{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:24:37Z","timestamp":1792027477748,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"13","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7,1]]},"DOI":"10.1093\/hmg\/ddq146","type":"journal-article","created":{"date-parts":[[2010,4,13]],"date-time":"2010-04-13T20:34:11Z","timestamp":1271190851000},"page":"2606-2615","source":"Crossref","is-referenced-by-count":136,"title":["Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice"],"prefix":"10.1093","volume":"19","author":[{"given":"Zai-Long","family":"Chi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Akahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Obazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Minami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Tomarev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhide","family":"Kawase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuko","family":"Noda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Sasaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Takada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,4,13]]},"reference":[{"key":"key\n\t\t\t\t20170522152906_DDQ146C1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1136\/bjo.80.5.389","article-title":"Number of people with glaucoma worldwide","volume":"80","author":"Quigley","year":"1996","journal-title":"Br. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/bjo.2005.081224","article-title":"The number of people with glaucoma world wide in 2010 and 2020","volume":"90","author":"Quigley","year":"2006","journal-title":"Br. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C3","first-page":"1641","article-title":"The prevalence of primary open-angle glaucoma in Japanese: the Tajimi Study","volume":"111","author":"Iwase","year":"2004","journal-title":"Ophthalmology"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C4","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.275.5300.668","article-title":"Identification of a gene that causes primary open angle glaucoma","volume":"275","author":"Stone","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C5","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/hmg\/6.4.641","article-title":"Identification of three different truncating mutations in cytochrome P4501B1 (CYP1B1) as the principal cause of primary congenital glaucoma (buphthalmos) in families linked to the GLC3A locus on chromosome 2p21","volume":"6","author":"Stoilov","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C6","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C7","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/hmg\/ddi068","article-title":"Identification of a novel adult-onset primary open-angle glaucoma (POAG) gene on 5q22.1","volume":"14","author":"Monemi","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C8","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1167\/iovs.04-1133","article-title":"Clinical features and course of patients with glaucoma with the E50K mutation in the optineurin gene","volume":"46","author":"Aung","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C9","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1167\/iovs.02-0693","article-title":"Different optineurin mutation pattern in primary open-angle glaucoma","volume":"44","author":"Leung","year":"2003","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00061198-200408000-00007","article-title":"Molecular genetic analysis of optineurin gene for primary open-angle and normal tension glaucoma in the Japanese population","volume":"13","author":"Fuse","year":"2004","journal-title":"J. Glaucoma"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C11","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0002-9394(03)00577-4","article-title":"Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma","volume":"136","author":"Alward","year":"2003","journal-title":"Am. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/01.ijg.0000212255.17950.42","article-title":"Distribution of optineurin sequence variations in an ethnically diverse population of low-tension glaucoma patients from the United States","volume":"15","author":"Hauser","year":"2006","journal-title":"J. Glaucoma"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C13","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1167\/iovs.06-0834","article-title":"A glaucoma-associated mutant of optineurin selectively induces death of retinal ganglion cells which is inhibited by antioxidants","volume":"48","author":"Chalasani","year":"2007","journal-title":"Invest. Ophthal. Vis. Sci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C14","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/hmg\/7.9.1463","article-title":"Huntingtin interacts with a family of WW domain proteins","volume":"7","author":"Faber","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C15","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1093\/nar\/28.9.1986","article-title":"Identification of a transcription factor IIIA-interacting protein","volume":"28","author":"Moreland","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C16","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0960-9822(00)00864-2","article-title":"FIP-2, a coiled-coil protein, links Huntingtin to Rab8 and modulates cellular morphogenesis","volume":"10","author":"Hattula","year":"2000","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C17","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.2353\/ajpath.2006.060400","article-title":"Studies of optineurin, a glaucoma gene: Golgi fragmentation and cell death from overexpression of wild-type and mutant optineurin in two ocular cell types","volume":"169","author":"Park","year":"2006","journal-title":"Am. J. Pathol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.200501162","article-title":"Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis","volume":"169","author":"Sahlender","year":"2005","journal-title":"J. Cell. Biol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C19","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1101\/gr.3510505","article-title":"Cell-free cotranslation and selection using in vitro virus for high-throughput analysis of protein\u2013protein interactions and complexes","volume":"15","author":"Miyamoto-Sato","year":"2005","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C20","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1101\/gr.2334104","article-title":"Functional proteomics mapping of a human signaling pathway","volume":"14","author":"Colland","year":"2004","journal-title":"Genome Res."