{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:12:50Z","timestamp":1774447970495,"version":"3.50.1"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"DOI":"10.1093\/hmg\/ddq145","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T02:23:37Z","timestamp":1271125417000},"page":"2594-2605","source":"Crossref","is-referenced-by-count":47,"title":["Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis"],"prefix":"10.1093","volume":"19","author":[{"given":"Ryan F.L.","family":"O'Shaughnessy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishaan","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John I.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2010,4,12]]},"reference":[{"key":"key\n\t\t\t\t20170522162239_DDQ145C1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1525-1470.1983.tb01087.x","article-title":"The ichthyoses\u2013pathogenesis and prenatal diagnosis: a review of recent advances","volume":"1","author":"Williams","year":"1983","journal-title":"Pediatr. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C2","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1600-0625.2007.00691.x","article-title":"An update on molecular aspects of the non-syndromic ichthyoses","volume":"17","author":"Akiyama","year":"2008","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.2165\/00128071-200304020-00002","article-title":"Ichthyosis: etiology, diagnosis, and management","volume":"4","author":"DiGiovanna","year":"2003","journal-title":"Am. J. Clin. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C4","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng0395-279","article-title":"Mutations in the gene for transglutaminase 1 in autosomal recessive lamellar ichthyosis","volume":"9","author":"Russell","year":"1995","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nrm1619","article-title":"The cornified envelope: a model of cell death in the skin","volume":"6","author":"Candi","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C6","doi-asserted-by":"crossref","first-page":"8402","DOI":"10.1073\/pnas.96.15.8402","article-title":"A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation","volume":"96","author":"Nemes","year":"1999","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C7","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1038\/jid.2008.410","article-title":"Development of an ichthyosiform phenotype in Alox12b-deficient mouse skin transplants","volume":"129","author":"de Juanes","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1172\/JCI0213563","article-title":"Development of ichthyosiform skin compensates for defective permeability barrier function in mice lacking transglutaminase 1","volume":"109","author":"Kuramoto","year":"2002","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C9","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1038\/sj.jid.5700825","article-title":"A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier","volume":"127","author":"Moran","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C10","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000017902","article-title":"Efficacy of urea therapy in children with ichthyosis. A multicenter randomized, placebo-controlled, double-blind, semilateral study","volume":"196","author":"Kuster","year":"1998","journal-title":"Dermatology"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2133.1996.tb07936.x","article-title":"An appraisal of acitretin therapy in children with inherited disorders of keratinization","volume":"134","author":"Lacour","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C12","first-page":"837","article-title":"Acitretin-related ossification","volume":"34","author":"Rood","year":"2007","journal-title":"J. Rheumatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C13","first-page":"531","article-title":"Retinoid effects on epidermal structure, differentiation, and permeability","volume":"44","author":"Elias","year":"1981","journal-title":"Lab. Invest."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C14","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/1523-1747.ep12532899","article-title":"The growth and differentiation of cultured newborn rat keratinocytes","volume":"80","author":"Baden","year":"1983","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C15","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1242\/dev.037010","article-title":"Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development","volume":"136","author":"O'Shaughnessy","year":"2009","journal-title":"Development"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C16","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1038\/jid.2009.18","article-title":"Transglutaminase-1 and bathing suit ichthyosis: molecular analysis of gene\/environment interactions","volume":"129","author":"Aufenvenne","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C17","doi-asserted-by":"crossref","first-page":"26382","DOI":"10.1074\/jbc.270.44.26382","article-title":"Biochemical, structural, and transglutaminase substrate properties of human loricrin, the major epidermal cornified cell envelope protein","volume":"270","author":"Candi","year":"1995","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C18","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1074\/jbc.272.3.2021","article-title":"Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope","volume":"272","author":"Steinert","year":"1997","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00372011","article-title":"Modified epidermal lipid composition in air-exposed culture of non-bullous congenital ichthyotic erythroderma (NBCIE) keratinocytes","volume":"285","author":"Haftek","year":"1993","journal-title":"Arch. Dermatol. Res."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C20","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1001\/archderm.1993.01680260088013","article-title":"Analysis of the cornified cell envelope in lamellar ichthyosis","volume":"129","author":"Hohl","year":"1993","journal-title":"Arch. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C21","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2340\/000155557697101","article-title":"Flow-cytometric investigation of epidermal cell characteristics in monogenic disorders of keratinization and their modulation by topical calcipotriol treatment","volume":"76","author":"Lucker","year":"1996","journal-title":"Acta Derm. Venereol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1046\/j.1432-0436.1999.6520119.x","article-title":"The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis","volume":"65","author":"Rothnagel","year":"1999","journal-title":"Differentiation"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.burns.2005.08.017","article-title":"Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting","volume":"32","author":"Smiley","year":"2006","journal-title":"Burns"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C24","first-page":"197","article-title":"Altered expression of immunoreactive involucrin in lamellar ichthyosis","volume":"9","author":"Pena-Penabad","year":"1999","journal-title":"Eur. J. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C25","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1600-0536.2008.01320.x","article-title":"Lipids and skin barrier function\u2013a clinical perspective","volume":"58","author":"Jungersted","year":"2008","journal-title":"Contact Dermatitis."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1365-2133.1993.tb00222.x","article-title":"Barrier function regulates epidermal lipid and DNA synthesis","volume":"128","author":"Proksch","year":"1993","journal-title":"Br. J. