{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:39:59Z","timestamp":1793036399991,"version":"4.5.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8,15]]},"DOI":"10.1093\/hmg\/ddq226","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T20:13:35Z","timestamp":1275768815000},"page":"3159-3168","source":"Crossref","is-referenced-by-count":121,"title":["PTEN depletion rescues axonal growth defect and improves survival in SMN-deficient motor neurons"],"prefix":"10.1093","volume":"19","author":[{"given":"Ke","family":"Ning","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Drepper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara F.","family":"Valori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansoor","family":"Ahsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wyles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Higginbottom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mimoun","family":"Azzouz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sendtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,6,4]]},"reference":[{"key":"key\n\t\t\t\t20170522130020_DDQ226C1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrn2670","article-title":"Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick?","volume":"10","author":"Burghes","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0092-8674(95)90460-3","article-title":"Identification and characterization of a spinal muscular atrophy-determining gene","volume":"80","author":"Lefebvre","year":"1995","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C3","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1083\/jcb.200303168","article-title":"Knockdown of the survival motor neuron (Smn) protein in zebrafish causes defects in motor axon outgrowth and pathfinding","volume":"162","author":"McWhorter","year":"2003","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C4","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1083\/jcb.200304128","article-title":"Smn, the spinal muscular atrophy-determining gene product, modulates axon growth and localization of beta-actin mRNA in growth cones of motoneurons","volume":"163","author":"Rossoll","year":"2003","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/neu.10313","article-title":"Axonal defects in mouse models of motoneuron disease","volume":"58","author":"Jablonka","year":"2004","journal-title":"J. Neurobiol."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C6","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1523\/JNEUROSCI.4434-08.2009","article-title":"Impaired synaptic vesicle release and immaturity of neuromuscular junctions in spinal muscular atrophy mice","volume":"29","author":"Kong","year":"2009","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C7","doi-asserted-by":"crossref","first-page":"20693","DOI":"10.1074\/jbc.274.29.20693","article-title":"PTEN interactions with focal adhesion kinase and suppression of the extracellular matrix-dependent phosphatidylinositol 3-kinase\/Akt cell survival pathway","volume":"274","author":"Tamura","year":"1999","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C8","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1523\/JNEUROSCI.20-04-01404.2000","article-title":"A role for nuclear PTEN in neuronal differentiation","volume":"20","author":"Lachyankar","year":"2000","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C9","first-page":"1820","article-title":"Differential expression of MMAC\/PTEN in glioblastoma multiforme: relationship to localization and prognosis","volume":"59","author":"Sano","year":"1999","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jcb.10312","article-title":"PTEN regulation of neural development and CNS stem cells","volume":"88","author":"Li","year":"2003","journal-title":"J. Cell Biochem."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C11","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1006\/mcne.2002.1115","article-title":"PTEN in neural precursor cells: regulation of migration, apoptosis, and proliferation","volume":"20","author":"Li","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C13","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1042\/BST0331507","article-title":"The regulation of cell migration by PTEN","volume":"33","author":"Leslie","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C14","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/ng781","article-title":"Pten regulates neuronal soma size: a mouse model of Lhermitte\u2013Duclos disease","volume":"29","author":"Kwon","year":"2001","journal-title":"Nat. Genet."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C15","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1126\/science.1065518","article-title":"Negative regulation of neural stem\/progenitor cell proliferation by the Pten tumor suppressor gene in vivo","volume":"294","author":"Groszer","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2006.03.023","article-title":"Pten regulates neuronal arborization and social interaction in mice","volume":"50","author":"Kwon","year":"2006","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C17","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0006-8993(02)03366-8","article-title":"Enhanced phosphorylation of PTEN in rat brain after transient middle cerebral artery occlusion","volume":"954","author":"Omori","year":"2002","journal-title":"Brain Res."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1385\/NMM:2:3:261","article-title":"PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis","volume":"2","author":"Gary","year":"2002","journal-title":"Neuromol. Med."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C19","doi-asserted-by":"crossref","first-page":"4052","DOI":"10.1523\/JNEUROSCI.5449-03.2004","article-title":"Dual neuroprotective signaling mediated by downregulating two distinct phosphatase activities of PTEN","volume":"24","author":"Ning","year":"2004","journal-title":"J. Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/hmg\/ddi078","article-title":"SMNDelta7, the major product of the centromeric survival motor neuron (SMN2) gene, extends survival in mice with spinal muscular atrophy and associates with full-length SMN","volume":"14","author":"Le","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1126\/science.1068999","article-title":"A system for stable expression of short interfering RNAs in mammalian cells","volume":"296","author":"Brummelkamp","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/83960","article-title":"Specific function of B-Raf in mediating survival of embryonic motoneurons and sensory neurons","volume":"4","author":"Wiese","year":"2001","journal-title":"Nat. Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1083\/jcb.200703187","article-title":"Defective Ca2+ channel clustering in axon terminals disturbs excitability in motoneurons in spinal muscular atrophy","volume":"179","author":"Jablonka","year":"2007","journal-title":"J. Cell Biol."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0896-6273(01)00357-9","article-title":"Neurotrophin-induced transport of a beta-actin mRNP complex increases beta-actin levels and stimulates growth cone motility","volume":"31","author":"Zhang","year":"2001","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C25","doi-asserted-by":"crossref","first-page":"27734","DOI":"10.1074\/jbc.M109.008177","article-title":"Specification of neuronal polarity regulated by local translation of CRMP2 and Tau via the mTOR-p70S6K pathway","volume":"284","author":"Morita","year":"2009","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C26","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.1038\/onc.2008.239","article-title":"PTEN signaling in brain: neuropathology and tumorigenesis","volume":"27","author":"Endersby","year":"2008","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170522130020_DDQ226C27","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.tins.2007.08.006","article-title":"Phosphatase PTEN in neuronal injury and brain disorders","volume":"30","author":"Chang","year":"2007","journal-title":"Trends Neurosci."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C28","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1128\/JVI.77.16.8957-8951.2003","article-title":"Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference","volume":"77","author":"Wiznerowicz","year":"2003","journal-title":"J. Virol."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1089\/10430340050016256","article-title":"Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease","volume":"11","author":"D\u00e9glon","year":"2000","journal-title":"Hum. Gene Ther."},{"key":"key\n\t\t\t\t20170522130020_DDQ226C30","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/nm1085","article-title":"Systemic delivery of genes to striated muscles using adeno-associated viral vectors","volume":"10","author":"Gregorevic","year":"2004","journal-title":"Nat. Med."}],"container-title":["Human Molecular Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/hmg\/article-pdf\/19\/16\/3159\/13909262\/ddq226.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T17:36:27Z","timestamp":1559151387000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/hmg\/article-lookup\/doi\/10.1093\/hmg\/ddq226"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,4]]},"references-count":30,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2010,6,4]]},"published-print":{"date-parts":[[2010,8,15]]}},"URL":"https:\/\/doi.org\/10.1093\/hmg\/ddq226","relation":{},"ISSN":["1460-2083","0964-6906"],"issn-type":[{"value":"1460-2083","type":"electronic"},{"value":"0964-6906","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6,4]]}}}