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C21","doi-asserted-by":"crossref","first-page":"34840","DOI":"10.1074\/jbc.M504508200","article-title":"Inhibition of metabotropic glutamate receptor signalling by the huntingtin binding protein optineurin","volume":"280","author":"Anborgh","year":"2005","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C22","doi-asserted-by":"crossref","first-page":"e5114","DOI":"10.1371\/journal.pone.0005114","article-title":"NF-kappaB mediates tumor necrosis factor alpha-induced expression of optineurin, a negative regulator of NF-kappaB","volume":"4","author":"Sudhakar","year":"2009","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C23","doi-asserted-by":"crossref","first-page":"e1000521","DOI":"10.1371\/journal.ppat.1000521","article-title":"NRP\/optineurin cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein","volume":"5","author":"Journo","year":"2009","journal-title":"PLoS Pathog."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C24","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1172\/JCI30178","article-title":"The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma","volume":"117","author":"Harada","year":"2007","journal-title":"J. Clin. Invest."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C25","doi-asserted-by":"crossref","first-page":"4359","DOI":"10.1167\/iovs.03-1403","article-title":"Variants in optineurin gene and their association with tumor necrosis factor-alpha polymorphisms in Japanese patients with glaucoma","volume":"45","author":"Funayama","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C26","first-page":"284","article-title":"Prevalence of myocilin and optineurin sequence variants in German normal tension glaucoma patients","volume":"11","author":"Weisschuh","year":"2005","journal-title":"Mol. Vis."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C27","first-page":"554","article-title":"Polymorphisms of myocilin and optineurin I primary open-angle glaucoma patients","volume":"86","author":"Yao","year":"2006","journal-title":"Zhonghua Yi Xue Za Zhi."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C28","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C29","doi-asserted-by":"crossref","first-page":"11903","DOI":"10.1523\/JNEUROSCI.3020-06.2006","article-title":"Expression of mutated mouse myocilin induces open-angle glaucoma in transgenic mice","volume":"26","author":"Senatorov","year":"2006","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C30","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1167\/iovs.07-1339","article-title":"Transgenic mice expressing the Tyr437His mutant of human myocilin protein develop glaucoma","volume":"49","author":"Zhou","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C31","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/bjo.86.2.238","article-title":"The definition and classification of glaucoma in prevalence surveys","volume":"86","author":"Foster","year":"2002","journal-title":"Br. J. Ophthalmol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/35052055","article-title":"Rab proteins as membrane organizers","volume":"2","author":"Zerial","year":"2001","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C33","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.123.1.35","article-title":"Rab8, a small GTPase involved in vesicular traffic between the TGN and the basolateral plasma membrane","volume":"123","author":"Huber","year":"1993","journal-title":"J. Cell. Biol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C34","doi-asserted-by":"crossref","first-page":"16147","DOI":"10.1074\/jbc.M601467200","article-title":"Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus","volume":"281","author":"De Marco","year":"2006","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C35","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1091\/mbc.E08-07-0726","article-title":"Mutant huntingtin impairs post-Golgi trafficking to lysosomes by delocalizing optineurin\/Rab8 complex from the Golgi apparatus","volume":"20","author":"del Toro","year":"2009","journal-title":"Mol. Biol. Cell."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C36","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1091\/mbc.12.8.2341","article-title":"Mutant rab8 impairs docking and fusion of rhodopsin-bearing post-Golgi membranes and causes cell death of transgenic Xenopus rods","volume":"12","author":"Moritz","year":"2001","journal-title":"Mol. Biol. Cell."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C37","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/nature05929","article-title":"The Rab8 GTPase regulates apical protein localization in intestinal cells","volume":"448","author":"Sato","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C38","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.cell.2007.03.053","article-title":"A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis","volume":"129","author":"Nachury","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522152906_DDQ146C39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1083\/jcb.200506099","article-title":"Retinal ganglion cell degeneration is topological but not cell type specific in DBA\/2J mice","volume":"171","author":"Jakobs","year":"2005","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522152906_DDQ146C40","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1083\/jcb.200706181","article-title":"Axons of retinal ganglion cells are insulted in the optic nerve early in DBA\/2J glaucoma","volume":"179","author":"Howell","year":"2007","journal-title":"J. Cell Biol."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/13\/2606\/17249227\/ddq146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:06:08Z","timestamp":1503446768000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddq146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,13]]},"references-count":40,"journal-issue":{"issue":"13","published-online":{"date-parts":[[2010,4,13]]},"published-print":{"date-parts":[[2010,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddq146","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4,13]]}}}