{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T21:33:54Z","timestamp":1772832834683,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Molecular Genetics"],"published-print":{"date-parts":[[2009,6,15]]},"DOI":"10.1093\/hmg\/ddp163","type":"journal-article","created":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T20:34:17Z","timestamp":1238618057000},"page":"2277-2287","source":"Crossref","is-referenced-by-count":61,"title":["Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate"],"prefix":"10.1093","volume":"18","author":[{"given":"T.","family":"Maeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V.","family":"Cideciyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Maeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Golczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. S.","family":"Aleman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. G.","family":"Jacobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Palczewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,4,1]]},"reference":[{"issue":"6","key":"1_29926780","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.ajo.2007.08.022","volume":"144","author":"Stone","year":"2007","journal-title":"American journal of ophthalmology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9394","issn-type":"print"},{"issue":"4","key":"2_31557293","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.preteyeres.2008.05.003","volume":"27","author":"den Hollander","year":"2008","journal-title":"Progress in retinal and eye research","ISSN":"https:\/\/id.crossref.org\/issn\/1350-9462","issn-type":"print"},{"key":"3_28382590","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.pharmtox.47.120505.105225","volume":"47","year":"2007","journal-title":"Annual review of pharmacology and toxicology"},{"issue":"4","key":"4_6252069","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/3813","volume":"20","author":"Redmond","year":"1998","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"key":"5_6227011","first-page":"23","volume":"4","author":"Aguirre","year":"1998","journal-title":"Molecular vision [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1090-0535","issn-type":"print"},{"issue":"4","key":"6_18759101","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1167\/iovs.04-0653","volume":"46","author":"Znoiko","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"15","key":"7_30763683","doi-asserted-by":"publisher","first-page":"4008","DOI":"10.1523\/JNEUROSCI.0317-08.2008","volume":"28","author":"Zhang","year":"2008","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"6","key":"8_30505473","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.1167\/iovs.08-1727","volume":"49","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"2","key":"9_29618213","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/hmg\/ddm304","volume":"17","year":"2008","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"7","key":"10_33480650","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1093\/hmg\/ddp026","volume":"18","year":"2009","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"17","key":"12_19689255","doi-asserted-by":"publisher","first-page":"6177","DOI":"10.1073\/pnas.0500646102","volume":"102","year":"2005","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"38","key":"13_29400863","doi-asserted-by":"publisher","first-page":"15123","DOI":"10.1073\/pnas.0706367104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"14_33841247","first-page":"69","volume":"36","year":"2002","ISSN":"https:\/\/id.crossref.org\/issn\/1097-4199","issn-type":"print"},{"issue":"1","key":"15_11130557","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/88327","volume":"28","author":"Acland","year":"2001","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"6","key":"16_19676667","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1016\/j.ymthe.2005.08.008","volume":"12","author":"Acland","year":"2005","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"15","key":"17_19669825","doi-asserted-by":"publisher","first-page":"8623","DOI":"10.1073\/pnas.150236297","volume":"97","year":"2000","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"21","key":"18_19554673","doi-asserted-by":"publisher","first-page":"19173","DOI":"10.1074\/jbc.M112384200","volume":"277","year":"2002","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"21","key":"19_30958588","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1056\/NEJMoa0802315","volume":"358","year":"2008","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"21","key":"20_30958586","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1056\/NEJMoa0802268","volume":"358","year":"2008","journal-title":"New England Journal of Medicine","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"issue":"39","key":"22_31996272","doi-asserted-by":"publisher","first-page":"15112","DOI":"10.1073\/pnas.0807027105","volume":"105","year":"2008","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"11","key":"23_19511127","doi-asserted-by":"publisher","first-page":"e333","DOI":"10.1371\/journal.pmed.0020333","volume":"2","author":"Batten","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1277","issn-type":"print"},{"issue":"23","key":"24_19689652","doi-asserted-by":"publisher","first-page":"8162","DOI":"10.1073\/pnas.0503318102","volume":"102","year":"2005","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"51","key":"25_21147790","doi-asserted-by":"publisher","first-page":"42263","DOI":"10.1074\/jbc.M509351200","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"15","key":"26_30275354","doi-asserted-by":"publisher","first-page":"9543","DOI":"10.1074\/jbc.M708982200","volume":"283","year":"2008","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"4","key":"27_22372102","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1124\/mol.106.026823","volume":"70","year":"2006","journal-title":"Molecular