{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:12:21Z","timestamp":1790439141813,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,5,1]]},"DOI":"10.1093\/hmg\/ddq049","type":"journal-article","created":{"date-parts":[[2010,2,11]],"date-time":"2010-02-11T03:53:58Z","timestamp":1265860438000},"page":"1726-1740","source":"Crossref","is-referenced-by-count":25,"title":["Dok-7 promotes slow muscle integrity as well as neuromuscular junction formation in a zebrafish model of congenital myasthenic syndromes"],"prefix":"10.1093","volume":"19","author":[{"given":"Juliane S.","family":"M\u00fcller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine D.","family":"Jepson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven H.","family":"Laval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Bushby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Straub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Lochm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2,10]]},"reference":[{"key":"key\n\t\t\t\t20170522142507_DDQ049C1","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1126\/science.1127142","article-title":"The muscle protein Dok-7 is essential for neuromuscular synaptogenesis","volume":"312","author":"Okada","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0092-8674(00)81251-9","article-title":"The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo","volume":"85","author":"DeChiara","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/377232a0","article-title":"Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice","volume":"377","author":"Gautam","year":"1995","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C4","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0092-8674(00)81253-2","article-title":"Defective neuromuscular synaptogenesis in agrin-deficient mutant mice","volume":"85","author":"Gautam","year":"1996","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C5","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1093\/brain\/awm068","article-title":"Phenotypical spectrum of DOK7 mutations in congenital myasthenic syndromes","volume":"130","author":"M\u00fcller","year":"2007","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C6","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1126\/science.1130837","article-title":"Dok-7 mutations underlie a neuromuscular junction synaptopathy","volume":"313","author":"Beeson","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C7","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/brain\/awm072","article-title":"Clinical features of the DOK7 neuromuscular junction synaptopathy","volume":"130","author":"Palace","year":"2007","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/ana.21408","article-title":"Dok-7 myasthenia: phenotypic and molecular genetic studies in 16 patients","volume":"64","author":"Selcen","year":"2008","journal-title":"Ann. Neurol."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/mus.20944","article-title":"Variable phenotypes associated with mutations in DOK7","volume":"37","author":"Anderson","year":"2008","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C10","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1093\/brain\/awl200","article-title":"Pre- and post-synaptic abnormalities associated with impaired neuromuscular transmission in a group of patients with \u2018limb-girdle myasthenia","volume":"129","author":"Slater","year":"2006","journal-title":"Brain"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C11","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/jmg.2008.065425","article-title":"Germline mutation in DOK7 associated with fetal akinesia deformation sequence","volume":"46","author":"Vogt","year":"2009","journal-title":"J. Med. Genet."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C12","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1074\/jbc.M708607200","article-title":"Mutations causing DOK7 congenital myasthenia ablate functional motifs in Dok-7","volume":"283","author":"Hamuro","year":"2008","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C13","doi-asserted-by":"crossref","first-page":"ra7","DOI":"10.1126\/scisignal.2000113","article-title":"Dok-7 activates the muscle receptor kinase MuSK and shapes synapse formation","volume":"2","author":"Inoue","year":"2009","journal-title":"Sci. Signal."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C14","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1242\/dev.122.11.3371","article-title":"Identification of separate slow and fast muscle precursor cells in vivo, prior to somite formation","volume":"122","author":"Devoto","year":"1996","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C15","doi-asserted-by":"crossref","first-page":"4471","DOI":"10.1242\/dev.02044","article-title":"Neuromuscular synapses can form in vivo by incorporation of initially aneural postsynaptic specializations","volume":"132","author":"Flanagan-Steet","year":"2005","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C16","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ydbio.2005.06.027","article-title":"Neuromuscular synaptogenesis in wild-type and mutant zebrafish","volume":"285","author":"Panzer","year":"2005","journal-title":"Dev. Biol."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C17","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1523\/JNEUROSCI.3656-05.2006","article-title":"In vivo imaging of preferential motor axon outgrowth to and synaptogenesis at prepatterned acetylcholine receptor clusters in embryonic zebrafish skeletal muscle","volume":"26","author":"Panzer","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/35074025","article-title":"Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse","volume":"410","author":"Lin","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/aja.1002030302","article-title":"Stages of embryonic development of the zebrafish","volume":"203","author":"Kimmel","year":"1995","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C20","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1523\/JNEUROSCI.06-08-02267.1986","article-title":"Identified motoneurons and their innervation of axial muscles in the zebrafish","volume":"6","author":"Westerfield","year":"1986","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/320269a0","article-title":"Pathway selection by growth cones of identified motoneurones in live zebra fish embryos","volume":"320","author":"Eisen","year":"1986","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C22","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/(SICI)1097-4695(199812)37:4<622::AID-NEU10>3.0.CO;2-S","article-title":"Time course of the development of motor behaviors in the zebrafish embryo","volume":"37","author":"Saint-Amant","year":"1998","journal-title":"J. Neurobiol."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C23","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.neuron.2008.12.025","article-title":"Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged\/MuSK receptor","volume":"61","author":"Jing","year":"2009","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C24","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1073\/pnas.0610822104","article-title":"Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation","volume":"104","author":"Lefebvre","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/dvdy.20592","article-title":"Mutation in the delta-subunit of the nAChR suppresses the muscle defects caused by lack of Dystrophin","volume":"234","author":"Etard","year":"2005","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/dneu.20569","article-title":"The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability","volume":"68","author":"Saint-Amant","year":"2008","journal-title":"Dev. Neurobiol."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C27","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/nn1350","article-title":"Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice","volume":"7","author":"Zhang","year":"2004","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C28","doi-asserted-by":"crossref","first-page":"6491","DOI":"10.1523\/JNEUROSCI.22-15-06491.2002","article-title":"The Zebrafish motility mutant twitch once reveals new roles for rapsyn in synaptic function","volume":"22","author":"Ono","year":"2002","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C29","volume-title":"The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio)","author":"Westerfield","year":"2000"},{"key":"key\n\t\t\t\t20170522142507_DDQ049C30","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1745-7270.2007.00283.x","article-title":"Validation of zebrafish (Danio rerio) reference genes for quantitative real-time RT\u2013PCR normalization","volume":"39","author":"Tang","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"key":"key\n\t\t\t\t20170522142507_DDQ049C32","article-title":"High resolution whole-mount in situ hybridization","volume-title":"The Zebrafish Book. A Guide for the Laboratory Use of Zebrafish (Danio rerio)","author":"Thisse","year":"2000"}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/9\/1726\/13924620\/ddq049.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T17:00:26Z","timestamp":1634922026000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddq049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,10]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,2,10]]},"published-print":{"date-parts":[[2010,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddq049","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2,10]]}}}