/phosphatidylinositol 3-kinase\/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu\/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death","volume":"280","author":"Kanekura","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145942_DDP136C10","doi-asserted-by":"crossref","first-page":"24612","DOI":"10.1074\/jbc.M313504200","article-title":"Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor","volume":"279","author":"Topp","year":"2004","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145942_DDP136C11","doi-asserted-by":"crossref","first-page":"34735","DOI":"10.1074\/jbc.M506216200","article-title":"ALS2\/alsin regulates Rac-PAK signaling and neurite outgrowth","volume":"280","author":"Tudor","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145942_DDP136C12","doi-asserted-by":"crossref","first-page":"16599","DOI":"10.1074\/jbc.M610682200","article-title":"The Rab5 activator ALS2\/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis","volume":"282","author":"Kunita","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522145942_DDP136C13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1086\/342359","article-title":"Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene","volume":"71","author":"Eymard-Pierre","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C14","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1002\/ana.20879","article-title":"Novel missense mutation in ALS2 gene results in infantile ascending hereditary spastic paralysis","volume":"59","author":"Eymard-Pierre","year":"2006","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C15","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ejhg.2008.108","article-title":"Novel homozygous ALS2 nonsense mutation (p.Gln715X) in sibs with infantile-onset ascending spastic paralysis: the first cases from northwestern Europe","volume":"16","author":"Verschuuren-Bemelmans","year":"2008","journal-title":"Eur. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C16","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ana.10422","article-title":"An ALS2 gene mutation causes hereditary spastic paraplegia in a Pakistani kindred","volume":"53","author":"Gros-Louis","year":"2003","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1034\/j.1399-0004.2003.00138.x","article-title":"The first nonsense mutation in alsin results in a homogeneous phenotype of infantile-onset ascending spastic paralysis with bulbar involvement in two siblings","volume":"64","author":"Devon","year":"2003","journal-title":"Clin. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/ng1001-166","article-title":"A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2","volume":"29","author":"Hadano","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ng1001-160","article-title":"The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis","volume":"29","author":"Yang","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C20","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/ana.20665","article-title":"Novel mutation in the ALS2 gene in juvenile amyotrophic lateral sclerosis","volume":"58","author":"Kress","year":"2005","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C21","doi-asserted-by":"crossref","first-page":"7567","DOI":"10.1523\/JNEUROSCI.1645-05.2005","article-title":"Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress","volume":"25","author":"Cai","year":"2005","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/hmg\/ddi440","article-title":"Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2\/alsin exhibit age-dependent neurological deficits and altered endosome trafficking","volume":"15","author":"Hadano","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C23","doi-asserted-by":"crossref","first-page":"9595","DOI":"10.1073\/pnas.0510197103","article-title":"Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities","volume":"103","author":"Devon","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145942_DDP136C24","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1093\/hmg\/ddm251","article-title":"Distal axonopathy in an alsin-deficient mouse model","volume":"16","author":"Deng","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/ana.20888","article-title":"Progressive spinal axonal degeneration and slowness in ALS2-deficient mice","volume":"60","author":"Yamanaka","year":"2006","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C26","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1093\/hmg\/ddn171","article-title":"Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knockdown zebrafish","volume":"17","author":"Gros-Louis","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C27","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1212\/WNL.47.4_Suppl_2.63S","article-title":"Neuropathology of ALS: an overview","volume":"47","author":"Hirano","year":"1996","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20170522145942_DDP136C28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00005072-199105000-00008","article-title":"Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain","volume":"50","author":"Kushner","year":"1991","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0022-510X(96)00073-1","article-title":"Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis","volume":"139","author":"Schiffer","year":"1996","journal-title":"J. Neurol. Sci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn2047","article-title":"Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis","volume":"11","author":"Yamanaka","year":"2008","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C31","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nn1876","article-title":"Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons","volume":"10","author":"Nagai","year":"2007","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C32","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/nn1885","article-title":"Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model","volume":"10","author":"Di Giorgio","year":"2007","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C33","doi-asserted-by":"crossref","first-page":"14825","DOI":"10.1073\/pnas.0705046104","article-title":"Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity","volume":"104","author":"Van Damme","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522145942_DDP136C34","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.conb.2008.07.013","article-title":"Signaling by death receptors in the nervous system","volume":"18","author":"Haase","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.brainresrev.2004.05.003","article-title":"A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis","volume":"47","author":"Barbeito","year":"2004","journal-title":"Brain Res. Brain Res. Rev."