Pharmacology","ISSN":"https:\/\/id.crossref.org\/issn\/0026-895X","issn-type":"print"},{"issue":"11","key":"28_19566575","doi-asserted-by":"publisher","first-page":"10422","DOI":"10.1074\/jbc.M312410200","volume":"279","year":"2004","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"29_23569020","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/0-387-32442-9_16","volume":"572","author":"Rohrer","year":"2006","journal-title":"Advances in experimental medicine and biology","ISSN":"https:\/\/id.crossref.org\/issn\/0065-2598","issn-type":"print"},{"issue":"10","key":"30_19433847","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.1167\/iovs.05-0533","volume":"46","author":"Rohrer","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"3","key":"31_21624207","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1167\/iovs.05-0965","volume":"47","author":"Chen","year":"2006","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"2","key":"32_23540997","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1167\/iovs.06-0652","volume":"48","author":"Wenzel","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"10","key":"33_23056558","doi-asserted-by":"publisher","first-page":"e347","DOI":"10.1371\/journal.pmed.0030347","volume":"3","author":"Bemelmans","year":"2006","ISSN":"https:\/\/id.crossref.org\/issn\/1549-1277","issn-type":"print"},{"issue":"10","key":"34_31247595","doi-asserted-by":"publisher","first-page":"4573","DOI":"10.1167\/iovs.08-2121","volume":"49","year":"2008","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"10","key":"35_22628534","doi-asserted-by":"publisher","first-page":"4540","DOI":"10.1167\/iovs.06-0215","volume":"47","author":"Maeda","year":"2006","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"1","key":"36_31718624","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1167\/iovs.08-2301","volume":"50","year":"2009","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"23","key":"37_19683848","doi-asserted-by":"publisher","first-page":"13662","DOI":"10.1073\/pnas.2234461100","volume":"100","year":"2003","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"3","key":"38_18024877","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1083\/jcb.200311079","volume":"164","year":"2004","journal-title":"The Journal of Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9525","issn-type":"print"},{"key":"39_34070382","first-page":"541","volume":"24","year":"1999","ISSN":"https:\/\/id.crossref.org\/issn\/1097-4199","issn-type":"print"},{"issue":"7","key":"40_29520375","doi-asserted-by":"publisher","first-page":"1940","DOI":"10.1111\/j.1460-9568.2007.05801.x","volume":"26","author":"Schonthaler","year":"2007","journal-title":"The European journal of neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0953-816X","issn-type":"print"},{"key":"41_30083664","doi-asserted-by":"crossref","first-page":"11715","DOI":"10.1021\/bi050942m","volume":"44","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"4","key":"43_18100511","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1167\/iovs.03-1230","volume":"45","author":"Aleman","year":"2004","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"key":"44_34899924","first-page":"516","volume":"17","year":"2008","journal-title":"Molecular therapy : the journal of the American Society of Gene Therapy","ISSN":"https:\/\/id.crossref.org\/issn\/1525-0016","issn-type":"print"},{"issue":"12","key":"46_6216095","first-page":"2405","volume":"39","author":"Huang","year":"1998","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"9","key":"47_17588950","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1093\/hmg\/ddg117","volume":"12","author":"Jacobson","year":"2003","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"10","key":"48_29938668","doi-asserted-by":"publisher","first-page":"4380","DOI":"10.1364\/OE.14.004380","volume":"14","author":"Zhang","year":"2006","ISSN":"https:\/\/id.crossref.org\/issn\/1094-4087","issn-type":"print"},{"issue":"15","key":"49_31589416","doi-asserted-by":"publisher","first-page":"11083","DOI":"10.1364\/OE.16.011083","volume":"16","author":"Fernandez","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1094-4087","issn-type":"print"},{"issue":"19","key":"50_31936045","doi-asserted-by":"publisher","first-page":"15149","DOI":"10.1364\/OE.16.015149","volume":"16","author":"Potsaid","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1094-4087","issn-type":"print"},{"issue":"21","key":"51_32207441","doi-asserted-by":"publisher","first-page":"16410","DOI":"10.1364\/OE.16.016410","volume":"16","author":"Gotzinger","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1094-4087","issn-type":"print"},{"issue":"25","key":"52_19670430","doi-asserted-by":"publisher","first-page":"13913","DOI":"10.1073\/pnas.250478897","volume":"97","year":"2000","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"49","key":"53_29929194","doi-asserted-by":"publisher","first-page":"19565","DOI":"10.1073\/pnas.0707477104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"11","key":"54_19500782","doi-asserted-by":"publisher","first-page":"4320","DOI":"10.1167\/iovs.05-0478","volume":"46","author":"Maeda","year":"2005","journal-title":"Investigative Ophthalmology & Visual Science","ISSN":"https:\/\/id.crossref.org\/issn\/0020-9988","issn-type":"print"},{"issue":"19","key":"55_19574322","doi-asserted-by":"publisher","first-page":"18822","DOI":"10.1074\/jbc.M501757200","volume":"280","year":"2005","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/18\/12\/2277\/1813674\/ddp163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T01:02:49Z","timestamp":1550538169000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddp163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4,1]]},"references-count":51,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2009,5,22]]},"published-print":{"date-parts":[[2009,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddp163","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,4,1]]}}}