{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:31:37Z","timestamp":1777555897338,"version":"3.51.4"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Molecular Genetics"],"published-print":{"date-parts":[[2010,2,15]]},"DOI":"10.1093\/hmg\/ddp531","type":"journal-article","created":{"date-parts":[[2009,12,17]],"date-time":"2009-12-17T04:47:17Z","timestamp":1261025237000},"page":"634-647","source":"Crossref","is-referenced-by-count":33,"title":["Specific saposin C deficiency: CNS impairment and acid \u00a0-glucosidase effects in the mouse"],"prefix":"10.1093","volume":"19","author":[{"given":"Y.","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Zamzow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kitatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Skelton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. T.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. V.","family":"Vorhees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. P.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. A.","family":"Hannun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. A.","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2009,12,16]]},"reference":[{"issue":"29","key":"1_16294737","doi-asserted-by":"publisher","first-page":"17312","DOI":"10.1074\/jbc.271.29.17312","volume":"271","author":"Qi","year":"1996","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"1","key":"2_6081582","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.1749-6632.1998.tb09667.x","volume":"845","author":"SANDHOFF","year":"1998","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"issue":"14","key":"3_4895233","doi-asserted-by":"crossref","first-page":"6588","DOI":"10.1016\/S0021-9258(18)68681-8","volume":"263","author":"Li","year":"1988","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"15","key":"4_31090752","doi-asserted-by":"publisher","first-page":"2345","DOI":"10.1093\/hmg\/ddn135","volume":"17","year":"2008","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"4","key":"5_5548447","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.1073\/pnas.87.4.1426","volume":"87","author":"Zhang","year":"1990","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"key":"6_30088022","doi-asserted-by":"crossref","first-page":"11544","DOI":"10.1021\/bi980785+","volume":"37","year":"1998","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"34","key":"7_19563073","doi-asserted-by":"publisher","first-page":"31918","DOI":"10.1074\/jbc.M302752200","volume":"278","year":"2003","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"1","key":"8_10185577","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01233949","volume":"19","author":"Rafi","year":"1993","journal-title":"Somatic cell and molecular genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0740-7750","issn-type":"print"},{"issue":"1","key":"9_10717814","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s004010050960","volume":"97","author":"P\u00a0\u00a0mpols","year":"1999","journal-title":"Acta neuropathologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6322","issn-type":"print"},{"issue":"1","key":"10_15507158","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1432-1033.1994.tb18844.x","volume":"222","author":"Zschoche","year":"1994","journal-title":"FEBS Journal","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2956","issn-type":"print"},{"key":"11_11006655","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0079-6603(00)66030-0","volume":"66","author":"Qi","year":"2001","journal-title":"Progress in nucleic acid research and molecular biology","ISSN":"https:\/\/id.crossref.org\/issn\/0079-6603","issn-type":"print"},{"issue":"24","key":"12_15514351","doi-asserted-by":"crossref","first-page":"16746","DOI":"10.1016\/S0021-9258(19)89454-1","volume":"269","author":"Qi","year":"1994","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"3","key":"13_5835992","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/S0014-5793(97)01302-1","volume":"417","author":"Harzer","year":"1997","journal-title":"FEBS Letters","ISSN":"https:\/\/id.crossref.org\/issn\/1873-3468","issn-type":"print"},{"issue":"2","key":"14_15511009","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1006\/abbi.1994.1248","volume":"311","author":"Azuma","year":"1994","journal-title":"Archives of Biochemistry and Biophysics","ISSN":"https:\/\/id.crossref.org\/issn\/1096-0384","issn-type":"print"},{"issue":"17","key":"15_15854066","doi-asserted-by":"publisher","first-page":"9953","DOI":"10.1074\/jbc.270.17.9953","volume":"270","author":"Salvioli","year":"1995","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"44","key":"16_29751063","doi-asserted-by":"publisher","first-page":"17394","DOI":"10.1073\/pnas.0704998104","volume":"104","year":"2007","journal-title":"PNAS","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8424","issn-type":"print"},{"issue":"1","key":"17_18510709","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.chemphyslip.2004.09.002","volume":"132","author":"You","year":"2004","journal-title":"Chemistry and Physics of Lipids","ISSN":"https:\/\/id.crossref.org\/issn\/1873-2941","issn-type":"print"},{"key":"18_35695433","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1021\/bi051944+","volume":"45","year":"2006","ISSN":"https:\/\/id.crossref.org\/issn\/1520-4995","issn-type":"print"},{"issue":"1","key":"19_17671443","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0003-9861(03)00219-4","volume":"415","author":"Wang","year":"2003","journal-title":"Archives