},{"key":"key\n\t\t\t\t20170522145942_DDP136C36","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.nbd.2004.10.002","article-title":"Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood","volume":"18","author":"Devon","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"key\n\t\t\t\t20170522145942_DDP136C37","doi-asserted-by":"crossref","first-page":"11798","DOI":"10.1523\/JNEUROSCI.2084-06.2006","article-title":"Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking","volume":"26","author":"Lai","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ana.20886","article-title":"Alsin\/Rac1 signaling controls survival and growth of spinal motoneurons","volume":"60","author":"Jacquier","year":"2006","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C39","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbrc.2008.01.177","article-title":"ALS2\/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth","volume":"370","author":"Otomo","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"key\n\t\t\t\t20170522145942_DDP136C40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/aja.1001940306","article-title":"Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons","volume":"194","author":"Cashman","year":"1992","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522145942_DDP136C41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/ncpneuro0355","article-title":"Mechanisms of disease: astrocytes in neurodegenerative disease","volume":"2","author":"Maragakis","year":"2006","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C42","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn1722","article-title":"Astrocytes, from brain glue to communication elements: the revolution continues","volume":"6","author":"Volterra","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1023\/B:NEUR.0000046576.70319.3a","article-title":"Neurite outgrowth from hippocampal neurons is promoted by choroid plexus ependymal cells in vitro","volume":"33","author":"Kimura","year":"2004","journal-title":"J. Neurocytol."},{"key":"key\n\t\t\t\t20170522145942_DDP136C44","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1523\/JNEUROSCI.08-04-01454.1988","article-title":"The establishment of polarity by hippocampal neurons in culture","volume":"8","author":"Dotti","year":"1988","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C45","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nn1789","article-title":"IGF-I specifically enhances axon outgrowth of corticospinal motor neurons","volume":"9","author":"Ozdinler","year":"2006","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C46","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0092-8674(02)00835-8","article-title":"Directed differentiation of embryonic stem cells into motor neurons","volume":"110","author":"Wichterle","year":"2002","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522145942_DDP136C47","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1038\/sj.emboj.7600988","article-title":"Neuronal survival depends on EGFR signaling in cortical but not midbrain astrocytes","volume":"25","author":"Wagner","year":"2006","journal-title":"EMBO J."},{"key":"key\n\t\t\t\t20170522145942_DDP136C48","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1111\/j.1460-9568.2004.03249.x","article-title":"Glial fibrillary acidic protein gene promoter is differently modulated by transforming growth factor-beta 1 in astrocytes from distinct brain regions","volume":"19","author":"Sousa Vde","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C49","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/jnr.490190308","article-title":"Region-specific neuro-astroglial interactions: ultrastructural study of the in vitro expression of neuronal polarity","volume":"19","author":"Autillo-Touati","year":"1988","journal-title":"J. Neurosci. Res."},{"key":"key\n\t\t\t\t20170522145942_DDP136C50","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/glia.440010111","article-title":"Brain astrocytes express region-specific surface glycoproteins in culture","volume":"1","author":"Barbin","year":"1988","journal-title":"Glia"},{"key":"key\n\t\t\t\t20170522145942_DDP136C51","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrn1788","article-title":"Axon degeneration mechanisms: commonality amid diversity","volume":"6","author":"Coleman","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-2236(90)90065-I","article-title":"Astrocyte heterogeneity","volume":"13","author":"Wilkin","year":"1990","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C53","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/(SICI)1098-1136(199809)24:1<50::AID-GLIA6>3.0.CO;2-4","article-title":"Intercellular calcium signaling and gap junctional communication in astrocytes","volume":"24","author":"Giaume","year":"1998","journal-title":"Glia"},{"key":"key\n\t\t\t\t20170522145942_DDP136C54","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0165-3806(85)90135-X","article-title":"Motoneurone survival is induced by immature astrocytes from developing avian spinal cord","volume":"349","author":"Eagleson","year":"1985","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170522145942_DDP136C55","doi-asserted-by":"crossref","first-page":"7629","DOI":"10.1523\/JNEUROSCI.14-12-07629.1994","article-title":"Cell death of spinal motoneurons in the chick embryo following deafferentation: rescue effects of tissue extracts, soluble proteins, and neurotrophic agents","volume":"14","author":"Yin","year":"1994","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522145942_DDP136C56","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1210\/en.2005-0014","article-title":"Astrocyte-derived transforming growth factor-{beta} mediates the neuroprotective effects of 17{beta}-estradiol: involvement of nonclassical genomic signaling pathways","volume":"146","author":"Dhandapani","year":"2005","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170522145942_DDP136C57","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1086\/425287","article-title":"A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis","volume":"75","author":"Nishimura","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"key\n\t\t\t\t20170522145942_DDP136C58","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/brain\/113.2.347","article-title":"Hereditary motor system diseases (chronic juvenile amyotrophic lateral sclerosis). Conditions combining a bilateral pyramidal syndrome with limb and bulbar amyotrophy","volume":"113","author":"Ben Hamida","year":"1990","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522145942_DDP136C59","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0896-6273(02)00905-4","article-title":"Motoneuron death triggered by a specific pathway downstream of Fas. Potentiation by ALS-linked SOD1 mutations","volume":"35","author":"Raoul","year":"2002","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522145942_DDP136C60","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(03)00645-7","article-title":"The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1","volume":"40","author":"Krapivinsky","year":"2003","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522145942_DDP136C61","first-page":"207","volume-title":"Culturing Nerve Cells","author":"Goslin","year":"1991"},{"key":"key\n\t\t\t\t20170522145942_DDP136C62","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1634\/stemcells.2008-0371","article-title":"Directed evolution of motor neurons from genetically engineered neural precursors","volume":"26","author":"Bohl","year":"2008","journal-title":"Stem Cells"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/18\/12\/2127\/17246407\/ddp136.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T00:40:08Z","timestamp":1558226408000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddp136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3,20]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,3,20]]},"published-print":{"date-parts":[[2009,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddp136","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3,20]]}}}