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C27","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1111\/j.1600-0625.2008.00786.x","article-title":"The skin: an indispensable barrier","volume":"17","author":"Proksch","year":"2008","journal-title":"Exp. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0004017","article-title":"Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes","volume":"3","author":"Saaf","year":"2008","journal-title":"PLoS. One"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C29","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/1523-1747.ep12874591","article-title":"Potent inflammatory properties in human skin of interleukin-1 alpha-like material isolated from normal skin","volume":"94","author":"Camp","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C30","doi-asserted-by":"crossref","first-page":"108S","DOI":"10.1111\/1523-1747.ep12874966","article-title":"Leukocyte chemoattractant cytokines of the epidermis","volume":"95","author":"Camp","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C31","first-page":"1048","article-title":"Detection of interleukin-1 receptors in human epidermis. Induction of the type II receptor after organ culture and in psoriasis","volume":"145","author":"Groves","year":"1994","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C32","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0014-5793(91)81360-K","article-title":"Interleukin 1 receptor antagonist in human epidermis and cultured keratinocytes","volume":"294","author":"Gruaz-Chatellard","year":"1991","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C33","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI115896","article-title":"Interleukin-1 receptor antagonist in normal and psoriatic epidermis","volume":"90","author":"Hammerberg","year":"1992","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C34","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/1523-1747.ep12413597","article-title":"Occlusion lowers cytokine mRNA levels in essential fatty acid-deficient and normal mouse epidermis, but not after acute barrier disruption","volume":"103","author":"Wood","year":"1994","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C35","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/j.0022-202X.2005.23684.x","article-title":"Counter-regulation of interleukin-1alpha (IL-1alpha) and IL-1 receptor antagonist in murine keratinocytes","volume":"124","author":"Mee","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C36","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.bbalip.2007.02.004","article-title":"Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease","volume":"1771","author":"Michalik","year":"2007","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C37","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1083\/jcb.200809028","article-title":"Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta\/delta is essential for skin homeostasis and wound healing","volume":"184","author":"Chong","year":"2009","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C38","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1523-1747.2000.00076.x","article-title":"Keratinocyte differentiation in hyperproliferative epidermis: topical application of PPARalpha activators restores tissue homeostasis","volume":"115","author":"Komuves","year":"2000","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1101\/gad.1160904","article-title":"NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK","volume":"18","author":"Zhang","year":"2004","journal-title":"Genes. Dev."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/embor.2009.10","article-title":"Phosphorylation of NF-kappaB p65 at Ser458 controls its COMMD-dependent ubiquitination and target gene-specific proteosomal elimination","volume":"10","author":"Geng","year":"2009","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C41","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1101\/gad.1748409","article-title":"GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB\/RelA","volume":"23","author":"Mao","year":"2009","journal-title":"Genes Dev."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C42","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1073\/pnas.92.5.1714","article-title":"Soluble type II interleukin 1 (IL-1) receptor binds and block processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist","volume":"92","author":"Symons","year":"1995","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C43","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1242\/jcs.03392","article-title":"Suprabasal Dsg2 expression in transgenic mouse skin confers a hyperproliferative and apoptosis-resistant phenotype to keratinocytes","volume":"120","author":"Brennan","year":"2007","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C44","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.cell.2005.11.043","article-title":"p120-catenin mediates inflammatory responses in the skin","volume":"124","author":"Perez-Moreno","year":"2006","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522162239_DDQ145C45","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.jaad.2004.04.032","article-title":"Effect of a single course of isotretinoin therapy on bone mineral density in adolescent patients with severe, recalcitrant, nodular acne","volume":"51","author":"DiGiovanna","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C46","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1468-3083.2006.01598.x","article-title":"The effects of isotretinoin treatment on bone mineral density in patients with nodulocystic acne","volume":"20","author":"Erdogan","year":"2006","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jaad.2005.03.025","article-title":"Isotretinoin does have an adverse effect on bone mineral density","volume":"53","author":"Milstone","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C48","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/jcp.21784","article-title":"Retinoid-responsive transcriptional changes in epidermal keratinocytes","volume":"220","author":"Lee","year":"2009","journal-title":"J. Cell Physiol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C49","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00417713","article-title":"The antipsoriatic drug metabolite etretin (Ro 10-1670) alters the metabolism of fatty acids in human keratinocytes in culture","volume":"280","author":"Punnonen","year":"1988","journal-title":"Arch. Dermatol. Res."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C50","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/sj.jid.5700968","article-title":"Effects of topically applied acitretin in reconstructed human epidermis and the rhino mouse","volume":"128","author":"Hsia","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"key\n\t\t\t\t20170522162239_DDQ145C51","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","author":"Huang","year":"2009","journal-title":"Nat. Protoc."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/13\/2594\/13912080\/ddq145.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T19:04:53Z","timestamp":1711393493000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddq145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,12]]},"references-count":51,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2010,4,12]]},"published-print":{"date-parts":[[2010,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddq145","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4,12]]}}}