of Biochemistry and Biophysics","ISSN":"https:\/\/id.crossref.org\/issn\/1096-0384","issn-type":"print"},{"issue":"12","key":"20_16221332","doi-asserted-by":"publisher","first-page":"6874","DOI":"10.1074\/jbc.271.12.6874","volume":"271","author":"Qin","year":"1996","journal-title":"Journal of Biological Chemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"issue":"3","key":"21_17156671","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S1096-7192(02)00040-9","volume":"76","author":"Qi","year":"2002","journal-title":"Molecular genetics and metabolism","ISSN":"https:\/\/id.crossref.org\/issn\/1096-7192","issn-type":"print"},{"issue":"6","key":"22_30024264","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1399-0004.2007.00899.x","volume":"72","author":"Tylki-Szymanska","year":"2007","journal-title":"Clinical genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9163","issn-type":"print"},{"key":"23_10022521","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-77377-8_1","volume":"181","author":"Gordon","year":"1992","journal-title":"Current topics in microbiology and immunology","ISSN":"https:\/\/id.crossref.org\/issn\/0070-217X","issn-type":"print"},{"issue":"2","key":"24_16417765","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1203\/00006450-199602000-00021","volume":"39","author":"Xu","year":"1996","journal-title":"Pediatric Research","ISSN":"https:\/\/id.crossref.org\/issn\/0031-3998","issn-type":"print"},{"issue":"1","key":"25_19426871","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1196\/annals.1344.021","volume":"1053","author":"CHU","year":"2005","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"key":"26_19458016","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev.cellbio.21.122303.120013","volume":"21","author":"Kolter","year":"2005","journal-title":"Annual review of cell and developmental biology","ISSN":"https:\/\/id.crossref.org\/issn\/1081-0706","issn-type":"print"},{"issue":"3","key":"27_15492051","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1006\/bbrc.1994.1612","volume":"200","author":"Klein","year":"1994","journal-title":"Biochemical and biophysical research communications","ISSN":"https:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"issue":"8","key":"28_23757910","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1093\/hmg\/ddm040","volume":"16","year":"2007","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"9","key":"29_11116643","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1093\/hmg\/10.9.927","volume":"10","author":"Hulkova","year":"2001","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"6","key":"30_16373122","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/hmg\/5.6.711","volume":"5","author":"Fujita","year":"1996","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"1-3","key":"31_18328312","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbalip.2004.08.011","volume":"1685","author":"Walkley","year":"2004","journal-title":"Biochimica et Biophysica Acta. Protein Structure and Molecular Enzymology","ISSN":"https:\/\/id.crossref.org\/issn\/0006-3002","issn-type":"print"},{"issue":"3","key":"32_21714356","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1254\/jphs.FMJ05004X3","volume":"100","author":"Morimura","year":"2006","journal-title":"Journal of pharmacological sciences","ISSN":"https:\/\/id.crossref.org\/issn\/1347-8613","issn-type":"print"},{"issue":"8","key":"33_19468071","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1161\/01.RES.0000185327.45463.A8","volume":"97","year":"2005","journal-title":"Circulation Research","ISSN":"https:\/\/id.crossref.org\/issn\/0009-7330","issn-type":"print"},{"key":"34_35112964","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1471-4159.2007.04822.x","volume":"103","year":"2007","journal-title":"Journal of neurochemistry","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3042","issn-type":"print"},{"issue":"Pt 3","key":"35_17867689","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1042\/BJ20030613","volume":"375","author":"Lloyd-Evans","year":"2003","journal-title":"The Biochemical journal","ISSN":"https:\/\/id.crossref.org\/issn\/0264-6021","issn-type":"print"},{"issue":"1","key":"36_19492555","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1371\/journal.pgen.0010081","volume":"1","author":"Ko","year":"2005","ISSN":"https:\/\/id.crossref.org\/issn\/1553-7390","issn-type":"print"},{"issue":"41","key":"37_18471515","doi-asserted-by":"publisher","first-page":"9117","DOI":"10.1523\/JNEUROSCI.2729-04.2004","volume":"24","author":"Sleat","year":"2004","journal-title":"Journal of Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/0270-6474","issn-type":"print"},{"issue":"21","key":"38_18477527","doi-asserted-by":"publisher","first-page":"2709","DOI":"10.1093\/hmg\/ddh281","volume":"13","year":"2004","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"3","key":"39_22543711","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00401-006-0092-6","volume":"112","author":"Rudelius","year":"2006","journal-title":"Acta neuropathologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6322","issn-type":"print"},{"issue":"4","key":"40_18624820","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s10048-004-0197-9","volume":"5","author":"Mannan","year":"2004","journal-title":"Neurogenetics","ISSN":"https:\/\/id.crossref.org\/issn\/1364-6745","issn-type":"print"},{"issue":"2","key":"41_31888434","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.expneurol.2008.07.026","volume":"214","author":"Macauley","year":"2008","journal-title":"Experimental neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4886","issn-type":"print"},{"issue":"2","key":"42_18619268","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.yexcr.2004.09.029","volume":"303","author":"Chu","year":"2005","journal-title":"Experimental cell research","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4827","issn-type":"print"},{"issue":"1","key":"43_5498248","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/BF02024331","volume":"149","author":"Harzer","year":"1989","journal-title":"European journal of pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6199","issn-type":"print"},{"issue":"1","key":"44_11137435","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/mrd.1007","volume":"59","author":"Morales","year":"2001","journal-title":"Molecular reproduction and development","ISSN":"https:\/\/id.crossref.org\/issn\/1040-452X","issn-type":"print"},{"issue":"1","key":"45_16060529","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/0022-510X(95)00124-K","volume":"132","author":"Wolfe","year":"1995","journal-title":"Journal of the neurological sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"issue":"2","key":"46_18184061","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.expneurol.2004.03.002","volume":"187","author":"Ohara","year":"2004","journal-title":"Experimental neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0014-4886","issn-type":"print"},{"issue":"1","key":"47_13633008","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/BF00688958","volume":"68","author":"Huxtable","year":"1985","journal-title":"Acta neuropathologica","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6322","issn-type":"print"},{"issue":"1","key":"48_9595132","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0022-510X(91)90208-O","volume":"104","author":"Walkley","year":"1991","journal-title":"Journal of the neurological sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0022-510X","issn-type":"print"},{"issue":"1","key":"49_28003522","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1196\/annals.1379.003","volume":"1097","author":"GRUTZENDLER","year":"2007","journal-title":"Annals of the New York Academy of Sciences","ISSN":"https:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"issue":"11","key":"50_19415915","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nrn1788","volume":"6","author":"Coleman","year":"2005","journal-title":"Nature reviews. Neuroscience","ISSN":"https:\/\/id.crossref.org\/issn\/1471-003X","issn-type":"print"},{"issue":"11","key":"51_11162728","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1093\/hmg\/10.11.1191","volume":"10","author":"Matsuda","year":"2001","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"2","key":"52_16680766","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/S0960-9822(06)00059-5","volume":"7","author":"Lewandoski","year":"1997","journal-title":"Current biology : CB","ISSN":"https:\/\/id.crossref.org\/issn\/0960-9822","issn-type":"print"},{"issue":"10","key":"53_19526910","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1194\/jlr.M500202-JLR200","volume":"46","year":"2005","journal-title":"The Journal of Lipid Research","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2275","issn-type":"print"},{"issue":"5","key":"54_17873695","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1016\/S0002-9440(10)63566-3","volume":"163","author":"Xu","year":"2003","journal-title":"American Journal Of Pathology","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"issue":"10","key":"55_19526910","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1194\/jlr.M500202-JLR200","volume":"46","year":"2005","journal-title":"The Journal of Lipid Research","ISSN":"https:\/\/id.crossref.org\/issn\/0022-2275","issn-type":"print"},{"issue":"2","key":"56_22441379","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.ymeth.2006.05.004","volume":"39","author":"Bielawski","year":"2006","journal-title":"Methods (San Diego, Calif.)","ISSN":"https:\/\/id.crossref.org\/issn\/1046-2023","issn-type":"print"},{"key":"57_31652640","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1471-2202-9-76","volume":"9","author":"Sun","year":"2008","journal-title":"BMC neuroscience [electronic resource]","ISSN":"https:\/\/id.crossref.org\/issn\/1471-2202","issn-type":"print"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/4\/634\/1672155\/ddp531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T05:45:51Z","timestamp":1634363151000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddp531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12,16]]},"references-count":57,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2010,1,15]]},"published-print":{"date-parts":[[2010,2,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddp531","relation":{},"ISSN":["0964-6906","1460-2083"],"issn-type":[{"value":"0964-6906","type":"print"},{"value":"1460-2083","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,12,16]]}}}